{"id":"https://openalex.org/W4394969667","doi":"https://doi.org/10.1097/moh.0000000000000819","title":"The impact of obesity-induced inflammation on clonal hematopoiesis","display_name":"The impact of obesity-induced inflammation on clonal hematopoiesis","publication_year":2024,"publication_date":"2024-04-19","ids":{"openalex":"https://openalex.org/W4394969667","doi":"https://doi.org/10.1097/moh.0000000000000819","pmid":"https://pubmed.ncbi.nlm.nih.gov/38640133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11197996"},"language":"en","primary_location":{"id":"doi:10.1097/moh.0000000000000819","doi":"https://doi.org/10.1097/moh.0000000000000819","is_oa":false,"landing_page_url":"https://doi.org/10.1097/moh.0000000000000819","pdf_url":null,"source":{"id":"https://openalex.org/S15004046","display_name":"Current Opinion in Hematology","issn_l":"1065-6251","issn":["1065-6251","1080-8213","1531-7048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11197996/pdf/nihms-1999053.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018541250","display_name":"Santhosh Kumar Pasupuleti","orcid":"https://orcid.org/0000-0001-5770-7187","observed_orcids":["https://orcid.org/0000-0001-5770-7187"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Santhosh Kumar Pasupuleti","raw_affiliation_strings":["Herman B Wells Center for Pediatric Research, Department of Pediatrics","to Santhosh Kumar Pasupuleti, PhD, Assistant Research Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-169, Indianapolis, IN 46202, USA. Tel: +1 317 274 0303"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B Wells Center for Pediatric Research, Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"to Santhosh Kumar Pasupuleti, PhD, Assistant Research Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W. Walnut Street, R4-169, Indianapolis, IN 46202, USA. Tel: +1 317 274 0303","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035841414","display_name":"Reuben Kapur","orcid":"https://orcid.org/0000-0003-2225-1700","observed_orcids":["https://orcid.org/0000-0003-2225-1700","https://orcid.org/0009-0008-1025-5126"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reuben Kapur","raw_affiliation_strings":["Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA","Herman B Wells Center for Pediatric Research, Department of Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Herman B Wells Center for Pediatric Research, Department of Pediatrics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018541250"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":null,"apc_paid":null,"fwci":0.7934,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62906611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"4","first_page":"193","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":0.9700000286102295},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"myeloid leukemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/waist-to-hip-ratio","display_name":"waist-to-hip ratio","score":0.8619999885559082},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.453000009059906},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.640999972820282},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7515628337860107},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6550164818763733},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.47628775238990784},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39889708161354065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3456684947013855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33979639410972595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2288210690021515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18184080719947815},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.13050222396850586}],"mesh":[{"descriptor_ui":"D000082182","descriptor_name":"Clonal Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/moh.0000000000000819","doi":"https://doi.org/10.1097/moh.0000000000000819","is_oa":false,"landing_page_url":"https://doi.org/10.1097/moh.0000000000000819","pdf_url":null,"source":{"id":"https://openalex.org/S15004046","display_name":"Current Opinion in Hematology","issn_l":"1065-6251","issn":["1065-6251","1080-8213","1531-7048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Hematology","raw_type":"journal-article"},{"id":"pmid:38640133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38640133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in hematology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11197996","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11197996","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11197996/pdf/nihms-1999053.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Hematol","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/43347","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/43347","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/354121da-7a4a-4a8f-ba94-5b2344edcb85/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11197996","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11197996","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11197996/pdf/nihms-1999053.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Hematol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1799403042","display_name":"Targeting Novel Pathways in JMML","funder_award_id":"R01HL146137","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5370055700","display_name":"Role of Shp2 in FLT3-ITD induced leukemogenesis","funder_award_id":"R01CA134777","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G541845018","display_name":"Hyperglycemia mediated myeloproliferative disease","funder_award_id":"R01HL140961","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000870434","display_name":"Role of p21 activated kinase in Leukemogenesis","funder_award_id":"R01CA173852","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000906626","display_name":"Hematopoietic stem and progenitor cell regulation for enhanced clinical efficacy","funder_award_id":"U54DK106846","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000918645","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant","funder_award_id":"P30CA082709","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320316717","display_name":"Riley Children's Foundation","ror":"https://ror.org/03sabpy05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394969667.pdf","grobid_xml":"https://content.openalex.org/works/W4394969667.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W173084735","https://openalex.org/W1513833217","https://openalex.org/W1926757141","https://openalex.org/W1933999406","https://openalex.org/W1963825693","https://openalex.org/W1964381719","https://openalex.org/W1984460413","https://openalex.org/W1992371348","https://openalex.org/W1999249928","https://openalex.org/W2007324841","https://openalex.org/W2018591383","https://openalex.org/W2020937563","https://openalex.org/W2023392000","https://openalex.org/W2030778616","https://openalex.org/W2034825007","https://openalex.org/W2053712883","https://openalex.org/W2069295502","https://openalex.org/W2082151578","https://openalex.org/W2096112294","https://openalex.org/W2106427090","https://openalex.org/W2123018120","https://openalex.org/W2126816979","https://openalex.org/W2143757227","https://openalex.org/W2149858388","https://openalex.org/W2156882950","https://openalex.org/W2159082795","https://openalex.org/W2206373663","https://openalex.org/W2261405626","https://openalex.org/W2324976104","https://openalex.org/W2415267894","https://openalex.org/W2510411424","https://openalex.org/W2518579383","https://openalex.org/W2628145035","https://openalex.org/W2745259295","https://openalex.org/W2762208322","https://openalex.org/W2787334626","https://openalex.org/W2790610652","https://openalex.org/W2791941924","https://openalex.org/W2905501602","https://openalex.org/W2909892147","https://openalex.org/W2913323072","https://openalex.org/W2935860497","https://openalex.org/W2963102805","https://openalex.org/W2972427995","https://openalex.org/W2984667130","https://openalex.org/W3003265560","https://openalex.org/W3008279587","https://openalex.org/W3095611843","https://openalex.org/W3138449921","https://openalex.org/W3194236970","https://openalex.org/W3196419038","https://openalex.org/W3199343829","https://openalex.org/W3214447846","https://openalex.org/W4293677274","https://openalex.org/W4365145093","https://openalex.org/W4366235880","https://openalex.org/W4383872780","https://openalex.org/W4385264186","https://openalex.org/W4391542949"],"related_works":["https://openalex.org/W4366235880","https://openalex.org/W4380364230","https://openalex.org/W3211577069","https://openalex.org/W4390792714","https://openalex.org/W4389741694","https://openalex.org/W7147675299","https://openalex.org/W4383303048","https://openalex.org/W3126263753","https://openalex.org/W48950785","https://openalex.org/W3161869643"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3,74],"review":[4],"meticulously":[5],"delves":[6],"into":[7,42,168],"existing":[8],"literature":[9],"and":[10,20,48,83,100,123,134,145,151,156],"recent":[11,166],"findings":[12],"to":[13,32,64,173],"elucidate":[14],"the":[15,78,89,110,130,182],"intricate":[16,183],"link":[17,131],"between":[18,121,132,143],"obesity":[19,133,144],"clonal":[21,28,186],"hematopoiesis":[22],"of":[23,36,80,91,112,185],"indeterminate":[24],"potential":[25,43],"(CHIP)":[26],"associated":[27],"hematopoiesis.":[29,187],"It":[30],"aims":[31],"enhance":[33],"our":[34],"comprehension":[35],"this":[37],"multifaceted":[38],"association,":[39],"offering":[40,176],"insights":[41,54,167],"avenues":[44],"for":[45,178],"future":[46,179],"research":[47,116],"therapeutic":[49],"interventions.":[50],"RECENT":[51],"FINDINGS:":[52],"Recent":[53,137],"reveal":[55],"that":[56],"mutations":[57],"in":[58,71,109,148,160,181],"CHIP-associated":[59,92,170],"genes":[60],"are":[61,68],"not":[62],"limited":[63],"symptomatic":[65],"patients":[66],"but":[67],"also":[69],"present":[70],"asymptomatic":[72],"individuals.":[73,162],"section":[75],"focuses":[76],"on":[77,88],"impact":[79],"obesity-induced":[81,174],"inflammation":[82],"fatty":[84],"bone":[85],"marrow":[86],"(FBM)":[87],"development":[90],"diseases.":[93],"Common":[94],"comorbidities":[95],"such":[96],"as":[97],"obesity,":[98],"diabetes,":[99],"infection,":[101],"fostering":[102],"pro-inflammatory":[103],"environments,":[104],"play":[105],"a":[106,118,140],"pivotal":[107],"role":[108],"acceleration":[111],"these":[113],"pathologies.":[114],"Our":[115],"underscores":[117],"notable":[119],"association":[120],"CHIP":[122],"an":[124],"increased":[125,154],"waist-to-hip":[126],"ratio":[127],"(WHR),":[128],"emphasizing":[129],"myeloid":[135,146],"leukemia.":[136],"studies":[138,180],"highlight":[139],"strong":[141],"correlation":[142],"leukemias":[147],"both":[149],"children":[150],"adults,":[152],"with":[153],"risks":[155],"poorer":[157],"survival":[158],"outcomes":[159],"overweight":[161],"SUMMARY:":[163],"We":[164],"discuss":[165],"how":[169],"pathologies":[171],"respond":[172],"inflammation,":[175],"implications":[177],"field":[184]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-20T00:00:00"}