{"id":"https://openalex.org/W4394966252","doi":"https://doi.org/10.17116/anaesthesiology2024021114","title":"Biomarkers of intestinal wall damage in multiple organ dysfunction syndrome","display_name":"Biomarkers of intestinal wall damage in multiple organ dysfunction syndrome","publication_year":2024,"publication_date":"2024-04-19","ids":{"openalex":"https://openalex.org/W4394966252","doi":"https://doi.org/10.17116/anaesthesiology2024021114"},"language":"en","primary_location":{"id":"doi:10.17116/anaesthesiology2024021114","doi":"https://doi.org/10.17116/anaesthesiology2024021114","is_oa":false,"landing_page_url":"https://doi.org/10.17116/anaesthesiology2024021114","pdf_url":null,"source":{"id":"https://openalex.org/S4210183675","display_name":"Russian Journal of Anesthesiology and Reanimatology","issn_l":"0201-7563","issn":["0201-7563","2410-4698"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321066","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310321066"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Anesthesiology and Reanimatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032732468","display_name":"Yermek Meiramovich Turgunov","orcid":"https://orcid.org/0000-0002-6486-3847","observed_orcids":["https://orcid.org/0000-0002-6486-3847"]},"institutions":[{"id":"https://openalex.org/I4210115547","display_name":"Karaganda Medical University","ror":"https://ror.org/024cz2s53","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210115547"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"Ye.M. Turgunov","raw_affiliation_strings":["Karaganda Medical University"],"raw_orcid":"https://orcid.org/0000-0002-6486-3847","affiliations":[{"raw_affiliation_string":"Karaganda Medical University","institution_ids":["https://openalex.org/I4210115547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075080690","display_name":"Alina V. Ogizbayeva","orcid":"https://orcid.org/0000-0003-1006-1870","observed_orcids":["https://orcid.org/0000-0003-1006-1870"]},"institutions":[{"id":"https://openalex.org/I4210115547","display_name":"Karaganda Medical University","ror":"https://ror.org/024cz2s53","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210115547"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"A.V. Ogizbayeva","raw_affiliation_strings":["Karaganda Medical University"],"raw_orcid":"https://orcid.org/0000-0003-1006-1870","affiliations":[{"raw_affiliation_string":"Karaganda Medical University","institution_ids":["https://openalex.org/I4210115547"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018672307","display_name":"Miras Mugazov","orcid":"https://orcid.org/0000-0002-7739-8999","observed_orcids":["https://orcid.org/0000-0002-7739-8999"]},"institutions":[{"id":"https://openalex.org/I4210115547","display_name":"Karaganda Medical University","ror":"https://ror.org/024cz2s53","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210115547"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"M.M. Mugazov","raw_affiliation_strings":["Karaganda Medical University"],"raw_orcid":"https://orcid.org/0000-0002-7739-8999","affiliations":[{"raw_affiliation_string":"Karaganda Medical University","institution_ids":["https://openalex.org/I4210115547"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054996216","display_name":"Sofiko Asamidanova","orcid":"https://orcid.org/0000-0002-9819-3079","observed_orcids":["https://orcid.org/0000-0002-9819-3079"]},"institutions":[{"id":"https://openalex.org/I4210115547","display_name":"Karaganda Medical University","ror":"https://ror.org/024cz2s53","country_code":"KZ","type":"education","lineage":["https://openalex.org/I4210115547"]}],"countries":["KZ"],"is_corresponding":false,"raw_author_name":"S.G. Asamidanova","raw_affiliation_strings":["Karaganda Medical University"],"raw_orcid":"https://orcid.org/0000-0002-9819-3079","affiliations":[{"raw_affiliation_string":"Karaganda Medical University","institution_ids":["https://openalex.org/I4210115547"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115547"],"apc_list":null,"apc_paid":null,"fwci":0.8286,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68306906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":"2","first_page":"114","last_page":"114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.9660000205039978},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.9200000166893005},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9539999961853027},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7919999957084656},{"id":"https://openalex.org/keywords/zonulin","display_name":"zonulin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intestinal-fatty-acid-binding-protein","display_name":"intestinal fatty acid binding protein","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reg3a","display_name":"REG3A","score":0.8870000243186951},{"id":"https://openalex.org/keywords/citrulline","display_name":"citrulline","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2780835948","wikidata":"https://www.wikidata.org/wiki/Q1193870","display_name":"Multiple organ dysfunction syndrome","level":3,"score":0.6162973642349243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49099233746528625},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.478786826133728},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4035266935825348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3271907567977905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29762762784957886},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.07214391231536865}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17116/anaesthesiology2024021114","doi":"https://doi.org/10.17116/anaesthesiology2024021114","is_oa":false,"landing_page_url":"https://doi.org/10.17116/anaesthesiology2024021114","pdf_url":null,"source":{"id":"https://openalex.org/S4210183675","display_name":"Russian Journal of Anesthesiology and Reanimatology","issn_l":"0201-7563","issn":["0201-7563","2410-4698"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321066","host_organization_name":"Meditsina","host_organization_lineage":["https://openalex.org/P4310321066"],"host_organization_lineage_names":["Meditsina"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Anesthesiology and Reanimatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1605506716","https://openalex.org/W1988279036","https://openalex.org/W1995084062","https://openalex.org/W1995964031","https://openalex.org/W2010507197","https://openalex.org/W2016171397","https://openalex.org/W2018116362","https://openalex.org/W2018247592","https://openalex.org/W2063897043","https://openalex.org/W2073241389","https://openalex.org/W2074535574","https://openalex.org/W2112724457","https://openalex.org/W2296126905","https://openalex.org/W2302902092","https://openalex.org/W2319413424","https://openalex.org/W2532623505","https://openalex.org/W2558803112","https://openalex.org/W2613906711","https://openalex.org/W2736357751","https://openalex.org/W2748404087","https://openalex.org/W2761612793","https://openalex.org/W2767875510","https://openalex.org/W2794334679","https://openalex.org/W2800825250","https://openalex.org/W2807650575","https://openalex.org/W2815658273","https://openalex.org/W2883272774","https://openalex.org/W2886776552","https://openalex.org/W2887788105","https://openalex.org/W2894429885","https://openalex.org/W2909802429","https://openalex.org/W2939020962","https://openalex.org/W2944202799","https://openalex.org/W2969786980","https://openalex.org/W2974348637","https://openalex.org/W2981466509","https://openalex.org/W2981776153","https://openalex.org/W2991131818","https://openalex.org/W3003833992","https://openalex.org/W3009072071","https://openalex.org/W3010869934","https://openalex.org/W3029420556","https://openalex.org/W3161415320","https://openalex.org/W3169168293","https://openalex.org/W3174686567","https://openalex.org/W3193088599","https://openalex.org/W3207256610","https://openalex.org/W3213590744","https://openalex.org/W3214780384","https://openalex.org/W4206557664","https://openalex.org/W4214759086","https://openalex.org/W4307264903","https://openalex.org/W4310230928","https://openalex.org/W4311376069","https://openalex.org/W4366774069","https://openalex.org/W4367182300","https://openalex.org/W4389494402"],"related_works":["https://openalex.org/W2319413424","https://openalex.org/W4403825557","https://openalex.org/W4407784568","https://openalex.org/W4312628242","https://openalex.org/W2981776153","https://openalex.org/W4379981138","https://openalex.org/W2165018613","https://openalex.org/W7103142640","https://openalex.org/W2412232461","https://openalex.org/W2053338950"],"abstract_inverted_index":{"Increased":[0],"intestinal":[1,20,32,58,68,72],"wall":[2,69],"permeability":[3],"and":[4,17,37,48,61,78,101,113],"impaired":[5],"barrier":[6,59],"function":[7],"in":[8],"ICU":[9],"patients":[10,95],"are":[11,90],"due":[12],"to":[13,40,55],"microcirculation":[14],"disorders,":[15],"ischemia":[16],"hypoxia":[18],"of":[19,57,67,99],"wall.":[21],"As":[22],"a":[23],"result,":[24],"bacteria":[25],"and/or":[26],"their":[27],"endotoxins":[28],"penetrate":[29],"the":[30,62],"damaged":[31],"wall,":[33],"enhance":[34],"immune":[35],"response":[36],"can":[38,110],"lead":[39],"systemic":[41],"inflammation,":[42],"multiple":[43],"organ":[44],"dysfunction":[45],"syndrome,":[46],"sepsis":[47],"even":[49],"death.":[50],"This":[51],"review":[52],"is":[53],"devoted":[54],"mechanisms":[56],"disruption":[60],"most":[63],"effective":[64],"serum":[65],"biomarkers":[66,89],"damage:":[70],"zonulin,":[71],"fatty":[73],"acid":[74],"binding":[75],"protein":[76],"(I-FABP)":[77],"regenerating":[79],"islet-derived":[80],"3-alpha":[81],"(REG3\u03b1),":[82],"citrulline.":[83],"Despite":[84],"various":[85],"study":[86],"limitations,":[87],"these":[88],"interesting":[91],"candidates":[92],"for":[93,103],"identifying":[94],"with":[96],"high":[97],"risk":[98],"complications":[100],"screening":[102],"timely":[104],"intensive":[105],"care":[106],"measures.":[107],"These":[108],"approaches":[109],"reduce":[111],"ICU-stay":[112],"mortality.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-20T00:00:00"}