{"id":"https://openalex.org/W4394956572","doi":"https://doi.org/10.1002/yea.3939","title":"Yeast Crf1p is an activator with different roles in regulation of target genes","display_name":"Yeast Crf1p is an activator with different roles in regulation of target genes","publication_year":2024,"publication_date":"2024-04-19","ids":{"openalex":"https://openalex.org/W4394956572","doi":"https://doi.org/10.1002/yea.3939","pmid":"https://pubmed.ncbi.nlm.nih.gov/38639144"},"language":"en","primary_location":{"id":"doi:10.1002/yea.3939","doi":"https://doi.org/10.1002/yea.3939","is_oa":true,"landing_page_url":"https://doi.org/10.1002/yea.3939","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3939","source":{"id":"https://openalex.org/S80252601","display_name":"Yeast","issn_l":"0749-503X","issn":["0749-503X","1097-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3939","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101528520","display_name":"Sanjay Kumar","orcid":"https://orcid.org/0000-0002-5439-5015","observed_orcids":["https://orcid.org/0000-0002-5439-5015"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Kumar","raw_affiliation_strings":["Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044214884","display_name":"Muneera Mashkoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muneera Mashkoor","raw_affiliation_strings":["Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072952307","display_name":"Priya Balamurugan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Balamurugan","raw_affiliation_strings":["Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012467017","display_name":"Anne Grove","orcid":"https://orcid.org/0000-0002-4390-0354","observed_orcids":["https://orcid.org/0000-0002-4390-0354"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anne Grove","raw_affiliation_strings":["Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA"],"raw_orcid":"https://orcid.org/0000-0002-4390-0354","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Louisiana State University Baton Rouge Louisiana USA","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012467017"],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.2713,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.44398769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"41","issue":"6","first_page":"379","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.23960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.18140000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1-inhibition","display_name":"mTORC1 inhibition","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ribosomal-protein-genes","display_name":"ribosomal protein genes","score":0.7020000219345093},{"id":"https://openalex.org/keywords/pre-rrna-processing","display_name":"pre-rRNA processing","score":0.8330000042915344},{"id":"https://openalex.org/keywords/rna-polymerase-ii-occupancy","display_name":"RNA polymerase II occupancy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4320000112056732},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.9085149168968201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.834410548210144},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.7461060881614685},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.6734945774078369},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.6559141278266907},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6227291226387024},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.594580888748169},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.5055019855499268},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.4910590648651123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42448025941848755},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.398593008518219},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38266509771347046},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3263448178768158},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2935217618942261},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.07051035761833191},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006609","descriptor_name":"High Mobility Group Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/yea.3939","doi":"https://doi.org/10.1002/yea.3939","is_oa":true,"landing_page_url":"https://doi.org/10.1002/yea.3939","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3939","source":{"id":"https://openalex.org/S80252601","display_name":"Yeast","issn_l":"0749-503X","issn":["0749-503X","1097-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast","raw_type":"journal-article"},{"id":"pmid:38639144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38639144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast (Chichester, England)","raw_type":"Journal Article"},{"id":"pmh:oai:repository.lsu.edu:biosci_pubs-6045","doi":null,"is_oa":true,"landing_page_url":"https://repository.lsu.edu/biosci_pubs/5039","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1002/yea.3939","doi":"https://doi.org/10.1002/yea.3939","is_oa":true,"landing_page_url":"https://doi.org/10.1002/yea.3939","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/yea.3939","source":{"id":"https://openalex.org/S80252601","display_name":"Yeast","issn_l":"0749-503X","issn":["0749-503X","1097-0061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394956572.pdf","grobid_xml":"https://content.openalex.org/works/W4394956572.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1602034986","https://openalex.org/W1972718290","https://openalex.org/W1975471112","https://openalex.org/W1979266333","https://openalex.org/W1987027200","https://openalex.org/W1987330798","https://openalex.org/W1987535942","https://openalex.org/W1992614713","https://openalex.org/W2015115860","https://openalex.org/W2020726089","https://openalex.org/W2025176940","https://openalex.org/W2037235549","https://openalex.org/W2040483206","https://openalex.org/W2047138284","https://openalex.org/W2051918752","https://openalex.org/W2063013559","https://openalex.org/W2063679723","https://openalex.org/W2068879129","https://openalex.org/W2070783217","https://openalex.org/W2077612844","https://openalex.org/W2078143516","https://openalex.org/W2081319746","https://openalex.org/W2086198999","https://openalex.org/W2087913200","https://openalex.org/W2092226109","https://openalex.org/W2093707058","https://openalex.org/W2095973976","https://openalex.org/W2100811799","https://openalex.org/W2106217652","https://openalex.org/W2108591387","https://openalex.org/W2115998813","https://openalex.org/W2120934046","https://openalex.org/W2124204438","https://openalex.org/W2132717119","https://openalex.org/W2135573097","https://openalex.org/W2137372494","https://openalex.org/W2137497140","https://openalex.org/W2140952049","https://openalex.org/W2141450355","https://openalex.org/W2149480306","https://openalex.org/W2151127375","https://openalex.org/W2152600551","https://openalex.org/W2155937527","https://openalex.org/W2161594264","https://openalex.org/W2162980545","https://openalex.org/W2167840211","https://openalex.org/W2168320506","https://openalex.org/W2169333620","https://openalex.org/W2189479580","https://openalex.org/W2266968783","https://openalex.org/W2424610658","https://openalex.org/W2471036526","https://openalex.org/W2546775177","https://openalex.org/W2556778337","https://openalex.org/W2558107935","https://openalex.org/W2576890255","https://openalex.org/W2625294924","https://openalex.org/W2735764451","https://openalex.org/W2749108823","https://openalex.org/W2800448430","https://openalex.org/W2806201197","https://openalex.org/W2890407682","https://openalex.org/W2896869836","https://openalex.org/W2897853747","https://openalex.org/W2907899595","https://openalex.org/W2922105014","https://openalex.org/W2949343582","https://openalex.org/W3094615982","https://openalex.org/W3175747841","https://openalex.org/W3177828909","https://openalex.org/W3184128910","https://openalex.org/W4308616064","https://openalex.org/W4319061395","https://openalex.org/W6660672886","https://openalex.org/W6680220988","https://openalex.org/W6684820988","https://openalex.org/W6730361479","https://openalex.org/W6931699076"],"related_works":["https://openalex.org/W3120719994","https://openalex.org/W4200002520","https://openalex.org/W2735764451","https://openalex.org/W2078143516","https://openalex.org/W2749108823","https://openalex.org/W2020726089","https://openalex.org/W3094615982","https://openalex.org/W2546775177","https://openalex.org/W3025928694","https://openalex.org/W3179760805"],"abstract_inverted_index":{"Under":[0],"stress":[1],"conditions,":[2],"ribosome":[3,18],"biogenesis":[4,19,102],"is":[5,211],"downregulated.":[6],"This":[7],"process":[8,64],"requires":[9],"that":[10,65,71,182,190,215],"expression":[11,156],"of":[12,30,52,58,114,120,150,157,171,177,198,218,226],"ribosomal":[13,15,53,101,227,237],"RNA,":[14],"protein,":[16],"and":[17,89,106,140,159,189],"genes":[20,55,133,219,229,239],"be":[21,193],"controlled":[22],"in":[23,36,45,62,74,85,145,207,230],"a":[24,63,69,79,94,146,186],"coordinated":[25],"fashion.":[26],"The":[27],"mechanistic":[28],"Target":[29],"Rapamycin":[31],"Complex":[32],"1":[33],"(mTORC1)":[34],"participates":[35],"sensing":[37],"unfavorable":[38],"conditions":[39],"to":[40,123,195,200,241],"effect":[41],"the":[42,59,107,169,174,216,231,236],"requisite":[43],"change":[44],"gene":[46,202],"expression.":[47],"In":[48],"Saccharomyces":[49],"cerevisiae,":[50],"downregulation":[51,225],"protein":[54,70,111,228,238],"involves":[56],"dissociation":[57],"activator":[60,130],"Ifh1p":[61,77,199,210],"depends":[66],"on":[67,99,131,155,163,167],"Utp22p,":[68],"also":[72],"functions":[73,127,184],"pre-rRNA":[75],"processing.":[76],"has":[78,152],"paralog,":[80],"Crf1p,":[81],"which":[82,115],"was":[83,91],"implicated":[84],"communicating":[86],"mTORC1":[87,121,151,205,246],"inhibition":[88,122,206],"hence":[90],"perceived":[92],"as":[93,128,134,185,235],"repressor.":[95],"We":[96,213],"focus":[97],"here":[98],"two":[100],"genes,":[103],"encoding":[104,220],"Utp22p":[105],"high":[108],"mobility":[109],"group":[110],"Hmo1p,":[112],"both":[113],"are":[116],"required":[117,194,222],"for":[118,161,223],"communication":[119],"target":[124],"genes.":[125],"Crf1p":[126,172,183],"an":[129],"these":[132],"evidenced":[135],"by":[136],"reduced":[137],"mRNA":[138],"abundance":[139],"RNA":[141],"polymerase":[142],"II":[143],"occupancy":[144],"crf1\u0394":[147],"strain.":[148],"Inhibition":[149],"distinct":[153],"effects":[154],"HMO1":[158],"UTP22;":[160],"example,":[162],"UTP22,":[164],"but":[165],"not":[166],"HMO1,":[168],"presence":[170],"promotes":[173],"stable":[175],"depletion":[176],"Ifh1p.":[178],"Our":[179],"data":[180],"suggest":[181],"weak":[187],"activator,":[188],"it":[191],"may":[192],"prevent":[196],"re-binding":[197],"some":[201],"promoters":[203],"after":[204],"situations":[208],"when":[209],"available.":[212],"propose":[214],"inclusion":[217],"proteins":[221],"mTORC1-mediated":[224],"same":[232],"regulatory":[233],"circuit":[234],"serves":[240],"optimize":[242],"transcriptional":[243],"responses":[244],"during":[245],"inhibition.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-20T00:00:00"}
