{"id":"https://openalex.org/W4394918901","doi":"https://doi.org/10.1093/sleep/zsae089","title":"Is sleep the new treatment for pain? Two issues need resolving before deciding","display_name":"Is sleep the new treatment for pain? Two issues need resolving before deciding","publication_year":2024,"publication_date":"2024-04-18","ids":{"openalex":"https://openalex.org/W4394918901","doi":"https://doi.org/10.1093/sleep/zsae089","pmid":"https://pubmed.ncbi.nlm.nih.gov/38632974","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11168756"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/zsae089","doi":"https://doi.org/10.1093/sleep/zsae089","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsae089","pdf_url":"https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsae089/57265979/zsae089.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsae089/57265979/zsae089.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086368203","display_name":"David Murray Klyne","orcid":"https://orcid.org/0000-0002-4993-5101","observed_orcids":["https://orcid.org/0000-0002-4993-5101"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I42131985","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70","country_code":"AU","type":"government","lineage":["https://openalex.org/I2801453606","https://openalex.org/I3149551504","https://openalex.org/I42131985"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"David M Klyne","raw_affiliation_strings":["NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland , Brisbane, QLD , Australia"],"raw_orcid":"https://orcid.org/0000-0002-4993-5101","affiliations":[{"raw_affiliation_string":"NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland , Brisbane, QLD , Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I42131985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067536328","display_name":"Michelle Hall","orcid":"https://orcid.org/0000-0003-2024-4945","observed_orcids":["https://orcid.org/0000-0003-2024-4945"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michelle Hall","raw_affiliation_strings":["Sydney Musculoskeletal Health, The Kolling Institute, School of Health Sciences, University of Sydney , Sydney, NSW , Australia","Sydney Musculoskeletal Health, The Kolling Institute, School of Health Sciences, The University of Sydney, Sydney 2065, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sydney Musculoskeletal Health, The Kolling Institute, School of Health Sciences, University of Sydney , Sydney, NSW , Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Sydney Musculoskeletal Health, The Kolling Institute, School of Health Sciences, The University of Sydney, Sydney 2065, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086368203"],"corresponding_institution_ids":["https://openalex.org/I165143802","https://openalex.org/I42131985"],"apc_list":{"value":4607,"currency":"USD","value_usd":4607},"apc_paid":{"value":4607,"currency":"USD","value_usd":4607},"fwci":4.1392,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.94739309,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"47","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7616999745368958,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7616999745368958,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.13729999959468842,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.5400000214576721},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.492000013589859},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5856751799583435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48170143365859985},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36144334077835083},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3214038610458374},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22267919778823853},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/sleep/zsae089","doi":"https://doi.org/10.1093/sleep/zsae089","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsae089","pdf_url":"https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsae089/57265979/zsae089.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11168756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11168756","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11168756/pdf/zsae089.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"Text"},{"id":"pmid:38632974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38632974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/sleep/zsae089","doi":"https://doi.org/10.1093/sleep/zsae089","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsae089","pdf_url":"https://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsae089/57265979/zsae089.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426414350","display_name":"UNDERSTANDING ACUTE TO CHRONIC BACK PAIN PATHWAYS AND TESTING NEW SOLUTIONS. NEW AWARD.","funder_award_id":"W81XWH2010909","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G1475271532","display_name":"What causes low back pain to flare: Has a major opportunity to understand back pain been missed?","funder_award_id":"1r01ar080354-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6339644153","display_name":"Enhancing the therapeutic effects of exercise for hip and knee osteoarthritis","funder_award_id":"1172928","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G6480922406","display_name":"The role of sleep, physical activity and central sensitisation in chronic back pain development","funder_award_id":"2027008","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G7306217793","display_name":null,"funder_award_id":"R01 AR080354","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8560868955","display_name":null,"funder_award_id":"R01AR080354-01","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394918901.pdf","grobid_xml":"https://content.openalex.org/works/W4394918901.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1559462948","https://openalex.org/W1773909344","https://openalex.org/W1890934353","https://openalex.org/W1965612030","https://openalex.org/W1971744720","https://openalex.org/W1972748441","https://openalex.org/W1982249239","https://openalex.org/W1987782779","https://openalex.org/W1992914313","https://openalex.org/W2005396232","https://openalex.org/W2009831405","https://openalex.org/W2015417570","https://openalex.org/W2021789617","https://openalex.org/W2030421130","https://openalex.org/W2030710544","https://openalex.org/W2031371356","https://openalex.org/W2045027490","https://openalex.org/W2050739994","https://openalex.org/W2055755492","https://openalex.org/W2069272625","https://openalex.org/W2071174103","https://openalex.org/W2082307168","https://openalex.org/W2087726866","https://openalex.org/W2089623849","https://openalex.org/W2093694233","https://openalex.org/W2101759370","https://openalex.org/W2111173867","https://openalex.org/W2119685876","https://openalex.org/W2148230248","https://openalex.org/W2150852249","https://openalex.org/W2155524482","https://openalex.org/W2155954337","https://openalex.org/W2281809314","https://openalex.org/W2323457822","https://openalex.org/W2507645382","https://openalex.org/W2566577628","https://openalex.org/W2585386737","https://openalex.org/W2594852016","https://openalex.org/W2776476861","https://openalex.org/W2788938534","https://openalex.org/W2904772173","https://openalex.org/W2927147597","https://openalex.org/W2944592785","https://openalex.org/W2960982983","https://openalex.org/W2970911287","https://openalex.org/W2972951384","https://openalex.org/W2980191110","https://openalex.org/W2980604742","https://openalex.org/W2983723992","https://openalex.org/W3117339351","https://openalex.org/W3126439595","https://openalex.org/W3128925023","https://openalex.org/W3131514505","https://openalex.org/W3165837403","https://openalex.org/W3182632177","https://openalex.org/W3210517924","https://openalex.org/W4213151995","https://openalex.org/W4225015591","https://openalex.org/W4297372029","https://openalex.org/W4389616660","https://openalex.org/W4391649243","https://openalex.org/W6812256887"],"related_works":["https://openalex.org/W4232388130","https://openalex.org/W2005396232","https://openalex.org/W6908216595","https://openalex.org/W2052211155","https://openalex.org/W7128703425","https://openalex.org/W3011719728","https://openalex.org/W4300688534","https://openalex.org/W2586887762","https://openalex.org/W7129662051","https://openalex.org/W4254744083"],"abstract_inverted_index":{"It":[0],"is":[1,22,41,217,485,489,619,657,908,964,977,990,1029,1049,1119],"well":[2],"known":[3,397,522],"that":[4,52,78,121,211,453,620,637,697,808,888,954,1081,1205],"chronic":[5,32,108,132,140,186,450,948,1004],"pain":[6,33,44,53,69,90,109,141,193,213,400,493,513,583,599,618,871,896,907,918,928,963,986,1005,1017,1035,1064,1079],"[1,":[7,151],"2]":[8,152],"and":[9,15,40,128,142,153,184,192,196,235,252,281,302,305,371,389,405,420,427,472,512,518,557,579,633,640,642,677,709,717,733,737,805,820,897,924,930,938,945,962,997,1065,1110,1133,1135,1146,1162,1192,1208],"poor":[10,79,143,205,442,1061],"sleep":[11,29,67,80,125,144,174,191,206,230,356,365,426,443,459,511,597,616,625,644,655,703,706,724,731,742,746,777,816,822,831,851,886,894,899,940,952,961,994,1062,1086,1102],"[3\u20135]":[12],"are":[13,137,194,346,396,520,627,712,809,1073,1206],"enormous":[14],"growing":[16],"health":[17],"problems.":[18],"Less":[19],"recognized,":[20],"however,":[21],"the":[23,26,49,65,103,116,158,202,236,255,261,275,322,335,340,387,428,445,552,568,576,612,649,662,729,734,760,881,891,991,1057,1066,1106,1115,1122,1172,1178,1225,1233],"relationship":[24],"between":[25],"two.":[27],"Poor":[28],"cooccurs":[30],"with":[31,43,55,99,328,781,1001,1021,1229],"in":[34,86,97,165,317,321,392,491,509,572,837,867,895,917,1114],"up":[35],"to":[36,48,107,207,369,379,398,449,457,499,541,555,587,593,610,762,774,818,824,883,958,980,1032,1034,1044,1068,1089,1098,1108,1200,1224],"90%":[37],"of":[38,113,157,221,229,239,247,307,325,331,354,364,374,386,432,476,561,570,615,666,702,728,739,850,893,912,914,947,975,985,999,1047,1060,1078,1095,1126,1131,1151,1165,1175,1232],"cases":[39],"associated":[42],"severity":[45],"[6\u20139].":[46],"Contrary":[47],"traditional":[50],"view":[51],"interferes":[54],"sleep,":[56],"emerging":[57],"studies":[58,416,690,887,1204],"including":[59],"our":[60,74,1050],"own":[61],"preclinical":[62,1051],"work,":[63],"suggest":[64],"opposite\u2014poor":[66],"increases":[68],"[6,":[70],"7,":[71],"10\u201312].":[72],"Moreover,":[73],"group":[75],"has":[76,439,955],"shown":[77,957],"predicts":[81],"a":[82,179,218,318,530,607,687,745,903,982,1221,1230],"clinically":[83],"relevant":[84,1075],"increase":[85,556],"next-day":[87],"low":[88],"back":[89],"symptoms":[91],"(i.e.":[92,231,278,726,741,858],"\u201cflare\u201d)":[93],"[13]":[94],"and,":[95],"when":[96,1019],"conjunction":[98],"specific":[100],"immune":[101,271],"profiles,":[102],"transition":[104,446,1067],"from":[105,447,585,1203],"acute":[106,448,465,586],"[14].":[110],"This":[111,314,1117],"body":[112],"work":[114,1052,1118],"opens":[115],"enticing,":[117],"yet":[118,418,854],"under-investigated,":[119],"possibility":[120],"interventions":[122,941,1009],"aimed":[123],"at":[124,161,575,721],"could":[126],"improve":[127,819,960],"perhaps":[129],"even":[130],"prevent":[131],"pain.":[133,187,433,451,559,949],"The":[134,226,482,1092],"potential":[135,531,979],"implications":[136],"huge":[138],"as":[139,178,349,351,582,752,759,811,829,902,1026],"on":[145,547,551,603,617,694,771,1016,1063],"average":[146],"affect":[147],"more":[148],"than":[149,338],"20%":[150],"35%":[154],"[4,":[155],"15]":[156],"world\u2019s":[159],"population":[160],"any":[162],"one":[163,352,437],"point":[164,484],"time,":[166],"respectively.":[167],"However,":[168,785],"two":[169],"issues":[170],"need":[171],"resolving":[172],"before":[173],"can":[175,268,315,367,889],"be":[176,592,877,1217],"confirmed":[177,421],"legitimate":[180],"target":[181],"for":[182,204,257,461,524,622,629,652,792,862,879,906,927,935,942,968,1076,1167],"preventing":[183],"managing":[185],"First,":[188],"mechanisms":[189,210,913],"linking":[190,425],"diverse":[195],"unclear.":[197],"One":[198,950],"likely":[199,920],"explanation":[200],"involves":[201,661],"capacity":[203,498],"drive":[208],"inflammatory":[209,248,258,290,326,376],"sensitize":[212],"pathways":[214,292,424,494,564],"[16].":[215],"Sleep":[216,264,901,1008],"powerful":[219],"modulator":[220],"systemic":[222,382,474],"inflammation":[223,383,537,571,1039],"[17,":[224,312],"18].":[225],"different":[227,730],"stages":[228,238],"rapid":[232,840],"eye":[233,241,678,841],"movement":[234,842],"three":[237],"non-rapid":[240,838],"movement)":[242],"differently":[243],"regulate":[244,500],"nocturnal":[245],"levels":[246,259,330,475],"factors":[249,390,507],"(e.g.":[250,293,514,705,796,833,1087],"cytokines),":[251],"this":[253,270,375,393,413,874,1045],"lays":[254],"foundation":[256,1107],"throughout":[260],"day":[262,336],"[19\u201322].":[263],"loss":[265,357],"or":[266,361,430,720,864,1197,1214],"disturbance":[267,460],"alter":[269],"balance":[272],"via":[273,401,495,544,600],"activating":[274],"\u201cstress":[276],"response\u201d":[277,395],"hypothalamic-pituitary-adrenal":[279],"axis":[280],"sympathetic":[282],"nervous":[283,407,553],"system":[284,408,554],"activation,":[285],"see":[286],"[18,":[287],"23\u201325])":[288],"and/or":[289],"signaling":[291],"those":[294,1000],"involving":[295],"nuclear":[296],"factor-\u03baB":[297],"[NF-\u03baB],":[298],"activation":[299,373],"protein-1":[300],"[AP-1],":[301],"signal":[303],"transducer":[304],"activator":[306],"transcription":[308],"[STAT]":[309],"family":[310],"proteins":[311],"26\u201328]).":[313],"result":[316],"transient":[319],"shift":[320],"temporal":[323],"pattern":[324],"responses,":[327],"increased":[329],"pro-inflammatory":[332,506],"cytokines":[333,388,545],"during":[334,339],"rather":[337],"night":[341,353],"[19,":[342],"29].":[343],"These":[344,766,1071],"effects":[345,1059],"observed":[347],"after":[348,464],"little":[350],"partial":[355],"[7,":[358],"30\u201332].":[359],"Repeated":[360],"persistent":[362],"periods":[363],"loss/disturbance":[366],"lead":[368],"excessive":[370],"sustained":[372],"response,":[377],"leading":[378],"chronically":[380],"elevated":[381],"[33\u201335].":[384],"Many":[385],"involved":[391,490,508],"\u201cinflammatory":[394],"amplify":[399],"directly":[402],"sensitizing":[403,492],"peripheral":[404],"central":[406],"tissues":[409],"[36,":[410],"37].":[411],"Despite":[412],"knowledge,":[414],"no":[415,1195],"have":[417,691,756,768,852,1012,1194],"tested":[419,440],"these":[422,562,573,764,847,1112],"\u201ccomplete\u201d":[423],"enhancement":[429],"chronification":[431],"In":[434,452],"fact,":[435],"only":[436],"study":[438],"whether":[441,595],"drives":[444],"study,":[454],"rats":[455],"exposed":[456],"regular":[458],"4":[462],"weeks":[463],"limb":[466],"injury":[467],"displayed":[468],"prolonged":[469],"forepaw":[470],"sensitivity":[471],"enhanced":[473],"brain-derived":[477],"neurotrophic":[478],"factor":[479],"(BDNF)":[480],"[11].":[481,1070],"latter":[483],"important":[486,590],"because":[487],"BDNF":[488,525],"its":[496,978],"strong":[497],"synaptic":[501],"plasticity":[502],"[38\u201340].":[503],"Interestingly,":[504],"key":[505],"both":[510],"tumor":[515],"necrosis":[516],"factor-\u03b1":[517],"interleukin-6)":[519],"also":[521,1011,1030],"triggers":[523],"release":[526],"[40,":[527],"41],":[528],"highlighting":[529],"crucial":[532],"mechanism":[533],"by":[534,714,1037,1121,1171,1210],"which":[535,660,1028],"sleep-induced":[536,915],"indirectly":[538],"(in":[539],"addition":[540],"directly,":[542],"e.g.":[543],"acting":[546],"nociceptive":[548],"neurons)":[549],"acts":[550],"maintain":[558],"Confirmation":[560,911],"sleep-activated":[563],"will":[565,591,876,1104,1216],"require":[566,634],"disentangling":[567],"role":[569,892],"processes":[574,1103],"systemic,":[577],"tissue,":[578],"molecular":[580],"level":[581],"evolves":[584],"chronic.":[588],"Equally":[589],"establish":[594],"improved":[596,943],"impacts":[598],"reverse":[601],"actions":[602],"similar":[604],"pathways.":[605],"Second,":[606],"major":[608,973],"barrier":[609],"realizing":[611],"true":[613],"impact":[614],"methods":[621],"accurately":[623,1099],"quantifying":[624],"\u201cquality\u201d":[626,848],"impractical":[628],"long-term":[630],"personal/home":[631],"use":[632,866],"extensive":[635],"equipment":[636],"limits":[638],"comfort":[639],"movement,":[641,679],"ultimately":[643],"quality":[645,656,704,826],"[42\u201344].":[646],"For":[647],"example,":[648],"gold":[650],"standard":[651],"objectively":[653],"monitoring":[654,793],"polysomnography":[658],"(PSG)":[659],"costly":[663],"combined":[664,1020],"recordings":[665],"brain":[667],"activity,":[668,672],"muscle":[669],"tone,":[670],"heart":[671,797,799],"respiratory":[673],"rate,":[674,798],"nasal":[675],"airflow,":[676],"among":[680],"other":[681,790],"physiological":[682,794],"features":[683],"[45,":[684],"46].":[685],"As":[686],"result,":[688],"\u201creal-world\u201d":[689],"traditionally":[692,769],"relied":[693,770],"self-reported":[695],"questionnaires":[696],"invariably":[698],"capture":[699],"subjective":[700],"aspects":[701],"efficiency,":[707],"latency,":[708],"disturbance),":[710],"but":[711],"limited":[713],"recall":[715],"bias":[716],"cannot":[718,1082],"accurately,":[719],"all,":[722],"inform":[723],"architecture":[725,832],"amount":[727],"stages)":[732],"amount,":[735],"duration":[736],"frequency":[738],"awakenings":[740],"fragmentation)":[743],"across":[744],"episode.":[747],"Consumer":[748],"wearable":[749],"technologies":[750],"such":[751,828,1025],"wrist-worn":[753],"activity":[754],"monitors":[755],"been":[757,855,956],"pegged":[758],"solution":[761],"overcoming":[763],"barriers.":[765],"devices":[767,788],"accelerometer":[772],"data":[773],"estimate":[775],"basic":[776,830],"versus":[778],"wake":[779],"parameters":[780],"questionable":[782],"precision":[783],"[47].":[784],"newer":[786],"generation":[787],"contain":[789],"sensors":[791],"signals":[795],"rate":[800],"variability,":[801],"blood":[802],"oxygen":[803],"saturation,":[804],"respiration":[806],"rate)":[807],"used":[810],"additional":[812],"inputs":[813],"into":[814],"proprietary":[815],"algorithms":[817],"expand":[821],"measures":[823,849],"include":[825],"indices":[827],"percent":[834],"time":[835],"spent":[836],"vs.":[839],"sleep)":[843],"[48\u201352].":[844],"Although":[845],"promising,":[846],"not":[853],"robustly":[856],"validated":[857],"against":[859,1056],"PSG":[860],"setups)":[861],"clinical":[863,922],"research":[865],"real-world":[868],"settings":[869],"or/in":[870],"populations.":[872],"Addressing":[873],"issue":[875],"critical":[878],"opening":[880],"door":[882],"large-scale":[884],"home-based":[885],"confirm":[890,1111],"testing":[898,939],"interventions.":[900],"first-line":[904,1023],"treatment":[905],"within":[909],"sight.":[910],"changes":[916],"would":[919],"guide":[921],"advice":[923],"self-management":[925],"strategies":[926],"relief,":[929],"provide":[931],"an":[932,1013],"evidence-based":[933],"basis":[934],"developing,":[936],"refining,":[937],"prevention":[944],"management":[946],"\u201cready-to-test\u201d":[951],"intervention":[953],"concurrently":[959],"cognitive":[965],"behavioral":[966],"therapy":[967],"insomnia":[969,989,1002],"(CBT-I)":[970],"[53\u201358].":[971],"A":[972],"advantage":[974],"CBT-I":[976],"benefit":[981],"substantial":[983],"proportion":[984],"suffers":[987,1080],"given":[988],"most":[992],"common":[993],"disorder":[995],"[59]":[996],"50%":[998],"experience":[1003],"[60,":[1006],"61].":[1007],"may":[1010],"additive":[1014],"effect":[1015],"relief":[1018,1036],"core":[1022],"treatments":[1024],"exercise,":[1027],"thought":[1031],"contribute":[1033],"reducing":[1038],"[62,":[1040],"63].":[1041],"Closely":[1042],"related":[1043],"line":[1046],"inquiry":[1048],"showing":[1053],"exercise":[1054],"protects":[1055],"negative":[1058],"chronicity":[1069],"observations":[1072],"particularly":[1074],"subgroups":[1077],"easily":[1083],"modify":[1084],"their":[1085],"due":[1088],"shiftwork":[1090],"constraints).":[1091],"successful":[1093],"validation":[1094],"simple":[1096],"wearables":[1097],"monitor":[1100],"neurological":[1101],"lay":[1105],"test":[1109],"ideas":[1113],"real-world.":[1116],"supported":[1120],"U.S.":[1123,1173],"National":[1124,1129,1144],"Institutes":[1125],"Health":[1127,1145,1168],"(NIH)":[1128],"Institute":[1130],"Arthritis":[1132],"Musculoskeletal":[1134],"Skin":[1136],"Diseases":[1137],"(NIAMS)":[1138],"(Dr.":[1139,1153],"Klyne,":[1140,1154,1186],"Grant":[1141,1187],"ID:":[1142,1156,1160,1188],"R01AR080354-01),":[1143],"Medical":[1147],"Research":[1148,1183],"Council":[1149],"(NHMRC)":[1150],"Australia":[1152],"Grant/Fellowship":[1155],"2027008;":[1157],"Dr.":[1158],"Hall,":[1159],"1172928),":[1161],"Assistant":[1163],"Secretary":[1164],"Defense":[1166,1176],"Affairs":[1169],"endorsed":[1170],"Department":[1174],"through":[1177],"FY19":[1179],"Chronic":[1180],"Pain":[1181],"Management":[1182],"Program":[1184],"(Dr":[1185],"W81XWH2010909).":[1189],"Drs.":[1190,1212],"Klyne":[1191,1213],"Hall":[1193,1215],"financial":[1196],"nonfinancial":[1198],"interests":[1199],"disclose.":[1201],"Data":[1202],"mentioned":[1207],"owned":[1209],"either":[1211],"made":[1218],"available":[1219],"following":[1220],"written":[1222],"request":[1223],"corresponding":[1226],"author,":[1227],"along":[1228],"summary":[1231],"planned":[1234],"research.":[1235]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-19T00:00:00"}
