{"id":"https://openalex.org/W4394909375","doi":"https://doi.org/10.1158/1535-7163.mct-23-0527","title":"Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody","display_name":"Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody","publication_year":2024,"publication_date":"2024-04-18","ids":{"openalex":"https://openalex.org/W4394909375","doi":"https://doi.org/10.1158/1535-7163.mct-23-0527","pmid":"https://pubmed.ncbi.nlm.nih.gov/38638034"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-23-0527","doi":"https://doi.org/10.1158/1535-7163.mct-23-0527","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-23-0527","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072074213","display_name":"Teruki Kobayashi","orcid":"https://orcid.org/0009-0004-7595-1094","observed_orcids":["https://orcid.org/0009-0004-7595-1094"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruki Kobayashi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0009-0004-7595-1094","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076268036","display_name":"Kazuhiro Noma","orcid":"https://orcid.org/0000-0002-5584-3908","observed_orcids":["https://orcid.org/0000-0002-5584-3908"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiro Noma","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Hospital, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5584-3908","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Hospital, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015433929","display_name":"Seitaro Nishimura","orcid":"https://orcid.org/0009-0004-5135-1473","observed_orcids":["https://orcid.org/0009-0004-5135-1473"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seitaro Nishimura","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0009-0004-5135-1473","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085355727","display_name":"Takuya Kato","orcid":"https://orcid.org/0000-0003-0673-1077","observed_orcids":["https://orcid.org/0000-0003-0673-1077"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takuya Kato","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","National Cancer Institute, Bethesda, MD, United States"],"raw_orcid":"https://orcid.org/0000-0003-0673-1077","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074550730","display_name":"Noriyuki Nishiwaki","orcid":"https://orcid.org/0000-0003-4048-3003","observed_orcids":["https://orcid.org/0000-0003-4048-3003"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriyuki Nishiwaki","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4048-3003","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078170508","display_name":"Toshiaki Ohara","orcid":"https://orcid.org/0000-0003-1557-1589","observed_orcids":["https://orcid.org/0000-0003-1557-1589"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Ohara","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 2","Okayama University, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1557-1589","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 2","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052271348","display_name":"Tomoyoshi Kunitomo","orcid":"https://orcid.org/0009-0009-7065-0440","observed_orcids":["https://orcid.org/0009-0009-7065-0440","https://orcid.org/0009-0001-0085-3850"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyoshi Kunitomo","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0009-0009-7065-0440","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073536333","display_name":"Kento Kawasaki","orcid":"https://orcid.org/0009-0006-7547-5926","observed_orcids":["https://orcid.org/0009-0006-7547-5926"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kento Kawasaki","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0009-0006-7547-5926","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071650554","display_name":"Masaaki Akai","orcid":"https://orcid.org/0000-0002-0742-7272","observed_orcids":["https://orcid.org/0000-0002-0742-7272"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Akai","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0742-7272","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Satoshi Komoto","orcid":"https://orcid.org/0009-0001-8748-5789","observed_orcids":["https://orcid.org/0009-0001-8748-5789"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Komoto","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0009-0001-8748-5789","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043442664","display_name":"Hajime Kashima","orcid":"https://orcid.org/0000-0002-6048-8314","observed_orcids":["https://orcid.org/0000-0002-6048-8314"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Kashima","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University, OKAYAMA, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6048-8314","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University, OKAYAMA, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034496276","display_name":"Satoru Kikuchi","orcid":"https://orcid.org/0000-0002-7671-0696","observed_orcids":["https://orcid.org/0000-0002-7671-0696"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Kikuchi","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7671-0696","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421086","display_name":"Hiroshi Tazawa","orcid":"https://orcid.org/0000-0003-4658-1050","observed_orcids":["https://orcid.org/0000-0003-4658-1050"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tazawa","raw_affiliation_strings":["Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan. 3","Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Hospital, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4658-1050","affiliations":[{"raw_affiliation_string":"Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan. 3","institution_ids":["https://openalex.org/I4210100185"]},{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Hospital, Okayama, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055129091","display_name":"Yasuhiro Shirakawa","orcid":"https://orcid.org/0000-0003-4698-5119","observed_orcids":["https://orcid.org/0000-0003-4698-5119"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4405283031","display_name":"Hiroshima City Hiroshima Citizens Hospital","ror":"https://ror.org/00wk7rn29","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283031"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Shirakawa","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan. 4","Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4698-5119","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan. 4","institution_ids":["https://openalex.org/I4405283031"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082080836","display_name":"Peter L. Choyke","orcid":"https://orcid.org/0000-0003-1086-8826","observed_orcids":["https://orcid.org/0000-0003-1086-8826"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter L. Choyke","raw_affiliation_strings":["Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 5","National Cancer Institute, Bethesda, MD, United States"],"raw_orcid":"https://orcid.org/0000-0003-1086-8826","affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 5","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090173640","display_name":"Hisataka Kobayashi","orcid":"https://orcid.org/0000-0003-1019-4112","observed_orcids":["https://orcid.org/0000-0003-1019-4112"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hisataka Kobayashi","raw_affiliation_strings":["Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 5","National Cancer Institute, Bethesda, MD, United States"],"raw_orcid":"https://orcid.org/0000-0003-1019-4112","affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 5","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068717107","display_name":"Toshiyoshi Fujiwara","orcid":"https://orcid.org/0000-0002-5377-6051","observed_orcids":["https://orcid.org/0000-0002-5377-6051"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyoshi Fujiwara","raw_affiliation_strings":["Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","Okayama University Graduate School of Medicine, Okayama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5377-6051","affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan. 1","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Okayama University Graduate School of Medicine, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076268036"],"corresponding_institution_ids":["https://openalex.org/I163770644","https://openalex.org/I4210100185"],"apc_list":null,"apc_paid":null,"fwci":2.4857,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.90153484,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"23","issue":"7","first_page":"1031","last_page":"1042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.45190000534057617,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/near-infrared-photoimmunotherapy","display_name":"near-infrared photoimmunotherapy","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.9350000023841858},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8479999899864197},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6299999952316284},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6708452105522156},{"id":"https://openalex.org/C111798993","wikidata":"https://www.wikidata.org/wiki/Q21117471","display_name":"Fibroblast activation protein, alpha","level":3,"score":0.6515536308288574},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.616208016872406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5746700763702393},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5340145230293274},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47276049852371216},{"id":"https://openalex.org/C2777092746","wikidata":"https://www.wikidata.org/wiki/Q5939625","display_name":"Humanized antibody","level":4,"score":0.4611208140850067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3113066554069519},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2895974814891815},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.21998992562294006},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.20584222674369812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13228100538253784},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072645","descriptor_name":"Cancer-Associated Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000072645","descriptor_name":"Cancer-Associated Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000099167","descriptor_name":"Fibroblast Activation Protein Alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010789","descriptor_name":"Phototherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.mct-23-0527","doi":"https://doi.org/10.1158/1535-7163.mct-23-0527","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-23-0527","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:38638034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38638034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4972345780","display_name":"Preclinical study of photoimmunotherapy for tumor microenvironment","funder_award_id":"20K09009","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5994492471","display_name":"Exploratory study on the relationship between CAFs and the PD1/PD-L1","funder_award_id":"21K08754","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1518520618","https://openalex.org/W1983692618","https://openalex.org/W2028726843","https://openalex.org/W2033278321","https://openalex.org/W2085121865","https://openalex.org/W2086834665","https://openalex.org/W2102251969","https://openalex.org/W2102339709","https://openalex.org/W2118323175","https://openalex.org/W2118952409","https://openalex.org/W2121960517","https://openalex.org/W2133622132","https://openalex.org/W2156569937","https://openalex.org/W2290262760","https://openalex.org/W2513056697","https://openalex.org/W2563470051","https://openalex.org/W2777276783","https://openalex.org/W2801372304","https://openalex.org/W2809125618","https://openalex.org/W2898549803","https://openalex.org/W2900131693","https://openalex.org/W2913062750","https://openalex.org/W2946904796","https://openalex.org/W2951755598","https://openalex.org/W3099376746","https://openalex.org/W3125250662","https://openalex.org/W3128646645","https://openalex.org/W3133091495","https://openalex.org/W3158479474","https://openalex.org/W3201074200","https://openalex.org/W3203960170","https://openalex.org/W3205475594","https://openalex.org/W4229449304","https://openalex.org/W4283646956","https://openalex.org/W4291415522","https://openalex.org/W4304807904","https://openalex.org/W4309837641","https://openalex.org/W4310780834","https://openalex.org/W4319870995"],"related_works":["https://openalex.org/W2951755598","https://openalex.org/W6944664031","https://openalex.org/W2317337175","https://openalex.org/W4285089754","https://openalex.org/W7111267082","https://openalex.org/W2955423225","https://openalex.org/W2562107153","https://openalex.org/W2887257067","https://openalex.org/W4393093896","https://openalex.org/W2172348769"],"abstract_inverted_index":{"Esophageal":[0],"cancer":[1,50,112],"remains":[2],"a":[3,8,27,38,48,194,226],"highly":[4],"aggressive":[5],"malignancy":[6],"with":[7,55,110,140,179,236],"poor":[9],"prognosis,":[10],"despite":[11],"ongoing":[12],"advancements":[13],"in":[14,30,100,129,153,156,158,197],"treatments":[15],"such":[16,122,187],"as":[17,59,103,123,127,188,225],"immunotherapy.":[18],"The":[19,132],"tumor":[20,176,202],"microenvironment,":[21],"particularly":[22],"cancer-associated":[23],"fibroblasts":[24,152],"(CAF),":[25],"plays":[26],"crucial":[28],"role":[29],"driving":[31],"the":[32,117,141,201,209,218,231],"aggressiveness":[33],"of":[34,119,134,150,175,204,211,220,234],"esophageal":[35,111,237],"cancer.":[36,238],"In":[37,63],"previous":[39],"study":[40,216],"utilizing":[41,82],"human-derived":[42],"xenograft":[43,78,165],"models,":[44,168,206],"we":[45,66],"successfully":[46],"developed":[47],"novel":[49],"treatment":[51,233],"that":[52],"targeted":[53],"CAFs":[54,198],"near-infrared":[56],"photoimmunotherapy":[57],"(NIR-PIT),":[58],"an":[60,89],"adjuvant":[61],"therapy.":[62],"this":[64],"study,":[65],"sought":[67],"to":[68,172],"translate":[69],"our":[70,157,212,215],"findings":[71],"toward":[72],"clinical":[73,101,232],"practice":[74],"by":[75],"employing":[76,223],"patient-derived":[77],"(PDX)":[79],"models":[80,106],"and":[81,96,125,147,166],"humanized":[83],"mAbs,":[84],"specifically":[85],"sibrotuzumab,":[86,138],"which":[87],"is":[88],"antihuman":[90],"fibroblast":[91],"activation":[92],"protein":[93],"(FAP)":[94],"Ab":[95],"already":[97],"being":[98],"investigated":[99],"trials":[102],"monotherapy.":[104],"PDX":[105,167],"derived":[107],"from":[108],"patients":[109,235],"were":[113],"effectively":[114],"established,":[115],"preserving":[116],"expression":[118],"key":[120],"biomarkers":[121],"EGFR":[124],"FAP,":[126],"observed":[128],"primary":[130],"tumors.":[131],"application":[133],"FAP-targeted":[135,169],"NIR-PIT":[136,170,222],"using":[137,161],"conjugated":[139],"photosensitizer":[142],"IR700DX,":[143],"exhibited":[144],"precise":[145],"binding":[146],"selective":[148],"elimination":[149],"FAP-expressing":[151],"vitro.":[154],"Notably,":[155],"vivo":[159],"investigations":[160],"both":[162,205],"cell":[163],"line-derived":[164],"led":[171],"significant":[173],"inhibition":[174],"progression":[177],"compared":[178],"control":[180],"groups,":[181],"all":[182],"without":[183],"inducing":[184],"adverse":[185],"events":[186],"weight":[189],"loss.":[190],"Immunohistologic":[191],"assessments":[192],"revealed":[193],"substantial":[195],"reduction":[196],"exclusively":[199],"within":[200],"microenvironment":[203],"further":[207],"supporting":[208],"efficacy":[210],"approach.":[213],"Thus,":[214],"demonstrates":[217],"potential":[219],"CAF-targeted":[221],"sibrotuzumab":[224],"promising":[227],"therapeutic":[228],"avenue":[229],"for":[230]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-04-19T00:00:00"}