{"id":"https://openalex.org/W4394904841","doi":"https://doi.org/10.1016/j.tranon.2024.101961","title":"A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma","display_name":"A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma","publication_year":2024,"publication_date":"2024-04-17","ids":{"openalex":"https://openalex.org/W4394904841","doi":"https://doi.org/10.1016/j.tranon.2024.101961","pmid":"https://pubmed.ncbi.nlm.nih.gov/38631259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11040172"},"language":"en","primary_location":{"id":"doi:10.1016/j.tranon.2024.101961","doi":"https://doi.org/10.1016/j.tranon.2024.101961","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.101961","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.tranon.2024.101961","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082721751","display_name":"R.A. Assal","orcid":"https://orcid.org/0000-0002-6207-836X","observed_orcids":["https://orcid.org/0000-0002-6207-836X"]},"institutions":[{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reem A. Assal","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Heliopolis University for Sustainable Development, Cairo-Ismailia Desert Road, 11785, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Heliopolis University for Sustainable Development, Cairo-Ismailia Desert Road, 11785, Cairo, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079845874","display_name":"Noha Mousaad Elemam","orcid":"https://orcid.org/0000-0002-3586-6731","observed_orcids":["https://orcid.org/0000-0002-3586-6731"]},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Noha M. Elemam","raw_affiliation_strings":["Clinical Sciences Department, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, 27272, Sharjah, United Arab Emirates","Clinical Sciences Department, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates","Research Institute for Medical and Health Sciences, University of Sharjah, 27272, Sharjah, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-3586-6731","affiliations":[{"raw_affiliation_string":"Clinical Sciences Department, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, 27272, Sharjah, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"Clinical Sciences Department, College of Medicine, University of Sharjah, 27272, Sharjah, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"Research Institute for Medical and Health Sciences, University of Sharjah, 27272, Sharjah, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060354518","display_name":"Radwa Y. Mekky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I895027328","display_name":"October University of Modern Sciences and Arts","ror":"https://ror.org/01nvnhx40","country_code":"EG","type":"education","lineage":["https://openalex.org/I895027328"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Radwa Y. Mekky","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA University), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA University), Cairo, Egypt","institution_ids":["https://openalex.org/I895027328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065120957","display_name":"Abdelrahman A. Attia","orcid":"https://orcid.org/0009-0007-2848-6558","observed_orcids":["https://orcid.org/0009-0007-2848-6558"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdelrahman A. Attia","raw_affiliation_strings":["General Surgery Department, Ain Shams University, Demerdash Hospital, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery Department, Ain Shams University, Demerdash Hospital, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aya Hesham Soliman","orcid":"https://orcid.org/0009-0002-8182-0213","observed_orcids":["https://orcid.org/0009-0002-8182-0213"]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aya Hesham Soliman","raw_affiliation_strings":["Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0009-0002-8182-0213","affiliations":[{"raw_affiliation_string":"Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060704642","display_name":"Asmaa Ibrahim Gomaa","orcid":"https://orcid.org/0000-0001-9376-4461","observed_orcids":["https://orcid.org/0000-0001-9376-4461"]},"institutions":[{"id":"https://openalex.org/I4405261924","display_name":"National Liver Institute","ror":"https://ror.org/00avfvp71","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]},{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Asmaa Ibrahim Gomaa","raw_affiliation_strings":["Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt","institution_ids":["https://openalex.org/I4405261924","https://openalex.org/I63601056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012060869","display_name":"Eleni \u039a. Efthimiadou","orcid":"https://orcid.org/0000-0002-6293-7881","observed_orcids":["https://orcid.org/0000-0002-6293-7881","https://orcid.org/0000-0002-0756-5181"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Eleni K. Efthimiadou","raw_affiliation_strings":["Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023214943","display_name":"Maria Braoudaki","orcid":"https://orcid.org/0000-0003-4658-7225","observed_orcids":["https://orcid.org/0000-0003-4658-7225"]},"institutions":[{"id":"https://openalex.org/I141584323","display_name":"University of Hertfordshire","ror":"https://ror.org/0267vjk41","country_code":"GB","type":"education","lineage":["https://openalex.org/I141584323"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Braoudaki","raw_affiliation_strings":["Department of Clinical, Pharmaceutical, and Biological Science, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical, Pharmaceutical, and Biological Science, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK","institution_ids":["https://openalex.org/I141584323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008450363","display_name":"Sherif Ashraf Fahmy","orcid":"https://orcid.org/0000-0003-3056-8281","observed_orcids":["https://orcid.org/0000-0003-3056-8281"]},"institutions":[{"id":"https://openalex.org/I141584323","display_name":"University of Hertfordshire","ror":"https://ror.org/0267vjk41","country_code":"GB","type":"education","lineage":["https://openalex.org/I141584323"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sherif Ashraf Fahmy","raw_affiliation_strings":["Chemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, 11835, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, New Administrative Capital, 11835, Cairo, Egypt","institution_ids":["https://openalex.org/I141584323"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009963718","display_name":"Rana Ahmed Youness","orcid":"https://orcid.org/0000-0001-6268-7942","observed_orcids":["https://orcid.org/0000-0001-6268-7942"]},"institutions":[{"id":"https://openalex.org/I4405266782","display_name":"German International University","ror":"https://ror.org/05j3zem39","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405266782"]},{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Rana A. Youness","raw_affiliation_strings":["Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt; Molecular Biology and Biochemistry Department, Molecular Genetics Research Team (MGRT), Faculty of Biotechnology, German International University (GIU), New Administrative Capital, 11835, Cairo, Egypt. Electronic address: rana.youness21@gmail.com","Molecular Biology and Biochemistry Department, Molecular Genetics Research Team (MGRT), Faculty of Biotechnology, German International University (GIU), New Administrative Capital, 11835, Cairo, Egypt","Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-6268-7942","affiliations":[{"raw_affiliation_string":"Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt; Molecular Biology and Biochemistry Department, Molecular Genetics Research Team (MGRT), Faculty of Biotechnology, German International University (GIU), New Administrative Capital, 11835, Cairo, Egypt. Electronic address: rana.youness21@gmail.com","institution_ids":["https://openalex.org/I4405266782","https://openalex.org/I96823368"]},{"raw_affiliation_string":"Molecular Biology and Biochemistry Department, Molecular Genetics Research Team (MGRT), Faculty of Biotechnology, German International University (GIU), New Administrative Capital, 11835, Cairo, Egypt","institution_ids":["https://openalex.org/I4405266782"]},{"raw_affiliation_string":"Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, 11835, Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5009963718"],"corresponding_institution_ids":["https://openalex.org/I4405266782","https://openalex.org/I96823368"],"apc_list":{"value":3130,"currency":"USD","value_usd":3130},"apc_paid":{"value":3130,"currency":"USD","value_usd":3130},"fwci":4.9605,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.96883546,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"45","issue":null,"first_page":"101961","last_page":"101961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8569999933242798},{"id":"https://openalex.org/keywords/pd-1-pd-l1","display_name":"PD-1/PD-L1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.7229999899864197},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.984000027179718},{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/h19","display_name":"H19","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-486-5p","display_name":"miR-486-5p","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mir-30a-5p","display_name":"miR-30a-5p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2779118045","wikidata":"https://www.wikidata.org/wiki/Q21114021","display_name":"TIGIT","level":4,"score":0.9782059192657471},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.754807710647583},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6129876971244812},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.522363007068634},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5005948543548584},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.44768384099006653},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4218781292438507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4089812636375427},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33600419759750366},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.22726479172706604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2111981213092804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06261813640594482},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.tranon.2024.101961","doi":"https://doi.org/10.1016/j.tranon.2024.101961","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.101961","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11040172","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11040172","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11040172/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Oncol","raw_type":"Text"},{"id":"pmid:38631259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38631259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational oncology","raw_type":"Journal Article"},{"id":"pmh:oai:uhra.herts.ac.uk:11159","doi":null,"is_oa":true,"landing_page_url":"https://uhra.herts.ac.uk/view/author_id/m=2Ebraoudaki=40herts=2Eac=2Euk.html>,","pdf_url":"https://uhra.herts.ac.uk/id/eprint/11159/1/1-s2.0-S1936523324000883-main.pdf","source":{"id":"https://openalex.org/S4306400241","display_name":"University of Hertfordshire Research Archive (University of Hertfordshire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141584323","host_organization_name":"University of Hertfordshire","host_organization_lineage":["https://openalex.org/I141584323"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:b97b1893d1e349859fc3e36bc60843bb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b97b1893d1e349859fc3e36bc60843bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Oncology, Vol 45, Iss , Pp 101961- (2024)","raw_type":"article"},{"id":"pmh:oai:uhra.herts.ac.uk:2299/27858","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2299/27858","pdf_url":null,"source":{"id":"https://openalex.org/S4306400241","display_name":"University of Hertfordshire Research Archive (University of Hertfordshire)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I141584323","host_organization_name":"University of Hertfordshire","host_organization_lineage":["https://openalex.org/I141584323"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.tranon.2024.101961","doi":"https://doi.org/10.1016/j.tranon.2024.101961","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tranon.2024.101961","pdf_url":null,"source":{"id":"https://openalex.org/S106638657","display_name":"Translational Oncology","issn_l":"1936-5233","issn":["1936-5233","1944-7124"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394904841.pdf","grobid_xml":"https://content.openalex.org/works/W4394904841.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1013088823","https://openalex.org/W1471040074","https://openalex.org/W1787595709","https://openalex.org/W1863751964","https://openalex.org/W2016430576","https://openalex.org/W2050216826","https://openalex.org/W2103028860","https://openalex.org/W2145917258","https://openalex.org/W2149312162","https://openalex.org/W2168089202","https://openalex.org/W2168459600","https://openalex.org/W2169810189","https://openalex.org/W2467692530","https://openalex.org/W2485812469","https://openalex.org/W2630396004","https://openalex.org/W2729008247","https://openalex.org/W2741706728","https://openalex.org/W2761031851","https://openalex.org/W2790355794","https://openalex.org/W2805592007","https://openalex.org/W2887691183","https://openalex.org/W2898568606","https://openalex.org/W2899573186","https://openalex.org/W2905364781","https://openalex.org/W2914875381","https://openalex.org/W2934224496","https://openalex.org/W2936520574","https://openalex.org/W2964566962","https://openalex.org/W2972170831","https://openalex.org/W2975640451","https://openalex.org/W2977688804","https://openalex.org/W2991887382","https://openalex.org/W2995440672","https://openalex.org/W2998812916","https://openalex.org/W3024259706","https://openalex.org/W3042737539","https://openalex.org/W3045130184","https://openalex.org/W3047541887","https://openalex.org/W3049335772","https://openalex.org/W3083807426","https://openalex.org/W3109655646","https://openalex.org/W3113011562","https://openalex.org/W3114049193","https://openalex.org/W3122632056","https://openalex.org/W3134047937","https://openalex.org/W3134956067","https://openalex.org/W3139051492","https://openalex.org/W3141600657","https://openalex.org/W3152534107","https://openalex.org/W3155566102","https://openalex.org/W3167515501","https://openalex.org/W3175038176","https://openalex.org/W3176025865","https://openalex.org/W3185743503","https://openalex.org/W3193127644","https://openalex.org/W3197002431","https://openalex.org/W3205209468","https://openalex.org/W3205722390","https://openalex.org/W3211957571","https://openalex.org/W3214942072","https://openalex.org/W3215999777","https://openalex.org/W4205764297","https://openalex.org/W4211179942","https://openalex.org/W4214834022","https://openalex.org/W4221024547","https://openalex.org/W4224317064","https://openalex.org/W4232620598","https://openalex.org/W4293482752","https://openalex.org/W4297855275","https://openalex.org/W4302022990","https://openalex.org/W4304690259","https://openalex.org/W4306247722","https://openalex.org/W4307634603","https://openalex.org/W4323924506","https://openalex.org/W4378674852","https://openalex.org/W4384401280","https://openalex.org/W4386520925","https://openalex.org/W4388796221","https://openalex.org/W4390667591","https://openalex.org/W4390748232","https://openalex.org/W4390974002","https://openalex.org/W4392112305","https://openalex.org/W4392247097","https://openalex.org/W6628730318","https://openalex.org/W6638262044","https://openalex.org/W6767782892","https://openalex.org/W6843179321"],"related_works":["https://openalex.org/W4200351747","https://openalex.org/W7215937367","https://openalex.org/W2898338156","https://openalex.org/W4224235343","https://openalex.org/W4313588844","https://openalex.org/W3117540160","https://openalex.org/W7203687037","https://openalex.org/W2807322325","https://openalex.org/W2783884669","https://openalex.org/W4389130677"],"abstract_inverted_index":{"Tumor":[0,23],"microenvironment":[1,24],"is":[2,25],"an":[3,12],"intricate":[4,49],"web":[5],"of":[6,63,84,142,147,178,204,214,222,231,242,255,270,280,292],"stromal":[7],"and":[8,57,74,80,96,116,125,136,152,166,176,186,194,201,224,226,248,272,282,323,333],"immune":[9,13,31,50,65,158,234,238,330,335],"cells":[10,56,140],"creating":[11],"suppressive":[14],"cordon":[15],"around":[16],"the":[17,36,42,48,60,64,89,173,199,208,220,229,237,243,252,265,278,289,300,329],"tumor.":[18],"In":[19,39,309],"hepatocellular":[20],"carcinoma":[21],"(HCC),":[22],"a":[26,314],"formidable":[27],"barrier":[28],"towards":[29],"novel":[30,315],"therapeutic":[32],"approaches":[33],"recently":[34],"evading":[35],"oncology":[37],"field.":[38],"this":[40,311],"study,":[41],"main":[43],"aim":[44],"was":[45,112],"to":[46,58,114,129,155,183,326],"identify":[47],"evasion":[51,336],"tactics":[52],"mediated":[53],"by":[54],"HCC":[55,105,120,143,179,205,307],"study":[59,312],"epigenetic":[61],"modulation":[62],"checkpoints;":[66,331],"Programmed":[67,70],"death-1":[68],"(PD-1)/":[69],"death-Ligand":[71],"1":[72],"(PD-L1)":[73],"T":[75],"cell":[76,210],"immunoreceptor":[77],"with":[78,259],"Ig":[79],"ITIM":[81],"domains":[82],"(TIGIT)/Cluster":[83],"Differentiation":[85],"155":[86],"(CD155)":[87],"at":[88],"tumor-immune":[90],"synapse.":[91],"Thus,":[92],"liver":[93,134,202],"tissues,":[94],"PBMCs":[95,258,275,293,304],"sera":[97,200],"were":[98,127,160,168,196],"collected":[99],"from":[100],"Hepatitis":[101],"C":[102],"Virus":[103],"(HCV),":[104],"as":[106,108,181],"well":[107],"healthy":[109,187],"individuals.":[110],"Screening":[111],"performed":[113],"PD-L1/PD-1":[115,332],"CD155/TIGIT":[117,334],"axes":[118],"in":[119,133,172,198,257,274,338],"patients.":[121,144,206],"PDL1,":[122],"CD155,":[123],"PD-1":[124,256,281],"TIGIT":[126],"found":[128],"be":[130],"significantly":[131,170,250],"upregulated":[132,171],"tissues":[135,177,203],"peripheral":[137],"blood":[138],"mononuclear":[139],"(PBMCs)":[141],"An":[145],"array":[146],"long":[148],"non-coding":[149],"RNAs":[150],"(lncRNAs)":[151],"microRNAs":[153],"validated":[154],"regulate":[156],"such":[157],"checkpoints":[159],"screened.":[161],"The":[162],"lncRNAs;":[163],"CCAT-1,":[164],"H19,":[165],"MALAT-1":[167],"all":[169,285],"sera,":[174],"PBMCs,":[175],"patients":[180,185],"compared":[182],"HCV":[184],"controls.":[188],"However,":[189,297],"miR-944-5p,":[190],"miR-105-5p,":[191],"miR-486-5p,":[192,246],"miR-506-5p,":[193,247],"miR-30a-5p":[195,249],"downregulated":[197],"On":[207,236,264],"tumor":[209],"side,":[211,239],"knocking":[212],"down":[213],"lncRNAs-CCAT-1,":[215],"MALAT-1,":[216,321],"or":[217],"H19-markedly":[218],"repressed":[219],"co-expression":[221,279],"PD-L1":[223],"CD155":[225],"accordingly":[227],"induced":[228],"cytotoxicity":[230,305],"co-cultured":[232],"primary":[233],"cells.":[235,296,308],"ectopic":[240,268],"expression":[241,269],"under-expressed":[244],"microRNAs;":[245],"decreased":[251],"transcript":[253],"levels":[254],"no":[260],"effect":[261],"on":[262],"TIGIT.":[263,283],"other":[266],"hand,":[267],"miR-944-5p":[271],"miR-105-5p":[273,298,319],"dramatically":[276],"reduced":[277],"Finally,":[284],"studied":[286],"miRNAs":[287],"enhanced":[288],"cytotoxic":[290],"effects":[291],"against":[294,306],"Huh7":[295],"showed":[299],"highest":[301],"augmentation":[302],"for":[303],"conclusion,":[310],"highlights":[313],"co-targeting":[316],"strategy":[317],"using":[318],"mimics,":[320],"CCAT-1":[322],"H19":[324],"siRNAs":[325],"efficiently":[327],"hampers":[328],"properties":[337],"HCC.":[339]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-18T00:00:00"}
