{"id":"https://openalex.org/W4394875111","doi":"https://doi.org/10.1097/phm.0000000000002488","title":"Tnfaip8 and Tipe2 Gene Deletion Ameliorates Immediate Proteoglycan Loss and Inflammatory Responses in the Injured Mouse Intervertebral Disc","display_name":"Tnfaip8 and Tipe2 Gene Deletion Ameliorates Immediate Proteoglycan Loss and Inflammatory Responses in the Injured Mouse Intervertebral Disc","publication_year":2024,"publication_date":"2024-04-08","ids":{"openalex":"https://openalex.org/W4394875111","doi":"https://doi.org/10.1097/phm.0000000000002488","pmid":"https://pubmed.ncbi.nlm.nih.gov/38630557","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11398987"},"language":"en","primary_location":{"id":"doi:10.1097/phm.0000000000002488","doi":"https://doi.org/10.1097/phm.0000000000002488","is_oa":false,"landing_page_url":"https://doi.org/10.1097/phm.0000000000002488","pdf_url":null,"source":{"id":"https://openalex.org/S137284937","display_name":"American Journal of Physical Medicine & Rehabilitation","issn_l":"0894-9115","issn":["0894-9115","1537-7385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physical Medicine &amp; Rehabilitation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4394875111"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11398987/pdf/nihms-1971327.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102279088","display_name":"Jiawei Lu","orcid":"https://orcid.org/0009-0008-7281-1669","observed_orcids":["https://orcid.org/0009-0008-7281-1669"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]},{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jiawei Lu","raw_affiliation_strings":["From the Departments of Physical Medicine & Rehabilitation (ZT, YZ), Emergency Medicine (FSS), Orthopaedic Surgery (LQ), Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (HS); Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (JL); and Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA (YZ)","Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 150 Jimo Road, Pudong new, 200120, China","Departments of Physical Medicine & Rehabilitation","Jiawei Lu is in training"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Physical Medicine & Rehabilitation (ZT, YZ), Emergency Medicine (FSS), Orthopaedic Surgery (LQ), Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (HS); Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (JL); and Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA (YZ)","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175","https://openalex.org/I4210133394","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 150 Jimo Road, Pudong new, 200120, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]},{"raw_affiliation_string":"Departments of Physical Medicine & Rehabilitation","institution_ids":[]},{"raw_affiliation_string":"Jiawei Lu is in training","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051607119","display_name":"Zuozhen Tian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuozhen Tian","raw_affiliation_strings":["Departments of Physical Medicine & Rehabilitation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physical Medicine & Rehabilitation","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025322559","display_name":"Frances Susan Shofer","orcid":"https://orcid.org/0000-0001-6813-4791","observed_orcids":["https://orcid.org/0000-0001-6813-4791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frances S. Shofer","raw_affiliation_strings":["Emergency Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071922281","display_name":"Ling Qin","orcid":"https://orcid.org/0000-0002-2582-0078","observed_orcids":["https://orcid.org/0000-0002-2582-0078"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Qin","raw_affiliation_strings":["Orthopaedic Surgery"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Surgery","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110571796","display_name":"Honghong Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Honghong Sun","raw_affiliation_strings":["Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090695667","display_name":"Yejia Zhang","orcid":"https://orcid.org/0000-0002-7484-8800","observed_orcids":["https://orcid.org/0000-0002-7484-8800"]},"institutions":[{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yejia Zhang","raw_affiliation_strings":["Corresponding author: Yejia Zhang, MD, PhD, Department of Physical Medicine & Rehabilitation, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, and Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, Tel: 215-893-2645; Fax: 215-893-2685. E-mail: [email\u00a0protected]; [email\u00a0protected]","Departments of Physical Medicine & Rehabilitation","Emergency Medicine","Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA","Fax: 215-893-2685. E-mail: [email\u00a0protected]","[email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author: Yejia Zhang, MD, PhD, Department of Physical Medicine & Rehabilitation, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, and Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 19104, Tel: 215-893-2645; Fax: 215-893-2685. E-mail: [email\u00a0protected]; [email\u00a0protected]","institution_ids":["https://openalex.org/I4210133394","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Departments of Physical Medicine & Rehabilitation","institution_ids":[]},{"raw_affiliation_string":"Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Fax: 215-893-2685. E-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"[email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090695667"],"corresponding_institution_ids":["https://openalex.org/I4210133394","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.7337,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80556722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"103","issue":"10","first_page":"918","last_page":"924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12249","display_name":"Veterinary Orthopedics and Neurology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnfaip8","display_name":"TNFAIP8","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tipe2","display_name":"TIPE2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.8809999823570251},{"id":"https://openalex.org/keywords/intervertebral-disc-injury","display_name":"intervertebral disc injury","score":0.8510000109672546},{"id":"https://openalex.org/keywords/proteoglycan-loss","display_name":"proteoglycan loss","score":0.9649999737739563},{"id":"https://openalex.org/keywords/disc-inflammation","display_name":"disc inflammation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8159999847412109},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.753000020980835},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8669999837875366},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.6399999856948853},{"id":"https://openalex.org/keywords/adam8","display_name":"ADAM8","score":0.5899999737739563},{"id":"https://openalex.org/keywords/nucleus-pulposus","display_name":"nucleus pulposus","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6904657483100891},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6791599988937378},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5465606451034546},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.4943678379058838},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.4430859386920929},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43604737520217896},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.43121153116226196},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33583950996398926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.263720840215683},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2273944616317749},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21121400594711304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14551758766174316},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.08965778350830078},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05228358507156372}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007403","descriptor_name":"Intervertebral Disc","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/phm.0000000000002488","doi":"https://doi.org/10.1097/phm.0000000000002488","is_oa":false,"landing_page_url":"https://doi.org/10.1097/phm.0000000000002488","pdf_url":null,"source":{"id":"https://openalex.org/S137284937","display_name":"American Journal of Physical Medicine & Rehabilitation","issn_l":"0894-9115","issn":["0894-9115","1537-7385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physical Medicine &amp; Rehabilitation","raw_type":"journal-article"},{"id":"pmid:38630557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38630557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physical medicine & rehabilitation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11398987","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11398987/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11398987/pdf/nihms-1971327.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Phys Med Rehabil","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11286689","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11398987","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11398987","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11398987/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11398987/pdf/nihms-1971327.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Phys Med Rehabil","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1236714046","display_name":null,"funder_award_id":"P30-AR069619","funder_id":"https://openalex.org/F4320337897","funder_display_name":"Penn Center for Musculoskeletal Disorders"},{"id":"https://openalex.org/G8781981257","display_name":"Inhibition of TNF-alpha Signaling to Reduce Intervertebral Disc Inflammation","funder_award_id":"R21AR078386","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000865223","display_name":"Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)","funder_award_id":"P30AR069619","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337897","display_name":"Penn Center for Musculoskeletal Disorders","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394875111.pdf","grobid_xml":"https://content.openalex.org/works/W4394875111.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1638157380","https://openalex.org/W1902549464","https://openalex.org/W1996335333","https://openalex.org/W1997249154","https://openalex.org/W2006688060","https://openalex.org/W2007108717","https://openalex.org/W2013071061","https://openalex.org/W2014622765","https://openalex.org/W2015020679","https://openalex.org/W2053261488","https://openalex.org/W2071876602","https://openalex.org/W2077127766","https://openalex.org/W2082012229","https://openalex.org/W2090321984","https://openalex.org/W2114570899","https://openalex.org/W2116531985","https://openalex.org/W2319728559","https://openalex.org/W2595088645","https://openalex.org/W2612724210","https://openalex.org/W2753192494","https://openalex.org/W2767191656","https://openalex.org/W2893896055","https://openalex.org/W2914698736","https://openalex.org/W3016699128","https://openalex.org/W3036614559","https://openalex.org/W3081718739","https://openalex.org/W3184297834","https://openalex.org/W4250766511","https://openalex.org/W4377141088","https://openalex.org/W4388233594"],"related_works":["https://openalex.org/W3036614559","https://openalex.org/W4413849257","https://openalex.org/W4377141088","https://openalex.org/W4213064910","https://openalex.org/W4200448539","https://openalex.org/W4403262711","https://openalex.org/W4406027821","https://openalex.org/W2888431468","https://openalex.org/W2992644657","https://openalex.org/W2753192494"],"abstract_inverted_index":{"OBJECTIVE:":[0],"TNFAIP8":[1,181],"and":[2,14,33,65,76,80,102,106,129,154,165,182,190,207],"TIPE2":[3,183],"belong":[4],"to":[5,31,94,203],"TNFa-induced":[6],"protein":[7],"8":[8],"(TNFAIP8/TIPE)":[9],"family.":[10],"They":[11,197],"control":[12],"apoptosis":[13],"direct":[15],"leukocyte":[16],"migration.":[17],"Nucleus":[18],"pulposus":[19],"cell":[20],"loss":[21,184,189],"is":[22],"a":[23],"hallmark":[24],"of":[25,43,122,137,151,176,185],"intervertebral":[26,48,58,120,149,174,195],"disc":[27,205],"degeneration":[28],"in":[29,50,60,146,171,192],"response":[30],"injury,":[32],"inflammation":[34,191],"may":[35,198],"cause":[36],"pain.":[37],"Here,":[38],"we":[39],"examined":[40,111],"the":[41,47,147,172,193],"effects":[42],"TNFAIP8/TIPE2":[44],"deficiency":[45],"on":[46],"discs":[49,59,121,150,175],"mice":[51,68,132,157],"with":[52,91],"these":[53],"genes":[54],"deleted.":[55],"DESIGN:":[56],"Tail":[57],"Tnfaip8":[61,70],"or":[62],"Tipe2":[63,73,126,152],"single":[64],"double":[66],"knockout":[67],"(":[69],"-/-":[71,74,124,127,153],",":[72,75,79,125,128,162,164],"Tnfaip8/Tipe2":[77,130,155],"dko)":[78],"wild-type":[81,140],"controls":[82],"were":[83,89,98,144],"injured.":[84],"The":[85,117],"spine":[86],"motion":[87],"segments":[88],"stained":[90],"safranin":[92],"O":[93],"reveal":[95],"proteoglycans.":[96],"Macrophages":[97],"identified":[99],"by":[100,112],"immunostaining,":[101],"selected":[103],"inflammatory":[104],"marker":[105],"collagen":[107],"gene":[108,167],"expression":[109,168],"was":[110,169],"Real":[113],"Time":[114],"PCR.":[115],"RESULTS:":[116],"injured":[118,148,173,194],"tail":[119],"Tnfaip":[123],"dko":[131,156,178],"all":[133],"displayed":[134],"higher":[135],"levels":[136],"proteoglycans":[138],"than":[139,158],"controls.":[141],"Fewer":[142],"macrophages":[143],"found":[145],"wild":[159],"type.":[160],"Il6":[161],"Adam8":[163],"Col1":[166],"downregulated":[170],"Tnfip8/Tipe2":[177],"mice.":[179],"CONCLUSIONS:":[180],"function":[186],"ameliorated":[187],"proteoglycan":[188],"discs.":[196],"serve":[199],"as":[200],"molecular":[201],"targets":[202],"preserve":[204],"structure":[206],"reduce":[208],"inflammation.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-04-18T00:00:00"}
