{"id":"https://openalex.org/W4394874151","doi":"https://doi.org/10.1021/acs.accounts.4c00057","title":"Structural, Functional, and Genetic Changes Surrounding Electrodes Implanted in the Brain","display_name":"Structural, Functional, and Genetic Changes Surrounding Electrodes Implanted in the Brain","publication_year":2024,"publication_date":"2024-04-17","ids":{"openalex":"https://openalex.org/W4394874151","doi":"https://doi.org/10.1021/acs.accounts.4c00057","pmid":"https://pubmed.ncbi.nlm.nih.gov/38630432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11079975"},"language":"en","primary_location":{"id":"doi:10.1021/acs.accounts.4c00057","doi":"https://doi.org/10.1021/acs.accounts.4c00057","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.accounts.4c00057","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.accounts.4c00057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107952814","display_name":"Bhavna Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavna Gupta","raw_affiliation_strings":["Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Neuroscience Program, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Neuroscience Program, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024027025","display_name":"Akash Saxena","orcid":"https://orcid.org/0000-0002-1878-2579","observed_orcids":["https://orcid.org/0000-0002-1878-2579"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akash Saxena","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092019689","display_name":"Mason L. Perillo","orcid":"https://orcid.org/0000-0003-2143-1419","observed_orcids":["https://orcid.org/0000-0003-2143-1419"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mason L. Perillo","raw_affiliation_strings":["Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003289587","display_name":"Lauren C. Wade-Kleyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren C. Wade-Kleyn","raw_affiliation_strings":["Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001930658","display_name":"Cort H. Thompson","orcid":"https://orcid.org/0000-0001-6111-3488","observed_orcids":["https://orcid.org/0000-0001-6111-3488"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cort H. Thompson","raw_affiliation_strings":["Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103167803","display_name":"Erin K. Purcell","orcid":"https://orcid.org/0000-0003-1523-7513","observed_orcids":["https://orcid.org/0000-0003-1523-7513"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erin K. Purcell","raw_affiliation_strings":["Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Department of Electrical and Computer Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","Neuroscience Program, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States"],"raw_orcid":"https://orcid.org/0000-0003-1523-7513","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Institute for Quantitative Health Science and Engineering, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Neuroscience Program, Michigan State University, 775 Woodlot Dr., East Lansing, Michigan 48824, United States","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103167803"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.137,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.92637747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"57","issue":"9","first_page":"1346","last_page":"1359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-implants","display_name":"neural implants","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neural-electrodes","display_name":"neural electrodes","score":0.6129999756813049},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dendritic-spine-loss","display_name":"dendritic spine loss","score":0.9240000247955322},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-currents","display_name":"excitatory postsynaptic currents","score":0.9800000190734863},{"id":"https://openalex.org/keywords/excitatory-neurotransmission","display_name":"excitatory neurotransmission","score":0.8130000233650208},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.7900000214576721},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6646993160247803},{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.60561203956604},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5421579480171204},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.4936862885951996},{"id":"https://openalex.org/C166345560","wikidata":"https://www.wikidata.org/wiki/Q555840","display_name":"Brain implant","level":2,"score":0.4934162199497223},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.45681890845298767},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.4555841386318207},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4232049584388733},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34990620613098145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2986833155155182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2934098243713379},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1649145483970642},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1583862602710724},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09319064021110535},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.accounts.4c00057","doi":"https://doi.org/10.1021/acs.accounts.4c00057","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.accounts.4c00057","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11079975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11079975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acc Chem Res","raw_type":"Text"},{"id":"pmid:38630432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38630432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of chemical research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acs.accounts.4c00057","doi":"https://doi.org/10.1021/acs.accounts.4c00057","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.accounts.4c00057","pdf_url":null,"source":{"id":"https://openalex.org/S145378405","display_name":"Accounts of Chemical Research","issn_l":"0001-4842","issn":["0001-4842","1520-4898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Accounts of Chemical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2990466147","display_name":"Structural and Functional Plasticity Surrounding Implanted Neuroprostheses","funder_award_id":"R01NS107451","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5270921465","display_name":"CAREER:Genetic approaches to establish design rules for implantable neurotechnology","funder_award_id":"1943716","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W17652285","https://openalex.org/W883069622","https://openalex.org/W1516562527","https://openalex.org/W1550402445","https://openalex.org/W1798313689","https://openalex.org/W1804209253","https://openalex.org/W1872235122","https://openalex.org/W1895553207","https://openalex.org/W1964380577","https://openalex.org/W1972879677","https://openalex.org/W1973275441","https://openalex.org/W1975669290","https://openalex.org/W1977197102","https://openalex.org/W1994221731","https://openalex.org/W1994626614","https://openalex.org/W2001477745","https://openalex.org/W2021112406","https://openalex.org/W2026100867","https://openalex.org/W2042728692","https://openalex.org/W2042950092","https://openalex.org/W2045747400","https://openalex.org/W2047933600","https://openalex.org/W2060705109","https://openalex.org/W2065943966","https://openalex.org/W2066188896","https://openalex.org/W2079294719","https://openalex.org/W2094871000","https://openalex.org/W2095898243","https://openalex.org/W2095913976","https://openalex.org/W2096577216","https://openalex.org/W2104137141","https://openalex.org/W2131461939","https://openalex.org/W2140386475","https://openalex.org/W2143950431","https://openalex.org/W2144910141","https://openalex.org/W2150685615","https://openalex.org/W2153156720","https://openalex.org/W2158211937","https://openalex.org/W2162399638","https://openalex.org/W2171493957","https://openalex.org/W2279313673","https://openalex.org/W2310345462","https://openalex.org/W2317519131","https://openalex.org/W2323419362","https://openalex.org/W2328435466","https://openalex.org/W2412198820","https://openalex.org/W2566254829","https://openalex.org/W2572710398","https://openalex.org/W2590309737","https://openalex.org/W2762611248","https://openalex.org/W2764034312","https://openalex.org/W2765960015","https://openalex.org/W2769655723","https://openalex.org/W2790610272","https://openalex.org/W2868815831","https://openalex.org/W2883506190","https://openalex.org/W2885518311","https://openalex.org/W2890792765","https://openalex.org/W2923383923","https://openalex.org/W2945668633","https://openalex.org/W2947408214","https://openalex.org/W2966591465","https://openalex.org/W2997325579","https://openalex.org/W2997601619","https://openalex.org/W3000896265","https://openalex.org/W3003577533","https://openalex.org/W3005175012","https://openalex.org/W3084165069","https://openalex.org/W3089379338","https://openalex.org/W3109846467","https://openalex.org/W3112177143","https://openalex.org/W3119379269","https://openalex.org/W3128914402","https://openalex.org/W3141117025","https://openalex.org/W3164561513","https://openalex.org/W4200163964","https://openalex.org/W4200300408","https://openalex.org/W4286222570","https://openalex.org/W4294975038","https://openalex.org/W4310680362","https://openalex.org/W4313813488","https://openalex.org/W4320913175","https://openalex.org/W4362633183","https://openalex.org/W4367043415","https://openalex.org/W4367839611","https://openalex.org/W4381490661","https://openalex.org/W4385175592","https://openalex.org/W4385260199","https://openalex.org/W4389450391"],"related_works":["https://openalex.org/W4385260199","https://openalex.org/W2888320296","https://openalex.org/W4296149832","https://openalex.org/W2947408214","https://openalex.org/W2090157379","https://openalex.org/W7136886820","https://openalex.org/W3141117025","https://openalex.org/W1518437769","https://openalex.org/W2769655723","https://openalex.org/W2107635023"],"abstract_inverted_index":{"Implantable":[0],"neurotechnology":[1,419],"enables":[2],"monitoring":[3],"and":[4,15,39,59,69,90,108,161,198,315,340,343,436],"stimulating":[5,316],"of":[6,34,36,44,57,67,72,93,110,129,138,188,208,218,240,274,288,329,331,362,376,390,408,418,431,450],"the":[7,22,28,42,60,65,70,83,88,94,105,111,122,144,158,167,231,272,285,327,360,363,387,391,398,406,415,429,445,448],"brain":[8,23,191,399],"signals":[9],"responsible":[10],"for":[11,193,404],"performing":[12],"cognitive,":[13],"motor,":[14],"sensory":[16],"tasks.":[17],"Electrode":[18],"arrays":[19],"implanted":[20,170,183,396],"in":[21,27,99,166,221,244,261,271,284,301,355,397],"are":[24,101,142,152,367],"increasingly":[25,425],"used":[26],"clinic":[29],"to":[30,82,119,126,134,156,180,298,312,373,394,427],"treat":[31],"a":[32,45,50,176,237,249,259,269,356],"variety":[33],"sources":[35],"neurological":[37],"diseases":[38],"injuries.":[40],"However,":[41],"implantation":[43,323],"foreign":[46],"body":[47],"typically":[48],"initiates":[49],"tissue":[51,85,192,209],"response":[52,393],"characterized":[53],"by":[54,104,268],"physical":[55],"disruption":[56,217],"vasculature":[58],"neuropil":[61],"as":[62,64,266,442,444],"well":[63,443],"initiation":[66],"inflammation":[68],"induction":[71,328,449],"reactive":[73],"glial":[74,336],"states.":[75],"Likewise,":[76],"electrical":[77,345],"stimulation":[78,346],"can":[79],"induce":[80],"damage":[81,352],"surrounding":[84,169,211,264,304],"depending":[86],"on":[87,230,412,439],"intensity":[89,361],"waveform":[91],"parameters":[92],"applied":[95,311,364],"stimulus.":[96,365],"These":[97,384],"phenomena,":[98],"turn,":[100],"likely":[102],"influenced":[103],"surface":[106,434],"chemistry":[107],"characteristics":[109],"materials":[112],"employed,":[113],"but":[114],"further":[115],"information":[116],"is":[117,324,420],"needed":[118],"effectively":[120],"link":[121],"biological":[123,392],"responses":[124],"observed":[125],"specific":[127,451],"aspects":[128],"device":[130,322,440],"design.":[131],"In":[132,292],"order":[133],"inform":[135],"improved":[136],"design":[137],"implantable":[139],"neurotechnology,":[140],"we":[141,173,294,310],"investigating":[143],"basic":[145],"science":[146],"principles":[147],"governing":[148],"device-tissue":[149,377],"integration.":[150],"We":[151,318,366],"employing":[153],"multiple":[154],"techniques":[155],"characterize":[157],"structural,":[159],"functional,":[160],"genetic":[162],"changes":[163,283,300],"that":[164,320],"occur":[165],"cells":[168],"electrodes.":[171],"First,":[172],"have":[174],"developed":[175],"new":[177,206,296,402],"\"device-in-slice\"":[178],"technique":[179],"capture":[181],"chronically":[182],"electrodes":[184,395],"within":[185],"thick":[186],"slices":[187],"live":[189],"rat":[190],"interrogation":[194],"with":[195,248,326,334,351,447],"single-cell":[196],"electrophysiology":[197],"two-photon":[199],"imaging":[200],"techniques.":[201],"Our":[202],"data":[203,382],"revealed":[204],"several":[205],"observations":[207],"remodeling":[210],"devices:":[212],"(a)":[213,321],"there":[214,281],"was":[215,236,258],"significant":[216,238],"dendritic":[219,241],"arbors":[220],"neurons":[222,245],"near":[223,246],"implants,":[224,247,265],"where":[225],"losses":[226],"were":[227,282],"driven":[228],"asymmetrically":[229],"implant-facing":[232],"side.":[233],"(b)":[234,344],"There":[235,257],"loss":[239],"spine":[242],"densities":[243],"shift":[250],"toward":[251],"more":[252],"immature":[253],"(nonfunctional)":[254],"morphologies.":[255],"(c)":[256],"reduction":[260,270],"excitatory":[262,275],"neurotransmission":[263],"evidenced":[267],"frequency":[273],"postsynaptic":[276],"currents":[277],"(EPSCs).":[278],"Lastly,":[279],"(d)":[280],"electrophysiological":[286],"underpinnings":[287],"neuronal":[289],"spiking":[290],"regularity.":[291],"parallel,":[293],"initiated":[295],"studies":[297],"explore":[299],"gene":[302,348],"expression":[303,349],"devices":[305],"through":[306],"spatial":[307],"transcriptomics,":[308],"which":[309],"both":[313],"recording":[314],"arrays.":[317],"found":[319],"associated":[325,333,350],"hundreds":[330],"genes":[332],"neuroinflammation,":[335],"reactivity,":[337],"oligodendrocyte":[338],"function,":[339],"cellular":[341,452],"metabolism":[342],"induces":[347],"or":[353],"plasticity":[354],"manner":[357],"dependent":[358],"upon":[359],"currently":[368],"developing":[369],"computational":[370],"analysis":[371],"tools":[372],"distill":[374],"biomarkers":[375,403],"interactions":[378],"from":[379],"large":[380],"transcriptomics":[381],"sets.":[383],"results":[385],"improve":[386],"current":[388],"understanding":[389],"while":[400],"producing":[401],"benchmarking":[405],"effects":[407],"novel":[409,432],"electrode":[410],"designs":[411],"responses.":[413],"As":[414],"next":[416],"generation":[417],"developed,":[421],"it":[422],"will":[423],"be":[424],"important":[426],"understand":[428],"influence":[430],"materials,":[433],"chemistries,":[435],"implant":[437],"architectures":[438],"performance":[441],"relationship":[446],"signaling":[453],"pathways.":[454]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-18T00:00:00"}