{"id":"https://openalex.org/W4394844659","doi":"https://doi.org/10.7554/elife.89499.2","title":"CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues","display_name":"CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues","publication_year":2024,"publication_date":"2024-04-16","ids":{"openalex":"https://openalex.org/W4394844659","doi":"https://doi.org/10.7554/elife.89499.2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.89499.2","doi":"https://doi.org/10.7554/elife.89499.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89499.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.89499.2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107299635","display_name":"Rapha\u00ebl Aguillon","orcid":"https://orcid.org/0000-0002-1149-0362","observed_orcids":["https://orcid.org/0000-0002-1149-0362","https://orcid.org/0000-0001-7362-8446"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Raphael Aguillon","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","The Multidisciplinary Brain Research Center, Bar-Ilan University"],"raw_orcid":"https://orcid.org/0000-0002-1149-0362","affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"The Multidisciplinary Brain Research Center, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046798580","display_name":"Mieka Rinsky","orcid":"https://orcid.org/0000-0002-6707-4202","observed_orcids":["https://orcid.org/0000-0002-6707-4202"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mieka Rinsky","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111008561","display_name":"Noa Simon\u2010Blecher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Noa Simon-Blecher","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056279786","display_name":"Tirza Doniger","orcid":"https://orcid.org/0000-0001-6708-8404","observed_orcids":["https://orcid.org/0000-0001-6708-8404"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Tirza Doniger","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University"],"raw_orcid":"https://orcid.org/0000-0001-6708-8404","affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027650124","display_name":"Lior Appelbaum","orcid":"https://orcid.org/0000-0002-9248-5919","observed_orcids":["https://orcid.org/0000-0002-9248-5919"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lior Appelbaum","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","The Multidisciplinary Brain Research Center, Bar-Ilan University"],"raw_orcid":"https://orcid.org/0000-0002-9248-5919","affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"The Multidisciplinary Brain Research Center, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051118860","display_name":"Oren Levy","orcid":"https://orcid.org/0000-0002-5478-6307","observed_orcids":["https://orcid.org/0000-0002-5478-6307"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oren Levy","raw_affiliation_strings":["Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University"],"raw_orcid":"https://orcid.org/0000-0002-5478-6307","affiliations":[{"raw_affiliation_string":"Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9290000200271606},{"id":"https://openalex.org/keywords/clock-genes","display_name":"clock genes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nematostella-vectensis","display_name":"Nematostella vectensis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cnidaria","display_name":"Cnidaria","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transcription-translation-feedback-loop","display_name":"transcription-translation feedback loop","score":0.8659999966621399},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.5519999861717224},{"id":"https://openalex.org/keywords/light-dark-cycle","display_name":"light-dark cycle","score":0.6539999842643738},{"id":"https://openalex.org/keywords/constant-light","display_name":"constant light","score":0.8119999766349792},{"id":"https://openalex.org/keywords/rhythmic-gene-expression","display_name":"rhythmic gene expression","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cell-division","display_name":"cell division","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.855105996131897},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8026821613311768},{"id":"https://openalex.org/C2778880379","wikidata":"https://www.wikidata.org/wiki/Q7805543","display_name":"Timeless","level":3,"score":0.7904236912727356},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.744816780090332},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.6569463014602661},{"id":"https://openalex.org/C125168821","wikidata":"https://www.wikidata.org/wiki/Q7106408","display_name":"Oscillating gene","level":5,"score":0.5332419872283936},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.5228743553161621},{"id":"https://openalex.org/C201176492","wikidata":"https://www.wikidata.org/wiki/Q6546168","display_name":"Light effects on circadian rhythm","level":4,"score":0.49226418137550354},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.48824504017829895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4345391094684601},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43397560715675354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4222126603126526},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27442431449890137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18067237734794617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.89499.2","doi":"https://doi.org/10.7554/elife.89499.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89499.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.89499.2","doi":"https://doi.org/10.7554/elife.89499.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89499.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4223123264","display_name":null,"funder_award_id":"G-1566-413.13/2023","funder_id":"https://openalex.org/F4320320947","funder_display_name":"German-Israeli Foundation for Scientific Research and Development"},{"id":"https://openalex.org/G4853542560","display_name":null,"funder_award_id":"961/19","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320315960","display_name":"Moore Family Foundation","ror":"https://ror.org/01px12r72"},{"id":"https://openalex.org/F4320320947","display_name":"German-Israeli Foundation for Scientific Research and Development","ror":"https://ror.org/00tntzp09"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320323139","display_name":"Azrieli Foundation","ror":"https://ror.org/009svts64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1969846799","https://openalex.org/W1976391205","https://openalex.org/W1978243388","https://openalex.org/W1992494470","https://openalex.org/W1996282927","https://openalex.org/W1997637686","https://openalex.org/W2005961318","https://openalex.org/W2008098458","https://openalex.org/W2022321112","https://openalex.org/W2029351879","https://openalex.org/W2029808234","https://openalex.org/W2031422709","https://openalex.org/W2041622577","https://openalex.org/W2048908186","https://openalex.org/W2069688519","https://openalex.org/W2077429257","https://openalex.org/W2089357209","https://openalex.org/W2106035773","https://openalex.org/W2106070783","https://openalex.org/W2117402541","https://openalex.org/W2121260094","https://openalex.org/W2132453098","https://openalex.org/W2134526812","https://openalex.org/W2137252071","https://openalex.org/W2146656260","https://openalex.org/W2149946849","https://openalex.org/W2155925660","https://openalex.org/W2167279371","https://openalex.org/W2169220425","https://openalex.org/W2175171485","https://openalex.org/W2179438025","https://openalex.org/W2252534172","https://openalex.org/W2336105149","https://openalex.org/W2512732565","https://openalex.org/W2782194555","https://openalex.org/W2789947474","https://openalex.org/W2805781739","https://openalex.org/W2949193645","https://openalex.org/W2949499461","https://openalex.org/W2953643960","https://openalex.org/W2987116017","https://openalex.org/W3005604287","https://openalex.org/W3027246842","https://openalex.org/W3155487948","https://openalex.org/W3178987458","https://openalex.org/W3192993898","https://openalex.org/W4386934385","https://openalex.org/W4388034593"],"related_works":["https://openalex.org/W4386378502","https://openalex.org/W2077429257","https://openalex.org/W2155925660","https://openalex.org/W2252534172","https://openalex.org/W2980999487","https://openalex.org/W2106035773","https://openalex.org/W4362658108","https://openalex.org/W4309387177","https://openalex.org/W6948773142","https://openalex.org/W2953643960"],"abstract_inverted_index":{"Abstract":[0],"The":[1,122],"circadian":[2,88,180],"clock":[3,181],"enables":[4],"anticipation":[5],"of":[6,45,47,76,128,144,156],"the":[7,39,55,74,139,173,183],"day/night":[8],"cycle":[9],"in":[10,36,49,91,113,117,136,188,197],"animals":[11,51],"ranging":[12],"from":[13],"cnidarians":[14,189],"to":[15,120,190],"mammals.":[16],"Circadian":[17],"rhythms":[18],"are":[19,52],"generated":[20,81],"through":[21],"a":[22,32,82,99],"transcription-translation":[23],"feedback":[24],"loop":[25],"(TTFL":[26],"or":[27],"pacemaker)":[28],"with":[29,160],"CLOCK":[30,48],"as":[31],"conserved":[33],"positive":[34],"factor":[35],"animals.":[37],"However,":[38],"functional":[40],"evolutionary":[41],"origin":[42],"and":[43,96,163,195],"mechanism":[44],"action":[46],"basal":[50],"unknown.":[53],"In":[54],"cnidarian":[56],"Nematostella":[57],"vectensis,":[58],"pacemaker":[59,146],"genes":[60,112,116,147,158],"transcription":[61],"including":[62],"NvClk":[63,83],"(the":[64],"Clock":[65,184],"ortholog)":[66],"appears":[67],"arrhythmic":[68],"under":[69,104],"constant":[70,92,198],"light":[71,93],"conditions,":[72],"questioning":[73],"role":[75],"NvCLK.":[77],"Utilizing":[78],"CRISPR/Cas9,":[79],"we":[80],"allele":[84],"mutant":[85],"(NvClk1),":[86],"revealing":[87],"behavior":[89,196],"loss":[90],"conditions":[94],"(LL":[95],"DD)":[97],"while":[98,172],"24-hour":[100,192],"rhythm":[101],"was":[102,166],"maintained":[103],"light-dark":[105],"condition":[106],"(LD).":[107],"Transcriptomics":[108],"showed":[109,125,142],"distinct":[110],"rhythmic":[111,129,193],"wild-type":[114],"(WT)":[115],"LD":[118,123,140],"compared":[119],"DD.":[121,137],"NvClk1-/-":[124,141],"comparable":[126],"numbers":[127],"genes,":[130],"whereas":[131],"they":[132],"were":[133],"greatly":[134],"reduced":[135],"Furthermore,":[138],"alterations":[143],"temporal":[145],"expression,":[148],"affecting":[149],"their":[150],"potential":[151],"interactions.":[152],"Additionally,":[153],"differential":[154],"expression":[155],"non-rhythmic":[157],"associated":[159],"cell":[161],"division":[162],"neuronal":[164],"differentiation":[165],"observed.":[167],"These":[168],"findings":[169],"suggest":[170],"that":[171],"light-responsive":[174],"pathway":[175],"can":[176],"partially":[177],"compensate":[178],"for":[179],"disruption,":[182],"gene":[185],"has":[186],"evolved":[187],"maintain":[191],"physiology":[194],"conditions.":[199]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-04-17T00:00:00"}