{"id":"https://openalex.org/W4394842841","doi":"https://doi.org/10.1016/j.cbpa.2024.102454","title":"Advances in understanding and exploiting Siglec\u2013glycan interactions","display_name":"Advances in understanding and exploiting Siglec\u2013glycan interactions","publication_year":2024,"publication_date":"2024-04-16","ids":{"openalex":"https://openalex.org/W4394842841","doi":"https://doi.org/10.1016/j.cbpa.2024.102454","pmid":"https://pubmed.ncbi.nlm.nih.gov/38631213"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbpa.2024.102454","doi":"https://doi.org/10.1016/j.cbpa.2024.102454","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2024.102454","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cbpa.2024.102454","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095705896","display_name":"Zeinab Jame-Chenarboo","orcid":"https://orcid.org/0009-0003-4687-8652","observed_orcids":["https://orcid.org/0009-0003-4687-8652"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zeinab Jame-Chenarboo","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022444540","display_name":"Taylor E. Gray","orcid":"https://orcid.org/0000-0002-0016-0405","observed_orcids":["https://orcid.org/0000-0002-0016-0405"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Taylor E. Gray","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087354201","display_name":"Matthew Scott Macauley","orcid":"https://orcid.org/0000-0003-4579-1048","observed_orcids":["https://orcid.org/0000-0003-4579-1048"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Matthew S. Macauley","raw_affiliation_strings":["Department of Chemistry, University of Alberta, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Canada. Electronic address: macauley@ualberta.ca","Department of Chemistry, University of Alberta, Canada","Department of Medical Microbiology and Immunology, University of Alberta, Canada"],"raw_orcid":"https://orcid.org/0000-0003-4579-1048","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Canada; Department of Medical Microbiology and Immunology, University of Alberta, Canada. Electronic address: macauley@ualberta.ca","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Chemistry, University of Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, University of Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087354201"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":{"value":4660,"currency":"USD","value_usd":4660},"fwci":0.7204,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.59558514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"80","issue":null,"first_page":"102454","last_page":"102454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/siglecs","display_name":"Siglecs","score":0.8629999756813049},{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.8330000042915344},{"id":"https://openalex.org/keywords/inhibitory-receptors","display_name":"inhibitory receptors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/immune-cell-activation","display_name":"immune cell activation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chemical-biology","display_name":"chemical biology","score":0.6179999709129333},{"id":"https://openalex.org/keywords/ligand-discovery","display_name":"ligand discovery","score":0.6700000166893005},{"id":"https://openalex.org/keywords/receptor-modulation","display_name":"receptor modulation","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2778017598","wikidata":"https://www.wikidata.org/wiki/Q7390325","display_name":"SIGLEC","level":3,"score":0.9610486030578613},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.8174713850021362},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6437943577766418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4014020264148712},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3664429485797882},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34968864917755127},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14547395706176758},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13354083895683289},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.06422439217567444},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.05824249982833862}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063265","descriptor_name":"Sialic Acid Binding Immunoglobulin-like Lectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbpa.2024.102454","doi":"https://doi.org/10.1016/j.cbpa.2024.102454","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2024.102454","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},{"id":"pmid:38631213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38631213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in chemical biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cbpa.2024.102454","doi":"https://doi.org/10.1016/j.cbpa.2024.102454","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2024.102454","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319946","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W2056802740","https://openalex.org/W2508974650","https://openalex.org/W2588228538","https://openalex.org/W2893525181","https://openalex.org/W2924483954","https://openalex.org/W2934339908","https://openalex.org/W2953347000","https://openalex.org/W2971559630","https://openalex.org/W3003215804","https://openalex.org/W3029507080","https://openalex.org/W3032900890","https://openalex.org/W3033663536","https://openalex.org/W3045681195","https://openalex.org/W3047512063","https://openalex.org/W3047840630","https://openalex.org/W3048973619","https://openalex.org/W3087503712","https://openalex.org/W3092500707","https://openalex.org/W3093206728","https://openalex.org/W3113017727","https://openalex.org/W3114065842","https://openalex.org/W3116060911","https://openalex.org/W3119555546","https://openalex.org/W3125874893","https://openalex.org/W3131248149","https://openalex.org/W3155392711","https://openalex.org/W3158185358","https://openalex.org/W3159899980","https://openalex.org/W3162916603","https://openalex.org/W3165412759","https://openalex.org/W3169296854","https://openalex.org/W3172180133","https://openalex.org/W3172711652","https://openalex.org/W3183409407","https://openalex.org/W3194694436","https://openalex.org/W3195079877","https://openalex.org/W3199652116","https://openalex.org/W3207828649","https://openalex.org/W3216449336","https://openalex.org/W4206987421","https://openalex.org/W4220848626","https://openalex.org/W4221073929","https://openalex.org/W4224260082","https://openalex.org/W4225811022","https://openalex.org/W4226354103","https://openalex.org/W4281251571","https://openalex.org/W4281565847","https://openalex.org/W4281629206","https://openalex.org/W4285401225","https://openalex.org/W4286435957","https://openalex.org/W4289938927","https://openalex.org/W4291002775","https://openalex.org/W4291020898","https://openalex.org/W4304080250","https://openalex.org/W4307234997","https://openalex.org/W4307930338","https://openalex.org/W4312203591","https://openalex.org/W4323825245","https://openalex.org/W4366768510","https://openalex.org/W4380538319","https://openalex.org/W4380785415","https://openalex.org/W4382359282","https://openalex.org/W4383816775","https://openalex.org/W4384522220","https://openalex.org/W4384819401","https://openalex.org/W4386223468","https://openalex.org/W4386257851","https://openalex.org/W4386567481","https://openalex.org/W4387601569","https://openalex.org/W4388554686","https://openalex.org/W4388768921","https://openalex.org/W4390052645","https://openalex.org/W4390918315","https://openalex.org/W4390945491","https://openalex.org/W6779126409","https://openalex.org/W6794726538","https://openalex.org/W6860028799"],"related_works":["https://openalex.org/W3041196067","https://openalex.org/W6921844933","https://openalex.org/W2588228538","https://openalex.org/W3091993418","https://openalex.org/W4405614232","https://openalex.org/W4296632864","https://openalex.org/W4211114435","https://openalex.org/W4409799760","https://openalex.org/W4375824583","https://openalex.org/W1988621302"],"abstract_inverted_index":{"Sialic-acid-binding":[0],"immunoglobulin-type":[1],"lectins":[2],"(Siglecs)":[3],"are":[4,52,75,112,120],"a":[5,115],"family":[6,65],"of":[7,17,33,40,86,98,104],"cell-surface":[8],"immunomodulatory":[9,38],"receptors":[10],"that":[11],"recognize":[12],"sialic-acid-containing":[13],"glycans.":[14],"The":[15],"majority":[16],"Siglecs":[18,41],"have":[19],"an":[20,84],"inhibitory":[21],"motif":[22],"in":[23,89],"their":[24],"intercellular":[25],"domain":[26],"and":[27,69,123],"can":[28],"regulate":[29],"the":[30,37,58,96,102],"cellular":[31],"activation":[32],"immune":[34],"cells.":[35],"Importantly,":[36],"role":[39],"is":[42],"regulated":[43],"by":[44,62],"engagement":[45],"with":[46,114],"distinct":[47],"sialoglycan":[48],"ligands.":[49],"However,":[50],"there":[51],"still":[53],"many":[54],"unanswered":[55],"questions":[56],"about":[57],"precise":[59],"ligand(s)":[60],"recognized":[61],"individual":[63],"Siglec":[64,91],"members.":[66],"New":[67],"tools":[68],"approaches":[70,99,111],"to":[71,100],"study":[72],"Siglec-ligand":[73],"interactions":[74],"rapidly":[76],"filling":[77],"this":[78],"knowledge":[79],"gap.":[80],"This":[81],"review":[82],"provides":[83],"overview":[85],"recent":[87],"advances":[88],"discovering":[90],"ligands":[92],"as":[93,95],"well":[94],"development":[97],"modulate":[101],"function":[103],"Siglecs.":[105],"In":[106],"both":[107],"aspects,":[108],"chemical":[109],"biology":[110],"emphasized":[113],"discussion":[116],"on":[117],"how":[118],"these":[119],"complementing":[121],"biochemical":[122],"genetic":[124],"strategies.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-17T00:00:00"}