{"id":"https://openalex.org/W4394842829","doi":"https://doi.org/10.4103/jpbs.jpbs_407_23","title":"Study of Culture Conversion in Drug-Resistant Pulmonary Tuberculosis on All-Oral Longer Regimen at IGIMS, Patna","display_name":"Study of Culture Conversion in Drug-Resistant Pulmonary Tuberculosis on All-Oral Longer Regimen at IGIMS, Patna","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4394842829","doi":"https://doi.org/10.4103/jpbs.jpbs_407_23","pmid":"https://pubmed.ncbi.nlm.nih.gov/38882839","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11174214"},"language":"en","primary_location":{"id":"doi:10.4103/jpbs.jpbs_407_23","doi":"https://doi.org/10.4103/jpbs.jpbs_407_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jpbs.jpbs_407_23","pdf_url":null,"source":{"id":"https://openalex.org/S109681697","display_name":"Journal of Pharmacy And Bioallied Sciences","issn_l":"0975-7406","issn":["0975-7406","0976-4879"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Bioallied Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4394842829"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.4103/jpbs.jpbs_407_23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104281715","display_name":"Gudesh Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Gudesh Kumar","raw_affiliation_strings":["Department of Microbiology, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056174188","display_name":"Manish Kumar","orcid":"https://orcid.org/0000-0001-5947-7469","observed_orcids":["https://orcid.org/0000-0001-5947-7469"]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manish Kumar","raw_affiliation_strings":["Department of Microbiology, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067572341","display_name":"Sweta Muni","orcid":"https://orcid.org/0000-0003-1160-5868","observed_orcids":["https://orcid.org/0000-0003-1160-5868"]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sweta Muni","raw_affiliation_strings":["Department of Microbiology, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rakesh Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rakesh Kumar","raw_affiliation_strings":["Department of Microbiology, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102046878","display_name":"Manish Shankar","orcid":"https://orcid.org/0009-0006-6565-2263","observed_orcids":["https://orcid.org/0009-0006-6565-2263"]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Shankar","raw_affiliation_strings":["Department of Pulmonary Medicine, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012737520","display_name":"Randhir Kumar","orcid":"https://orcid.org/0000-0002-6887-7269","observed_orcids":["https://orcid.org/0000-0002-6887-7269"]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Randhir Kumar","raw_affiliation_strings":["Department of Microbiology, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104152324","display_name":"Namrata Kumari","orcid":"https://orcid.org/0000-0002-3239-7220","observed_orcids":["https://orcid.org/0000-0002-3239-7220"]},"institutions":[{"id":"https://openalex.org/I238035932","display_name":"Indira Gandhi Institute of Medical Sciences","ror":"https://ror.org/049pcfs17","country_code":"IN","type":"education","lineage":["https://openalex.org/I238035932"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Namrata Kumari","raw_affiliation_strings":["Department of Microbiology, IGIMS, Patna, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, IGIMS, Patna, Bihar, India","institution_ids":["https://openalex.org/I238035932"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012737520","https://openalex.org/A5056174188","https://openalex.org/A5104281715"],"corresponding_institution_ids":["https://openalex.org/I238035932"],"apc_list":{"value":250,"currency":"USD","value_usd":250},"apc_paid":{"value":250,"currency":"USD","value_usd":250},"fwci":0.5653,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.59313256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"16","issue":"Suppl 2","first_page":"S1549","last_page":"S1553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sputum-culture-conversion","display_name":"sputum conversion","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bedaquiline","display_name":"bedaquiline","score":0.996999979019165},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.6549999713897705},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2777768864","wikidata":"https://www.wikidata.org/wiki/Q18387898","display_name":"Culture conversion","level":4,"score":0.839505672454834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7506412863731384},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6453711986541748},{"id":"https://openalex.org/C2908628106","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Pulmonary tuberculosis","level":3,"score":0.6034672856330872},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5573785305023193},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.47599613666534424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38732457160949707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31792569160461426},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13323745131492615}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4103/jpbs.jpbs_407_23","doi":"https://doi.org/10.4103/jpbs.jpbs_407_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jpbs.jpbs_407_23","pdf_url":null,"source":{"id":"https://openalex.org/S109681697","display_name":"Journal of Pharmacy And Bioallied Sciences","issn_l":"0975-7406","issn":["0975-7406","0976-4879"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Bioallied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11174214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11174214","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11174214/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pharm Bioallied Sci","raw_type":"Text"},{"id":"pmid:38882839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38882839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacy & bioallied sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6abe1cb4a85641ddb18735dc16b40297","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6abe1cb4a85641ddb18735dc16b40297","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1549-1553 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/jpbs.jpbs_407_23","doi":"https://doi.org/10.4103/jpbs.jpbs_407_23","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jpbs.jpbs_407_23","pdf_url":null,"source":{"id":"https://openalex.org/S109681697","display_name":"Journal of Pharmacy And Bioallied Sciences","issn_l":"0975-7406","issn":["0975-7406","0976-4879"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Bioallied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394842829.pdf","grobid_xml":"https://content.openalex.org/works/W4394842829.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W203186","https://openalex.org/W1953797045","https://openalex.org/W2024680254","https://openalex.org/W2083336723","https://openalex.org/W2125568924","https://openalex.org/W2125921446","https://openalex.org/W2146416369","https://openalex.org/W2207271647","https://openalex.org/W2216603764","https://openalex.org/W2548811489","https://openalex.org/W2781002339","https://openalex.org/W2796977572","https://openalex.org/W2884109900","https://openalex.org/W3044366608","https://openalex.org/W3126922003","https://openalex.org/W3155425060","https://openalex.org/W3166151627","https://openalex.org/W3196232496","https://openalex.org/W4306160147","https://openalex.org/W4308590004","https://openalex.org/W6600006135"],"related_works":["https://openalex.org/W4404104713","https://openalex.org/W2763250436","https://openalex.org/W4381248372","https://openalex.org/W7168378893","https://openalex.org/W2897122949","https://openalex.org/W3118917490","https://openalex.org/W2553397486","https://openalex.org/W6892502611","https://openalex.org/W4220681017","https://openalex.org/W7202276160"],"abstract_inverted_index":{"Background:":[0],"Multidrug-resistant":[1],"tuberculosis":[2,6,83,236],"(MDR-TB)":[3,237],"refers":[4],"to":[5,32,74,144,162,249],"that":[7],"resists":[8],"at":[9,64,123],"least":[10],"two":[11,103],"primary":[12],"drugs,":[13],"namely":[14],"isoniazid":[15],"and":[16,52,91,109,154,189,221,267],"rifampicin.":[17],"To":[18],"assess":[19],"the":[20,34,65,139,244],"management":[21],"of":[22,38,67,95,105,138,147,165,170,176,202,208,246,258,271,277],"MDR-TB,":[23],"sputum":[24,96,185,195,217,226,260],"culture":[25,35,187,197,219,228,265],"conversion":[26,36,78],"is":[27],"performed.":[28],"This":[29,47],"study":[30,54,61],"aimed":[31],"determine":[33],"status":[37],"MDR-TB":[39],"patients":[40,183,193,215,224,232],"undergoing":[41],"an":[42,50,240],"all-oral":[43,85,106,241],"longer":[44,86,107,172,204,242],"regimen.":[45],"Methods:":[46],"research":[48],"constitutes":[49],"observational":[51],"prospective":[53],"conducted":[55],"within":[56],"a":[57,132,255,262,268,273],"hospital":[58],"setting.":[59],"The":[60],"was":[62],"done":[63],"Department":[66],"Microbiology,":[68],"IGIMS,":[69],"Patna,":[70],"from":[71],"October":[72],"2020":[73],"March":[75],"2022.":[76],"Culture":[77],"in":[79,112,264],"multidrug":[80],"resistance":[81],"pulmonary":[82,235],"on":[84],"regimens":[87,108],"took":[88],"one":[89,92],"spot":[90],"morning":[93],"sample":[94],"as":[97,252],"per":[98],"standard":[99],"protocol":[100],"after":[101],"completing":[102],"months":[104,128,169,201],"culturing":[110],"it":[111],"liquid":[113],"broth":[114],"using":[115],"Mycobacterium":[116],"Growth":[117],"Indicator":[118],"Tube":[119],"(MGIT)":[120],"960":[121],"System":[122],"two,":[124],"four":[125],"then":[126],"six":[127],"till":[129],"we":[130,179,211],"got":[131],"negative":[133,259],"result.":[134],"Results:":[135],"Maximum":[136],"number":[137,257],"cases,":[140,178,210],"77":[141],"(74.8%),":[142],"belonged":[143],"19-35":[145],"years":[146],"age":[148],"group.":[149],"Males":[150],"were":[151,156],"68":[152],"(66.1%)":[153],"females":[155],"35":[157],"(33.9%),":[158],"respectively,":[159],"with":[160,233],"male":[161],"female":[163],"ratio":[164],"1.9:1.":[166],"After":[167,199],"2":[168],"oral":[171,203],"regimen":[173,205],"treatment,":[174,206],"out":[175,207],"103":[177],"found":[180,212],"98":[181],"(95.1%)":[182],"had":[184,194,216,225],"for":[186,196,218,227],"positive":[188,220,250],"only":[190],"five":[191],"(4.2%)":[192],"negative.":[198,229],"6":[200],"101":[209],"16":[213],"(15.8%)":[214],"85":[222],"(85.2%)":[223],"Conclusion:":[230],"In":[231],"multidrug-resistant":[234],"who":[238],"received":[239],"regimen,":[243],"introduction":[245],"bedaquiline":[247],"led":[248],"outcomes":[251],"evidenced":[253],"by":[254],"greater":[256],"cultures,":[261],"decrease":[263],"reversions,":[266],"reduced":[269],"risk":[270],"developing":[272],"more":[274],"resistant":[275],"form":[276],"MDR-TB.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2024-04-17T00:00:00"}