{"id":"https://openalex.org/W4394840883","doi":"https://doi.org/10.26442/00403660.2024.03.202639","title":"Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen","display_name":"Rehabilitation program of post-COVID-19 syndrome with the use of nitric oxide and molecular hydrogen","publication_year":2024,"publication_date":"2024-04-16","ids":{"openalex":"https://openalex.org/W4394840883","doi":"https://doi.org/10.26442/00403660.2024.03.202639","pmid":"https://pubmed.ncbi.nlm.nih.gov/38713041"},"language":"ru","primary_location":{"id":"doi:10.26442/00403660.2024.03.202639","doi":"https://doi.org/10.26442/00403660.2024.03.202639","is_oa":true,"landing_page_url":"https://doi.org/10.26442/00403660.2024.03.202639","pdf_url":"https://ter-arkhiv.ru/0040-3660/article/download/622758/pdf","source":{"id":"https://openalex.org/S27897580","display_name":"Terapevticheskii arkhiv","issn_l":"0040-3660","issn":["0040-3660","2309-5342"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4320800547","host_organization_name":"Consilium Medicum","host_organization_lineage":["https://openalex.org/P4320800547"],"host_organization_lineage_names":["Consilium Medicum"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ter-arkhiv.ru/0040-3660/article/download/622758/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093896891","display_name":"Darya D. Pozdnyakova","orcid":"https://orcid.org/0000-0002-7410-4297","observed_orcids":["https://orcid.org/0000-0002-7410-4297"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Darya D. Pozdnyakova","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0002-7410-4297","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095705429","display_name":"Tatiana \u0410. Bakhareva","orcid":"https://orcid.org/0000-0002-0206-6420","observed_orcids":["https://orcid.org/0000-0002-0206-6420"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana \u0410. Bakhareva","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0002-0206-6420","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017397910","display_name":"Irina Aleksandrovna Baranova","orcid":"https://orcid.org/0000-0002-2469-7346","observed_orcids":["https://orcid.org/0000-0002-2469-7346"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina A. Baranova","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0002-2469-7346","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046231223","display_name":"Victor D. Selemir","orcid":"https://orcid.org/0000-0001-7331-2679","observed_orcids":["https://orcid.org/0000-0001-7331-2679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor D. Selemir","raw_affiliation_strings":["Russian Federal Nuclear Center \u2013 All-Russian Research Institute of Experimental Physics"],"raw_orcid":"https://orcid.org/0000-0001-7331-2679","affiliations":[{"raw_affiliation_string":"Russian Federal Nuclear Center \u2013 All-Russian Research Institute of Experimental Physics","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029120416","display_name":"\u0410. \u0413. \u0427\u0443\u0447\u0430\u043b\u0438\u043d","orcid":"https://orcid.org/0000-0002-6808-5528","observed_orcids":["https://orcid.org/0000-0002-6808-5528","https://orcid.org/0000-0002-5070-5450"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander G. Chuchalin","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0002-6808-5528","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8631,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.84698174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"96","issue":"3","first_page":"260","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pulmonary-rehabilitation","display_name":"pulmonary rehabilitation","score":0.625},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8180000185966492},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/conjunctival-microcirculation","display_name":"conjunctival microcirculation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/6-minute-walk-test","display_name":"6-minute walk test","score":0.7739999890327454},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.5360000133514404},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8019999861717224},{"id":"https://openalex.org/keywords/covid-19-recovery","display_name":"COVID-19 recovery","score":0.5509999990463257},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7914153337478638},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.694175124168396},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5670349597930908},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.5411710739135742},{"id":"https://openalex.org/C2776403943","wikidata":"https://www.wikidata.org/wiki/Q1123260","display_name":"Palpitations","level":2,"score":0.4651091694831848},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4030238687992096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35221898555755615},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3469441831111908},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094024","descriptor_name":"Post-Acute COVID-19 Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.26442/00403660.2024.03.202639","doi":"https://doi.org/10.26442/00403660.2024.03.202639","is_oa":true,"landing_page_url":"https://doi.org/10.26442/00403660.2024.03.202639","pdf_url":"https://ter-arkhiv.ru/0040-3660/article/download/622758/pdf","source":{"id":"https://openalex.org/S27897580","display_name":"Terapevticheskii arkhiv","issn_l":"0040-3660","issn":["0040-3660","2309-5342"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4320800547","host_organization_name":"Consilium Medicum","host_organization_lineage":["https://openalex.org/P4320800547"],"host_organization_lineage_names":["Consilium Medicum"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"journal-article"},{"id":"pmid:38713041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38713041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"English Abstract"},{"id":"pmh:oai:doaj.org/article:12a1b59e151344f0a0d859c3e6d8bd59","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/12a1b59e151344f0a0d859c3e6d8bd59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432, Vol 96, Iss 3, Pp 260-265 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26442/00403660.2024.03.202639","doi":"https://doi.org/10.26442/00403660.2024.03.202639","is_oa":true,"landing_page_url":"https://doi.org/10.26442/00403660.2024.03.202639","pdf_url":"https://ter-arkhiv.ru/0040-3660/article/download/622758/pdf","source":{"id":"https://openalex.org/S27897580","display_name":"Terapevticheskii arkhiv","issn_l":"0040-3660","issn":["0040-3660","2309-5342"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4320800547","host_organization_name":"Consilium Medicum","host_organization_lineage":["https://openalex.org/P4320800547"],"host_organization_lineage_names":["Consilium Medicum"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Terapevticheskii arkhiv","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394840883.pdf","grobid_xml":"https://content.openalex.org/works/W4394840883.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2022759794","https://openalex.org/W2031517252","https://openalex.org/W2759847566","https://openalex.org/W2765557965","https://openalex.org/W2892549192","https://openalex.org/W3136955306","https://openalex.org/W3163862822","https://openalex.org/W3165449608","https://openalex.org/W3196688992","https://openalex.org/W3205504592","https://openalex.org/W4200091524","https://openalex.org/W4210647298","https://openalex.org/W4211184994","https://openalex.org/W4224043752","https://openalex.org/W4303696359","https://openalex.org/W4306399086","https://openalex.org/W4385379686"],"related_works":["https://openalex.org/W7137875742","https://openalex.org/W4403357857","https://openalex.org/W1963939986","https://openalex.org/W4399661074","https://openalex.org/W3193631190","https://openalex.org/W4211184994","https://openalex.org/W4407216067","https://openalex.org/W3103364554","https://openalex.org/W4283170186","https://openalex.org/W4387249054"],"abstract_inverted_index":{"\u0420ost-COVID-19":[0],"syndrome":[1],"(PS)":[2],"is":[3],"one":[4],"of":[5,15,23,41,51,55,65,106,127,132,170,175,188,199,234,244,252,310,321],"the":[6,39,47,52,82,90,112,115,125,130,133,144,151,166,173,176,179,200,205,213,224,241,250,255,260,272,280,283,292,304,311],"medical":[7,24],"and":[8,31,49,57,68,154,221,231,271,291,298,324],"social":[9],"problem.":[10],"According":[11],"to":[12,129,259],"WHO,":[13],"10\u201320%":[14],"COVID-19":[16,128],"patients":[17,61,71,327],"suffer":[18],"from":[19,124],"PS.":[20,66,329],"The":[21,122,138,147,185,211,308],"use":[22],"gases":[25],"\u2013":[26,35],"inhaled":[27],"nitric":[28],"oxide":[29],"(iNO)":[30],"molecular":[32],"hydrogen":[33],"(iH2)":[34],"may":[36],"influence":[37],"on":[38,317],"mechanisms":[40],"development":[42],"PC.":[43],"Aim.":[44],"To":[45],"evaluate":[46],"safety":[48],"efficacy":[50,315],"combined":[53],"inhalation":[54],"NO":[56,107],"H2":[58],"(iNO/iH2)":[59],"in":[60,81,87,111,143,178,226,254,267,276,282,288,294,303,326],"with":[62,72,328],"respiratory":[63],"manifestations":[64],"Materials":[67],"methods.":[69],"34":[70],"PS":[73],"(11":[74],"men/23":[75],"women,":[76],"60.0\u00b111.7":[77],"years)":[78],"were":[79,183,247],"included":[80],"prospective":[83],"open-label":[84],"controlled":[85],"study":[86,134,312],"parallel":[88],"groups:":[89],"main":[91,256],"group":[92,117,257],"(n=17)":[93,118],"received":[94],"iNO/iH2":[95,316],"for":[96,102],"90":[97],"minutes":[98],"once":[99],"a":[100,193,232],"day":[101],"10":[103],"days":[104],"(concentration":[105],"60":[108],"ppm,":[109],"H24%":[110],"gas":[113],"mixture),":[114],"control":[116,261],"didn\u2019t":[119],"receive":[120],"inhalations.":[121],"period":[123],"confirmation":[126],"start":[131],"was":[135,207],"641.8\u00b1230.5":[136],"days.":[137],"groups":[139],"did":[140],"not":[141],"differ":[142],"baseline":[145],"parameters.":[146],"clinical":[148,314,318],"symptoms":[149,214],"(from":[150],"self-observation":[152],"diary":[153],"mMRC":[155],"questionnaires,":[156],"\"dyspnea":[157],"language\"),":[158],"FAS,":[159],"HADS,":[160],"SF-36":[161,227],"scores,":[162],"6-minute":[163,277],"walk":[164,278],"test,":[165,279],"blood":[167,285,305],"serum":[168],"parameters":[169,302,320],"oxidative":[171,295,322],"stress,":[172],"dynamics":[174,198],"microcirculation":[177,201,325],"eye":[180],"bulbar":[181],"conjunctiva":[182],"evaluated.":[184],"individual":[186],"dose":[187,206],"iNO":[189],"has":[190],"chosen":[191],"during":[192],"15-minute":[194],"test":[195],"(the":[196],"positive":[197],"have":[202],"indicated":[203],"that":[204],"selected":[208],"correctly).":[209],"Results.":[210],"decrease":[212],"severity,":[215],"such":[216],"as":[217,238,240],"dyspnea,":[218],"cough,":[219],"fatigue":[220],"palpitations":[222],"(p0.005),":[223],"increase":[225,281],"questionnaire":[228],"scores":[229],"(p=0.006)":[230],"reducing":[233],"FAS":[235],"score":[236],"(p=0.001),":[237],"well":[239],"anxiety":[242],"component":[243],"HADS":[245],"(p=0.02)":[246],"revealed":[248],"at":[249],"end":[251],"treatment":[253],"compared":[258],"group.":[262],"We":[263],"observed":[264],"an":[265],"improvement":[266],"distance":[268],"walked":[269],"(p=0.01)":[270],"values":[273],"SpO2":[274],"(p=0.04)":[275],"volumetric":[284],"flow":[286],"velocity":[287],"venules":[289],"(p0.001),":[290],"date":[293],"damage":[296],"(p0.001)":[297],"antioxidant":[299],"activity":[300],"(p=0.03)":[301],"serum.":[306],"Conclusion.":[307],"results":[309],"demonstrate":[313],"indicators,":[319],"stress":[323]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-04-17T00:00:00"}