{"id":"https://openalex.org/W4394802599","doi":"https://doi.org/10.1021/acschemneuro.4c00011","title":"4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase","display_name":"4-Amidophenol Quinone Methide Precursors: Effective and Broad-Scope Nonoxime Reactivators of Organophosphorus-Inhibited Cholinesterases and Resurrectors of Organophosphorus-Aged Acetylcholinesterase","publication_year":2024,"publication_date":"2024-04-15","ids":{"openalex":"https://openalex.org/W4394802599","doi":"https://doi.org/10.1021/acschemneuro.4c00011","pmid":"https://pubmed.ncbi.nlm.nih.gov/38621296"},"language":"en","primary_location":{"id":"doi:10.1021/acschemneuro.4c00011","doi":"https://doi.org/10.1021/acschemneuro.4c00011","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.4c00011","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095690761","display_name":"Alex R. Lovins","orcid":"https://orcid.org/0009-0002-5850-1708","observed_orcids":["https://orcid.org/0009-0002-5850-1708"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex R. Lovins","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0009-0002-5850-1708","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044936320","display_name":"Kevin A. Miller","orcid":"https://orcid.org/0000-0001-7749-6794","observed_orcids":["https://orcid.org/0000-0001-7749-6794"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin A. Miller","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0001-7749-6794","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anne K. Buck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne K. Buck","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095690762","display_name":"D. Sophia Ensey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Sophia Ensey","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095690763","display_name":"Rose K. Homoelle","orcid":"https://orcid.org/0009-0007-4722-4916","observed_orcids":["https://orcid.org/0009-0007-4722-4916"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose K. Homoelle","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095690764","display_name":"Megan C. Murtha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan C. Murtha","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108913032","display_name":"Nathan A. Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan A. Ward","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095690765","display_name":"Liam A. Shanahan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liam A. Shanahan","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045108858","display_name":"Gopichand Gutti","orcid":"https://orcid.org/0000-0002-5284-2379","observed_orcids":["https://orcid.org/0000-0002-5284-2379"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gopichand Gutti","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026896669","display_name":"Pratik Shriwas","orcid":"https://orcid.org/0000-0003-2582-2118","observed_orcids":["https://orcid.org/0000-0003-2582-2118"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratik Shriwas","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060042170","display_name":"Craig A. McElroy","orcid":"https://orcid.org/0000-0001-5950-0120","observed_orcids":["https://orcid.org/0000-0001-5950-0120"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig A. McElroy","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0001-5950-0120","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082977698","display_name":"Christopher S. Callam","orcid":"https://orcid.org/0000-0002-7655-2982","observed_orcids":["https://orcid.org/0000-0002-7655-2982"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Callam","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0002-7655-2982","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062225029","display_name":"Christopher M. Hadad","orcid":"https://orcid.org/0000-0003-1211-4315","observed_orcids":["https://orcid.org/0000-0003-1211-4315"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Hadad","raw_affiliation_strings":["Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States"],"raw_orcid":"https://orcid.org/0000-0003-1211-4315","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, College of Arts and Sciences, Ohio State University, Columbus, Ohio 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062225029"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.1797,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86441089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"9","first_page":"1813","last_page":"1827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organophosphate-poisoning","display_name":"organophosphate poisoning","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cholinesterase-reactivation","display_name":"cholinesterase reactivation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/quinone-methides","display_name":"quinone methides","score":0.6800000071525574},{"id":"https://openalex.org/keywords/methylphosphonate","display_name":"methylphosphonate","score":0.7350000143051147},{"id":"https://openalex.org/keywords/phosphoramidates","display_name":"phosphoramidates","score":0.7300000190734863},{"id":"https://openalex.org/keywords/oxime-reactivators","display_name":"oxime reactivators","score":0.5870000123977661},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.7555084228515625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6597986817359924},{"id":"https://openalex.org/C2778706303","wikidata":"https://www.wikidata.org/wiki/Q2612896","display_name":"Nerve agent","level":4,"score":0.5432158708572388},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.5225847959518433},{"id":"https://openalex.org/C2778407918","wikidata":"https://www.wikidata.org/wiki/Q7272333","display_name":"Quinone methide","level":3,"score":0.47386932373046875},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35711854696273804},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3389601707458496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30499622225761414},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2199956476688385},{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.20261293649673462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13121351599693298},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.048695534467697144},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002801","descriptor_name":"Cholinesterase Reactivators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002801","descriptor_name":"Cholinesterase Reactivators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045563","descriptor_name":"Indolequinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acschemneuro.4c00011","doi":"https://doi.org/10.1021/acschemneuro.4c00011","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acschemneuro.4c00011","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"pmid:38621296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38621296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2827965089","display_name":null,"funder_award_id":"CB10791 MCDC 1905-006","funder_id":"https://openalex.org/F4320332186","funder_display_name":"Defense Threat Reduction Agency"}],"funders":[{"id":"https://openalex.org/F4320332186","display_name":"Defense Threat Reduction Agency","ror":"https://ror.org/04tz64554"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1589964883","https://openalex.org/W1816667331","https://openalex.org/W1913376786","https://openalex.org/W1969970105","https://openalex.org/W1987600705","https://openalex.org/W1990583466","https://openalex.org/W1995721837","https://openalex.org/W2013593571","https://openalex.org/W2025773423","https://openalex.org/W2026976753","https://openalex.org/W2029563989","https://openalex.org/W2029669944","https://openalex.org/W2032865438","https://openalex.org/W2034772181","https://openalex.org/W2037625408","https://openalex.org/W2056666326","https://openalex.org/W2060891382","https://openalex.org/W2073101936","https://openalex.org/W2077595171","https://openalex.org/W2083881141","https://openalex.org/W2085666934","https://openalex.org/W2085907924","https://openalex.org/W2094096972","https://openalex.org/W2106527666","https://openalex.org/W2140788274","https://openalex.org/W2144361299","https://openalex.org/W2156300379","https://openalex.org/W2166189502","https://openalex.org/W2315996261","https://openalex.org/W2612047920","https://openalex.org/W2805297238","https://openalex.org/W2901844048","https://openalex.org/W2980724460","https://openalex.org/W3132452654"],"related_works":["https://openalex.org/W7110585534","https://openalex.org/W7110660145","https://openalex.org/W7130553874","https://openalex.org/W7024201868","https://openalex.org/W7170991576","https://openalex.org/W7110616198","https://openalex.org/W7110475594","https://openalex.org/W4393364583","https://openalex.org/W6980653180","https://openalex.org/W3211224863"],"abstract_inverted_index":{"Acetylcholinesterase":[0],"(AChE)":[1],"inhibition":[2],"by":[3],"organophosphorus":[4],"(OP)":[5],"compounds":[6,107,130,181],"poses":[7],"a":[8,28,68,99,161,170,244,280,306],"serious":[9],"health":[10],"risk":[11],"to":[12,89,98,174,297,303],"humans.":[13],"While":[14],"many":[15],"therapeutics":[16,42],"have":[17,43],"been":[18],"tested":[19,132],"for":[20,30,133,146,216,234,251,265],"treatment":[21],"after":[22,96],"OP":[23,37,121,180],"exposure,":[24],"there":[25],"is":[26,114,229,318,326],"still":[27],"need":[29],"efficient":[31],"reactivation":[32,80,134,147,235,246,285],"against":[33,81,178,287],"all":[34],"kinds":[35],"of":[36,63,71,85,94,120,127,137,140,148,236,241,309,320,330],"compounds,":[38],"and":[39,135,143,145,157,210,282,289,311],"current":[40,328],"oxime":[41,299],"poor":[44],"blood\u2013brain":[45],"barrier":[46],"penetration":[47],"into":[48],"the":[49,60,91,223],"central":[50],"nervous":[51],"system,":[52],"while":[53],"offering":[54],"no":[55],"recovery":[56],"in":[57,87,116,124,202,218,272],"activity":[58,198],"from":[59,160,199],"OP-aged":[61],"forms":[62,84,139,240],"AChE.":[64],"Herein,":[65],"we":[66,313],"report":[67],"novel":[69],"library":[70],"4-amidophenol":[72],"quinone":[73],"methide":[74],"precursors":[75],"(QMP)":[76],"that":[77,259,277,316],"provide":[78],"effective":[79,224],"multiple":[82,179],"OP-inhibited":[83,110,252],"AChE":[86,95,142,201,310],"addition":[88,302],"resurrecting":[90,321],"aged":[92],"form":[93],"exposure":[97],"pesticide":[100],"or":[101],"some":[102],"phosphoramidates.":[103],"Furthermore,":[104,270],"these":[105,128],"QMP":[106,129],"also":[108,314],"reactivate":[109],"butyrylcholinesterase":[111],"(BChE)":[112],"which":[113,325],"an":[115,271,298],"vivo,":[117],"endogenous":[118],"scavenger":[119],"compounds.":[122,269],"The":[123],"vitro":[125,273],"efficacies":[126],"were":[131],"resurrection":[136],"soluble":[138],"human":[141,151,203],"BChE":[144],"cholinesterases":[149],"within":[150],"blood":[152,156,204,209],"as":[153,155,169,182,184,205,207],"well":[154,183,206],"brain":[158],"samples":[159],"humanized":[162],"mouse":[163,208],"model.":[164],"We":[165],"identify":[166],"compound":[167,189],"10c":[168,190,254,278,304,317],"lead":[171],"candidate":[172],"due":[173],"its":[175,214],"broad-scope":[176],"efficacy":[177],"both":[185],"cholinesterases.":[186],"With":[187],"methylphosphonates,":[188],"(250":[191],"\u03bcM,":[192],"1":[193],"h)":[194],"shows":[195],">60%":[196],"recovered":[197],"OEt-inhibited":[200,288],"brain,":[211],"thus":[212],"highlighting":[213],"potential":[215],"future":[217],"vivo":[219],"analysis.":[220],"For":[221],"10c,":[222],"concentration":[225],"(EC":[226],"50":[227,257],")":[228],"less":[230,261],"than":[231,262],"25":[232],"\u03bcM":[233,264],"three":[237],"different":[238,267],"methylphosphonate-inhibited":[239],"AChE,":[242,293,324],"with":[243],"maximum":[245],"yield":[247],"above":[248],"80%.":[249],"Similarly,":[250],"BChE,":[253,312],"has":[255,279],"EC":[256],"values":[258],"are":[260],"150":[263],"two":[266],"methylphosphonate":[268],"kinetic":[274],"analysis":[275],"show":[276,315],"2.2-":[281],"92.1-fold":[283],"superior":[284],"efficiency":[286],"O":[290],"i":[291],"Bu-inhibited":[292],"respectively,":[294],"when":[295],"compared":[296],"control.":[300],"In":[301],"being":[305],"potent":[307],"reactivator":[308],"capable":[319],"(ethyl":[322],"paraoxon)-aged":[323],"another":[327],"limitation":[329],"oximes.":[331]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-16T00:00:00"}