{"id":"https://openalex.org/W4394801921","doi":"https://doi.org/10.1097/01.ju.0001009436.52988.91.14","title":"MP63-14 IMPACT OF OBESITY AND AGING ON TURNOVER OF ASCORBIC ACID TO URINARY OXALATE IN THE GULO DEFICIENT MOUSE","display_name":"MP63-14 IMPACT OF OBESITY AND AGING ON TURNOVER OF ASCORBIC ACID TO URINARY OXALATE IN THE GULO DEFICIENT MOUSE","publication_year":2024,"publication_date":"2024-04-15","ids":{"openalex":"https://openalex.org/W4394801921","doi":"https://doi.org/10.1097/01.ju.0001009436.52988.91.14"},"language":"en","primary_location":{"id":"doi:10.1097/01.ju.0001009436.52988.91.14","doi":"https://doi.org/10.1097/01.ju.0001009436.52988.91.14","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0001009436.52988.91.14","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Brody Rhodes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brody Rhodes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101911724","display_name":"Xingsheng Li","orcid":"https://orcid.org/0000-0002-1683-9498","observed_orcids":["https://orcid.org/0000-0002-1683-9498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xingsheng Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061252104","display_name":"Joseph J. Crivelli","orcid":"https://orcid.org/0000-0001-6140-279X","observed_orcids":["https://orcid.org/0000-0001-6140-279X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph J. Crivelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034680241","display_name":"John L Knight","orcid":"https://orcid.org/0000-0002-9683-8064","observed_orcids":["https://orcid.org/0000-0002-9683-8064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Knight","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12134197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"211","issue":"5S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-oxalate","display_name":"urinary oxalate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/calcium-oxalate-stones","display_name":"calcium oxalate stones","score":0.8949999809265137},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dietary-ascorbic-acid","display_name":"dietary ascorbic acid","score":0.5569999814033508},{"id":"https://openalex.org/keywords/stone-prevention","display_name":"stone prevention","score":0.4690000116825104},{"id":"https://openalex.org/keywords/metabolic-bone-disease","display_name":"metabolic bone disease","score":0.3720000088214874},{"id":"https://openalex.org/keywords/vitamin-c-deficiency","display_name":"scurvy","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.8828821182250977},{"id":"https://openalex.org/C2776351790","wikidata":"https://www.wikidata.org/wiki/Q417351","display_name":"Oxalate","level":2,"score":0.6784095764160156},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.642549455165863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49814343452453613},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.49085789918899536},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47038474678993225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4325453042984009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41194599866867065},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3521948456764221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27348360419273376},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.09682992100715637}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.ju.0001009436.52988.91.14","doi":"https://doi.org/10.1097/01.ju.0001009436.52988.91.14","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0001009436.52988.91.14","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225842627","https://openalex.org/W2604525894","https://openalex.org/W2786001144","https://openalex.org/W7098821854","https://openalex.org/W2897420388","https://openalex.org/W2467318539","https://openalex.org/W2315189416","https://openalex.org/W2336253384","https://openalex.org/W2037820402","https://openalex.org/W4301666921"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,109,127,152,157,182,189,206,227,238,250,289,311,350,352,380,390,408],"UrologyStone":[4],"Disease:":[5],"Basic":[6],"Research":[7,431,437],"&":[8,464],"Pathophysiology":[9],"(MP63)1":[10],"May":[11],"2024MP63-14":[12],"IMPACT":[13],"OF":[14,20],"OBESITY":[15],"AND":[16,72],"AGING":[17],"ON":[18],"TURNOVER":[19],"ASCORBIC":[21],"ACID":[22],"TO":[23],"URINARY":[24],"OXALATE":[25],"IN":[26],"THE":[27],"GULO":[28],"DEFICIENT":[29],"MOUSE":[30],"Brody":[31,41,477],"Rhodes,":[32],"Xingsheng":[33,45,484],"Li,":[34],"Joseph":[35,49,491],"J.":[36,50,52,492],"Crivelli,":[37],"and":[38,55,100,144,184,203,259,276,334,362,400,426,444,454,472],"John":[39,56,499],"Knight":[40,58,500],"RhodesBrody":[42],"Rhodes":[43,478],",":[44,48,54],"LiXingsheng":[46],"Li":[47,485],"CrivelliJoseph":[51],"Crivelli":[53,493],"KnightJohn":[57],"View":[59],"All":[60,507],"Author":[61,475],"Informationhttps://doi.org/10.1097/01.JU.0001009436.52988.91.14AboutPDF":[62],"ToolsAdd":[63],"to":[64,98,129,159,164,191,196,223,284,291,346,383],"favoritesDownload":[65],"CitationsTrack":[66],"CitationsPermissionsReprints":[67],"ShareFacebookLinked":[68],"InTwitterEmail":[69],"Abstract":[70],"INTRODUCTION":[71],"OBJECTIVE:":[73],"Increased":[74],"urinary":[75,160,192,292,353,391],"oxalate":[76,84,112,130,161,174,273,354,384,392],"excretion":[77],"is":[78,91,95,104],"a":[79,218,242,248,317,323,347],"risk":[80,108],"factor":[81],"for":[82,172,257,265,303,368,373,386],"calcium":[83,111,173],"kidney":[85],"stone":[86,175],"formation.":[87],"Ascorbic":[88],"acid":[89,382],"(AsA)":[90],"an":[92,132,335],"antioxidant":[93],"that":[94,343],"non-enzymatically":[96],"degraded":[97],"oxalate,":[99],"increased":[101,107,401],"AsA":[102,120,128,158,190,215,220,290,344],"intake":[103],"associated":[105],"with":[106,234,301,403],"forming":[110],"stones.":[113],"Most":[114],"animals,":[115],"unlike":[116],"humans,":[117,140],"can":[118],"synthesize":[119,147],"which":[121],"has":[122],"made":[123],"studying":[124],"the":[125,155,180,187,235,286,397,417,427,433],"conversion":[126,156,379],"in":[131,269,396,414],"animal":[133],"model":[134],"difficult.":[135],"The":[136],"Gulo-/-":[137,312,398],"mouse,":[138],"like":[139],"lacks":[141],"gulonolactone":[142],"oxidase":[143],"therefore":[145],"cannot":[146],"AsA.":[148,228],"A":[149],"better":[150],"understanding":[151],"factors":[153],"influencing":[154],"may":[162],"lead":[163],"improved":[165],"dietary":[166],"recommendations":[167],"or":[168],"novel":[169],"pharmaceutical":[170],"targets":[171],"formers.":[176],"Thus,":[177],"we":[178],"examined":[179],"influence":[181],"obesity":[183],"aging":[185],"on":[186],"turnover":[188],"oxalate.":[193,293],"METHODS:":[194],"Prior":[195],"beginning":[197],"infusion":[198],"studies,":[199],"baseline,":[200],"diet-induced":[201,324],"obese,":[202],"aged":[204,336,365,374],"cohorts":[205],"Gulo-/-mice":[207],"were":[208,230,263,278],"provided":[209],"ad-libitum":[210],"water":[211],"containing":[212],"330":[213],"mg/L":[214],"followed":[216],"by":[217,416,449,467,481,488,496,503],"5-day":[219],"depletion":[221],"period":[222],"eliminate":[224],"tissue":[225],"stores":[226],"Mice":[229],"then":[231],"intravenously":[232],"infused":[233],"stable":[236],"isotope":[237],"AsA,":[239],"13C6-AsA,":[240],"via":[241],"surgically":[243],"implanted":[244],"osmotic":[245],"pump":[246],"at":[247],"rate":[249],"10":[251],"\u00b5moles/kg/h.":[252],"After":[253],"allowing":[254],"8":[255],"days":[256,268],"recovery":[258],"equilibration,":[260],"24-hour":[261],"urines":[262],"collected":[264],"3":[266,309],"consecutive":[267],"metabolic":[270],"cages.":[271],"Urinary":[272],"isotopomers,":[274],"12C2-oxalate,":[275],"13C2-oxalate,":[277],"measured":[279],"using":[280,298],"ion":[281],"chromatography/mass":[282],"spectrometry":[283],"calculate":[285],"percent":[287],"contribution":[288],"Statistical":[294],"analysis":[295],"was":[296,412],"performed":[297],"one-way":[299],"ANOVA":[300],"adjustment":[302],"multiple":[304],"comparisons.":[305],"RESULTS:":[306],"We":[307,341],"compared":[308],"groups":[310],"mice":[313],"(n=4-5":[314],"per":[315],"group):":[316],"baseline":[318,356,394],"cohort":[319,326,337],"(age":[320,338],"14-24":[321],"weeks),":[322,333],"obese":[325,360,369],"(60%":[327],"high":[328],"fat":[329],"diet,":[330],"age":[331],"23-31":[332],"79-101":[339],"weeks).":[340],"found":[342],"contributes":[345],"mean\u00b1standard":[348],"deviation":[349],"23.5\u00b11.6%":[351],"under":[355,359,364,393],"conditions,":[357,361],"27.4\u00b11.7%":[358],"33.1\u00b12.7%":[363],"conditions":[366,395],"(p=0.06":[367],"vs.":[370,375],"baseline;":[371],"p<0.001":[372],"baseline).":[376],"CONCLUSIONS:":[377],"Non-enzymatic":[378],"ascorbic":[381],"accounted":[385],"almost":[387],"one":[388],"quarter":[389],"mouse":[399],"significantly":[402],"aging.":[404],"Download":[405],"PPT":[406],"Source":[407],"Funding:":[409],"This":[410],"work":[411],"supported":[413],"part":[415],"Urology":[418,434],"Care":[419,435],"Foundation":[420,436],"Summer":[421],"Medical":[422],"Student":[423],"Fellowship":[424],"Program":[425],"Herbert":[428],"Brendler,":[429],"MD,":[430],"Fund;":[432],"Scholar":[438],"Endourological":[439],"Society/Raju":[440],"Thomas,":[441],"MD":[442],"Award;":[443],"NIH":[445],"1R01DK126774":[446],"\u00a9":[447],"2024":[448,466],"American":[450,468],"Urological":[451,469],"Association":[452,470],"Education":[453,471],"Research,":[455,473],"Inc.FiguresReferencesRelatedDetails":[456],"Volume":[457],"211Issue":[458],"5SMay":[459],"2024Page:":[460],"e1036":[461],"Advertisement":[462,508],"Copyright":[463],"Permissions\u00a9":[465],"Inc.Metrics":[474],"Information":[476],"More":[479,486,494,501],"articles":[480,487,495,502],"this":[482,489,497,504],"author":[483,490,498,505],"Expand":[506],"PDF":[509],"downloadLoading":[510],"...":[511]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-16T00:00:00"}
