{"id":"https://openalex.org/W4394801525","doi":"https://doi.org/10.1097/01.ju.0001008848.77629.6f.08","title":"PD30-08 ELUCIDATING THE RESPONSE RATES TO CONTINUED BACILLUS CALMETTE-GUERIN (BCG) IN PATIENTS WITH BCG EXPOSED BLADDER CANCER: IMPLICATIONS FOR CLINICAL TRIAL DESIGN","display_name":"PD30-08 ELUCIDATING THE RESPONSE RATES TO CONTINUED BACILLUS CALMETTE-GUERIN (BCG) IN PATIENTS WITH BCG EXPOSED BLADDER CANCER: IMPLICATIONS FOR CLINICAL TRIAL DESIGN","publication_year":2024,"publication_date":"2024-04-15","ids":{"openalex":"https://openalex.org/W4394801525","doi":"https://doi.org/10.1097/01.ju.0001008848.77629.6f.08"},"language":"en","primary_location":{"id":"doi:10.1097/01.ju.0001008848.77629.6f.08","doi":"https://doi.org/10.1097/01.ju.0001008848.77629.6f.08","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0001008848.77629.6f.08","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060113344","display_name":"Amanda A. Myers","orcid":"https://orcid.org/0000-0002-5219-2978","observed_orcids":["https://orcid.org/0000-0002-5219-2978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda A. Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079640210","display_name":"Wei Shen Tan","orcid":"https://orcid.org/0000-0002-6119-4043","observed_orcids":["https://orcid.org/0000-0002-6119-4043","https://orcid.org/0000-0003-2651-781X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Shen Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016041981","display_name":"Valentina Grajales","orcid":"https://orcid.org/0000-0002-1866-6148","observed_orcids":["https://orcid.org/0000-0002-1866-6148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentina Grajales","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085348528","display_name":"Hyunsoo Hwang","orcid":"https://orcid.org/0000-0003-0308-5145","observed_orcids":["https://orcid.org/0000-0003-0308-5145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyunsoo Hwang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072980507","display_name":"Kelly K. Bree","orcid":"https://orcid.org/0000-0003-4532-7763","observed_orcids":["https://orcid.org/0000-0003-4532-7763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly K. Bree","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002421938","display_name":"Neema Navai","orcid":"https://orcid.org/0000-0001-8457-3786","observed_orcids":["https://orcid.org/0000-0001-8457-3786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neema Navai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070471092","display_name":"Byron Lee","orcid":"https://orcid.org/0000-0002-8755-9688","observed_orcids":["https://orcid.org/0000-0002-8755-9688"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byron H. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002737792","display_name":"Colin P. Dinney","orcid":"https://orcid.org/0000-0002-8969-711X","observed_orcids":["https://orcid.org/0000-0002-8969-711X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin P. N. Dinney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034005227","display_name":"Ashish M. Kamat","orcid":"https://orcid.org/0000-0003-3546-9928","observed_orcids":["https://orcid.org/0000-0003-3546-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashish M. Kamat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08770761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"211","issue":"5S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-muscle-invasive-bladder-cancer","display_name":"non-muscle-invasive bladder cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.746999979019165},{"id":"https://openalex.org/keywords/trial-power","display_name":"trial power","score":0.48100000619888306},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.3179999887943268},{"id":"https://openalex.org/keywords/bcg-naive-patients","display_name":"BCG-naive patients","score":0.5230000019073486},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.49799999594688416},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.36500000953674316},{"id":"https://openalex.org/keywords/non-invasive-bladder-cancer","display_name":"non-invasive bladder cancer","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6711102724075317},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.6087255477905273},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.554644763469696},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5071473121643066},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46324506402015686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4592336118221283}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.ju.0001008848.77629.6f.08","doi":"https://doi.org/10.1097/01.ju.0001008848.77629.6f.08","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.ju.0001008848.77629.6f.08","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393041981","https://openalex.org/W4394836007","https://openalex.org/W4394802547","https://openalex.org/W4200180513","https://openalex.org/W7154592055","https://openalex.org/W4408018991","https://openalex.org/W4378619101","https://openalex.org/W4306934086","https://openalex.org/W3028413201","https://openalex.org/W4412783227"],"abstract_inverted_index":{"You":[0],"have":[1],"accessJournal":[2],"of":[3,188,211,254,311,335,359,381,386,429,467],"UrologyBladder":[4],"Cancer:":[5],"Non-invasive":[6],"II":[7],"(PD30)1":[8],"May":[9],"2024PD30-08":[10],"ELUCIDATING":[11],"THE":[12],"RESPONSE":[13],"RATES":[14],"TO":[15],"CONTINUED":[16],"BACILLUS":[17],"CALMETTE-GUERIN":[18],"(BCG)":[19],"IN":[20],"PATIENTS":[21],"WITH":[22],"BCG":[23,130,140,176,198,228,240,259,316,329,337,396,443,448,461],"EXPOSED":[24],"BLADDER":[25],"CANCER:":[26],"IMPLICATIONS":[27],"FOR":[28],"CLINICAL":[29],"TRIAL":[30],"DESIGN":[31],"Amanda":[32,58,500],"A.":[33,59,61,501],"Myers,":[34],"Wei":[35,64,508],"Shen":[36,65,67,509],"Tan,":[37],"Valentina":[38,70,516],"Grajales,":[39],"Hyunsoo":[40,74,523],"Hwang,":[41],"Kelly":[42,78,530],"K.":[43,79,81,531],"Bree,":[44],"Neema":[45,84,538],"Navai,":[46],"Byron":[47,88,545],"H.":[48,89,91,546],"Lee,":[49],"Colin":[50,94,553],"P.":[51,95,98,554],"N.":[52,96,99,555],"Dinney,":[53],"and":[54,102,220,302,346,414,420,426,432,477,495],"Ashish":[55,103,562],"M.":[56,104,106,563],"Kamat":[57,107,564],"MyersAmanda":[60],"Myers":[62,502],",":[63,69,73,77,83,87,93,101],"TanWei":[66],"Tan":[68,510],"GrajalesValentina":[71],"Grajales":[72,517],"HwangHyunsoo":[75],"Hwang":[76,524],"BreeKelly":[80],"Bree":[82,532],"NavaiNeema":[85],"Navai":[86,539],"LeeByron":[90],"Lee":[92,547],"DinneyColin":[97],"Dinney":[100,556],"KamatAshish":[105],"View":[108],"All":[109,571],"Author":[110,498],"Informationhttps://doi.org/10.1097/01.JU.0001008848.77629.6f.08AboutPDF":[111],"ToolsAdd":[112],"to":[113,137,180,196,223,287,295,404],"favoritesDownload":[114],"CitationsTrack":[115],"CitationsPermissionsReprints":[116],"ShareFacebookLinked":[117],"InTwitterEmail":[118],"Abstract":[119],"INTRODUCTION":[120],"AND":[121],"OBJECTIVE:":[122],"BCG-exposed":[123],"NMIBC":[124,216],"includes":[125],"patients":[126,147,200,213,225,255,313,323,355,445],"who":[127,226,256,324],"are":[128,158,167,397,406],"not":[129,134,159,243],"na\u00efve":[131,177],"yet":[132,151],"do":[133],"meet":[135],"criteria":[136,230,245,327],"be":[138],"considered":[139],"unresponsive.":[141],"The":[142,263,280,391],"standard":[143],"treatment":[144],"for":[145,246,328],"these":[146,360],"is":[148,451],"additional":[149,258,336,351,395,442],"BCG,":[150,352],"response":[152,173,194,392,440],"rates":[153,174,393],"in":[154,175,182,199,399,444,456],"this":[155,457,506,514,521,528,536,543,551,560,568],"patient":[156],"group":[157],"well":[160],"elucidated.":[161],"Clinical":[162],"trials":[163,455],"evaluating":[164],"novel":[165],"agents":[166],"often":[168],"powered":[169],"based":[170],"on":[171],"historical":[172],"patients,":[178],"leading":[179],"delays":[181],"readout.":[183],"To":[184],"fill":[185],"the":[186,193,252,308,326,437],"lack":[187],"data,":[189],"herein,":[190],"we":[191,320],"report":[192],"rate":[195],"continued":[197],"classified":[201,446],"as":[202,260,272,447,462],"BCG-exposed.":[203],"METHODS:":[204],"We":[205,250],"performed":[206],"an":[207],"IRB":[208],"approved":[209],"review":[210],"consecutive":[212],"diagnosed":[214],"with":[215,315,441],"between":[217],"January":[218],"2000":[219],"September":[221],"2021":[222],"identify":[224],"met":[227,325],"exposed":[229],"i.e.,":[231],"having":[232],"high":[233,274],"grade":[234,275],"recurrence":[235],"within":[236],"two":[237],"years":[238,371,380],"after":[239,394],"exposure":[241],"but":[242],"meeting":[244],"being":[247],"'BCG":[248],"unresponsive'.":[249],"analyzed":[251],"outcomes":[253],"received":[257,363],"primary":[261,264],"therapy.":[262],"outcome":[265],"was":[266,285,338,369,412,418],"event":[267],"free":[268,291,299],"survival":[269,292,300,304],"(EFS)":[270],"defined":[271],"any":[273],"recurrence,":[276],"progression,":[277],"or":[278,297],"death.":[279],"Kaplan":[281],"Meier":[282],"(KM)":[283],"method":[284],"used":[286],"estimate":[288],"EFS,":[289],"cystectomy":[290],"(CysFS),":[293],"progression":[294],"muscle-invasive":[296],"metastatic":[298],"(PFS)":[301],"overall":[303],"(OS).":[305],"RESULTS:":[306],"From":[307],"total":[309],"dataset":[310],"858":[312],"treated":[314],"at":[317,333,378,409,415,423],"our":[318],"institution,":[319],"identified":[321],"50":[322],"exposed.":[330],"Tumor":[331],"stage":[332],"initiation":[334],"T1":[339],"(1),":[340],"Ta":[341],"(37),":[342],"CIS":[343,348],"only":[344],"(12),":[345],"concomitant":[347],"(6).":[349],"After":[350],"39":[353],"(78%)":[354],"showed":[356],"no":[357],"disease;":[358],"37":[361],"(95%)":[362],"ongoing":[364],"maintenance":[365],"BCG.":[366],"Median":[367],"follow-up":[368],"4.9":[370],"(IQR":[372],"2.8-8).":[373],"At":[374],"a":[375,463],"prespecified":[376],"analysis":[377],"three":[379],"follow-up;":[382],"20":[383],"(40%)":[384],"recurred,":[385],"which":[387],"6":[388],"(12%)":[389],"progressed.":[390],"summarized":[398],"Table":[400],"1.":[401],"Major":[402],"points":[403],"emphasize":[405],"1)":[407],"EFS":[408],"12":[410],"months":[411,417,428],"67%":[413],"24":[416,425],"60%":[419],"2)":[421],"CysFS":[422],"12,":[424],"36":[427],"86%,":[430],"82%":[431],"82%,":[433],"respectively.":[434],"CONCLUSIONS:":[435],"Given":[436],"demonstrable":[438],"durable":[439],"exposed,":[449],"it":[450],"essential":[452],"that":[453],"clinical":[454],"population":[458],"compare":[459],"against":[460],"control":[464],"arm.":[465],"Source":[466],"Funding:":[468],"None":[469],"\u00a9":[470],"2024":[471,489],"by":[472,490,505,513,520,527,535,542,550,559,567],"American":[473,491],"Urological":[474,492],"Association":[475,493],"Education":[476,494],"Research,":[478,496],"Inc.FiguresReferencesRelatedDetails":[479],"Volume":[480],"211Issue":[481],"5SMay":[482],"2024Page:":[483],"e627":[484],"Advertisement":[485,572],"Copyright":[486],"&":[487],"Permissions\u00a9":[488],"Inc.Metrics":[497],"Information":[499],"More":[503,511,518,525,533,540,548,557,565],"articles":[504,512,519,526,534,541,549,558,566],"author":[507,515,522,529,537,544,552,561,569],"Expand":[570],"PDF":[573],"downloadLoading":[574],"...":[575]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-04-16T00:00:00"}