{"id":"https://openalex.org/W4394792609","doi":"https://doi.org/10.1007/s00204-024-03740-3","title":"Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells","display_name":"Sub-acute oral exposure to lowest observed adverse effect level of nivalenol exacerbates atopic dermatitis in mice via direct activation of mitogen-activated protein kinase signal in antigen-presenting cells","publication_year":2024,"publication_date":"2024-04-14","ids":{"openalex":"https://openalex.org/W4394792609","doi":"https://doi.org/10.1007/s00204-024-03740-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/38616237"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-024-03740-3","doi":"https://doi.org/10.1007/s00204-024-03740-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00204-024-03740-3","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://az.repo.nii.ac.jp/record/2000551/files/ATOX-S-24-00326.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095688010","display_name":"Reo Matsuzaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reo Matsuzaka","raw_affiliation_strings":["School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681386","display_name":"Hiroki Yamaguchi","orcid":"https://orcid.org/0009-0007-4117-6167","observed_orcids":["https://orcid.org/0009-0007-4117-6167"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Yamaguchi","raw_affiliation_strings":["School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072935732","display_name":"Chiharu Ohira","orcid":"https://orcid.org/0009-0006-7018-6287","observed_orcids":["https://orcid.org/0009-0006-7018-6287"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chiharu Ohira","raw_affiliation_strings":["School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109672170","display_name":"Tomoe Kurita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoe Kurita","raw_affiliation_strings":["School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079749680","display_name":"Naoki Iwashita","orcid":"https://orcid.org/0000-0003-1348-2013","observed_orcids":["https://orcid.org/0000-0003-1348-2013"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Iwashita","raw_affiliation_strings":["Bioalch Co., Ltd, 3-28 Honshuku-Cho, Fuchu, Tokyo, Japan","School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioalch Co., Ltd, 3-28 Honshuku-Cho, Fuchu, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112137654","display_name":"Yoshiichi Takagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiichi Takagi","raw_affiliation_strings":["Japan SLC, Inc, 85 Ohara-Cho, Chuo-Ku, Hamamatsu, Shizuoka, Japan","School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan SLC, Inc, 85 Ohara-Cho, Chuo-Ku, Hamamatsu, Shizuoka, Japan","institution_ids":[]},{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026099211","display_name":"Tomomi Nishino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Nishino","raw_affiliation_strings":["School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042982154","display_name":"Kyoko Noda","orcid":"https://orcid.org/0009-0005-3698-3816","observed_orcids":["https://orcid.org/0009-0005-3698-3816"]},"institutions":[{"id":"https://openalex.org/I26120043","display_name":"Ochanomizu University","ror":"https://ror.org/03599d813","country_code":"JP","type":"education","lineage":["https://openalex.org/I26120043"]},{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Noda","raw_affiliation_strings":["Department of Nutrition and Food Science, Ochanomizu University, 2-1-1, Otsuka, Bunkyo-Ku, Tokyo, Japan","School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Food Science, Ochanomizu University, 2-1-1, Otsuka, Bunkyo-Ku, Tokyo, Japan","institution_ids":["https://openalex.org/I26120043"]},{"raw_affiliation_string":"School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044347584","display_name":"Kazutoshi Sugita","orcid":"https://orcid.org/0009-0008-9190-3649","observed_orcids":["https://orcid.org/0009-0008-9190-3649"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutoshi Sugita","raw_affiliation_strings":["School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043310015","display_name":"Masayo Kushiro","orcid":"https://orcid.org/0000-0002-8876-0316","observed_orcids":["https://orcid.org/0000-0002-8876-0316"]},"institutions":[{"id":"https://openalex.org/I1323638106","display_name":"National Agriculture and Food Research Organization","ror":"https://ror.org/023v4bd62","country_code":"JP","type":"government","lineage":["https://openalex.org/I1323638106"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayo Kushiro","raw_affiliation_strings":["Institute of Food Research, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Food Research, National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan","institution_ids":["https://openalex.org/I1323638106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064339304","display_name":"Shiro M\u00edyake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Miyake","raw_affiliation_strings":["School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049295699","display_name":"Tomoki Fukuyama","orcid":"https://orcid.org/0000-0003-3510-3272","observed_orcids":["https://orcid.org/0000-0003-3510-3272"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoki Fukuyama","raw_affiliation_strings":["Center for Human and Animal Symbiosis Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan. t-fukuyama@azabu-u.ac.jp","Laboratory of Veterinary Pharmacology, Azabu University, 1-17-71, Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan. t-fukuyama@azabu-u.ac.jp","School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan. t-fukuyama@azabu-u.ac.jp","Center for Human and Animal Symbiosis Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3510-3272","affiliations":[{"raw_affiliation_string":"Center for Human and Animal Symbiosis Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan. t-fukuyama@azabu-u.ac.jp","institution_ids":["https://openalex.org/I57361664"]},{"raw_affiliation_string":"Laboratory of Veterinary Pharmacology, Azabu University, 1-17-71, Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, 252-5201, Japan. t-fukuyama@azabu-u.ac.jp","institution_ids":["https://openalex.org/I57361664"]},{"raw_affiliation_string":"School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan. t-fukuyama@azabu-u.ac.jp","institution_ids":["https://openalex.org/I57361664"]},{"raw_affiliation_string":"Center for Human and Animal Symbiosis Science, Azabu University, 1-17-71 Fuchinobe, Chuo-Ku, Sagamihara, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049295699"],"corresponding_institution_ids":["https://openalex.org/I57361664"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":null,"fwci":0.8966,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72187723,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"98","issue":"7","first_page":"2173","last_page":"2183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10520","display_name":"Mycotoxins in Agriculture and Food","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.09950000047683716,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nivalenol","display_name":"nivalenol","score":1.0},{"id":"https://openalex.org/keywords/mycotoxins","display_name":"mycotoxins","score":0.8859999775886536},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8199999928474426},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7250000238418579},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9980000257492065},{"id":"https://openalex.org/keywords/t-helper-cells","display_name":"T helper cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/oral-exposure","display_name":"oral exposure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/subacute-exposure","display_name":"subacute exposure","score":0.6420000195503235},{"id":"https://openalex.org/keywords/lowest-observed-adverse-effect-level","display_name":"lowest observed adverse effect level","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6682940721511841},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5198400616645813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5096144676208496},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.46931764483451843},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4651105999946594},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44219422340393066},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.43612784147262573},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41641953587532043},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4156477451324463},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3952328860759735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38300850987434387},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2985538840293884},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19889435172080994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11997842788696289}],"mesh":[{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000067996","descriptor_name":"RAW 264.7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014255","descriptor_name":"Trichothecenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00204-024-03740-3","doi":"https://doi.org/10.1007/s00204-024-03740-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00204-024-03740-3","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:38616237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38616237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01462:0007409502","doi":null,"is_oa":true,"landing_page_url":"https://az.repo.nii.ac.jp/records/2000551","pdf_url":"https://az.repo.nii.ac.jp/record/2000551/files/ATOX-S-24-00326.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Toxicology","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01462:0007409502","doi":null,"is_oa":true,"landing_page_url":"https://az.repo.nii.ac.jp/records/2000551","pdf_url":"https://az.repo.nii.ac.jp/record/2000551/files/ATOX-S-24-00326.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Archives of Toxicology","raw_type":"journal article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323626","display_name":"Tojuro Iijima Foundation for Food Science and Technology","ror":"https://ror.org/031ww6378"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394792609.pdf","grobid_xml":"https://content.openalex.org/works/W4394792609.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1493776746","https://openalex.org/W1942668068","https://openalex.org/W1970338952","https://openalex.org/W1971590284","https://openalex.org/W1988750805","https://openalex.org/W2019318663","https://openalex.org/W2066906832","https://openalex.org/W2078551188","https://openalex.org/W2134261811","https://openalex.org/W2143233745","https://openalex.org/W2772827269","https://openalex.org/W2774225198","https://openalex.org/W2889399523","https://openalex.org/W2895523214","https://openalex.org/W2908333219","https://openalex.org/W2981453935","https://openalex.org/W3003828997","https://openalex.org/W3071810698","https://openalex.org/W3091172085","https://openalex.org/W3099148334","https://openalex.org/W3117078967","https://openalex.org/W3148651913","https://openalex.org/W3186705268","https://openalex.org/W4214633170","https://openalex.org/W4289528892","https://openalex.org/W4308119344","https://openalex.org/W4313327570","https://openalex.org/W4317042808","https://openalex.org/W4327545865","https://openalex.org/W4366992681","https://openalex.org/W4384824588","https://openalex.org/W4384932457","https://openalex.org/W4385898573","https://openalex.org/W4386780367","https://openalex.org/W4389616869"],"related_works":["https://openalex.org/W2361792103","https://openalex.org/W2589983708","https://openalex.org/W2145416872","https://openalex.org/W2137969630","https://openalex.org/W2113188459","https://openalex.org/W2101601869","https://openalex.org/W2465639950","https://openalex.org/W1964956439","https://openalex.org/W2035915452","https://openalex.org/W2056962091"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}