{"id":"https://openalex.org/W4394792147","doi":"https://doi.org/10.29296/24999490-2024-02-10","title":"EVALUATION OF IMMUNOTROPIC PROPERTIES OF GLYPROLINE COMPOUNDS IN EXPERIMENTAL HYPERTHYROIDISM","display_name":"EVALUATION OF IMMUNOTROPIC PROPERTIES OF GLYPROLINE COMPOUNDS IN EXPERIMENTAL HYPERTHYROIDISM","publication_year":2024,"publication_date":"2024-04-04","ids":{"openalex":"https://openalex.org/W4394792147","doi":"https://doi.org/10.29296/24999490-2024-02-10"},"language":"en","primary_location":{"id":"doi:10.29296/24999490-2024-02-10","doi":"https://doi.org/10.29296/24999490-2024-02-10","is_oa":true,"landing_page_url":"https://doi.org/10.29296/24999490-2024-02-10","pdf_url":"https://molmedjournal.ru/en/system/files/24999490-2024-02-10_1.pdf","source":{"id":"https://openalex.org/S4210170970","display_name":"Molekulyarnaya Meditsina (Molecular medicine)","issn_l":"1728-2918","issn":["1728-2918","2499-9490"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4327874082","host_organization_name":"Russkiy Vrach Publishing House","host_organization_lineage":["https://openalex.org/P4327874082"],"host_organization_lineage_names":["Russkiy Vrach Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molekulyarnaya Meditsina (Molecular medicine)","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4394792147"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://molmedjournal.ru/en/system/files/24999490-2024-02-10_1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063542630","display_name":"\u041c\u0430\u0440\u0438\u044f\u043c \u0423\u0442\u0435\u0436\u0430\u043d\u043e\u0432\u043d\u0430 \u0421\u0435\u0440\u0433\u0430\u043b\u0438\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-9630-2913","observed_orcids":["https://orcid.org/0000-0002-9630-2913"]},"institutions":[{"id":"https://openalex.org/I4210112215","display_name":"Astrakhan State Medical University","ror":"https://ror.org/01yvmh709","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210112215"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.U. Sergalieva","raw_affiliation_strings":["Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation","institution_ids":["https://openalex.org/I4210112215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089841458","display_name":"\u0410. \u0410. \u0426\u0438\u0431\u0438\u0437\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-9994-4751","observed_orcids":["https://orcid.org/0000-0002-9994-4751"]},"institutions":[{"id":"https://openalex.org/I4210112215","display_name":"Astrakhan State Medical University","ror":"https://ror.org/01yvmh709","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210112215"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.A. Tsibizova","raw_affiliation_strings":["Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation","institution_ids":["https://openalex.org/I4210112215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045407041","display_name":"V.Kh. Murtalieva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112215","display_name":"Astrakhan State Medical University","ror":"https://ror.org/01yvmh709","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210112215"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.Kh. Murtalieva","raw_affiliation_strings":["Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation","institution_ids":["https://openalex.org/I4210112215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024713614","display_name":"\u041b. \u0410. \u0410\u043d\u0434\u0440\u0435\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-3927-8590","observed_orcids":["https://orcid.org/0000-0002-3927-8590"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L.A. Andreeva","raw_affiliation_strings":["Institute of Molecular Genetics of the SIC \u00abKurchatov Institute\u00bb, akad. Kurchatov Square, 2, Moscow, 123182, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Genetics of the SIC \u00abKurchatov Institute\u00bb, akad. Kurchatov Square, 2, Moscow, 123182, Russian Federation","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042631712","display_name":"Nikolai F. Myasoedov","orcid":"https://orcid.org/0000-0003-1294-102X","observed_orcids":["https://orcid.org/0000-0003-1294-102X"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N.F. Myasoedov","raw_affiliation_strings":["Institute of Molecular Genetics of the SIC \u00abKurchatov Institute\u00bb, akad. Kurchatov Square, 2, Moscow, 123182, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Genetics of the SIC \u00abKurchatov Institute\u00bb, akad. Kurchatov Square, 2, Moscow, 123182, Russian Federation","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064005941","display_name":"\u041c. \u0410. \u0421\u0430\u043c\u043e\u0442\u0440\u0443\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0001-5336-4455","observed_orcids":["https://orcid.org/0000-0001-5336-4455"]},"institutions":[{"id":"https://openalex.org/I4210112215","display_name":"Astrakhan State Medical University","ror":"https://ror.org/01yvmh709","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210112215"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.A. Samotrueva","raw_affiliation_strings":["Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astrakhan State Medical University, Bakinskaya St., 121, Astrakhan, 414000, Russian Federation","institution_ids":["https://openalex.org/I4210112215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"60","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.46459999680519104,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/neuropeptide-analogues","display_name":"neuropeptide analogs","score":0.7049999833106995},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6129601001739502},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5020887851715088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4924643933773041},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.48620882630348206},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4771147072315216},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46285951137542725},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.42711806297302246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37210536003112793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2661776840686798}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.29296/24999490-2024-02-10","doi":"https://doi.org/10.29296/24999490-2024-02-10","is_oa":true,"landing_page_url":"https://doi.org/10.29296/24999490-2024-02-10","pdf_url":"https://molmedjournal.ru/en/system/files/24999490-2024-02-10_1.pdf","source":{"id":"https://openalex.org/S4210170970","display_name":"Molekulyarnaya Meditsina (Molecular medicine)","issn_l":"1728-2918","issn":["1728-2918","2499-9490"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4327874082","host_organization_name":"Russkiy Vrach Publishing House","host_organization_lineage":["https://openalex.org/P4327874082"],"host_organization_lineage_names":["Russkiy Vrach Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molekulyarnaya Meditsina (Molecular medicine)","raw_type":"journal-article"},{"id":"pmh:https://cyberleninka.ru/article/n/otsenka-immunotropnyh-svoystv-gliprolinovyh-soedineniy-v-usloviyah-eksperimentalnogo-gipertireoza","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/otsenka-immunotropnyh-svoystv-gliprolinovyh-soedineniy-v-usloviyah-eksperimentalnogo-gipertireoza","pdf_url":"https://cyberleninka.ru/article/n/otsenka-immunotropnyh-svoystv-gliprolinovyh-soedineniy-v-usloviyah-eksperimentalnogo-gipertireoza/pdf","source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"doi:10.29296/24999490-2024-02-10","doi":"https://doi.org/10.29296/24999490-2024-02-10","is_oa":true,"landing_page_url":"https://doi.org/10.29296/24999490-2024-02-10","pdf_url":"https://molmedjournal.ru/en/system/files/24999490-2024-02-10_1.pdf","source":{"id":"https://openalex.org/S4210170970","display_name":"Molekulyarnaya Meditsina (Molecular medicine)","issn_l":"1728-2918","issn":["1728-2918","2499-9490"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4327874082","host_organization_name":"Russkiy Vrach Publishing House","host_organization_lineage":["https://openalex.org/P4327874082"],"host_organization_lineage_names":["Russkiy Vrach Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molekulyarnaya Meditsina (Molecular medicine)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394792147.pdf","grobid_xml":"https://content.openalex.org/works/W4394792147.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1970513668","https://openalex.org/W2606398179","https://openalex.org/W2617402993","https://openalex.org/W2792411929","https://openalex.org/W2910142527","https://openalex.org/W2948057680","https://openalex.org/W2963035103","https://openalex.org/W3004954461","https://openalex.org/W3035358789","https://openalex.org/W3121364493","https://openalex.org/W3135868329","https://openalex.org/W3150034268","https://openalex.org/W3202326514","https://openalex.org/W4388450791","https://openalex.org/W4392545024","https://openalex.org/W6887496672"],"related_works":["https://openalex.org/W7165244092","https://openalex.org/W4224233528","https://openalex.org/W4394602049","https://openalex.org/W4210423710","https://openalex.org/W4408056571","https://openalex.org/W4405480389","https://openalex.org/W4413346086","https://openalex.org/W2444425066","https://openalex.org/W4300809673","https://openalex.org/W4402197199"],"abstract_inverted_index":{"Introduction.":[0],"Thyroid":[1],"disease":[2],"is":[3,15,205],"currently":[4],"the":[5,24,34,65,70,75,94,175,189,195,199,208,215,219,232,235,246],"most":[6],"common":[7],"among":[8,50],"endocrine":[9],"pathology.":[10],"Hyperproduction":[11],"of":[12,19,26,64,69,78,93,116,165,183,191,202,210,218,234,238,248],"thyroid":[13],"hormones":[14],"accompanied":[16],"by":[17,113,207],"stimulation":[18],"humoral":[20,200],"reactions,":[21],"contributing":[22],"to":[23,36,46,73],"development":[25],"immune-mediated":[27],"pathology":[28],"under":[29,84,188,242],"certain":[30],"conditions,":[31],"which":[32,51,204],"actualizes":[33],"need":[35],"develop":[37],"means":[38],"for":[39,126,160],"correcting":[40,185],"neuroimmunoendocrine":[41],"processes.":[42],"Gliproline":[43],"compounds":[44,80,96,179,241],"analogous":[45],"neuropeptide":[47],"protein":[48],"molecules,":[49],"are":[52],"Thr-Lys-Pro-Arg-Pro-Gly-Pro":[53,81,97,152,180,252],"and":[54,82,88,98,154,167,181,221,253],"Pro-Gly-Pro,":[55],"can":[56],"be":[57],"considered":[58],"as":[59],"such":[60],"agents.":[61],"The":[62,67,90,171],"aim":[63,68],"study.":[66],"study":[71,74,233],"was":[72,111],"immunotropic":[76,91,236],"properties":[77,92,237],"gliproline":[79,95,178,239],"Pro-Gly-Pro":[83,99,157,182,254],"experimental":[85,192,243],"hyperthyroidism.":[86],"Material":[87],"methods.":[89],"were":[100,131],"studied":[101],"in":[102,109,177,214,225,251],"white":[103],"nonlinear":[104],"male":[105],"rats.":[106],"Hyperthyroid":[107],"status":[108],"animals":[110,130,140,142],"modeled":[112],"intragastric":[114],"administration":[115],"L-thyroxine":[117,145],"sodium":[118,146],"salt":[119,147],"pentahydrate":[120,148],"(\u00abSigma\u00bb;":[121],"USA)":[122],"at":[123,163],"150":[124],"\u03bcg/kg":[125],"21":[127,161],"days.":[128],"Laboratory":[129],"divided":[132],"into":[133],"groups":[134],"(n=10):":[135],"control":[136],"group":[137],"\u2013":[138],"intact":[139],"(control);":[141],"treated":[143],"with":[144,194],"(hyperthyroidism);":[149],"rats":[150,155],"receiving":[151,156],"(selanc)":[153],"intraperitoneally":[158],"daily":[159],"days":[162],"doses":[164],"87":[166],"33":[168],"\u03bcg/kg/day.":[169],"Results.":[170],"obtained":[172],"results":[173],"indicate":[174],"presence":[176,209,247],"immune":[184],"activity":[186,250],"manifested":[187],"conditions":[190],"hyperthyroidism,":[193],"greatest":[196],"impact":[197],"on":[198],"unit":[201],"immunity,":[203],"confirmed":[206],"statistically":[211],"significant":[212],"changes":[213],"cellular":[216],"parameters":[217],"spleen":[220],"titer":[222],"antierythrocytic":[223],"antibodies":[224],"a":[226],"direct":[227],"hemagglutination":[228],"reaction.":[229],"Conclusion.":[230],"Thus,":[231],"peptide":[240],"hyperthyroidism":[244],"established":[245],"immune-correcting":[249],"substances.":[255]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-14T00:00:00"}
