{"id":"https://openalex.org/W4394770045","doi":"https://doi.org/10.1016/j.phymed.2024.155631","title":"Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4","display_name":"Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4","publication_year":2024,"publication_date":"2024-04-12","ids":{"openalex":"https://openalex.org/W4394770045","doi":"https://doi.org/10.1016/j.phymed.2024.155631","pmid":"https://pubmed.ncbi.nlm.nih.gov/38640858"},"language":"en","primary_location":{"id":"doi:10.1016/j.phymed.2024.155631","doi":"https://doi.org/10.1016/j.phymed.2024.155631","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2024.155631","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.phymed.2024.155631","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100765083","display_name":"Guoqing Zhang","orcid":"https://orcid.org/0000-0001-5388-0812","observed_orcids":["https://orcid.org/0000-0001-5388-0812"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqing Zhang","raw_affiliation_strings":["Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057145430","display_name":"Jinpeng Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinpeng Hu","raw_affiliation_strings":["Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359731","display_name":"Ao Li","orcid":"https://orcid.org/0000-0002-0442-7170","observed_orcids":["https://orcid.org/0000-0002-0442-7170"]},"institutions":[{"id":"https://openalex.org/I4210105835","display_name":"Liaoning Provincial People's Hospital","ror":"https://ror.org/01n3v7c44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105835"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ao Li","raw_affiliation_strings":["Emergency department, Liaoning Provincial People Hospital, Shenyang, 110016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emergency department, Liaoning Provincial People Hospital, Shenyang, 110016, China","institution_ids":["https://openalex.org/I4210105835"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haiying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800959905","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504","country_code":"CN","type":"education","lineage":["https://openalex.org/I2800959905"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Zhang","raw_affiliation_strings":["International Education College, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang, Liaoning, 110042, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Education College, Liaoning University of Traditional Chinese Medicine, No. 79 Chongshan East Road, Shenyang, Liaoning, 110042, China","institution_ids":["https://openalex.org/I2800959905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002676249","display_name":"Zhengting Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengting Guo","raw_affiliation_strings":["Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101478469","display_name":"Xinqiao Li","orcid":"https://orcid.org/0009-0002-0179-9072","observed_orcids":["https://orcid.org/0009-0002-0179-9072"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinqiao Li","raw_affiliation_strings":["Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113176862","display_name":"Zinan You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zinan You","raw_affiliation_strings":["Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686525","display_name":"Yongfeng Wang","orcid":"https://orcid.org/0000-0002-9660-345X","observed_orcids":["https://orcid.org/0000-0002-9660-345X"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongfeng Wang","raw_affiliation_strings":["Department of Radiology, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, PR China. Electronic address: wyf1208@163.com","Department of Radiology, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, PR China. Electronic address: wyf1208@163.com","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"Department of Radiology, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, People's Republic of China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060254396","display_name":"Zhitao Jing","orcid":"https://orcid.org/0000-0002-8915-9039","observed_orcids":["https://orcid.org/0000-0002-8915-9039"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhitao Jing","raw_affiliation_strings":["Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China. Electronic address: jingzhitao@hotmail.com","Department of Neurosurgery, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China. Electronic address: jingzhitao@hotmail.com","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"Department of Neurosurgery, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060254396","https://openalex.org/A5100686525"],"corresponding_institution_ids":["https://openalex.org/I4210140515"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":8.776,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.98465006,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"129","issue":null,"first_page":"155631","last_page":"155631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.1054999977350235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ginsenoside-rg5","display_name":"ginsenoside Rg5","score":1.0},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/nr3c1","display_name":"NR3C1","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hspb1","display_name":"HSPB1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ncoa4","display_name":"NCOA4","score":1.0},{"id":"https://openalex.org/keywords/glioma-stem-cells","display_name":"glioma stem cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6470000147819519},{"id":"https://openalex.org/keywords/neurosphere-formation","display_name":"neurosphere formation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.41100001335144043},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.8270000219345093},{"id":"https://openalex.org/keywords/intracranial-xenograft","display_name":"intracranial xenograft","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7064645886421204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5547020435333252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5152692794799805},{"id":"https://openalex.org/C2776539398","wikidata":"https://www.wikidata.org/wiki/Q59662497","display_name":"Ginsenoside","level":4,"score":0.48587197065353394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40098094940185547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21259739995002747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21206244826316833},{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.06024935841560364},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036145","descriptor_name":"Ginsenosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056918","descriptor_name":"Nuclear Receptor Coactivators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phymed.2024.155631","doi":"https://doi.org/10.1016/j.phymed.2024.155631","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2024.155631","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},{"id":"pmid:38640858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38640858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytomedicine : international journal of phytotherapy and phytopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phymed.2024.155631","doi":"https://doi.org/10.1016/j.phymed.2024.155631","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phymed.2024.155631","pdf_url":null,"source":{"id":"https://openalex.org/S180051340","display_name":"Phytomedicine","issn_l":"0944-7113","issn":["0944-7113","1618-095X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Phytomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325418","display_name":"Liaoning University of Traditional Chinese Medicine","ror":"https://ror.org/030e3n504"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W978308701","https://openalex.org/W1902577542","https://openalex.org/W1982740613","https://openalex.org/W2036044314","https://openalex.org/W2047480689","https://openalex.org/W2100671540","https://openalex.org/W2134807618","https://openalex.org/W2891625141","https://openalex.org/W2912997293","https://openalex.org/W2939322913","https://openalex.org/W2948278325","https://openalex.org/W2959353994","https://openalex.org/W2973076716","https://openalex.org/W2987812036","https://openalex.org/W2993060635","https://openalex.org/W2999469065","https://openalex.org/W3003960907","https://openalex.org/W3025211288","https://openalex.org/W3044388227","https://openalex.org/W3047942125","https://openalex.org/W3097646670","https://openalex.org/W3108493784","https://openalex.org/W3122102409","https://openalex.org/W3134840300","https://openalex.org/W3158558513","https://openalex.org/W3170519482","https://openalex.org/W3175670325","https://openalex.org/W3177084210","https://openalex.org/W3187945956","https://openalex.org/W3195514909","https://openalex.org/W4205602844","https://openalex.org/W4221112683","https://openalex.org/W4283747124","https://openalex.org/W4291123987","https://openalex.org/W4296783047","https://openalex.org/W4304758261","https://openalex.org/W4307820793","https://openalex.org/W4309040610","https://openalex.org/W4364353241","https://openalex.org/W4379203790","https://openalex.org/W4386439205","https://openalex.org/W6797025837","https://openalex.org/W6806226188","https://openalex.org/W6842005383"],"related_works":["https://openalex.org/W4306861371","https://openalex.org/W7154295848","https://openalex.org/W6921262811","https://openalex.org/W4377024410","https://openalex.org/W4393381802","https://openalex.org/W4403321014","https://openalex.org/W7164937261","https://openalex.org/W4402581221","https://openalex.org/W4220939635","https://openalex.org/W4389108755"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-13T00:00:00"}