{"id":"https://openalex.org/W4394765833","doi":null,"title":"Functioning and Cognition in Patients with Schizophrenia After Initiating Treatment with Aripiprazole Lauroxil: Secondary Outcomes and Post Hoc Analysis.","display_name":"Functioning and Cognition in Patients with Schizophrenia After Initiating Treatment with Aripiprazole Lauroxil: Secondary Outcomes and Post Hoc Analysis.","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4394765833","pmid":"https://pubmed.ncbi.nlm.nih.gov/38495608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10941858"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10941858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10941858","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10941858/pdf/icns_21_1-3_43.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10941858/pdf/icns_21_1-3_43.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102857596","display_name":"Mark G. A. Opler","orcid":"https://orcid.org/0009-0003-2205-7630","observed_orcids":["https://orcid.org/0009-0003-2205-7630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark G A Opler","raw_affiliation_strings":["Dr. Opler is with WCG, Inc. in New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Opler is with WCG, Inc. in New York, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083841367","display_name":"Amy Claxton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116259","display_name":"Alkermes (United States)","ror":"https://ror.org/038hqfn26","country_code":"US","type":"company","lineage":["https://openalex.org/I1328445063","https://openalex.org/I4210116259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Claxton","raw_affiliation_strings":["Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","Drs. Claxton and Wang and Ms. Gasper were employees of Alkermes, Inc. at the time of the study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","institution_ids":["https://openalex.org/I4210116259"]},{"raw_affiliation_string":"Drs. Claxton and Wang and Ms. Gasper were employees of Alkermes, Inc. at the time of the study","institution_ids":["https://openalex.org/I4210116259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039183024","display_name":"James A McGrory","orcid":"https://orcid.org/0000-0003-0906-023X","observed_orcids":["https://orcid.org/0000-0003-0906-023X"]},"institutions":[{"id":"https://openalex.org/I4210116259","display_name":"Alkermes (United States)","ror":"https://ror.org/038hqfn26","country_code":"US","type":"company","lineage":["https://openalex.org/I1328445063","https://openalex.org/I4210116259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James McGrory","raw_affiliation_strings":["Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","institution_ids":["https://openalex.org/I4210116259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065003520","display_name":"Sabina Gasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116259","display_name":"Alkermes (United States)","ror":"https://ror.org/038hqfn26","country_code":"US","type":"company","lineage":["https://openalex.org/I1328445063","https://openalex.org/I4210116259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabina Gasper","raw_affiliation_strings":["Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","Drs. Claxton and Wang and Ms. Gasper were employees of Alkermes, Inc. at the time of the study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","institution_ids":["https://openalex.org/I4210116259"]},{"raw_affiliation_string":"Drs. Claxton and Wang and Ms. Gasper were employees of Alkermes, Inc. at the time of the study","institution_ids":["https://openalex.org/I4210116259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101644298","display_name":"Meihua Wang","orcid":"https://orcid.org/0000-0002-0115-1041","observed_orcids":["https://orcid.org/0000-0002-0115-1041"]},"institutions":[{"id":"https://openalex.org/I4210116259","display_name":"Alkermes (United States)","ror":"https://ror.org/038hqfn26","country_code":"US","type":"company","lineage":["https://openalex.org/I1328445063","https://openalex.org/I4210116259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meihua Wang","raw_affiliation_strings":["Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","Drs. Claxton and Wang and Ms. Gasper were employees of Alkermes, Inc. at the time of the study"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","institution_ids":["https://openalex.org/I4210116259"]},{"raw_affiliation_string":"Drs. Claxton and Wang and Ms. Gasper were employees of Alkermes, Inc. at the time of the study","institution_ids":["https://openalex.org/I4210116259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073592161","display_name":"Sergey Yagoda","orcid":"https://orcid.org/0000-0002-4103-4827","observed_orcids":["https://orcid.org/0000-0002-4103-4827"]},"institutions":[{"id":"https://openalex.org/I4210116259","display_name":"Alkermes (United States)","ror":"https://ror.org/038hqfn26","country_code":"US","type":"company","lineage":["https://openalex.org/I1328445063","https://openalex.org/I4210116259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey Yagoda","raw_affiliation_strings":["Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drs. Claxton, McGrory, Wang, and Yagoda and Ms. Gasper are with Alkermes, Inc. in Waltham, Massachusetts","institution_ids":["https://openalex.org/I4210116259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2298,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48382432,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"1-3","first_page":"43","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12308","display_name":"Mental Health and Psychiatry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13944","display_name":"Psychiatric care and mental health services","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/aripiprazole-lauroxil","display_name":"aripiprazole lauroxil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/long-acting-injectable-antipsychotics","display_name":"long-acting injectable antipsychotics","score":0.9929999709129333},{"id":"https://openalex.org/keywords/functional-status","display_name":"functional status","score":0.49300000071525574},{"id":"https://openalex.org/keywords/social-functioning","display_name":"social functioning","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7749999761581421},{"id":"https://openalex.org/keywords/physician-patient-agreement","display_name":"patient-physician agreement","score":0.765999972820282},{"id":"https://openalex.org/keywords/patient-caregiver-agreement","display_name":"patient-caregiver agreement","score":0.8859999775886536},{"id":"https://openalex.org/keywords/personal-and-social-performance","display_name":"Personal and Social Performance","score":0.6159999966621399},{"id":"https://openalex.org/keywords/self-reported-functioning","display_name":"self-reported functioning","score":0.5230000019073486},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6290000081062317},{"id":"https://openalex.org/keywords/treatment-stability","display_name":"treatment stability","score":0.3840000033378601},{"id":"https://openalex.org/keywords/secondary-outcomes","display_name":"secondary outcomes","score":0.4440000057220459},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.8695844411849976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7643641233444214},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6291277408599854},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.6219894886016846},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5602906942367554},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.5491363406181335},{"id":"https://openalex.org/C2780200951","wikidata":"https://www.wikidata.org/wiki/Q1531566","display_name":"Global Assessment of Functioning","level":3,"score":0.4937768876552582},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.46469447016716003},{"id":"https://openalex.org/C134290984","wikidata":"https://www.wikidata.org/wiki/Q5141241","display_name":"Cognitive skill","level":3,"score":0.4646213948726654},{"id":"https://openalex.org/C2780325297","wikidata":"https://www.wikidata.org/wiki/Q834047","display_name":"Schizoaffective disorder","level":3,"score":0.43481940031051636},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.42489221692085266},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.395760715007782},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.34349870681762695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.306079626083374},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.2455901801586151}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10941858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10941858","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10941858/pdf/icns_21_1-3_43.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},{"id":"pmid:38495608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38495608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovations in clinical neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10941858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10941858","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10941858/pdf/icns_21_1-3_43.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Clin Neurosci","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394765833.pdf","grobid_xml":"https://content.openalex.org/works/W4394765833.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1975586101","https://openalex.org/W1979291291","https://openalex.org/W1981682305","https://openalex.org/W1983861222","https://openalex.org/W1984233930","https://openalex.org/W1985202323","https://openalex.org/W2008134483","https://openalex.org/W2011675347","https://openalex.org/W2014990189","https://openalex.org/W2022493080","https://openalex.org/W2024078112","https://openalex.org/W2032712358","https://openalex.org/W2056679594","https://openalex.org/W2078384391","https://openalex.org/W2089153987","https://openalex.org/W2096437472","https://openalex.org/W2096803198","https://openalex.org/W2107201157","https://openalex.org/W2119501809","https://openalex.org/W2119971225","https://openalex.org/W2149255662","https://openalex.org/W2159977744","https://openalex.org/W2165955750","https://openalex.org/W2172249063","https://openalex.org/W2282014563","https://openalex.org/W2527103551","https://openalex.org/W2604285617","https://openalex.org/W2610316310","https://openalex.org/W2620112462","https://openalex.org/W2724104532","https://openalex.org/W2763925245","https://openalex.org/W2914818721","https://openalex.org/W2940417022","https://openalex.org/W3008394856","https://openalex.org/W3082177965","https://openalex.org/W3098743519","https://openalex.org/W3135464876","https://openalex.org/W3161355986","https://openalex.org/W3204811469","https://openalex.org/W4238924577","https://openalex.org/W4241771140","https://openalex.org/W4244847179","https://openalex.org/W4290841313","https://openalex.org/W4293516500","https://openalex.org/W4294068478","https://openalex.org/W4294214983","https://openalex.org/W4361304565"],"related_works":["https://openalex.org/W4283511994","https://openalex.org/W2922288156","https://openalex.org/W2109730453","https://openalex.org/W1963544666","https://openalex.org/W2912328200","https://openalex.org/W3171464279","https://openalex.org/W3000221757","https://openalex.org/W2050441893","https://openalex.org/W2921227529","https://openalex.org/W3198523382"],"abstract_inverted_index":{"Background:":[0],"Clinical":[1],"practice":[2],"guidelines":[3],"support":[4],"efforts":[5],"to":[6,60,251],"improve":[7],"functioning":[8,50,142,170,269],"in":[9,14,35,53,75,201,289],"patients":[10,22,55,108,134,165,206,235,262],"with":[11,23,31,56,263,306],"schizophrenia.":[12],"Discrepancies":[13],"the":[15,61,117],"perception":[16],"of":[17,73,77,133,156,164,275,297,304],"cognitive":[18,78,191,281,298],"status":[19,79],"between":[20,179,234],"clinicians,":[21],"schizophrenia,":[24],"and":[25,44,51,85,119,168,181,212,215,236,279,287],"their":[26],"caregivers":[27,213],"have":[28],"been":[29],"associated":[30],"impaired":[32],"functional":[33],"abilities":[34],"patients;":[36],"medication":[37],"side":[38],"effects":[39],"might":[40],"worsen":[41],"both":[42],"cognition":[43,52],"daily":[45],"functioning.":[46],"We":[47],"assessed":[48,71],"daily/social":[49],"stable":[54,178,261,284],"schizophrenia":[57,264],"who":[58,265],"switched":[59],"long-acting":[62],"injectable":[63],"(LAI)":[64],"antipsychotic":[65],"aripiprazole":[66],"lauroxil":[67],"(AL).":[68],"Methods:":[69],"analysis":[70],"level":[72,296],"agreement":[74,233,247,294],"ratings":[76],"among":[80],"respondents,":[81],"evaluated":[82],"at":[83,123,222,240,253,285],"baseline":[84,146,180,189,286],"last":[86,124,223,241,254],"assessment,":[87],"using":[88],"weighted":[89],"kappa":[90,229],"coefficients":[91,230],"(0.01-0.20,":[92],"slight":[93],"agreement;":[94,97,100],"0.21-0.40,":[95],"fair":[96],"0.41-0.60,":[98],"moderate":[99],"0.61-0.80,":[101],"substantial":[102],"agreement.).":[103],"Results:":[104],"All":[105],"51":[106],"enrolled":[107],"received":[109],"one":[110],"or":[111,175,199,220],"more":[112],"AL":[113,157],"doses;":[114],"35":[115],"completed":[116],"study,":[118],"45":[120],"contributed":[121],"data":[122],"assessment.":[125],"Mean":[126],"age":[127],"was":[128,143,270,283],"40.6":[129],"years;":[130],"72.5":[131],"percent":[132],"were":[135,193,218],"male.":[136],"Based":[137],"on":[138,295],"PSP":[139,186],"total":[140],"score,":[141],"maintained":[144,219,271,288],"from":[145,249],"(mean":[147,159],"[standard":[148],"deviation":[149],"(SD)]:":[150],"55.1":[151],"[10.5])":[152],"through":[153],"six":[154,273,302],"months":[155,274,303],"treatment":[158,305],"[SD]:":[160],"57.7":[161],"[13.2]).":[162],"Proportions":[163],"rating":[166],"personal":[167],"social":[169],"issues":[171],"as":[172],"\"not":[173,197],"present\"":[174,198],"\"mild\"":[176,200],"remained":[177],"Month":[182],"6":[183],"for":[184,225],"each":[185],"subscale.":[187],"At":[188],"(n=50),":[190],"difficulties":[192],"most":[194],"commonly":[195],"rated":[196],"all":[202,226,290],"NY-AACENT":[203,291],"domains":[204,239],"by":[205],"(58-86%":[207],"across":[208,238],"domains),":[209],"clinicians":[210,237],"(62-94%),":[211],"(50-92%),":[214],"these":[216],"rates":[217],"increased":[221,300],"assessment":[224,242,255],"reporters.":[227],"Weighted":[228],"indicated":[231],"fair-to-substantial":[232],"(0.32-0.64;":[243],"baseline:":[244],"0.14-0.55);":[245],"patient-caregiver":[246],"ranged":[248],"0.07":[250],"0.50":[252],"(baseline:":[256],"0.25-0.60).":[257],"Conclusion:":[258],"In":[259],"clinically":[260],"initiated":[266],"AL,":[267],"self-reported":[268],"over":[272,301],"treatment.":[276],"Clinician-,":[277],"caregiver-,":[278],"patient-reported":[280],"function":[282],"domains;":[292],"patient-clinician":[293],"impairment":[299],"AL.":[307]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-04-13T00:00:00"}
