{"id":"https://openalex.org/W4394727779","doi":"https://doi.org/10.21203/rs.3.rs-4244404/v1","title":"Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality","display_name":"Glymphatic dysfunction and choroid plexus volume increase in older adults with poor sleep quality","publication_year":2024,"publication_date":"2024-04-11","ids":{"openalex":"https://openalex.org/W4394727779","doi":"https://doi.org/10.21203/rs.3.rs-4244404/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-4244404/v1","doi":"https://doi.org/10.21203/rs.3.rs-4244404/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4244404/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-4244404/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051543871","display_name":"Junko Kikuta","orcid":"https://orcid.org/0000-0003-1324-8614","observed_orcids":["https://orcid.org/0000-0003-1324-8614"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junko Kikuta","raw_affiliation_strings":["Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1324-8614","affiliations":[{"raw_affiliation_string":"Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051543871"],"corresponding_institution_ids":["https://openalex.org/I34077901"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glymphatic-dysfunction","display_name":"glymphatic dysfunction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/choroid-plexus-volume","display_name":"choroid plexus volume","score":0.9940000176429749},{"id":"https://openalex.org/keywords/poor-sleep-quality","display_name":"poor sleep quality","score":0.9449999928474426},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9089999794960022},{"id":"https://openalex.org/keywords/perivascular-spaces","display_name":"perivascular spaces","score":0.8849999904632568},{"id":"https://openalex.org/keywords/alps-index","display_name":"ALPS index","score":0.8410000205039978},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.8460000157356262},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7080000042915344},{"id":"https://openalex.org/keywords/white-matter-lesions","display_name":"white matter lesions","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.8707555532455444},{"id":"https://openalex.org/C2776538271","wikidata":"https://www.wikidata.org/wiki/Q926250","display_name":"Choroid plexus","level":3,"score":0.8532678484916687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5352727770805359},{"id":"https://openalex.org/C2983189541","wikidata":"https://www.wikidata.org/wiki/Q35831","display_name":"Sleep quality","level":3,"score":0.4889723062515259},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4579415023326874},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.4548623263835907},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.35839033126831055},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34338968992233276},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.341352641582489},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2715170383453369},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.23183462023735046},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1337147057056427},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09056678414344788},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08635890483856201},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-4244404/v1","doi":"https://doi.org/10.21203/rs.3.rs-4244404/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4244404/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-4244404/v1","doi":"https://doi.org/10.21203/rs.3.rs-4244404/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-4244404/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3026050015","display_name":null,"funder_award_id":"S1411006","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G320730813","display_name":null,"funder_award_id":"2014?2018","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3698406884","display_name":"Construction of AI image diagnosis support systems for diagnosing and predicting serious emergency brain diseases","funder_award_id":"20K16737","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6869576664","display_name":"\u8133\u5bb9\u7a4d\u30fb\u767d\u8cea\u5fae\u7d30\u69cb\u9020\u306e\u5927\u898f\u6a21\u30c7\u30fc\u30bf\u89e3\u6790\u306b\u3088\u308b\u7761\u7720\u969c\u5bb3\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u63a2\u7d22","funder_award_id":"21K15833","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1543494855","https://openalex.org/W1604922098","https://openalex.org/W1822779864","https://openalex.org/W2009465625","https://openalex.org/W2037557484","https://openalex.org/W2054102117","https://openalex.org/W2089084689","https://openalex.org/W2110065044","https://openalex.org/W2127309075","https://openalex.org/W2146443559","https://openalex.org/W2151487996","https://openalex.org/W2160311930","https://openalex.org/W2163225965","https://openalex.org/W2164740566","https://openalex.org/W2167183660","https://openalex.org/W2582603400","https://openalex.org/W2588487507","https://openalex.org/W2612016156","https://openalex.org/W2789376055","https://openalex.org/W2808323657","https://openalex.org/W2901166225","https://openalex.org/W2929428992","https://openalex.org/W2945277326","https://openalex.org/W2951259091","https://openalex.org/W2972473185","https://openalex.org/W2973298703","https://openalex.org/W2979504260","https://openalex.org/W2999695880","https://openalex.org/W3049504890","https://openalex.org/W3097434651","https://openalex.org/W3126431987","https://openalex.org/W3157366223","https://openalex.org/W3160066062","https://openalex.org/W3170975817","https://openalex.org/W3173999622","https://openalex.org/W3181633410","https://openalex.org/W3212057793","https://openalex.org/W3213768884","https://openalex.org/W4200054335","https://openalex.org/W4200094951","https://openalex.org/W4200335367","https://openalex.org/W4210280461","https://openalex.org/W4220717718","https://openalex.org/W4220753844","https://openalex.org/W4280533969","https://openalex.org/W4280617885","https://openalex.org/W4296343725","https://openalex.org/W4313584475","https://openalex.org/W4361004532","https://openalex.org/W4382181213","https://openalex.org/W4387865747","https://openalex.org/W4401338748"],"related_works":["https://openalex.org/W4404860771","https://openalex.org/W4382181213","https://openalex.org/W4320483256","https://openalex.org/W4412881865","https://openalex.org/W4385302660","https://openalex.org/W4391568995","https://openalex.org/W4300689648","https://openalex.org/W7171452956","https://openalex.org/W4200335367","https://openalex.org/W4390194364"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"This":[2],"study":[3],"aimed":[4],"to":[5],"explore":[6],"alterations":[7],"in":[8,32,208,291,298],"diffusion":[9],"tensor":[10],"image":[11],"analysis":[12,182],"along":[13],"the":[14,29,104,119,162,167,171,184,188,200,209,240,243,252,272,292],"perivascular":[15],"space":[16],"(DTI-ALPS)":[17],"method":[18],"and":[19,56,68,82,103,122,150,187,194,227,295],"choroid":[20],"plexus":[21],"volume":[22,154],"(CPV),":[23],"which":[24],"could":[25],"be":[26],"biomarkers":[27],"of":[28,138],"glymphatic":[30,293],"system":[31,294],"older":[33,43],"adults":[34,44,285],"with":[35,45,205,251,271,286],"poor":[36],"sleep":[37],"quality":[38],"(PSQ).":[39],"Methods":[40],"Fifty-two":[41],"Japanese":[42],"Pittsburgh":[46],"Sleep":[47],"Quality":[48],"Index":[49],"(PSQI)":[50],"scores":[51],">":[52],"5":[53],"(22":[54],"men":[55],"30":[57],"women;":[58],"mean":[59,112,216,244],"age":[60],"\u00b1":[61,65],"SD":[62],"=":[63,220,224,233,237,256,264,277,281],"73.10":[64],"5.67":[66],"years)":[67],"52":[69],"healthy":[70],"controls":[71],"(HCs;":[72],"PSQI":[73,195],"score":[74,246,274],"\u2264":[75],"5)":[76],"were":[77,86],"included.":[78],"Diffusion-weighted":[79],"imaging":[80,101],"(DWI)":[81],"3D":[83],"T1-weighted":[84],"images":[85],"obtained":[87],"using":[88,98,108,125,166],"3T":[89],"magnetic":[90],"resonance":[91],"imaging.":[92],"The":[93,111,156],"ALPS":[94,113,185,217,245],"index":[95,114,186],"was":[96,106,115,158,247,267],"calculated":[97,107],"preprocessed":[99],"diffusion-weighted":[100],"(DWI),":[102],"CPV":[105,157,230,253],"FreeSurfer":[109],"6.0.":[110],"subsequently":[116],"compared":[117,160],"between":[118,161,183],"PSQ":[120,210,241,287],"group":[121,211],"HCs":[123],"by":[124,165],"a":[126,179,213,228,289],"general":[127],"linear":[128],"model":[129],"(GLM)":[130],"adjusted":[131],"for":[132,170,198],"covariates,":[133],"including":[134],"age,":[135],"sex,":[136],"years":[137],"education,":[139],"intracranial":[140],"volume,":[141],"systolic":[142],"blood":[143,146],"pressure,":[144,147],"diastolic":[145],"hemoglobin":[148],"A1c,":[149],"white":[151],"matter":[152],"lesion":[153],"(WMLV).":[155],"also":[159],"two":[163],"groups":[164],"GLM,":[168],"adjusting":[169,197],"same":[172],"covariates":[173],"mentioned":[174],"above.":[175],"Next,":[176],"we":[177],"conducted":[178],"partial":[180],"correlation":[181],"CPV,":[189],"Montreal":[190],"Cognitive":[191],"Assessment":[192],"(MoCA),":[193],"scores,":[196],"all":[199],"abovementioned":[201],"covariates.":[202],"Results":[203],"Compared":[204],"HCs,":[206],"patients":[207],"had":[212],"significantly":[214,248,268],"lower":[215],"(":[218,231,254,275],"p":[219,232,263,280],"0.04,":[221],"Cohen\u2019s":[222,235],"d":[223,236],"\u2212":[225,257],"0.28)":[226],"greater":[229],"0.11,":[234],"0.24).":[238],"In":[239],"group,":[242],"negatively":[249],"correlated":[250,270],"r":[255,276],"0.35,":[258,278],"false":[259],"discovery":[260],"rate":[261],"[FDR]-corrected":[262],"0.03)":[265],"but":[266],"positively":[269],"MoCA":[273],"FDR-corrected":[279],"0.03).":[282],"Conclusion":[283],"Older":[284],"exhibited":[288],"decrease":[290],"an":[296],"increase":[297],"CPV.":[299]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-12T00:00:00"}
