{"id":"https://openalex.org/W4394710322","doi":"https://doi.org/10.1172/jci174726","title":"Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae","display_name":"Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae","publication_year":2024,"publication_date":"2024-03-21","ids":{"openalex":"https://openalex.org/W4394710322","doi":"https://doi.org/10.1172/jci174726","pmid":"https://pubmed.ncbi.nlm.nih.gov/37292978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10245944"},"language":"en","primary_location":{"id":"doi:10.1172/jci174726","doi":"https://doi.org/10.1172/jci174726","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci174726","pdf_url":"http://www.jci.org/articles/view/174726/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jci.org/articles/view/174726/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047399019","display_name":"Aaron L. Hecht","orcid":"https://orcid.org/0000-0003-4077-9357","observed_orcids":["https://orcid.org/0000-0003-4077-9357"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron L. Hecht","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092025800","display_name":"Lisa C. Harling","orcid":"https://orcid.org/0009-0008-9991-7981","observed_orcids":["https://orcid.org/0009-0008-9991-7981"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa C. Harling","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084762162","display_name":"Elliot S. Friedman","orcid":"https://orcid.org/0000-0003-0050-4965","observed_orcids":["https://orcid.org/0000-0003-0050-4965"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot S. Friedman","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014500013","display_name":"Ceylan Tanes","orcid":"https://orcid.org/0000-0002-5823-4059","observed_orcids":["https://orcid.org/0000-0002-5823-4059"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ceylan Tanes","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, United States of America","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012137385","display_name":"Junhee Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junhee Lee","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020449003","display_name":"Jenni Firrman","orcid":"https://orcid.org/0000-0002-9586-5204","observed_orcids":["https://orcid.org/0000-0002-9586-5204"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210147002","display_name":"Eastern Regional Research Center","ror":"https://ror.org/052v5pn20","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210138094","https://openalex.org/I4210147002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenni Firrman","raw_affiliation_strings":["Dairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, Pennsylvania, USA","Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, Pennsylvania, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210147002"]},{"raw_affiliation_string":"Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, United States of America","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210147002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024289786","display_name":"Fuhua Hao","orcid":"https://orcid.org/0000-0002-0865-5269","observed_orcids":["https://orcid.org/0000-0002-0865-5269"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuhua Hao","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA","Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104278913","display_name":"Vincent Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Tu","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, United States of America","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076770272","display_name":"LinShu Liu","orcid":"https://orcid.org/0000-0003-3962-290X","observed_orcids":["https://orcid.org/0000-0003-3962-290X"]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210147002","display_name":"Eastern Regional Research Center","ror":"https://ror.org/052v5pn20","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210138094","https://openalex.org/I4210147002"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LinShu Liu","raw_affiliation_strings":["Dairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, Pennsylvania, USA","Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, Pennsylvania, USA","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210147002"]},{"raw_affiliation_string":"Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, Wyndmoor, United States of America","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I4210147002"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075033594","display_name":"Andrew D. Patterson","orcid":"https://orcid.org/0000-0003-2073-0070","observed_orcids":["https://orcid.org/0000-0003-2073-0070"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Patterson","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA","Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066967353","display_name":"Kyle L. Bittinger","orcid":"https://orcid.org/0000-0003-3472-5934","observed_orcids":["https://orcid.org/0000-0003-3472-5934"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Bittinger","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3472-5934","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, The Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, United States of America","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023992004","display_name":"Mark Goulian","orcid":"https://orcid.org/0000-0003-0076-023X","observed_orcids":["https://orcid.org/0000-0003-0076-023X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Goulian","raw_affiliation_strings":["Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Department of Biology, University of Pennsylvania, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biology, University of Pennsylvania, Philadelphia, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032759284","display_name":"Gary D. Wu","orcid":"https://orcid.org/0000-0002-1829-8795","observed_orcids":["https://orcid.org/0000-0002-1829-8795"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gary D. Wu","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Philadelphia, United States of America","institution_ids":["https://openalex.org/I2799810409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032759284"],"corresponding_institution_ids":["https://openalex.org/I2799810409"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":6.7424,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.98492727,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"134","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dietary-carbohydrates","display_name":"dietary carbohydrates","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.9919999837875366},{"id":"https://openalex.org/keywords/monosaccharides","display_name":"monosaccharides","score":0.8529999852180481},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7089999914169312},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antibiotic-associated-diarrhea","display_name":"antibiotic-associated diarrhea","score":0.4490000009536743},{"id":"https://openalex.org/keywords/lactulose","display_name":"lactulose","score":0.7179999947547913},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.5440000295639038},{"id":"https://openalex.org/keywords/bacterial-dissemination","display_name":"bacterial dissemination","score":0.5950000286102295},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.6119999885559082},{"id":"https://openalex.org/keywords/pathobionts","display_name":"pathobionts","score":0.7039999961853027},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2776927270","wikidata":"https://www.wikidata.org/wiki/Q815962","display_name":"Colonization","level":2,"score":0.7486816644668579},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.7042272686958313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6559574007987976},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6379982829093933},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6110832691192627},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4995906352996826},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4964614510536194},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.42496001720428467},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41758227348327637},{"id":"https://openalex.org/C189506811","wikidata":"https://www.wikidata.org/wiki/Q5148442","display_name":"Colonisation resistance","level":3,"score":0.4139712452888489},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34191054105758667},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.149633526802063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10231611132621765},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.08686956763267517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1172/jci174726","doi":"https://doi.org/10.1172/jci174726","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci174726","pdf_url":"http://www.jci.org/articles/view/174726/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"doi:10.1101/2023.05.25.542283","doi":"https://doi.org/10.1101/2023.05.25.542283","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.05.25.542283","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/11/2023.05.25.542283.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11060737","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11060737","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11060737/pdf/jci-134-174726.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:37292978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37292978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:38512401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38512401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10245944","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10245944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7c1416802635471faad081df7f0b71d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c1416802635471faad081df7f0b71d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Clinical Investigation, Vol 134, Iss 9 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1172/jci174726","doi":"https://doi.org/10.1172/jci174726","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci174726","pdf_url":"http://www.jci.org/articles/view/174726/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1659709005","display_name":null,"funder_award_id":"P30 DK050306","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G3786095936","display_name":"Training Program in Gastrointestinal Sciences","funder_award_id":"T32DK007066","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8120603862","display_name":null,"funder_award_id":"NIH P30DK050306","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G8247769123","display_name":null,"funder_award_id":"Research Fellowship Award,1049281","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G9000278650","display_name":null,"funder_award_id":"NIH P30\u2010DK050306","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000874870","display_name":"Phosphorelay signaling and regulation in bacteria","funder_award_id":"R35GM139541","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000909123","display_name":"Center for Molecular Studies in Digestive and Liver Diseases","funder_award_id":"P30DK050306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394710322.pdf","grobid_xml":"https://content.openalex.org/works/W4394710322.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1597959509","https://openalex.org/W1647551795","https://openalex.org/W1837062668","https://openalex.org/W1855226200","https://openalex.org/W1968105193","https://openalex.org/W1973066274","https://openalex.org/W1981504305","https://openalex.org/W2008093181","https://openalex.org/W2020913417","https://openalex.org/W2034400607","https://openalex.org/W2041284127","https://openalex.org/W2046753869","https://openalex.org/W2047059509","https://openalex.org/W2048093113","https://openalex.org/W2059005097","https://openalex.org/W2061853512","https://openalex.org/W2093795546","https://openalex.org/W2096666146","https://openalex.org/W2112696943","https://openalex.org/W2112931540","https://openalex.org/W2116727622","https://openalex.org/W2118085294","https://openalex.org/W2122125017","https://openalex.org/W2139284253","https://openalex.org/W2143485490","https://openalex.org/W2143777796","https://openalex.org/W2149489418","https://openalex.org/W2155395286","https://openalex.org/W2159482845","https://openalex.org/W2159954944","https://openalex.org/W2162748874","https://openalex.org/W2164175488","https://openalex.org/W2170325206","https://openalex.org/W2303656007","https://openalex.org/W2328023807","https://openalex.org/W2372148749","https://openalex.org/W2484230073","https://openalex.org/W2497427951","https://openalex.org/W2538058458","https://openalex.org/W2550352184","https://openalex.org/W2552041992","https://openalex.org/W2565803617","https://openalex.org/W2569730035","https://openalex.org/W2768740883","https://openalex.org/W2770933704","https://openalex.org/W2800136432","https://openalex.org/W2810245133","https://openalex.org/W2884679414","https://openalex.org/W2895984689","https://openalex.org/W2904430902","https://openalex.org/W2905953595","https://openalex.org/W2925100173","https://openalex.org/W2930454936","https://openalex.org/W2952539125","https://openalex.org/W2953093188","https://openalex.org/W2953115794","https://openalex.org/W2970037024","https://openalex.org/W2974099250","https://openalex.org/W3005585888","https://openalex.org/W3016527575","https://openalex.org/W3029420556","https://openalex.org/W3041753189","https://openalex.org/W3115358054","https://openalex.org/W3121119626","https://openalex.org/W3137820397","https://openalex.org/W3143063265","https://openalex.org/W3165463838","https://openalex.org/W3167659775","https://openalex.org/W3179557623","https://openalex.org/W3202567521","https://openalex.org/W4225388682","https://openalex.org/W4225424738","https://openalex.org/W4250467159","https://openalex.org/W4285224353","https://openalex.org/W4289780574","https://openalex.org/W4294012083","https://openalex.org/W4296709701","https://openalex.org/W4297980315","https://openalex.org/W4323670197","https://openalex.org/W4362658272","https://openalex.org/W4376636047","https://openalex.org/W4388673703"],"related_works":["https://openalex.org/W4396528527","https://openalex.org/W4383379416","https://openalex.org/W4313488507","https://openalex.org/W7071063254","https://openalex.org/W6884891881","https://openalex.org/W3080611838","https://openalex.org/W4296709701","https://openalex.org/W2997685292","https://openalex.org/W3170737486","https://openalex.org/W6925829635"],"abstract_inverted_index":{"Bacterial":[0],"translocation":[1],"from":[2,33,52],"the":[3,26,42,71,85,121,145,155,179],"gut":[4,20,68],"microbiota":[5,50],"is":[6],"a":[7,34,114,130,195],"source":[8],"of":[9,19,28,44,66,87,94,125,140,144,151,181],"sepsis":[10],"in":[11,41,70,77,81,97,106,120,178,198],"susceptible":[12],"patients.":[13,200],"Previous":[14],"work":[15],"suggests":[16],"that":[17,58,168,189],"overgrowth":[18],"pathobionts,":[21],"including":[22],"Klebsiella":[23],"pneumoniae,":[24],"increases":[25],"risk":[27],"disseminated":[29,186],"infection.":[30],"Our":[31,165],"data":[32],"human":[35],"dietary":[36,59,82,163,169,191],"intervention":[37],"study":[38,76],"found":[39],"that,":[40],"absence":[43],"fiber,":[45],"K.":[46,88,118,141,152],"pneumoniae":[47,89,119,153],"bloomed":[48],"during":[49],"recovery":[51,93],"antibiotic":[53],"treatment.":[54],"We":[55],"thus":[56],"hypothesized":[57],"nutrients":[60],"directly":[61],"support":[62],"or":[63],"suppress":[64],"colonization":[65,86,139,183],"this":[67],"pathobiont":[69,182],"microbiota.":[72],"Consistent":[73],"with":[74,128],"our":[75],"humans,":[78],"complex":[79,172],"carbohydrates":[80,112,173],"fiber":[83],"suppressed":[84],"and":[90,105,134,157,171],"allowed":[91],"for":[92,117],"competing":[95],"commensals":[96],"mouse":[98],"models.":[99],"In":[100],"contrast,":[101],"through":[102],"ex":[103],"vivo":[104,107],"modeling,":[108],"we":[109],"identified":[110],"simple":[111,132,170],"as":[113],"limiting":[115],"resource":[116],"gut.":[122],"As":[123],"proof":[124],"principle,":[126],"supplementation":[127],"lactulose,":[129],"nonabsorbed":[131],"carbohydrate":[133],"an":[135],"FDA-approved":[136],"therapy,":[137],"increased":[138],"pneumoniae.":[142],"Disruption":[143],"intestinal":[146],"epithelium":[147],"led":[148],"to":[149],"dissemination":[150],"into":[154],"bloodstream":[156],"liver,":[158],"which":[159],"was":[160],"prevented":[161],"by":[162],"fiber.":[164],"results":[166],"show":[167],"were":[174],"critical":[175],"not":[176],"only":[177],"regulation":[180],"but":[184],"also":[185],"infection,":[187],"suggesting":[188],"targeted":[190],"interventions":[192],"may":[193],"offer":[194],"preventative":[196],"strategy":[197],"high-risk":[199]},"counts_by_year":[{"year":2026,"cited_by_count":31},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-04-12T00:00:00"}
