{"id":"https://openalex.org/W4394684362","doi":"https://doi.org/10.1111/bcpt.14009","title":"Exploring clozapine pharmacokinetics in Tunisian schizophrenic patients: A population\u2010based modelling approach investigating the impact of genetic and non\u2010genetic variables","display_name":"Exploring clozapine pharmacokinetics in Tunisian schizophrenic patients: A population\u2010based modelling approach investigating the impact of genetic and non\u2010genetic variables","publication_year":2024,"publication_date":"2024-04-10","ids":{"openalex":"https://openalex.org/W4394684362","doi":"https://doi.org/10.1111/bcpt.14009","pmid":"https://pubmed.ncbi.nlm.nih.gov/38599832"},"language":"en","primary_location":{"id":"doi:10.1111/bcpt.14009","doi":"https://doi.org/10.1111/bcpt.14009","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bcpt.14009","pdf_url":null,"source":{"id":"https://openalex.org/S44074210","display_name":"Basic & Clinical Pharmacology & Toxicology","issn_l":"1742-7835","issn":["1742-7835","1742-7843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic &amp; Clinical Pharmacology &amp; Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037617961","display_name":"Khadija Mansour","orcid":"https://orcid.org/0000-0001-9397-1102","observed_orcids":["https://orcid.org/0000-0001-9397-1102"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":true,"raw_author_name":"Khadija Mansour","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":"https://orcid.org/0000-0001-9397-1102","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054555704","display_name":"Nadia Ben Fredj","orcid":"https://orcid.org/0000-0003-4820-4312","observed_orcids":["https://orcid.org/0000-0003-4820-4312"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Nadia Ben Fredj","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086706100","display_name":"Helmi Ammar","orcid":"https://orcid.org/0000-0002-9094-7243","observed_orcids":["https://orcid.org/0000-0002-9094-7243"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Helmi Ammar","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062771753","display_name":"Haifa Ben Romdhane","orcid":"https://orcid.org/0000-0002-5755-5117","observed_orcids":["https://orcid.org/0000-0002-5755-5117"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Haifa Ben Romdhane","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":"https://orcid.org/0000-0002-5755-5117","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013635919","display_name":"Ahmed Mhalla","orcid":"https://orcid.org/0000-0002-9787-3478","observed_orcids":["https://orcid.org/0000-0002-9787-3478"]},"institutions":[{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ahmed Mhalla","raw_affiliation_strings":["Department of Psychiatry, Fattouma Bourguiba Hospital, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Fattouma Bourguiba Hospital, Monastir, Tunisia","institution_ids":["https://openalex.org/I4210167430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031793718","display_name":"Amel Chaabane","orcid":"https://orcid.org/0000-0001-9703-1943","observed_orcids":["https://orcid.org/0000-0001-9703-1943"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Amel Chaabane","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078757084","display_name":"Zohra Chadli","orcid":"https://orcid.org/0000-0003-1500-7574","observed_orcids":["https://orcid.org/0000-0003-1500-7574"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Zohra Chadli","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000607963","display_name":"Karim Aouam","orcid":"https://orcid.org/0000-0001-5828-8076","observed_orcids":["https://orcid.org/0000-0001-5828-8076"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210167430","display_name":"Hospital Fatuma Bourguiba Monastir","ror":"https://ror.org/05t1yee64","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210167430"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Karim Aouam","raw_affiliation_strings":["Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Fattouma Bourguiba Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037617961"],"corresponding_institution_ids":["https://openalex.org/I166928557","https://openalex.org/I4210167430"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.9471,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66843231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"134","issue":"6","first_page":"805","last_page":"817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9959999918937683},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cyp2c19-2-polymorphism","display_name":"CYP2C19*2 polymorphism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7570000290870667},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.6700000166893005},{"id":"https://openalex.org/keywords/tunisian-patients","display_name":"Tunisian patients","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.6223365068435669},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5936939120292664},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.5404056310653687},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4989743232727051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4874732494354248},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4695326089859009},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.4538224935531616},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3174419701099396},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.29850077629089355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29584285616874695},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.23947632312774658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21998518705368042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16753050684928894},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10623812675476074},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065731","descriptor_name":"Cytochrome P-450 CYP2C19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/bcpt.14009","doi":"https://doi.org/10.1111/bcpt.14009","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bcpt.14009","pdf_url":null,"source":{"id":"https://openalex.org/S44074210","display_name":"Basic & Clinical Pharmacology & Toxicology","issn_l":"1742-7835","issn":["1742-7835","1742-7843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic &amp; Clinical Pharmacology &amp; Toxicology","raw_type":"journal-article"},{"id":"pmid:38599832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38599832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic & clinical pharmacology & toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W135224102","https://openalex.org/W188939835","https://openalex.org/W1500560407","https://openalex.org/W1541888681","https://openalex.org/W1866416827","https://openalex.org/W1927353980","https://openalex.org/W1968322454","https://openalex.org/W1978794710","https://openalex.org/W1981990731","https://openalex.org/W1985330332","https://openalex.org/W2003143162","https://openalex.org/W2004441521","https://openalex.org/W2007877434","https://openalex.org/W2018594504","https://openalex.org/W2026949784","https://openalex.org/W2038469872","https://openalex.org/W2040134200","https://openalex.org/W2041397333","https://openalex.org/W2049875787","https://openalex.org/W2054783695","https://openalex.org/W2061376955","https://openalex.org/W2073232204","https://openalex.org/W2075954611","https://openalex.org/W2080118751","https://openalex.org/W2085919453","https://openalex.org/W2086359743","https://openalex.org/W2105378950","https://openalex.org/W2117045056","https://openalex.org/W2117358660","https://openalex.org/W2118094114","https://openalex.org/W2140092874","https://openalex.org/W2146926568","https://openalex.org/W2154691983","https://openalex.org/W2179413094","https://openalex.org/W2330609787","https://openalex.org/W2402437958","https://openalex.org/W2411137832","https://openalex.org/W2412343056","https://openalex.org/W2560754155","https://openalex.org/W2734814729","https://openalex.org/W2886807324","https://openalex.org/W2922029374","https://openalex.org/W2946871204","https://openalex.org/W2989937144","https://openalex.org/W2999008070","https://openalex.org/W3005189402","https://openalex.org/W3093890315","https://openalex.org/W3139076690","https://openalex.org/W3207834723","https://openalex.org/W4243610639","https://openalex.org/W4247274516","https://openalex.org/W4320888592","https://openalex.org/W4382981508","https://openalex.org/W4386910352","https://openalex.org/W6922222858"],"related_works":["https://openalex.org/W2411137832","https://openalex.org/W3139076690","https://openalex.org/W2999008070","https://openalex.org/W4399355649","https://openalex.org/W2007877434","https://openalex.org/W4392520319","https://openalex.org/W4412573621","https://openalex.org/W2517428471","https://openalex.org/W7134280072","https://openalex.org/W2038469872"],"abstract_inverted_index":{"Clozapine":[0],"is":[1],"characterized":[2],"by":[3],"a":[4,38,112,125],"large":[5],"within-":[6],"and":[7,16,35,51,58,61,67,92,116,143,147,152,171,179,184,205],"between-patient":[8],"variability":[9],"in":[10,140,195],"its":[11],"pharmacokinetics,":[12],"attributed":[13],"to":[14,191],"non-genetic":[15],"genetic":[17,63],"factors.":[18],"A":[19],"cross-sectional":[20],"analysis":[21],"of":[22,46,77,114,127],"clozapine":[23,162],"trough":[24],"concentration":[25],"(Clz":[26],"C0)":[27],"issued":[28,133],"from":[29,134],"Tunisian":[30,196],"schizophrenic":[31,136,197],"patients":[32,137,198],"was":[33,86,95],"collected":[34],"analysed":[36],"using":[37,81,97,199],"nonparametric":[39],"modelling":[40],"approach.":[41],"We":[42,182],"assessed":[43,139],"the":[44,62,98,104,117,156,200],"impact":[45],"demographic":[47],"covariates":[48,158],"(age,":[49],"weight":[50],"sex),":[52],"patient's":[53],"habits":[54],"(smoking":[55],"status,":[56],"alcohol":[57],"caffeine":[59],"intake)":[60],"factors":[64],"(CYP1A2*1C,":[65],"CYP1A2*1F":[66,150,203],"CYP2C19*2":[68],"polymorphisms)":[69],"on":[70],"each":[71],"pharmacokinetic":[72,79,188],"parameter.":[73],"An":[74],"external":[75],"validation":[76,148],"this":[78,141],"model":[80,189],"an":[82,186],"independent":[83],"data":[84,94],"set":[85],"performed.":[87],"Fit":[88],"goodness":[89],"between":[90],"observed-":[91],"individual-predicted":[93],"evaluated":[96],"mean":[99,105,119],"prediction":[100,107],"error":[101,108,121],"(%":[102,109,122],"MPE),":[103],"absolute":[106],"MAPE)":[110],"as":[111,124,167],"measure":[113,126],"bias,":[115],"root":[118],"squared":[120],"RMSE)":[123],"precision.":[128],"Sixty-three":[129],"CLz":[130],"C0":[131,194],"values":[132],"51":[135],"were":[138,155,166],"study":[142],"divided":[144],"into":[145],"building":[146],"groups.":[149],"polymorphism":[151,204],"smoking":[153],"status":[154],"only":[157],"significantly":[159],"associated":[160],"with":[161],"clearance.":[163],"Precision":[164],"parameters":[165,202],"follows:":[168],"1.02%,":[169],"0.95%":[170],"22.4%,":[172],"respectively,":[173],"for":[174],"%":[175,177,180],"MPE,":[176],"MAPE":[178],"RMSE.":[181],"developed":[183],"validated":[185],"accurate":[187],"able":[190],"predict":[192],"Clz":[193],"two":[201],"smoking.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-11T00:00:00"}
