{"id":"https://openalex.org/W4394601481","doi":"https://doi.org/10.1212/wnl.0000000000204370","title":"Prevalence and Anatomical Generators of Movement Disorders in Relapsing and Progressive Multiple Sclerosis (P1-6.013)","display_name":"Prevalence and Anatomical Generators of Movement Disorders in Relapsing and Progressive Multiple Sclerosis (P1-6.013)","publication_year":2024,"publication_date":"2024-04-09","ids":{"openalex":"https://openalex.org/W4394601481","doi":"https://doi.org/10.1212/wnl.0000000000204370"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000204370","doi":"https://doi.org/10.1212/wnl.0000000000204370","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.0000000000204370","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076569393","display_name":"Hannah M. Kelly","orcid":"https://orcid.org/0000-0001-5818-1914","observed_orcids":["https://orcid.org/0000-0001-5818-1914"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Kelly","raw_affiliation_strings":["Case Western Reserve University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102366575","display_name":"Rongyi Sun","orcid":"https://orcid.org/0009-0002-6336-4090","observed_orcids":["https://orcid.org/0009-0002-6336-4090","https://orcid.org/0009-0001-2512-120X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongyi Sun","raw_affiliation_strings":["Case Western Reserve University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102975313","display_name":"Mohamed Elkasaby","orcid":"https://orcid.org/0000-0002-5713-4056","observed_orcids":["https://orcid.org/0000-0002-5713-4056"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Elkasaby","raw_affiliation_strings":["University Hospitals Cleveland Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Cleveland Medical Center","institution_ids":["https://openalex.org/I4210108791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101755064","display_name":"Alexander F. Wang","orcid":"https://orcid.org/0000-0002-7264-1312","observed_orcids":["https://orcid.org/0000-0002-7264-1312"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Wang","raw_affiliation_strings":["University Hospitals Cleveland Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Cleveland Medical Center","institution_ids":["https://openalex.org/I4210108791"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086775272","display_name":"Hesham Abboud","orcid":"https://orcid.org/0000-0001-5346-8254","observed_orcids":["https://orcid.org/0000-0001-5346-8254"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hesham Abboud","raw_affiliation_strings":["University Hospitals Cleveland Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Cleveland Medical Center","institution_ids":["https://openalex.org/I4210108791"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07097082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"17_supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10982","display_name":"Motor Control and Adaptation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/movement-disorders","display_name":"movement disorders","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.8230000138282776},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/progressive-multiple-sclerosis","display_name":"progressive multiple sclerosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/disease-stage","display_name":"disease stage","score":0.722000002861023},{"id":"https://openalex.org/keywords/motor-symptoms","display_name":"motor symptoms","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8433768153190613},{"id":"https://openalex.org/C2778261627","wikidata":"https://www.wikidata.org/wiki/Q2608695","display_name":"Movement disorders","level":3,"score":0.6973807215690613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5852601528167725},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5132491588592529},{"id":"https://openalex.org/C2780226923","wikidata":"https://www.wikidata.org/wiki/Q929848","display_name":"Movement (music)","level":2,"score":0.45791497826576233},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4279767870903015},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2722195088863373},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19192466139793396},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000204370","doi":"https://doi.org/10.1212/wnl.0000000000204370","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.0000000000204370","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408734386","https://openalex.org/W2901793724","https://openalex.org/W4389444951","https://openalex.org/W4415912205","https://openalex.org/W4386093461","https://openalex.org/W7204525688","https://openalex.org/W2790917615","https://openalex.org/W4411605116","https://openalex.org/W2768924232","https://openalex.org/W2130711128"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"determine":[2],"the":[3,47,149,195,301,337,358,377,395,413,431,450,474,498,522,547,571,590,609,628,648],"prevalence":[4,48],"and":[5,16,49,80,88,98,108,120,133,152,166,212,237,244,260,284,287],"anatomic":[6,100],"underpinnings":[7],"of":[8,40,51,156,176,192,339,350,360,379,397,415,433,452,476,500,524,549,573,592,611,630,650,662,674,685,696,707],"movement":[9,41,52,73,77,89,93,124,146,161,170,185,232,248,267,274,293],"disorders":[10,26,42,53,74,94,147,162,171,186,233,249,268,275,294],"in":[11,30,43,86,154,164,174,183,279,336,357,376,394,412,430,449,473,497,521,546,570,589,608,627,647],"multiple":[12],"sclerosis":[13],"(MS)":[14],"patients":[15,63,117,208,280],"compare":[17],"these":[18],"factors":[19],"at":[20,54],"different":[21,55],"disease":[22,56,303],"stages.":[23],"Background:":[24],"Movement":[25],"are":[27,276],"more":[28,227],"common":[29,151],"MS":[31,62,116,131,138,143,197,225,262,283],"than":[32,206],"previously":[33],"thought.":[34],"We":[35,91,178],"conducted":[36],"a":[37,76,83,188,297,344,365,384,402,420,438,457,481,505,529,554,578,597,616,635,655,726],"prospective":[38],"study":[39],"early":[44],"MS,":[45],"but":[46],"characteristics":[50],"stages":[57],"remain":[58],"unknown.":[59],"Design/Methods:":[60],"Adult":[61],"seen":[64,173,278],"over":[65],"five":[66],"years":[67],"(2017\u20132022)":[68],"were":[69,118,148,172,204,213,226,256],"evaluated":[70],"for":[71,263,341,346,362,367,381,386,399,404,417,422,435,440,454,465,478,489,502,513,526,537,551,562,575,581,594,600,613,619,632,638,652,658],"demyelination-related":[72,123,231],"via":[75],"disorder":[78],"survey":[79],"examination":[81],"by":[82],"neurologist":[84],"trained":[85],"neuroimmunology":[87],"disorders.":[90,125],"classified":[92],"based":[95],"on":[96,106,456,480,504,528,553,577,596,615,634,654],"phenomenology":[97],"identified":[99],"correlates":[101],"according":[102],"to":[103,110,216,229,238,310,316,322,328,729],"lesion":[104],"locations":[105],"MRI":[107],"relation":[109],"relapses.":[111],"Results:":[112],"In":[113,290],"total,":[114],"328":[115],"screened,":[119],"65%":[121],"had":[122,129,135],"Regarding":[126],"phenotype,":[127],"64%":[128],"relapsing-remitting":[130],"(RRMS)":[132],"36%":[134],"secondary":[136],"progressive":[137,142,224,259,282],"(SPMS)":[139],"or":[140,159,168,202,246,265,460,484,508,532,557],"primary":[141],"(PPMS).":[144],"Spinal":[145],"most":[150],"occurred":[153,163],"79%":[155],"patients.":[157,177],"Brainstem":[158],"cerebellar":[160,247],"26%,":[165],"striatal":[167,264],"thalamic":[169,266],"2%":[175],"observed":[179,257],"22":[180],"cases":[181],"(9%)":[182],"which":[184,193],"represented":[187],"new":[189,298],"relapse,":[190,299],"two":[191],"heralded":[194],"first":[196,302],"attack.":[198],"Patients":[199,222],"with":[200,223,281],"SPMS":[201],"PPMS":[203],"older":[205],"RRMS":[207],"(37.9,":[209],"34.1,":[210],"p=0.03)":[211],"less":[214],"likely":[215,228],"be":[217],"female":[218],"(63%,":[219],"75.6%,":[220],"p=0.0).":[221,252],"have":[230,239],"(81.5%,":[234],"56%,":[235],"p<.0)":[236,243],"spinal":[240,285],"(67.2%,":[241],"47.8%,":[242],"brainstem":[245],"(27.7%,":[250],"14.4%,":[251],"No":[253],"significant":[254],"differences":[255],"between":[258],"relapsing":[261],"(4.2%,":[269],"0.96%,":[270],"p=0.1).":[271],"Conclusions:":[272],"Demyelination-related":[273],"commonly":[277],"cord":[286],"infratentorial":[288],"lesions.":[289],"some":[291],"patients,":[292],"may":[295],"represent":[296],"including":[300],"presentation.":[304],"Disclosure:":[305],"Ms.":[306],"Kelly":[307],"has":[308,314,320,326,332,353,372,390,408,426,445,469,493,517,542,566,585,604,623,643,665,677,688,699,710,721],"nothing":[309,315,321,327],"disclose.":[311,317,323,329],"Dr.":[312,318,324,330,351,370,388,406,424,443,467,491,515,540,564,583,602,621,641,663,675,686,697,708,719],"Sun":[313],"Elkasaby":[319],"Wang":[325],"Abboud":[331,352,371,389,407,425,444,468,492,516,541,565,584,603,622,642,664,676,687,698,709,720],"received":[333,354,373,391,409,427,446,470,494,518,543,567,586,605,624,644,666,678,689,700,711,722],"personal":[334,355,374,392,410,428,447,471,495,519,544,568,587,606,625,645],"compensation":[335,356,375,393,411,429,448,472,496,520,545,569,588,607,626,646],"range":[338,359,378,396,414,432,451,475,499,523,548,572,591,610,629,649],"$5,000-$9,999":[340,361,574,593],"serving":[342,363,382,400,418,436,455,479,503,527,552,576,595,614,633,653],"as":[343,364,383,401,419,437],"Consultant":[345,366,385,403,421,439],"Biogen.":[347,582],"The":[348,660,672,683,694,705,715],"institution":[349,661,673,684,695,706],"Genentech":[368,670],".":[369,640,671],"$500-$4,999":[380,398,416,434,453,477,501,525,550,612,631,651],"Alexion.":[387,490],"Horizon.":[405,514,659],"BMS.":[423,620,693],"Alpine":[441],"Pharma.":[442,539],"Scientific":[458,482,506,530,555],"Advisory":[459,483,507,531,556],"Data":[461,485,509,533,558],"Safety":[462,486,510,534,559],"Monitoring":[463,487,511,535,560],"board":[464,488,512,536,561],"Genentech.":[466,601],"Cycle":[538],"Axonics.":[563],"Speakers":[579,598,617,636,656],"Bureau":[580,599,618,637,657],"Alexion":[639],"research":[667,679,690,701,712],"support":[668,680,691,702,713],"from":[669,681,692,703,714,725],"Novartis.":[682],"Sanofi-Genzyme.":[704],"Guthy-Jackson":[716],"Charitable":[717],"Foundation.":[718],"publishing":[723],"royalties":[724],"publication":[727],"relating":[728],"health":[730],"care.":[731]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2024-04-10T00:00:00"}