{"id":"https://openalex.org/W4394598755","doi":"https://doi.org/10.1212/wnl.0000000000204534","title":"Peripherally Administered Therapeutic One-armed Antibody Reversed Behavioral Abnormalities in a Marmoset Model of Anti-NMDAR Encephalitis (S4.004)","display_name":"Peripherally Administered Therapeutic One-armed Antibody Reversed Behavioral Abnormalities in a Marmoset Model of Anti-NMDAR Encephalitis (S4.004)","publication_year":2024,"publication_date":"2024-04-09","ids":{"openalex":"https://openalex.org/W4394598755","doi":"https://doi.org/10.1212/wnl.0000000000204534"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000204534","doi":"https://doi.org/10.1212/wnl.0000000000204534","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.0000000000204534","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075432487","display_name":"Mitsuyuki Matsumoto","orcid":"https://orcid.org/0000-0002-1172-2354","observed_orcids":["https://orcid.org/0000-0002-1172-2354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuyuki Matsumoto","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112341733","display_name":"Masashi Maeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masashi Maeda","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109134399","display_name":"Atsuo Kanno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atsuo Kanno","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Satoshi Kubo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Kubo","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054225326","display_name":"Shanni Yamaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanni Yamaki","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017833976","display_name":"Roghiye Kazimi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roghiye Kazimi","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019839677","display_name":"Amir S. Razai","orcid":"https://orcid.org/0000-0002-7172-0713","observed_orcids":["https://orcid.org/0000-0002-7172-0713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Razai","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079979350","display_name":"Vallari R. Eastman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vallari Eastman","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mathew Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mathew Mitchell","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025279301","display_name":"Carrolee Barlow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carrolee Barlow","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108796605","display_name":"Jay B. Lichter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay Lichter","raw_affiliation_strings":["Arialys Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arialys Therapeutics, Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2676,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5123766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"102","issue":"7_supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-nmda-receptor-encephalitis","display_name":"anti-NMDA receptor encephalitis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/peripheral-administration","display_name":"peripheral administration","score":0.7210000157356262},{"id":"https://openalex.org/keywords/marmoset-model","display_name":"marmoset model","score":0.890999972820282},{"id":"https://openalex.org/keywords/behavioral-abnormalities","display_name":"behavioral abnormalities","score":0.902999997138977},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2776453536","wikidata":"https://www.wikidata.org/wiki/Q19829485","display_name":"Marmoset","level":2,"score":0.9667965173721313},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.6975825428962708},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5246291756629944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5205729603767395},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4727376699447632},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4240518808364868},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39553338289260864},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3622891902923584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16216886043548584},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.09179851412773132},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000204534","doi":"https://doi.org/10.1212/wnl.0000000000204534","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.0000000000204534","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403206923","https://openalex.org/W4367305138","https://openalex.org/W4409228167","https://openalex.org/W7164209841","https://openalex.org/W4411524223","https://openalex.org/W2030047612","https://openalex.org/W4405792855","https://openalex.org/W1541485988","https://openalex.org/W4409222276","https://openalex.org/W2320305799"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"invent":[2],"and":[3,11,41,88,112,135,206,238,255,274,282,288],"evaluate":[4],"a":[5,47,77,218,263,269,371,387,424,438,475,487,524,538,580,644,665],"precision":[6],"medicine":[7],"with":[8,53,108,208],"fast":[9],"onset":[10],"improved":[12],"safety":[13],"for":[14,129,220,266,278,304,319,339,351,401,421,426,452,472,477,501,521,526,552,565,594,608,622,641,646,685,704,716],"anti-NMDAR":[15,73],"encephalitis":[16],"(ANRE).":[17],"Background:":[18],"ANRE":[19,81,279],"pathogenic":[20,86,193,233],"autoantibodies":[21],"(autoAbs)":[22],"bind":[23,52],"to":[24,51,56,132,153,168,174,292,376,392,443,492,543,585,670,677],"limited":[25],"epitopes":[26],"in":[27,116,138,144,162,185,241,286,295,334,359,416,467,516,636,654,699],"the":[28,57,70,117,145,163,335,347,417,468,517,637,700,712],"N-terminal":[29],"domain":[30],"(NTD)":[31],"of":[32,59,72,80,85,142,160,192,230,245,309,324,337,346,349,406,419,457,470,506,519,557,570,599,613,627,639,690,702,711,714],"NMDAR":[33],"NR1":[34],"subunit,":[35],"crosslink":[36],"NMDARs,":[37],"induce":[38],"receptor":[39,63],"internalization":[40],"associated":[42],"neurological":[43],"symptoms.":[44],"We":[45,75],"engineered":[46],"one-armed":[48],"IgG":[49],"(ART5803)":[50],"high":[54],"affinity":[55],"NTD":[58],"NMDAR-NR1":[60],"without":[61],"impacting":[62],"function.":[64],"Further":[65],"we":[66,99],"demonstrate":[67],"ART5803":[68,90,102,161,212,248,267],"blocks":[69],"pathogenicity":[71],"autoAbs.":[74,170],"established":[76],"marmoset":[78,118],"model":[79],"by":[82,182],"ICV":[83,91,127,190,228],"infusion":[84,92,191,229],"autoAbs":[87,122,143,194,234],"demonstrated":[89],"reversed":[93,249],"behavioral":[94,114,237],"abnormalities.":[95],"In":[96],"this":[97,176],"study,":[98],"tested":[100],"if":[101],"could":[103],"reach":[104],"therapeutic":[105,264],"CNS":[106],"levels":[107],"IP":[109,172,216,243],"peripheral":[110],"dosing":[111,244],"reverse":[113],"abnormalities":[115,137,240,251],"model.":[119],"Design/Methods:":[120],"Pathogenic":[121],"(10":[123,147],"\u03bcg/hr)":[124],"were":[125,198],"continuously":[126],"infused":[128],"21":[130],"days":[131,188],"evoke":[133],"mental":[134],"motor":[136,239],"marmosets.":[139,186,242],"The":[140,171],"concentration":[141,179],"CSF":[146,164,178],"\u2013":[148,157],"20":[149],"ug/ml)":[150],"was":[151,180,256],"used":[152],"predict":[154],"that":[155],"1":[156,253],"2":[158,221],"ug/ml":[159],"would":[165],"be":[166],"necessary":[167],"block":[169],"dose":[173],"achieve":[175],"target":[177],"determined":[181],"PK":[183,281],"studies":[184,285,294],"Six":[187],"after":[189],"(Day":[195],"6),":[196],"marmosets":[197],"equally":[199],"divided":[200],"into":[201],"two":[202],"cohorts":[203],"(n=7\u20138":[204],"each)":[205],"dosed":[207],"either":[209],"400":[210,246],"mg/kg":[211,247],"or":[213,344,373,389,440,489,540,582,667,709],"vehicle":[214],"via":[215],"twice":[217],"week":[219,254],"weeks":[222],"starting":[223],"on":[224],"Day":[225],"7.":[226],"Results:":[227],"ANRE-patient":[231],"derived":[232],"evoked":[235],"robust":[236],"these":[250],"within":[252],"well":[257],"tolerated.":[258],"Conclusions:":[259],"These":[260],"data":[261],"indicate":[262],"potential":[265],"as":[268,306,321,341,403,423,454,474,503,523,554,567,596,610,624,643,687,706],"faster":[270],"acting,":[271],"more":[272],"efficacious,":[273],"safer":[275],"treatment":[276],"option":[277],"patients.":[280],"GLP":[283],"toxicology":[284],"monkeys":[287],"rats":[289],"are":[290],"underway":[291],"support":[293],"humans.":[296],"Disclosure:":[297],"Dr.":[298,313,328,355,363,379,395,410,430,495,510,530,546,559,572,616,630,650,657,693],"Matsumoto":[299,314,329,356,364,380],"has":[300,315,330,357,365,381,397,412,432,448,463,481,497,512,532,548,561,574,590,604,618,632,652,659,675,681,695],"received":[301,316,331,366,382,398,413,433,449,464,482,498,513,533,549,562,575,591,605,619,633,660,682,696],"personal":[302,317,332,399,414,450,465,499,514,550,563,592,606,620,634,683,697],"compensation":[303,318,333,400,415,451,466,500,515,551,564,593,607,621,635,684,698],"serving":[305,320,340,402,422,453,473,502,522,553,566,595,609,623,642,686,705],"an":[307,322,342,404,455,504,555,568,597,611,625,688,707],"employee":[308,323,405,456,505,556,569,598,612,626,689],"Arialys":[310,352,360,427,527,600,628,691],"Therapeutics,":[311,353,361],"Inc.":[312,327,354,362,409,429,509,529],"Astellas":[325,407,458,507],"Pharma":[326,408,459,508],"range":[336,418,469,518,638,701],"$100,000-$499,999":[338],"officer":[343,708],"member":[345,710],"Board":[348,713],"Directors":[350,715],"stock":[358,653],"intellectual":[367,383,434,483,534,576,661],"property":[368,384,435,484,535,577,662],"interests":[369,385,436,485,536,578,663],"from":[370,386,437,486,537,579,664],"discovery":[372,388,439,488,539,581,666],"technology":[374,390,441,490,541,583,668],"relating":[375,391,442,491,542,584,669],"health":[377,393,444,493,544,586,671],"care.":[378,394,445,494,545,587,672],"Maeda":[396,411,431],"$10,000-$49,999":[420],"Consultant":[425,476,525,645],"Therapeytic":[428],"Mr.":[446,461,479,679],"Kanno":[447,462,480],"Inc,.":[460],"$5,000-$9,999":[471,520,640],"Arialys.":[478,558],"Kubo":[496,511,531],"Therapeutics":[528],"Yamaki":[547,560,573],"Astellas.":[571],"Mrs.":[588,602],"Kazimi":[589,603],"Therapeutics.":[601,692],"BPS":[614],"Bioscience.":[615],"Razai":[617,631,651,658],".":[629,649,656],"Aivocode":[647],"inc":[648],"Inhibrx":[655],"Ms.":[673],"Eastman":[674],"nothing":[676],"disclose.":[678],"Mitchell":[680],"Lichter":[694],"$50,000-$99,999":[703],"Janux.":[717]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-04-10T00:00:00"}
