{"id":"https://openalex.org/W4394598592","doi":"https://doi.org/10.1212/wnl.0000000000205403","title":"Anti-NMDA Encephalitis Co-positive with Aquaporin 4 Antibodies in a 4-year-old Female (P6-8.004)","display_name":"Anti-NMDA Encephalitis Co-positive with Aquaporin 4 Antibodies in a 4-year-old Female (P6-8.004)","publication_year":2024,"publication_date":"2024-04-09","ids":{"openalex":"https://openalex.org/W4394598592","doi":"https://doi.org/10.1212/wnl.0000000000205403"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000205403","doi":"https://doi.org/10.1212/wnl.0000000000205403","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000205403","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078552855","display_name":"C. Larochelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chloe LaRochelle","raw_affiliation_strings":["College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093643617","display_name":"Kirsten Consing","orcid":"https://orcid.org/0009-0007-5861-8048","observed_orcids":["https://orcid.org/0009-0007-5861-8048"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten Consing","raw_affiliation_strings":["Child Neurology, University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Neurology, University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087352478","display_name":"Carla D. Zingariello","orcid":"https://orcid.org/0000-0001-9884-2190","observed_orcids":["https://orcid.org/0000-0001-9884-2190"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Zingariello","raw_affiliation_strings":["University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"7_supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-nmda-receptor-encephalitis","display_name":"anti-NMDA receptor encephalitis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/aquaporin-4-antibodies","display_name":"aquaporin-4 antibodies","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pediatric-autoimmune-encephalitis","display_name":"pediatric autoimmune encephalitis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/refractory-seizures","display_name":"refractory seizures","score":0.7379999756813049},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9490000009536743},{"id":"https://openalex.org/keywords/spinal-cord-myelopathy","display_name":"spinal cord myelopathy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/neuromyelitis-optica-spectrum-disorder","display_name":"neuromyelitis optica spectrum disorder","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oligoclonal-bands","display_name":"oligoclonal bands","score":0.8650000095367432},{"id":"https://openalex.org/keywords/choreiform-movements","display_name":"choreiform movements","score":0.6620000004768372},{"id":"https://openalex.org/keywords/autonomic-dysfunction","display_name":"autonomic dysfunction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/language-regression","display_name":"language regression","score":0.7429999709129333},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.6700000166893005},{"id":"https://openalex.org/keywords/plasmapheresis","display_name":"plasmapheresis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mycophenolate","display_name":"mycophenolate","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6984285116195679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6515361070632935},{"id":"https://openalex.org/C15755913","wikidata":"https://www.wikidata.org/wiki/Q14902502","display_name":"Aquaporin 4","level":2,"score":0.594884991645813},{"id":"https://openalex.org/C2777604421","wikidata":"https://www.wikidata.org/wiki/Q2303951","display_name":"Myelopathy","level":3,"score":0.5508204102516174},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.5413001775741577},{"id":"https://openalex.org/C2778242525","wikidata":"https://www.wikidata.org/wiki/Q1340307","display_name":"Toddler","level":2,"score":0.5201404690742493},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4982638359069824},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.440030038356781},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37047290802001953},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3267500102519989},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3231070339679718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21685951948165894},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1443876028060913},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13990497589111328},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.04935598373413086},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000205403","doi":"https://doi.org/10.1212/wnl.0000000000205403","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000205403","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2962925985","https://openalex.org/W3015026033","https://openalex.org/W4229375842","https://openalex.org/W2567758517","https://openalex.org/W3135928522","https://openalex.org/W4416382715","https://openalex.org/W2557847105","https://openalex.org/W4408880125","https://openalex.org/W3022694304","https://openalex.org/W4403206474"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"report":[2,37,166],"the":[3,67,135,241,244],"co-existence":[4],"of":[5,41,69,134,139,162,201,222,246,265,277],"anti-NMDAR":[6,108,140,172,192,218,223,232],"antibodies":[7,10,28,49,109,123,184,224],"and":[8,18,47,78,95,106,120,131,158,178,193],"aquaporin-4":[9,48],"in":[11,33,82,217,240],"a":[12,42,167,236],"toddler":[13,43],"with":[14,25,44,62,116,152,160,171,175,185,199,231],"refractory":[15,74],"multifocal":[16],"seizures":[17],"spinal":[19],"cord":[20],"myelopathy.":[21,142,186],"Background:":[22],"Anti-NMDAR":[23,46],"encephalitis":[24,173,233],"other":[26],"autoimmune":[27,248],"is":[29,215,225],"not":[30],"well":[31],"studied":[32],"young":[34],"children.":[35],"We":[36,165],"an":[38],"unusual":[39],"case":[40,188],"co-positive":[45,182,191],"(AQP4).":[50],"Design/Methods:":[51],"NA":[52],"Results:":[53],"A":[54],"healthy,":[55],"normally":[56],"developing":[57,247],"3-year-old":[58],"African-American":[59],"female":[60],"presented":[61],"new-onset":[63],"generalized":[64,99],"seizures.":[65],"Over":[66],"course":[68],"2.5":[70],"months,":[71],"she":[72,89],"developed":[73,90],"seizures,":[75],"language":[76],"regression,":[77],"sleep":[79],"dysfunction":[80],"resulting":[81],"admission":[83],"for":[84,147],"status":[85,176],"epilepticus,":[86],"during":[87],"which":[88],"choreiform":[91],"movements,":[92],"orofacial":[93],"dyskinesias,":[94],"dysautonomia.":[96],"EEG":[97],"showed":[98],"delta":[100],"activity.":[101],"Work-up":[102],"revealed":[103,127],"positive":[104],"CSF":[105],"serum":[107,113],"(CSF":[110],"titer":[111,114],"1:40,":[112],"1:620)":[115],"7":[117],"oligoclonal":[118],"bands,":[119],"elevated":[121],"AQP4":[122,183,194],"(20.8":[124],"U/mL).":[125],"Neuroimaging":[126],"bilateral":[128],"supratentorial":[129],"atrophy":[130],"hyperintense":[132],"lesions":[133],"thoracic":[136],"spine":[137],"suggestive":[138],"associated":[141],"Pelvic":[143],"ultrasound":[144],"was":[145,150],"negative":[146],"tumor.":[148],"She":[149],"treated":[151],"high-dose":[153],"steroids,":[154],"plasmapheresis,":[155],"IVIG,":[156],"mycophenolate,":[157],"rituximab":[159],"improvement":[161],"symptoms.":[163],"Conclusions:":[164],"3":[168],"year":[169],"old":[170],"presenting":[174],"epilepticus":[177],"found":[179],"to":[180,255,261],"have":[181],"In":[187],"reports":[189],"documenting":[190],"antibodies,":[195],"patients":[196],"initially":[197],"present":[198],"features":[200],"neuromyelitis":[202],"optica":[203],"spectrum":[204],"disorder":[205],"(NMOSD),":[206],"making":[207],"our":[208],"patient\u2019s":[209,228],"presentation":[210,230],"unusual.":[211],"Overlapping":[212],"demyelinating":[213],"disease":[214],"uncommon":[216],"encephalitis.":[219],"The":[220,263,275],"origin":[221],"debated.":[226],"Our":[227],"primary":[229],"argues":[234],"suggests":[235],"general":[237],"pro-inflammatory":[238],"state":[239],"brain":[242],"increases":[243],"risk":[245],"antibodies.":[249],"Disclosure:":[250],"Miss":[251],"LaRochelle":[252],"has":[253,259,268,280],"nothing":[254,260],"disclose.":[256,262],"Dr.":[257,266,278],"Consing":[258],"institution":[264,276],"Zingariello":[267,279],"received":[269,281],"research":[270,282],"support":[271,283],"from":[272,284],"ML":[273],"Bio.":[274],"Edgewise":[285],"Therapeutics.":[286]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-04-10T00:00:00"}