{"id":"https://openalex.org/W4394598372","doi":"https://doi.org/10.1212/wnl.0000000000206727","title":"Intravenous Thrombolysis Versus Antiplatelet Therapy for Patients with Minor Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P2-5.013)","display_name":"Intravenous Thrombolysis Versus Antiplatelet Therapy for Patients with Minor Acute Ischemic Stroke: A Systematic Review and Meta-analysis (P2-5.013)","publication_year":2024,"publication_date":"2024-04-09","ids":{"openalex":"https://openalex.org/W4394598372","doi":"https://doi.org/10.1212/wnl.0000000000206727"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000206727","doi":"https://doi.org/10.1212/wnl.0000000000206727","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000206727","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059399373","display_name":"Marianna Gerardo Hidalgo Santos Jorge Leite","orcid":"https://orcid.org/0000-0001-5816-1438","observed_orcids":["https://orcid.org/0000-0001-5816-1438"]},"institutions":[{"id":"https://openalex.org/I4403386592","display_name":"Faculdade Santa Marcelina","ror":"https://ror.org/03b1fmh33","country_code":"BR","type":"education","lineage":["https://openalex.org/I4403386592","https://openalex.org/I4403386771"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marianna Gerardo Hidalgo Santos Jorge Leite","raw_affiliation_strings":["Faculdade Santa Marcelina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade Santa Marcelina","institution_ids":["https://openalex.org/I4403386592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015897227","display_name":"Lucca Moreira Lopes","orcid":"https://orcid.org/0000-0002-2770-2198","observed_orcids":["https://orcid.org/0000-0002-2770-2198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucca Moreira Lopes","raw_affiliation_strings":["Faculdade de Ci\u00eancias M\u00e9dicas de Santos"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas de Santos","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056796340","display_name":"Eric Pasqualotto","orcid":"https://orcid.org/0000-0002-6484-1162","observed_orcids":["https://orcid.org/0000-0002-6484-1162"]},"institutions":[{"id":"https://openalex.org/I4104125","display_name":"Universidade Federal de Santa Catarina","ror":"https://ror.org/041akq887","country_code":"BR","type":"education","lineage":["https://openalex.org/I4104125"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eric Pasqualotto","raw_affiliation_strings":["Federal University of Santa Catarina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Santa Catarina","institution_ids":["https://openalex.org/I4104125"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113172641","display_name":"Maria Eduarda Cavalvanti Souza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71437568","display_name":"Universidade de Pernambuco","ror":"https://ror.org/00gtcbp88","country_code":"BR","type":"education","lineage":["https://openalex.org/I71437568"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Eduarda Cavalvanti Souza","raw_affiliation_strings":["Universidade de Pernambuco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Pernambuco","institution_ids":["https://openalex.org/I71437568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093110103","display_name":"Renan Yuji Ura Sudo","orcid":"https://orcid.org/0000-0001-8117-2784","observed_orcids":["https://orcid.org/0000-0001-8117-2784"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Renan Yuji Ura Sudo","raw_affiliation_strings":["Universidade Federal Grande Dourados"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal Grande Dourados","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028845527","display_name":"Francisco C\u00e9zar Aquino de Moraes","orcid":"https://orcid.org/0000-0003-0623-8135","observed_orcids":["https://orcid.org/0000-0003-0623-8135"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Cezar Aquino de Moraes","raw_affiliation_strings":["Federal University of Par\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Par\u00e1","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044251466","display_name":"Artur Menegaz de Almeida","orcid":"https://orcid.org/0009-0004-3869-7373","observed_orcids":["https://orcid.org/0009-0004-3869-7373"]},"institutions":[{"id":"https://openalex.org/I32725510","display_name":"Universidade Federal de Mato Grosso","ror":"https://ror.org/01mqvjv41","country_code":"BR","type":"education","lineage":["https://openalex.org/I32725510"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Artur Menegaz de Almeida","raw_affiliation_strings":["Universidade Federal de Mato Grosso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Mato Grosso","institution_ids":["https://openalex.org/I32725510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094581831","display_name":"Vict\u00f3ria Morbach","orcid":"https://orcid.org/0009-0003-0326-647X","observed_orcids":["https://orcid.org/0009-0003-0326-647X"]},"institutions":[{"id":"https://openalex.org/I145689991","display_name":"Universidade Feevale","ror":"https://ror.org/05gefd119","country_code":"BR","type":"education","lineage":["https://openalex.org/I145689991"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vict\u00f3ria Morbach Siebel","raw_affiliation_strings":["Universidade Feevale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Feevale","institution_ids":["https://openalex.org/I145689991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060985546","display_name":"Agostinho C. Pinheiro","orcid":"https://orcid.org/0000-0002-2496-9479","observed_orcids":["https://orcid.org/0000-0002-2496-9479"]},"institutions":[{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agostinho Pinheiro","raw_affiliation_strings":["Mass General Brigham Neurology Residency"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Neurology Residency","institution_ids":["https://openalex.org/I48633490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2505,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48210197,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"102","issue":"7_supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/dual-antiplatelet-therapy","display_name":"dual antiplatelet therapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.8399999737739563},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8579999804496765},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.47999998927116394},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.5329999923706055},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.4410000145435333},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.37299999594688416},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8682965040206909},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.8661300539970398},{"id":"https://openalex.org/C3020581612","wikidata":"https://www.wikidata.org/wiki/Q593958","display_name":"Minor stroke","level":3,"score":0.7753225564956665},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5607084035873413},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5331277847290039},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.510735034942627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4864747226238251},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4236876368522644},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.41259026527404785},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.20800873637199402},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.1706106960773468},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.11306893825531006},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000206727","doi":"https://doi.org/10.1212/wnl.0000000000206727","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000206727","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7134968671","https://openalex.org/W4399533110","https://openalex.org/W7160379112","https://openalex.org/W4403790318","https://openalex.org/W4409222367","https://openalex.org/W7126059630","https://openalex.org/W4401502477","https://openalex.org/W4392661031","https://openalex.org/W4406707292","https://openalex.org/W4400952729"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"assess":[2,53],"the":[3,25,29,54,111],"efficacy":[4,55,235],"and":[5,56,67,90,154,174,191,214,236],"safety":[6,57,237],"of":[7,31,58,131,139,226],"IV-Thrombolysis":[8,39,70,153,190,233],"compared":[9],"with":[10,15,72,83,101,115,228,242],"antiplatelet":[11,73,76,240],"therapy":[12,22,74,77,241],"in":[13,81],"patients":[14,82,136,227],"minor":[16,32,84,229],"acute":[17,35,85,230],"ischemic":[18,36,86,231],"stroke.":[19,37,87],"Background:":[20],"Antiplatelet":[21],"has":[23,40,249,256,262,268,274,281,289,295,301],"been":[24],"conventional":[26],"treatment":[27],"for":[28,46,94,125,156,193],"management":[30],"non":[33],"disabling":[34],"However,":[38],"emerged":[41],"as":[42],"an":[43],"adequate":[44],"alternative":[45],"those":[47],"patients,":[48],"requiring":[49],"comprehensive":[50],"research":[51],"to":[52,109,145,239,251,258,264,270,276,283,291,297,303],"such":[59],"strategy.":[60],"Design/Methods:":[61],"We":[62],"performed":[63],"a":[64],"systematic":[65],"review":[66],"meta-analysis":[68,225],"comparing":[69],"(Alteplase)":[71],"(dual":[75],"(DAPT)":[78],"or":[79,98,244],"Aspirin)":[80],"PubMed,":[88],"Embase,":[89],"Cochrane":[91],"were":[92,137,143],"searched":[93],"randomized":[95,144],"controlled":[96],"trials":[97],"cohort":[99],"studies":[100,133],"propensity":[102],"scores.":[103],"A":[104,129],"random-effects":[105],"model":[106],"was":[107,123,148,185],"used":[108,124],"calculate":[110],"risk":[112],"ratios":[113],"(RRs)":[114],"95%":[116],"confidence":[117],"intervals":[118],"(CIs).":[119],"Review":[120],"Manager":[121],"5.4":[122],"statistical":[126],"analysis.":[127],"Results:":[128],"total":[130],"four":[132],"comprising":[134],"2,499":[135],"included,":[138],"whom":[140],"1,093":[141],"(44%)":[142],"IV-Thrombolysis.":[146],"There":[147],"no":[149,186],"significant":[150,187],"difference":[151,188],"between":[152,189],"DAPT":[155,243],"stroke":[157,194],"(RR":[158,169,177,195,201,209,217],"1.10;":[159],"95%CI":[160,171,179,197,203,211,219],"0.67\u20131.81;":[161],"p=0.69),":[162],"modified":[163],"Rankin":[164],"Scale":[165],"(mRS)":[166],"scores":[167,207],"0\u20131":[168,208],"1.00;":[170,210],"0.96\u20131.05;":[172],"p=0.84),":[173],"mRS":[175,206,215],"0\u20132":[176,216],"1.01;":[178,196,218],"0.98\u20131.03;":[180],"p=0.62).":[181],"In":[182,223],"addition,":[183],"there":[184],"Aspirin":[192],"0.61\u20131.69;":[198],"p=0.96),":[199],"mortality":[200],"0.50;":[202],"0.08\u20133.21;":[204],"p=0.46),":[205],"0.89\u20131.13;":[212],"p=0.95),":[213],"0.97\u20131.06;":[220],"p=0.58).":[221],"Conclusions:":[222],"this":[224],"stroke,":[232],"showed":[234],"equivalent":[238],"Aspirin.":[245],"Disclosure:":[246],"Miss":[247,266,293],"Leite":[248],"nothing":[250,257,263,269,275,282,290,296,302],"disclose.":[252,259,265,271,277,284,292,298,304],"Mr.":[253,260,272,285],"Moreira":[254],"Lopes":[255],"Pasqualotto":[261],"Souza":[267],"Sudo":[273],"Dr.":[278,299],"de":[279,287],"Moraes":[280],"Menegaz":[286],"Almeida":[288],"Siebel":[294],"Pinheiro":[300]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-04-10T00:00:00"}