{"id":"https://openalex.org/W4394580810","doi":"https://doi.org/10.1530/joe-24-0018","title":"Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice","display_name":"Urocortin 3 contributes to paracrine inhibition of islet alpha cells in mice","publication_year":2024,"publication_date":"2024-04-08","ids":{"openalex":"https://openalex.org/W4394580810","doi":"https://doi.org/10.1530/joe-24-0018","pmid":"https://pubmed.ncbi.nlm.nih.gov/38593829","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11095665"},"language":"en","primary_location":{"id":"doi:10.1530/joe-24-0018","doi":"https://doi.org/10.1530/joe-24-0018","is_oa":false,"landing_page_url":"https://doi.org/10.1530/joe-24-0018","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11095665/pdf/nihms-1988914.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022743703","display_name":"Glyn M. Noguchi","orcid":"https://orcid.org/0000-0003-1443-8313","observed_orcids":["https://orcid.org/0000-0003-1443-8313"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glyn M Noguchi","raw_affiliation_strings":["Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","G Noguchi, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"G Noguchi, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027875073","display_name":"Vincent Castillo","orcid":"https://orcid.org/0009-0001-6561-3022","observed_orcids":["https://orcid.org/0009-0001-6561-3022"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent C Castillo","raw_affiliation_strings":["Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","V Castillo, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"V Castillo, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055776264","display_name":"Cynthia J. Donaldson","orcid":"https://orcid.org/0000-0001-9731-7765","observed_orcids":["https://orcid.org/0000-0001-9731-7765"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia J Donaldson","raw_affiliation_strings":["Salk Institute for Biological Studies, La Jolla, California, USA","C Donaldson, Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies, La Jolla, California, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"C Donaldson, Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022341077","display_name":"Marcus F. Flisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus R Flisher","raw_affiliation_strings":["Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","M Flisher, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"M Flisher, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111169269","display_name":"Ariana T. Momen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariana T Momen","raw_affiliation_strings":["Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","A Momen, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"A Momen, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065981856","display_name":"Alan Saghatelian","orcid":"https://orcid.org/0000-0002-0427-563X","observed_orcids":["https://orcid.org/0000-0002-0427-563X"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Saghatelian","raw_affiliation_strings":["Salk Institute for Biological Studies, La Jolla, California, USA","A Saghatelian, Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies, La Jolla, California, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"A Saghatelian, Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, United States","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025694971","display_name":"Mark O. Huising","orcid":"https://orcid.org/0000-0002-6594-2205","observed_orcids":["https://orcid.org/0000-0002-6594-2205"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark O Huising","raw_affiliation_strings":["Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","Department of Physiology & Membrane Biology, University of California Davis, Davis, California, USA","M Huising, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States"],"raw_orcid":"https://orcid.org/0000-0002-6594-2205","affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Physiology & Behavior, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Physiology & Membrane Biology, University of California Davis, Davis, California, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"M Huising, Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, United States","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025694971"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":2.3382,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.87815871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"261","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urocortin-3","display_name":"urocortin 3","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.6809999942779541},{"id":"https://openalex.org/keywords/glucagon-secretion","display_name":"glucagon secretion","score":0.9800000190734863},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/delta-cells","display_name":"delta cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.5920000076293945},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8190000057220459},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8759999871253967},{"id":"https://openalex.org/keywords/glucose-regulation","display_name":"glucose regulation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/glucagon-inhibition","display_name":"glucagon inhibition","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7770792245864868},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7770168781280518},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.767824649810791},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.6290834546089172},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.6004224419593811},{"id":"https://openalex.org/C2777688879","wikidata":"https://www.wikidata.org/wiki/Q904550","display_name":"Urocortin","level":3,"score":0.5361255407333374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3822252154350281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3667113184928894},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2082885205745697},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10495993494987488},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050416","descriptor_name":"Glucagon-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050416","descriptor_name":"Glucagon-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054832","descriptor_name":"Urocortins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054832","descriptor_name":"Urocortins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1530/joe-24-0018","doi":"https://doi.org/10.1530/joe-24-0018","is_oa":false,"landing_page_url":"https://doi.org/10.1530/joe-24-0018","pdf_url":null,"source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:38593829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38593829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11095665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11095665","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11095665/pdf/nihms-1988914.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Endocrinol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11095665","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11095665","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11095665/pdf/nihms-1988914.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Endocrinol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1751591096","display_name":"Predoctoral Training in Pharmacological Sciences","funder_award_id":"T32GM099608","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G278597108","display_name":null,"funder_award_id":"1-19-IBS-078","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G3319984526","display_name":"University of California Davis Advancing Diversity in Aging Research Scholars Program","funder_award_id":"R25AG048787","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6225340028","display_name":null,"funder_award_id":"GM099608","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7512728213","display_name":"Functional Heterogeneity Among Pancreatic Alpha Cells","funder_award_id":"F31DK121442","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000861923","display_name":"Paracrine feedback by pancreatic delta cells to control glucagon and insulin release and manage diabetes","funder_award_id":"R01DK110276","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394580810.pdf","grobid_xml":"https://content.openalex.org/works/W4394580810.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1522924058","https://openalex.org/W1531005638","https://openalex.org/W1645430512","https://openalex.org/W1937983574","https://openalex.org/W1940160448","https://openalex.org/W1964872621","https://openalex.org/W1974522341","https://openalex.org/W1974907883","https://openalex.org/W1975032719","https://openalex.org/W1975758863","https://openalex.org/W1993610894","https://openalex.org/W1994867775","https://openalex.org/W2009127988","https://openalex.org/W2009248375","https://openalex.org/W2021920528","https://openalex.org/W2022138356","https://openalex.org/W2024212687","https://openalex.org/W2028710649","https://openalex.org/W2029559333","https://openalex.org/W2035095846","https://openalex.org/W2039299006","https://openalex.org/W2041346929","https://openalex.org/W2048903649","https://openalex.org/W2049927057","https://openalex.org/W2050019582","https://openalex.org/W2059665153","https://openalex.org/W2060932265","https://openalex.org/W2071475027","https://openalex.org/W2071824475","https://openalex.org/W2074446107","https://openalex.org/W2080837614","https://openalex.org/W2092700428","https://openalex.org/W2092834109","https://openalex.org/W2093664117","https://openalex.org/W2096595413","https://openalex.org/W2101814428","https://openalex.org/W2106657141","https://openalex.org/W2115337061","https://openalex.org/W2117848154","https://openalex.org/W2123668936","https://openalex.org/W2128215672","https://openalex.org/W2130103830","https://openalex.org/W2140488024","https://openalex.org/W2146680239","https://openalex.org/W2150567837","https://openalex.org/W2155334088","https://openalex.org/W2159937109","https://openalex.org/W2161741963","https://openalex.org/W2163595098","https://openalex.org/W2166243077","https://openalex.org/W2169062460","https://openalex.org/W2346764160","https://openalex.org/W2398350456","https://openalex.org/W2573896876","https://openalex.org/W2604852286","https://openalex.org/W2757711168","https://openalex.org/W2782114413","https://openalex.org/W2793685756","https://openalex.org/W2796065088","https://openalex.org/W2886098455","https://openalex.org/W2888657962","https://openalex.org/W2897308233","https://openalex.org/W2899339394","https://openalex.org/W2914141586","https://openalex.org/W2940492200","https://openalex.org/W2963266978","https://openalex.org/W2965253526","https://openalex.org/W2972217240","https://openalex.org/W2994879170","https://openalex.org/W3016802199","https://openalex.org/W3024746822","https://openalex.org/W3088879474","https://openalex.org/W4221069978","https://openalex.org/W4236238881","https://openalex.org/W4241398143","https://openalex.org/W4250120438","https://openalex.org/W4251346171","https://openalex.org/W4307840103","https://openalex.org/W4319308334","https://openalex.org/W4390706998"],"related_works":["https://openalex.org/W1940160448","https://openalex.org/W4389034297","https://openalex.org/W4205366654","https://openalex.org/W2074446107","https://openalex.org/W4394785612","https://openalex.org/W2009127988","https://openalex.org/W4416297609","https://openalex.org/W2109635522","https://openalex.org/W4221069978","https://openalex.org/W7165363374"],"abstract_inverted_index":{"Pancreatic":[0],"alpha":[1,46,95,143,156,163,178,220,232],"cell":[2,157,164,179],"activity":[3,206],"and":[4,28,66,97,131,166,169],"glucagon":[5,98,108,138,171,192,208,245,255],"secretion":[6,72,80,99,139,209],"lower":[7],"as":[8,134,136],"glucose":[9,20,112],"levels":[10,168,246],"increase.":[11],"While":[12],"part":[13,116],"of":[14,45,127,153,200,217,227,251],"the":[15,106,151,224,248],"decrease":[16],"is":[17,40,55,59,100,113,214],"regulated":[18,114],"by":[19,24,117,181],"itself,":[21],"paracrine":[22,244],"signaling":[23,176,230],"their":[25],"neighboring":[26],"beta":[27,62,120],"delta":[29,38,74,87],"cells":[30,39,47,63,96,144],"also":[31],"plays":[32],"an":[33,41],"important":[34,42],"role.":[35],"Somatostatin":[36],"from":[37,61,73,119,142],"local":[43,243],"inhibitor":[44],"at":[48,110,194],"high":[49,111,195],"glucose.":[50,196],"Additionally,":[51],"urocortin":[52],"3":[53],"(UCN3)":[54],"a":[56,82,125],"hormone":[57],"that":[58,105,236],"co-released":[60],"with":[64,86,92],"insulin":[65,79],"acts":[67],"locally":[68],"to":[69,94,149,155,211,241],"potentiate":[70],"somatostatin":[71,238],"cells.":[75,121],"UCN3":[76,118,154,160,175,213,229],"thus":[77,215],"inhibits":[78],"via":[81],"negative":[83],"feedback":[84],"loop":[85],"cells,":[88,221,233],"but":[89,185],"its":[90],"role":[91],"respect":[93],"not":[101,188,203],"understood.":[102],"We":[103],"hypothesize":[104],"somatostatin-driven":[107],"inhibition":[109],"in":[115,145,190,247],"Here,":[122],"we":[123,234],"use":[124],"combination":[126],"live":[128],"functional":[129],"Ca2+":[130,165,180,205],"cAMP":[132,167],"imaging":[133],"well":[135],"direct":[137],"measurement,":[140],"all":[141],"intact":[146],"mouse":[147,219],"islets,":[148],"determine":[150],"contributions":[152],"behavior.":[158],"Exogenous":[159],"treatment":[161],"decreased":[162],"inhibited":[170],"release.":[172,256],"Blocking":[173],"endogenous":[174,228],"increased":[177,191],"26.8":[182],"\u00b1":[183],"7.6%,":[184],"this":[186],"did":[187,202],"result":[189],"release":[193],"Furthermore,":[197],"constitutive":[198],"deletion":[199],"Ucn3":[201],"increase":[204],"or":[207],"relative":[210],"controls.":[212],"capable":[216],"inhibiting":[218,252],"but,":[222],"given":[223],"subtle":[225],"effects":[226],"on":[231],"propose":[235],"UCN3-driven":[237],"may":[239],"serve":[240],"regulate":[242],"islet":[249],"instead":[250],"gross":[253],"systemic":[254]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-04-09T00:00:00"}