{"id":"https://openalex.org/W4394580259","doi":"https://doi.org/10.1186/s40635-024-00617-8","title":"Isoflurane, like sepsis, decreases CYP1A2 liver enzyme activity in intensive care patients: a clinical study and network model","display_name":"Isoflurane, like sepsis, decreases CYP1A2 liver enzyme activity in intensive care patients: a clinical study and network model","publication_year":2024,"publication_date":"2024-04-08","ids":{"openalex":"https://openalex.org/W4394580259","doi":"https://doi.org/10.1186/s40635-024-00617-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/38589754","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11001842"},"language":"en","primary_location":{"id":"doi:10.1186/s40635-024-00617-8","doi":"https://doi.org/10.1186/s40635-024-00617-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s40635-024-00617-8","pdf_url":"https://icm-experimental.springeropen.com/counter/pdf/10.1186/s40635-024-00617-8","source":{"id":"https://openalex.org/S2737761232","display_name":"Intensive Care Medicine Experimental","issn_l":"2197-425X","issn":["2197-425X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Medicine Experimental","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://icm-experimental.springeropen.com/counter/pdf/10.1186/s40635-024-00617-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004207218","display_name":"Thomas K\u00f6hler","orcid":"https://orcid.org/0000-0003-0399-8382","observed_orcids":["https://orcid.org/0000-0003-0399-8382"]},"institutions":[{"id":"https://openalex.org/I4210131975","display_name":"Herford Hospital","ror":"https://ror.org/03p371b74","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210131975"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas K\u00f6hler","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care Medicine, AMEOS-Klinikum Halberstadt, Academic Teaching Hospital, Gleimstra\u00dfe 5, 38820, Halberstadt, Germany. Thomas.koehler@ruhr-uni-bochum.de","Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany. Thomas.koehler@ruhr-uni-bochum.de","Department of Anesthesiology and Intensive Care Medicine, AMEOS-Klinikum Halberstadt, Academic Teaching Hospital, Gleimstra\u00dfe 5, 38820, Halberstadt, Germany","Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0399-8382","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care Medicine, AMEOS-Klinikum Halberstadt, Academic Teaching Hospital, Gleimstra\u00dfe 5, 38820, Halberstadt, Germany. Thomas.koehler@ruhr-uni-bochum.de","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany. Thomas.koehler@ruhr-uni-bochum.de","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]},{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care Medicine, AMEOS-Klinikum Halberstadt, Academic Teaching Hospital, Gleimstra\u00dfe 5, 38820, Halberstadt, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048932145","display_name":"Elke Schwier","orcid":"https://orcid.org/0000-0002-9279-2986","observed_orcids":["https://orcid.org/0000-0002-9279-2986"]},"institutions":[{"id":"https://openalex.org/I4210131975","display_name":"Herford Hospital","ror":"https://ror.org/03p371b74","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210131975"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elke Schwier","raw_affiliation_strings":["Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9279-2986","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023930902","display_name":"Janina Praxenthaler","orcid":"https://orcid.org/0000-0002-8266-1800","observed_orcids":["https://orcid.org/0000-0002-8266-1800"]},"institutions":[{"id":"https://openalex.org/I4210131975","display_name":"Herford Hospital","ror":"https://ror.org/03p371b74","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210131975"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janina Praxenthaler","raw_affiliation_strings":["Department of Anesthesiology, Intensive Care and Pain Medicine, Southeast Bavaria Hospitals, Klinikum Traunstein, Traunstein, Germany","Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8266-1800","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Intensive Care and Pain Medicine, Southeast Bavaria Hospitals, Klinikum Traunstein, Traunstein, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081988681","display_name":"Carmen Kirchner","orcid":"https://orcid.org/0000-0003-2356-2877","observed_orcids":["https://orcid.org/0000-0003-2356-2877"]},"institutions":[{"id":"https://openalex.org/I4210131975","display_name":"Herford Hospital","ror":"https://ror.org/03p371b74","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210131975"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carmen Kirchner","raw_affiliation_strings":["Department of General and Visceral Surgery, Thoracic Surgery and Proctology, Ruhr University Bochum, Klinikum Herford, Herford, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2356-2877","affiliations":[{"raw_affiliation_string":"Department of General and Visceral Surgery, Thoracic Surgery and Proctology, Ruhr University Bochum, Klinikum Herford, Herford, Germany","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064774851","display_name":"G\u00fcnther Winde","orcid":"https://orcid.org/0000-0001-9131-5275","observed_orcids":["https://orcid.org/0000-0001-9131-5275"]},"institutions":[{"id":"https://openalex.org/I4210131975","display_name":"Herford Hospital","ror":"https://ror.org/03p371b74","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210131975"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnther Winde","raw_affiliation_strings":["Department of General and Visceral Surgery, Thoracic Surgery and Proctology, Ruhr University Bochum, Klinikum Herford, Herford, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9131-5275","affiliations":[{"raw_affiliation_string":"Department of General and Visceral Surgery, Thoracic Surgery and Proctology, Ruhr University Bochum, Klinikum Herford, Herford, Germany","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051184588","display_name":"Bj\u00f6rn Koos","orcid":"https://orcid.org/0000-0002-0544-4124","observed_orcids":["https://orcid.org/0000-0002-0544-4124"]},"institutions":[{"id":"https://openalex.org/I4210112654","display_name":"Universit\u00e4tsklinikum Knappschaftskrankenhaus Bochum","ror":"https://ror.org/024j3hn90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210112654"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Koos","raw_affiliation_strings":["Department of Anesthesiology, Intensive Care and Pain Medicine, Ruhr University Bochum, Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0544-4124","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Intensive Care and Pain Medicine, Ruhr University Bochum, Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany","institution_ids":["https://openalex.org/I4210112654","https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010120244","display_name":"Dietrich Henzler","orcid":"https://orcid.org/0000-0001-5511-6885","observed_orcids":["https://orcid.org/0000-0001-5511-6885"]},"institutions":[{"id":"https://openalex.org/I4210131975","display_name":"Herford Hospital","ror":"https://ror.org/03p371b74","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210131975"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietrich Henzler","raw_affiliation_strings":["Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5511-6885","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, Klinikum Herford, Herford, Germany","institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004207218"],"corresponding_institution_ids":["https://openalex.org/I4210131975","https://openalex.org/I904495901"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.22120000422000885,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/liver-function","display_name":"liver function","score":0.652999997138977},{"id":"https://openalex.org/keywords/limax-test","display_name":"LiMAx test","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.847000002861023},{"id":"https://openalex.org/keywords/lactate-accumulation","display_name":"lactate accumulation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/anaerobic-metabolism","display_name":"anaerobic metabolism","score":0.8550000190734863},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.7319999933242798},{"id":"https://openalex.org/keywords/network-models","display_name":"network models","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9569318890571594},{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.6973398923873901},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6355328559875488},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.5558270215988159},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5242472290992737},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.5077922940254211},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.47180429100990295},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4032739996910095},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3917790353298187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33268165588378906},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.17811739444732666},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.10943475365638733}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/s40635-024-00617-8","doi":"https://doi.org/10.1186/s40635-024-00617-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s40635-024-00617-8","pdf_url":"https://icm-experimental.springeropen.com/counter/pdf/10.1186/s40635-024-00617-8","source":{"id":"https://openalex.org/S2737761232","display_name":"Intensive Care Medicine Experimental","issn_l":"2197-425X","issn":["2197-425X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Medicine Experimental","raw_type":"journal-article"},{"id":"pmid:38589754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38589754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive care medicine experimental","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11001842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11001842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Med Exp","raw_type":"Text"},{"id":"pmh:oai:frl.publisso.de:frl:6497556","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11001842","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11001842/pdf/40635_2024_Article_617.pdf","source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Intensive care medicine experimental, 12(1):33","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:hss-opus.ub.ruhr-uni-bochum.de:11352","doi":null,"is_oa":true,"landing_page_url":"https://hss-opus.ub.ruhr-uni-bochum.de/opus4/frontdoor/index/index/docId/11352","pdf_url":"https://hss-opus.ub.ruhr-uni-bochum.de/opus4/files/11352/KoehlerThomas08042024.pdf","source":{"id":"https://openalex.org/S4306400167","display_name":"Dokumentenrepositorium der RUB (Ruhr University Bochum)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I904495901","host_organization_name":"Ruhr University Bochum","host_organization_lineage":["https://openalex.org/I904495901"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:698231156bee42bdb7c39f52720930b7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/698231156bee42bdb7c39f52720930b7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-10 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40635-024-00617-8","doi":"https://doi.org/10.1186/s40635-024-00617-8","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/s40635-024-00617-8","pdf_url":"https://icm-experimental.springeropen.com/counter/pdf/10.1186/s40635-024-00617-8","source":{"id":"https://openalex.org/S2737761232","display_name":"Intensive Care Medicine Experimental","issn_l":"2197-425X","issn":["2197-425X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intensive Care Medicine Experimental","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323715","display_name":"Ruhr-Universit\u00e4t Bochum","ror":"https://ror.org/04tsk2644"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394580259.pdf","grobid_xml":"https://content.openalex.org/works/W4394580259.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1999670883","https://openalex.org/W2005916128","https://openalex.org/W2006270515","https://openalex.org/W2011810742","https://openalex.org/W2035062238","https://openalex.org/W2060646721","https://openalex.org/W2064867029","https://openalex.org/W2071895328","https://openalex.org/W2085110060","https://openalex.org/W2085382266","https://openalex.org/W2087167331","https://openalex.org/W2090819282","https://openalex.org/W2106507081","https://openalex.org/W2116810060","https://openalex.org/W2119363042","https://openalex.org/W2124714191","https://openalex.org/W2132604934","https://openalex.org/W2146217294","https://openalex.org/W2160527903","https://openalex.org/W2165902578","https://openalex.org/W2275737843","https://openalex.org/W2280404143","https://openalex.org/W2319820892","https://openalex.org/W2468925656","https://openalex.org/W2511206446","https://openalex.org/W2618508049","https://openalex.org/W2738798965","https://openalex.org/W2750637538","https://openalex.org/W2751737102","https://openalex.org/W2793069357","https://openalex.org/W2809640354","https://openalex.org/W2952902264","https://openalex.org/W2997253419","https://openalex.org/W3195497415","https://openalex.org/W3202635655","https://openalex.org/W3204327015","https://openalex.org/W4229500531","https://openalex.org/W4248059810","https://openalex.org/W4296467164"],"related_works":["https://openalex.org/W6982671554","https://openalex.org/W6902243909","https://openalex.org/W4253722967","https://openalex.org/W7023826286","https://openalex.org/W3118005241","https://openalex.org/W1984806746","https://openalex.org/W4253092551","https://openalex.org/W4296283690","https://openalex.org/W4403984981","https://openalex.org/W2417880249"],"abstract_inverted_index":{"PURPOSE:":[0],"Liver":[1],"function":[2,30,206],"of":[3,36,57,110,162,171,178,196,203],"intensive":[4,87],"care":[5,88],"patients":[6],"is":[7],"routinely":[8],"monitored":[9],"by":[10,24,169,210],"static":[11],"blood":[12],"pathology.":[13],"For":[14],"specific":[15,18],"indications,":[16],"liver":[17,29,62,85,205],"cytochrome":[19,38],"activity":[20],"may":[21,189],"be":[22,92,215],"measured":[23,209],"the":[25,37,47,55,115,146,157,160,172,176,181,185,200],"commercially":[26],"available":[27],"maximum":[28],"capacity":[31],"(LiMAx)":[32],"test":[33,59,73],"via":[34,180],"quantification":[35],"P450":[39],"1A2":[40],"(CYP1A2)":[41],"dependent":[42],"C-methacetin":[43],"metabolism.":[44],"Sedation":[45],"with":[46,60,207],"volatile":[48],"anesthetic":[49],"isoflurane":[50,67,97,111,130,138,163,197],"was":[51,103,152],"suspected":[52],"to":[53,91,96,214],"abrogate":[54],"correlation":[56,202],"LiMAx":[58,72,101,211],"global":[61,204],"function.":[63],"We":[64],"hypothesized":[65],"that":[66,154],"has":[68],"a":[69],"CYP1A2-activity":[70,179,208],"and":[71,107,137,175],"result":[74,190],"decreasing":[75],"effect.":[76],"METHODS:":[77],"In":[78],"this":[79],"monocentric,":[80],"observational":[81],"clinical":[82,133],"study":[83],"previously":[84],"healthy":[86],"patients,":[89],"scheduled":[90],"changed":[93],"from":[94],"propofol":[95],"sedation,":[98],"were":[99],"enrolled.":[100],"testing":[102,212],"done":[104],"before,":[105],"during":[106,129],"after":[108],"termination":[109],"sedation.":[112],"RESULTS:":[113],"in":[114,191,217],"non-septic":[116],"group":[117],"while":[118],"laboratory":[119],"markers":[120],"did":[121],"not":[122],"imply":[123],"significant":[124],"hepatic":[125,147],"impairment.":[126],"Lactate":[127],"increased":[128,186],"inhalation":[131],"without":[132],"consequence.":[134],"CONCLUSION:":[135],"Sepsis":[136],"have":[139],"independently":[140],"demonstrated":[141],"an":[142],"effect":[143],"on":[144,164,199],"reducing":[145],"CYP1A2-activity.":[148],"A":[149],"network":[150],"model":[151],"constructed":[153],"could":[155],"explain":[156],"mechanism":[158],"through":[159],"influence":[161,195],"hypoxia":[165],"inducible":[166],"factor":[167],"(HIF-1\u03b1)":[168],"upregulation":[170],"hypoxia-inducible":[173],"pathway":[174],"downregulation":[177],"ligand-inducible":[182],"pathway.":[183],"Thus,":[184],"anaerobic":[187],"metabolism":[188],"lactate":[192],"accumulation.":[193],"The":[194],"sedation":[198],"validated":[201],"needs":[213],"investigated":[216],"more":[218],"detail.":[219]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-09T00:00:00"}