{"id":"https://openalex.org/W4394577494","doi":"https://doi.org/10.1002/cai2.113","title":"Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma","display_name":"Improvement of histone deacetylase inhibitor efficacy by SN38 through TWIST1 suppression in synovial sarcoma","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4394577494","doi":"https://doi.org/10.1002/cai2.113","pmid":"https://pubmed.ncbi.nlm.nih.gov/38946933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212284"},"language":"en","primary_location":{"id":"doi:10.1002/cai2.113","doi":"https://doi.org/10.1002/cai2.113","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cai2.113","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cai2.113","source":{"id":"https://openalex.org/S4387280922","display_name":"Cancer Innovation","issn_l":"2770-9183","issn":["2770-9183","2770-9191"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Innovation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cai2.113","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010146375","display_name":"Satoru Sasagawa","orcid":"https://orcid.org/0000-0001-5769-8700","observed_orcids":["https://orcid.org/0000-0001-5769-8700"]},"institutions":[{"id":"https://openalex.org/I4403928251","display_name":"Nozaki Tokushukai Hospital","ror":"https://ror.org/039pzq605","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4403928251"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoru Sasagawa","raw_affiliation_strings":["Molecular Biology Laboratory, Research Institute Nozaki Tokushukai Hospital Daito Osaka Japan"],"raw_orcid":"https://orcid.org/0000-0001-5769-8700","affiliations":[{"raw_affiliation_string":"Molecular Biology Laboratory, Research Institute Nozaki Tokushukai Hospital Daito Osaka Japan","institution_ids":["https://openalex.org/I4403928251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058919860","display_name":"Jun Kumai","orcid":"https://orcid.org/0009-0006-3040-4964","observed_orcids":["https://orcid.org/0009-0006-3040-4964"]},"institutions":[{"id":"https://openalex.org/I4403928251","display_name":"Nozaki Tokushukai Hospital","ror":"https://ror.org/039pzq605","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4403928251"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Kumai","raw_affiliation_strings":["Sarcoma Treatment Laboratory, Research Institute Nozaki Tokushukai Hospital Daito Osaka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Treatment Laboratory, Research Institute Nozaki Tokushukai Hospital Daito Osaka Japan","institution_ids":["https://openalex.org/I4403928251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021565293","display_name":"Toru Wakamatsu","orcid":"https://orcid.org/0000-0002-3073-0595","observed_orcids":["https://orcid.org/0000-0002-3073-0595"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Wakamatsu","raw_affiliation_strings":["Department of Musculoskeletal Oncology Service Osaka International Cancer Institute Osaka Japan"],"raw_orcid":"https://orcid.org/0000-0002-3073-0595","affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Oncology Service Osaka International Cancer Institute Osaka Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081960754","display_name":"Yoshihiro Yui","orcid":"https://orcid.org/0000-0002-5806-7801","observed_orcids":["https://orcid.org/0000-0002-5806-7801"]},"institutions":[{"id":"https://openalex.org/I4403928251","display_name":"Nozaki Tokushukai Hospital","ror":"https://ror.org/039pzq605","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4403928251"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiro Yui","raw_affiliation_strings":["Sarcoma Treatment Laboratory, Research Institute Nozaki Tokushukai Hospital Daito Osaka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Treatment Laboratory, Research Institute Nozaki Tokushukai Hospital Daito Osaka Japan","institution_ids":["https://openalex.org/I4403928251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010146375"],"corresponding_institution_ids":["https://openalex.org/I4403928251"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":{"value":0,"currency":"USD","value_usd":0},"fwci":0.6672,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59916993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"3","issue":"2","first_page":"e113","last_page":"e113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.9660000205039978},{"id":"https://openalex.org/keywords/twist1","display_name":"TWIST1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/spheroid-culture","display_name":"spheroid culture","score":0.8149999976158142},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8339999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cytostasis","display_name":"cytostasis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hdac1-2","display_name":"HDAC1/2","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2776910622","wikidata":"https://www.wikidata.org/wiki/Q2619315","display_name":"Synovial sarcoma","level":3,"score":0.8767192363739014},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.5956175327301025},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5060402750968933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4809219539165497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3873331546783447},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35769811272621155},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.33722826838493347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25980696082115173},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.21471041440963745},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09939408302307129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07254168391227722},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.04806548357009888}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/cai2.113","doi":"https://doi.org/10.1002/cai2.113","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cai2.113","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cai2.113","source":{"id":"https://openalex.org/S4387280922","display_name":"Cancer Innovation","issn_l":"2770-9183","issn":["2770-9183","2770-9191"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Innovation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11212284","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11212284","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11212284/pdf/CAI2-3-e113.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Innov","raw_type":"Text"},{"id":"pmid:38946933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38946933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer innovation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/cai2.113","doi":"https://doi.org/10.1002/cai2.113","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cai2.113","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cai2.113","source":{"id":"https://openalex.org/S4387280922","display_name":"Cancer Innovation","issn_l":"2770-9183","issn":["2770-9183","2770-9191"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","oarl"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Innovation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G694648919","display_name":"\u8089\u816b\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3092\u7528\u3044\u305f\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a","funder_award_id":"23K08600","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394577494.pdf","grobid_xml":"https://content.openalex.org/works/W4394577494.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1837554294","https://openalex.org/W1950937581","https://openalex.org/W1972805469","https://openalex.org/W1977076046","https://openalex.org/W2014622924","https://openalex.org/W2015182899","https://openalex.org/W2025847887","https://openalex.org/W2031248889","https://openalex.org/W2038195711","https://openalex.org/W2043079400","https://openalex.org/W2053638053","https://openalex.org/W2055924065","https://openalex.org/W2071376409","https://openalex.org/W2104557203","https://openalex.org/W2105017561","https://openalex.org/W2114033240","https://openalex.org/W2115235864","https://openalex.org/W2128803166","https://openalex.org/W2136445803","https://openalex.org/W2139607151","https://openalex.org/W2145234793","https://openalex.org/W2163261207","https://openalex.org/W2167920040","https://openalex.org/W2178296763","https://openalex.org/W2179882437","https://openalex.org/W2265419075","https://openalex.org/W2340739985","https://openalex.org/W2414279676","https://openalex.org/W2567908969","https://openalex.org/W2570959155","https://openalex.org/W2572094334","https://openalex.org/W2750663163","https://openalex.org/W2753735822","https://openalex.org/W2769426045","https://openalex.org/W2773879876","https://openalex.org/W2779263916","https://openalex.org/W2790555439","https://openalex.org/W2792052222","https://openalex.org/W2792431492","https://openalex.org/W2795208162","https://openalex.org/W2806892701","https://openalex.org/W2897372172","https://openalex.org/W2951980827","https://openalex.org/W2992625814","https://openalex.org/W3002151685","https://openalex.org/W3024306113","https://openalex.org/W3081056548","https://openalex.org/W3131221939","https://openalex.org/W3161211885","https://openalex.org/W3184322793","https://openalex.org/W4213197580","https://openalex.org/W4220861703","https://openalex.org/W4229638581","https://openalex.org/W4281289115","https://openalex.org/W4289536480","https://openalex.org/W4367320800","https://openalex.org/W4378190878"],"related_works":["https://openalex.org/W2753735822","https://openalex.org/W33127010","https://openalex.org/W2749537689","https://openalex.org/W2278797968","https://openalex.org/W2132090254","https://openalex.org/W3215754378","https://openalex.org/W1940951496","https://openalex.org/W2725587484","https://openalex.org/W2746334444","https://openalex.org/W1972805469"],"abstract_inverted_index":{"Background:":[0],"fusion":[1],"gene-driven":[2],"soft":[3],"tissue":[4],"sarcoma":[5],"with":[6,10,89,109,123,172,195,259,292],"mesenchymal":[7],"characteristics,":[8],"associated":[9],"a":[11,19,217],"poor":[12],"prognosis":[13],"due":[14,69],"to":[15,18,51,70,84,140,147,157,298],"frequent":[16],"metastasis":[17],"distant":[20],"organ,":[21],"such":[22],"as":[23,33,38,119],"the":[24,42,61,75,142,148,159,169,190,230,262,269],"lung.":[25],"Histone":[26],"deacetylase":[27],"(HDAC)":[28],"inhibitors":[29],"(HDACis)":[30],"are":[31],"arising":[32],"potent":[34],"molecular":[35,58,287],"targeted":[36],"drugs,":[37],"HDACi":[39,53,64,85,275,299],"treatment":[40,65,86,257,278,291],"disrupts":[41],"SS":[43,78,99,177,227,277],"oncoprotein":[44],"complex,":[45],"which":[46],"includes":[47],"HDACs,":[48],"in":[49,77,87,176,185,226,239,251,279],"addition":[50,146],"general":[52],"effects.":[54],"To":[55],"provide":[56],"further":[57],"evidence":[59,288],"for":[60,276],"advantages":[62],"of":[63,161,220,273],"and":[66,92,103,129,205,210,254,271,281,285],"its":[67],"limitations":[68],"drug":[71,122,143,296],"resistance":[72,297],"induced":[73],"by":[74,300],"microenvironment":[76,163],"cells,":[79,178,193,203],"we":[80,179,222],"examined":[81],"cellular":[82,170],"responses":[83],"combination":[88],"two-dimensional":[90],"(2D)":[91],"3D":[93,282],"culture":[94,151,154,283],"conditions.":[95],"Methods:":[96],"Using":[97],"several":[98],"cell":[100,104,187,198],"lines,":[101],"biochemical":[102],"biological":[105],"assays":[106],"were":[107,138,208],"performed":[108],"romidepsin,":[110],"an":[111,120],"HDAC1/2":[112],"selective":[113],"inhibitor.":[114],"SN38":[115,175,196,211,256,293],"was":[116,155,236],"concomitantly":[117],"used":[118],"ameliorant":[121],"romidepsin":[124,173,234,248,260],"treatment.":[125],"Cytostasis,":[126],"apoptosis":[127],"induction,":[128],"MHC":[130],"class":[131],"I":[132],"polypeptide-related":[133],"sequence":[134],"A/B":[135],"(MICA/B)":[136],"induction":[137,207,214],"monitored":[139],"evaluate":[141,158],"efficacy.":[144],"In":[145,189,200,229],"conventional":[149],"2D":[150,280],"condition,":[152,233],"spheroid":[153,231,252],"adopted":[156],"influence":[160],"cell-mass":[162],"on":[164],"chemoresistance.":[165],"Results:":[166],"By":[167],"monitoring":[168],"behavior":[171],"and/or":[174],"observed":[180],"that":[181,244,289],"responsiveness":[182],"is":[183],"diverse":[184],"each":[186],"line.":[188],"apoptotic":[191],"inducible":[192,202],"co-treatment":[194],"enhanced":[197],"death.":[199],"nonapoptotic":[201],"cytostasis":[204],"MICA/B":[206,213],"observed,":[209],"improved":[212],"further.":[215],"As":[216],"novel":[218],"efficacy":[219,235,249],"SN38,":[221],"revealed":[223],"TWIST1":[224,245,302],"suppression":[225],"cells.":[228,241],"(3D)":[232],"severely":[237],"restricted":[238],"TWIST1-positive":[240],"We":[242],"demonstrated":[243,268],"downregulation":[246],"restored":[247],"even":[250],"form,":[253],"concomitant":[255,290],"along":[258],"reproduced":[261],"reaction.":[263],"Conclusions:":[264],"The":[265],"current":[266],"study":[267],"benefits":[270],"concerns":[272],"using":[274],"conditions":[284],"provided":[286],"can":[294],"overcome":[295],"suppressing":[301],"expression.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-04-09T00:00:00"}