{"id":"https://openalex.org/W4394565893","doi":"https://doi.org/10.3390/biomedicines12040814","title":"Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Unraveling the Molecular Nexus","display_name":"Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: Unraveling the Molecular Nexus","publication_year":2024,"publication_date":"2024-04-07","ids":{"openalex":"https://openalex.org/W4394565893","doi":"https://doi.org/10.3390/biomedicines12040814","pmid":"https://pubmed.ncbi.nlm.nih.gov/38672169","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11048013"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines12040814","doi":"https://doi.org/10.3390/biomedicines12040814","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12040814","pdf_url":"https://www.mdpi.com/2227-9059/12/4/814/pdf?version=1712546338","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/12/4/814/pdf?version=1712546338","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004987987","display_name":"Chin-Ling Li","orcid":"https://orcid.org/0000-0003-3957-4522","observed_orcids":["https://orcid.org/0000-0003-3957-4522"]},"institutions":[{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chin-Ling Li","raw_affiliation_strings":["Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-3957-4522","affiliations":[{"raw_affiliation_string":"Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104036045","display_name":"Jui-Fang Liu","orcid":"https://orcid.org/0000-0002-1709-562X","observed_orcids":["https://orcid.org/0000-0002-1709-562X"]},"institutions":[{"id":"https://openalex.org/I141243467","display_name":"Chang Gung University of Science and Technology","ror":"https://ror.org/009knm296","country_code":"TW","type":"education","lineage":["https://openalex.org/I141243467"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Fang Liu","raw_affiliation_strings":["Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I141243467"]},{"raw_affiliation_string":"Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I141243467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028997500","display_name":"Shih\u2010Feng Liu","orcid":"https://orcid.org/0000-0003-1394-5401","observed_orcids":["https://orcid.org/0000-0003-1394-5401"]},"institutions":[{"id":"https://openalex.org/I141243467","display_name":"Chang Gung University of Science and Technology","ror":"https://ror.org/009knm296","country_code":"TW","type":"education","lineage":["https://openalex.org/I141243467"]},{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I4210093821","display_name":"Kaohsiung Chang Gung Memorial Hospital","ror":"https://ror.org/00k194y12","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210093821"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Feng Liu","raw_affiliation_strings":["Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","College of Medicine, Chang Gung University, Taoyuan 333, Taiwan","Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-1394-5401","affiliations":[{"raw_affiliation_string":"Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I141243467"]},{"raw_affiliation_string":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I141243467"]},{"raw_affiliation_string":"Department of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan","institution_ids":["https://openalex.org/I4210093821"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan","institution_ids":["https://openalex.org/I4210093821"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028997500"],"corresponding_institution_ids":["https://openalex.org/I141243467","https://openalex.org/I173093425","https://openalex.org/I4210093821"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2955},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2955},"fwci":3.1775,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.94524875,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"4","first_page":"814","last_page":"814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.4377000033855438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-haplogroups","display_name":"mtDNA haplogroups","score":0.9760000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5720000267028809},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":1.0},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mitochondria-targeted-compounds","display_name":"mitochondria-targeted compounds","score":0.9430000185966492},{"id":"https://openalex.org/keywords/copd-biomarkers","display_name":"COPD biomarkers","score":0.7839999794960022},{"id":"https://openalex.org/keywords/copd-susceptibility","display_name":"COPD susceptibility","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7417861819267273},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5557547807693481},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5185045003890991},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5180125832557678},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.49516478180885315},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.46795451641082764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45855826139450073},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45219334959983826},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4125918745994568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40350857377052307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2873128056526184},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2540057301521301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10968285799026489},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10455584526062012},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10410651564598083},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07243633270263672},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines12040814","doi":"https://doi.org/10.3390/biomedicines12040814","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12040814","pdf_url":"https://www.mdpi.com/2227-9059/12/4/814/pdf?version=1712546338","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11048013","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11048013","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11048013/pdf/biomedicines-12-00814.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:38672169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38672169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d297ce57da8f4f7da749a90aeda7d9e2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d297ce57da8f4f7da749a90aeda7d9e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 12, Iss 4, p 814 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines12040814","doi":"https://doi.org/10.3390/biomedicines12040814","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines12040814","pdf_url":"https://www.mdpi.com/2227-9059/12/4/814/pdf?version=1712546338","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4394565893.pdf","grobid_xml":"https://content.openalex.org/works/W4394565893.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1618134065","https://openalex.org/W1870141733","https://openalex.org/W1965198452","https://openalex.org/W1974567021","https://openalex.org/W1987943522","https://openalex.org/W2005574929","https://openalex.org/W2048023193","https://openalex.org/W2068167055","https://openalex.org/W2088240660","https://openalex.org/W2103456503","https://openalex.org/W2117696416","https://openalex.org/W2144477621","https://openalex.org/W2169986172","https://openalex.org/W2266967207","https://openalex.org/W2291366038","https://openalex.org/W2495450286","https://openalex.org/W2531910994","https://openalex.org/W2562156071","https://openalex.org/W2596449235","https://openalex.org/W2624659765","https://openalex.org/W2763650258","https://openalex.org/W2789704350","https://openalex.org/W2797015910","https://openalex.org/W2853559064","https://openalex.org/W2902994754","https://openalex.org/W2918380837","https://openalex.org/W2954246968","https://openalex.org/W2966165985","https://openalex.org/W2987073289","https://openalex.org/W3001036720","https://openalex.org/W3016777912","https://openalex.org/W3092447922","https://openalex.org/W3136410521","https://openalex.org/W3166218898","https://openalex.org/W3169906287","https://openalex.org/W3173948537","https://openalex.org/W3174899900","https://openalex.org/W3184332270","https://openalex.org/W3193018238","https://openalex.org/W4206216556","https://openalex.org/W4223541162","https://openalex.org/W4285095673","https://openalex.org/W4293733734","https://openalex.org/W4296444271","https://openalex.org/W4310212272","https://openalex.org/W4312785020","https://openalex.org/W4317380950","https://openalex.org/W4318912441","https://openalex.org/W4322719510","https://openalex.org/W4366692203","https://openalex.org/W4384825337","https://openalex.org/W4386028910","https://openalex.org/W4388033295","https://openalex.org/W4391046241"],"related_works":["https://openalex.org/W4400677452","https://openalex.org/W4415085575","https://openalex.org/W4406041623","https://openalex.org/W4318924926","https://openalex.org/W3136410521","https://openalex.org/W4416265829","https://openalex.org/W4286828304","https://openalex.org/W7167479692","https://openalex.org/W3209123151","https://openalex.org/W2136598956"],"abstract_inverted_index":{"Chronic":[0],"obstructive":[1],"pulmonary":[2],"disease":[3],"(COPD)":[4],"is":[5,75],"a":[6,34,70,78,202,209],"prevalent":[7],"and":[8,17,50,64,107,133,138,145,170,191,213,221,229],"debilitating":[9],"respiratory":[10],"disorder":[11],"characterized":[12],"by":[13,156],"persistent":[14],"airflow":[15],"limitation":[16],"chronic":[18],"inflammation.":[19],"In":[20],"recent":[21],"years,":[22],"the":[23,44,54,84,98,110,122,126,153,176,215],"role":[24,127],"of":[25,37,57,72,87,101,128,178,205],"mitochondrial":[26,48,62,73,102,129,158,219],"dysfunction":[27,49,159,220],"in":[28,115,135,175],"COPD":[29,91,116,136,161,197],"pathogenesis":[30],"has":[31],"emerged":[32],"as":[33,77],"focal":[35],"point":[36],"investigation.":[38],"This":[39,118,199],"review":[40,119],"endeavors":[41],"to":[42,90,109,195],"unravel":[43],"molecular":[45,216],"nexus":[46,217],"between":[47,218],"COPD,":[51,222],"delving":[52],"into":[53,152],"intricate":[55,85,154],"interplay":[56],"oxidative":[58],"stress,":[59,69],"bioenergetic":[60],"impairment,":[61],"genetics,":[63],"downstream":[65],"cellular":[66,105,146],"consequences.":[67],"Oxidative":[68],"consequence":[71],"dysfunction,":[74,103],"explored":[76],"driving":[79],"force":[80],"behind":[81],"inflammation,":[82],"exacerbating":[83],"cascade":[86],"events":[88],"leading":[89],"progression.":[92],"Bioenergetic":[93],"impairment":[94],"sheds":[95],"light":[96],"on":[97],"systemic":[99],"consequences":[100],"impacting":[104],"functions":[106],"contributing":[108],"overall":[111],"energy":[112],"imbalance":[113],"observed":[114],"patients.":[117],"navigates":[120],"through":[121],"genetic":[123],"landscape,":[124],"elucidating":[125],"DNA":[130],"mutations,":[131],"variations,":[132],"haplogroups":[134],"susceptibility":[137],"severity.":[139],"Cellular":[140],"consequences,":[141],"including":[142],"apoptosis,":[143],"autophagy,":[144],"senescence,":[147],"are":[148,173],"examined,":[149],"providing":[150],"insights":[151],"mechanisms":[155],"which":[157],"influences":[160],"pathology.":[162],"Therapeutic":[163],"implications,":[164],"spanning":[165],"antioxidant":[166],"strategies,":[167],"mitochondria-targeted":[168,189],"compounds,":[169],"lifestyle":[171],"modifications,":[172],"discussed":[174],"context":[177],"translational":[179],"research.":[180],"Important":[181],"future":[182],"directions":[183],"include":[184],"identifying":[185],"novel":[186],"biomarkers,":[187],"advancing":[188],"therapies,":[190],"embracing":[192],"patient-centric":[193],"approaches":[194],"redefine":[196],"management.":[198],"abstract":[200],"provides":[201],"comprehensive":[203],"overview":[204],"our":[206],"review,":[207],"offering":[208],"roadmap":[210],"for":[211,226],"understanding":[212],"addressing":[214],"with":[223],"potential":[224],"implications":[225],"precision":[227],"medicine":[228],"improved":[230],"patient":[231],"outcomes.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-04-09T00:00:00"}
