{"id":"https://openalex.org/W4394560100","doi":"https://doi.org/10.6084/m9.figshare.5129344","title":"Supplementary Material for: Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling","display_name":"Supplementary Material for: Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W4394560100","doi":"https://doi.org/10.6084/m9.figshare.5129344"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/5129344","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Estradiol_Rapidly_Attenuates_ORL-1_Receptor-Mediated_Inhibition_of_Proopiomelanocortin_Neurons_via_G_sub_q_sub_-Coupled_Membrane-Initiated_Signaling/5129344","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"supplementary-materials","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Estradiol_Rapidly_Attenuates_ORL-1_Receptor-Mediated_Inhibition_of_Proopiomelanocortin_Neurons_via_G_sub_q_sub_-Coupled_Membrane-Initiated_Signaling/5129344","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059245566","display_name":"Kristie Conde","orcid":"https://orcid.org/0000-0002-9525-4606","observed_orcids":["https://orcid.org/0000-0002-9525-4606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Conde, K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Meza, C.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meza, C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080065013","display_name":"Martin J. Kelly","orcid":"https://orcid.org/0000-0002-8633-2510","observed_orcids":["https://orcid.org/0000-0002-8633-2510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly, M.J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019022209","display_name":"Kevin Sinchak","orcid":"https://orcid.org/0000-0001-8843-4708","observed_orcids":["https://orcid.org/0000-0001-8843-4708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sinchak, K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019977038","display_name":"Edward J. Wagner","orcid":"https://orcid.org/0000-0002-9630-5217","observed_orcids":["https://orcid.org/0000-0002-9630-5217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wagner, E.J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.14480000734329224,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.10769999772310257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/orl1-receptor","display_name":"ORL1 receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/nociceptin","display_name":"nociceptin","score":0.7620000243186951},{"id":"https://openalex.org/keywords/proopiomelanocortin-neurons","display_name":"proopiomelanocortin neurons","score":0.9070000052452087},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.9869999885559082},{"id":"https://openalex.org/keywords/medial-preoptic-nucleus","display_name":"medial preoptic nucleus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7490000128746033},{"id":"https://openalex.org/keywords/girk-channels","display_name":"GIRK channels","score":0.7319999933242798},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9649999737739563},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9850000143051147},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.9810000061988831},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lordosis","display_name":"lordosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hypothalamic-neurons","display_name":"hypothalamic neurons","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2781309135","wikidata":"https://www.wikidata.org/wiki/Q418896","display_name":"Proopiomelanocortin","level":3,"score":0.8990572690963745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5564499497413635},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4892408847808838},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4666595160961151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45320701599121094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4474739730358124},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4314548373222351},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4145601987838745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2269442081451416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17619210481643677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15895843505859375}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/5129344","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Estradiol_Rapidly_Attenuates_ORL-1_Receptor-Mediated_Inhibition_of_Proopiomelanocortin_Neurons_via_G_sub_q_sub_-Coupled_Membrane-Initiated_Signaling/5129344","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.5129344","doi":"https://doi.org/10.6084/m9.figshare.5129344","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.5129344","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.5129344.v1","doi":"https://doi.org/10.6084/m9.figshare.5129344.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.5129344.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/5129344","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Estradiol_Rapidly_Attenuates_ORL-1_Receptor-Mediated_Inhibition_of_Proopiomelanocortin_Neurons_via_G_sub_q_sub_-Coupled_Membrane-Initiated_Signaling/5129344","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2281458905","https://openalex.org/W2063863918","https://openalex.org/W2086053918","https://openalex.org/W2072735196","https://openalex.org/W2004727796","https://openalex.org/W1025885356","https://openalex.org/W2054166775","https://openalex.org/W2883863577","https://openalex.org/W2041310888","https://openalex.org/W2942018948"],"abstract_inverted_index":{"Estradiol":[0],"rapidly":[1,48,224],"regulates":[2],"the":[3,15,40,59,70,131,141,149,157,204],"activity":[4],"of":[5,160,186,191,220],"arcuate":[6],"nucleus":[7,18],"(ARH)":[8],"proopiomelanocortin":[9],"(POMC)":[10],"neurons":[11,46,78,222],"that":[12,42,110,243],"project":[13],"to":[14,20,32,123],"medial":[16],"preoptic":[17],"(MPN)":[19],"regulate":[21],"lordosis.":[22],"Orphanin":[23],"FQ/nociceptin":[24],"(OFQ/N)":[25],"acts":[26],"via":[27,102,238],"opioid":[28],"receptor-like":[29],"(ORL)-1":[30],"receptors":[31],"inhibit":[33],"these":[34,54],"POMC":[35,45,221],"neurons.":[36,215],"Therefore,":[37],"we":[38],"tested":[39],"hypothesis":[41],"estradiol":[43,118],"excites":[44],"by":[47,92,113,130,140,228],"attenuating":[49],"inhibitory":[50],"ORL-1":[51,217],"signaling":[52],"in":[53,76,210],"cells.":[55],"Hypothalamic":[56],"slices":[57],"through":[58,245],"ARH":[60,77,214],"were":[61,74,111],"prepared":[62],"from":[63],"ovariectomized":[64],"rats":[65],"injected":[66],"with":[67,115],"Fluorogold":[68],"into":[69],"MPN.":[71],"Electrophysiological":[72],"recordings":[73],"generated":[75],"held":[79],"at":[80],"or":[81,120,176],"near":[82],"-60":[83],"mV,":[84],"and":[85,100,138,148,198,225,235,240,250],"neuronal":[86,177],"phenotype":[87],"was":[88,128,208],"determined":[89],"post":[90],"hoc":[91],"immunohistofluorescence.":[93],"OFQ/N":[94,205],"application":[95],"induced":[96],"robust":[97],"outward":[98],"currents":[99],"hyperpolarizations":[101],"G":[103],"protein-gated,":[104],"inwardly":[105],"rectifying":[106],"K+":[107],"(GIRK)":[108],"channels":[109],"attenuated":[112,203],"pretreatment":[114],"either":[116,164],"17-\u03b2":[117],"(E2)":[119],"E2":[121,184],"conjugated":[122],"bovine":[124],"serum":[125],"albumin.":[126],"This":[127,207],"blocked":[129,156],"estrogen":[132],"receptor":[133],"(ER)":[134],"antagonist":[135],"ICI":[136],"182,780":[137],"mimicked":[139],"Gq-coupled":[142],"membrane":[143,236],"ER":[144],"(Gq-mER)":[145],"ligand":[146],"STX":[147],"ER\u03b1":[150,241],"agonist":[151],"PPT.":[152],"Inhibiting":[153],"phosphatidylinositol-3-kinase":[154],"(PI3K)":[155],"estrogenic":[158],"attenuation":[159],"ORL-1/GIRK":[161,187],"currents.":[162],"Antagonizing":[163],"phospholipase":[165],"C":[166,170],"(PLC),":[167],"protein":[168,172,194],"kinase":[169,173,195],"(PKC),":[171],"A":[174],"(PKA)":[175],"nitric":[178],"oxide":[179],"synthase":[180],"(nNOS)":[181],"also":[182],"abrogated":[183],"inhibition":[185,219],"currents,":[188],"whereas":[189],"activation":[190,242],"PKC,":[192,247],"PKA,":[193,248],"B":[196],"(Akt)":[197],"nNOS":[199],"substrate":[200],"L-arginine":[201],"all":[202],"response.":[206],"observed":[209],"92":[211],"MPN-projecting,":[212],"POMC-positive":[213],"Thus,":[216],"receptor-mediated":[218],"is":[223,233],"negatively":[226],"modulated":[227],"E2,":[229],"an":[230],"effect":[231],"which":[232],"stereoselective":[234],"initiated":[237],"Gq-mER":[239],"signals":[244],"PLC,":[246],"PI3K":[249],"nNOS.":[251]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}
