{"id":"https://openalex.org/W4394548069","doi":"https://doi.org/10.6084/m9.figshare.11966076","title":"Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats","display_name":"Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W4394548069","doi":"https://doi.org/10.6084/m9.figshare.11966076"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/11966076","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Glutamine_protects_intestine_against_ischemia-reperfusion_injury_by_alleviating_endoplasmic_reticulum_stress_induced_apoptosis_in_rats/11966076","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Glutamine_protects_intestine_against_ischemia-reperfusion_injury_by_alleviating_endoplasmic_reticulum_stress_induced_apoptosis_in_rats/11966076","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101524528","display_name":"Hao Xu","orcid":"https://orcid.org/0000-0002-8443-3123","observed_orcids":["https://orcid.org/0000-0002-8443-3123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu, Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737332","display_name":"Guangyi Liu","orcid":"https://orcid.org/0000-0002-6813-174X","observed_orcids":["https://orcid.org/0000-0002-6813-174X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Guangyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gu, Haitao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gu, Haitao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108019660","display_name":"Jijian Wang","orcid":"https://orcid.org/0000-0002-1684-2195","observed_orcids":["https://orcid.org/0000-0002-1684-2195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Jijian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079524660","display_name":"Yang Li","orcid":"https://orcid.org/0000-0001-5706-1830","observed_orcids":["https://orcid.org/0000-0001-5706-1830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":1.0},{"id":"https://openalex.org/keywords/intestinal-ischemia-reperfusion-injury","display_name":"intestinal ischemia-reperfusion injury","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/intestinal-mucosa-protection","display_name":"intestinal mucosa protection","score":0.6890000104904175},{"id":"https://openalex.org/keywords/superior-mesenteric-artery-occlusion","display_name":"superior mesenteric artery occlusion","score":0.875},{"id":"https://openalex.org/keywords/grp78","display_name":"GRP78","score":0.8190000057220459},{"id":"https://openalex.org/keywords/gadd153","display_name":"GADD153","score":0.8939999938011169},{"id":"https://openalex.org/keywords/caspase-12","display_name":"caspase-12","score":0.9710000157356262},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.9850000143051147},{"id":"https://openalex.org/keywords/perk-phosphorylation","display_name":"PERK phosphorylation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.949999988079071},{"id":"https://openalex.org/keywords/enteral-nutrition","display_name":"enteral nutrition","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.8841416239738464},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6841409802436829},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5895116329193115},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5631586313247681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5038003325462341},{"id":"https://openalex.org/C142579037","wikidata":"https://www.wikidata.org/wiki/Q767749","display_name":"Reticulum","level":3,"score":0.4747767150402069},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.436414897441864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4053885042667389},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40248364210128784},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35860657691955566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.282401978969574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27067768573760986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20710867643356323},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0680604875087738}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/11966076","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Glutamine_protects_intestine_against_ischemia-reperfusion_injury_by_alleviating_endoplasmic_reticulum_stress_induced_apoptosis_in_rats/11966076","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.11966076","doi":"https://doi.org/10.6084/m9.figshare.11966076","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.11966076","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.11966076.v1","doi":"https://doi.org/10.6084/m9.figshare.11966076.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.11966076.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/11966076","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Glutamine_protects_intestine_against_ischemia-reperfusion_injury_by_alleviating_endoplasmic_reticulum_stress_induced_apoptosis_in_rats/11966076","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2419314409","https://openalex.org/W2069360313","https://openalex.org/W2605103738","https://openalex.org/W2417583153","https://openalex.org/W2365105343","https://openalex.org/W3028965490","https://openalex.org/W2389548115","https://openalex.org/W2442317132","https://openalex.org/W2024707784","https://openalex.org/W1982008222"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Glutamine,":[2],"as":[3],"an":[4],"essential":[5],"part":[6],"of":[7,22,36,54,71,82,91,95,99,104,123,133,139,169],"enteral":[8],"nutrition":[9,12],"and":[10,30,102,113,136,145,159,173,175,179],"parenteral":[11],"agent,":[13],"has":[14],"been":[15],"widely":[16],"recognized":[17],"to":[18,49],"be":[19,185],"a":[20],"kind":[21],"important":[23],"intestinal":[24,72,96,105,124,134,156,192],"mucosa":[25,125,193],"protectant":[26],"in":[27,65,74,187],"clinical":[28],"practice":[29],"experimental":[31,69],"research.":[32],"However,":[33,149],"the":[34,51,83,120,137,167],"mechanisms":[35],"its":[37],"protective":[38],"effects":[39],"are":[40],"still":[41],"not":[42],"fully":[43],"understand.":[44],"Consequently,":[45],"this":[46],"study":[47],"aimed":[48],"explore":[50],"potential":[52],"mechanism":[53],"glutamine":[55,152,163],"on":[56],"ischemia-reperfusion":[57],"(I/R)":[58],"injury":[59,158],"induced":[60,191],"endoplasmic":[61],"reticulum":[62],"(ER)":[63],"stress":[64,190],"intestine.":[66],"Methods":[67],"An":[68],"model":[70],"I/R":[73,157],"rats":[75],"was":[76],"established":[77],"by":[78,88],"1":[79],"hour":[80],"occlusion":[81],"superior":[84],"mesenteric":[85],"artery":[86],"followed":[87],"3":[89],"hours":[90],"reperfusion.":[92],"Morphologic":[93],"changes":[94],"mucosa,":[97,135],"apoptosis":[98,160],"epithelial":[100,126],"cells,":[101],"expression":[103,168],"Grp78,":[106,140,170],"Gadd153,":[107,141],"Caspase-12,":[108,142],"ATF4,":[109,143,177],"PERK":[110],"phosphorylation":[111],"(P-PERK)":[112],"elF2\u03b1phosphorylation(P-elF2\u03b1)":[114],"were":[115,147],"determined.":[116],"Results":[117],"After":[118],"I/R,":[119],"apoptotic":[121],"index":[122],"cells":[127,194],"observably":[128],"increased":[129],"with":[130,151],"notable":[131],"necrosis":[132],"expressions":[138],"P-PERK":[144,172],"P-elF2\u03b1all":[146],"increased.":[148],"treatment":[150],"could":[153,164],"significantly":[154],"relieve":[155],"index.":[161],"Moreover,":[162],"clearly":[165],"up-regulate":[166],"restrain":[171],"P-elF2\u03b1,":[174],"reduce":[176],"Gadd153":[178],"Caspase-12":[180],"expressions.":[181],"Conclusion":[182],"Glutamine":[183],"may":[184],"involved":[186],"alleviating":[188],"ER":[189],"apoptosis.":[195]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}