{"id":"https://openalex.org/W4394530232","doi":"https://doi.org/10.6084/m9.figshare.11965848","title":"Although with intact mucosa at colonoscopy, chagasic megacolons have an overexpression of Gal-3","display_name":"Although with intact mucosa at colonoscopy, chagasic megacolons have an overexpression of Gal-3","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W4394530232","doi":"https://doi.org/10.6084/m9.figshare.11965848"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/11965848","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Although_with_intact_mucosa_at_colonoscopy_chagasic_megacolons_have_an_overexpression_of_Gal-3/11965848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Although_with_intact_mucosa_at_colonoscopy_chagasic_megacolons_have_an_overexpression_of_Gal-3/11965848","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046693847","display_name":"Mariana Pac\u00edfico Garvil","orcid":"https://orcid.org/0000-0002-8923-9207","observed_orcids":["https://orcid.org/0000-0002-8923-9207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garvil, Mariana Pac\u00edfico","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022691250","display_name":"Ta\u00edssa C\u00e1ssia de Souza Furtado","orcid":"https://orcid.org/0000-0002-8186-1798","observed_orcids":["https://orcid.org/0000-0002-8186-1798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ta\u00edssa C\u00e1ssia De Souza Furtado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017756546","display_name":"Nat\u00e1lia de Lima","orcid":"https://orcid.org/0000-0002-1375-4077","observed_orcids":["https://orcid.org/0000-0002-1375-4077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lima, Nat\u00e1lia Biagioni De","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078137586","display_name":"Maria Vit\u00f3ria Mattar Marteleto","orcid":"https://orcid.org/0000-0002-6963-6301","observed_orcids":["https://orcid.org/0000-0002-6963-6301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marteleto, Maria Vit\u00f3ria Mattar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037745358","display_name":"Juliana Barbosa de Faria","orcid":"https://orcid.org/0000-0002-9681-2278","observed_orcids":["https://orcid.org/0000-0002-9681-2278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faria, Juliana Barbosa De","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054519106","display_name":"Denise Bertulucci Rocha Rodrigues","orcid":"https://orcid.org/0000-0003-4003-542X","observed_orcids":["https://orcid.org/0000-0003-4003-542X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodrigues, Denise Bertulucci Rocha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017365821","display_name":"San\u00edvia Aparecida de Lima Pereira","orcid":"https://orcid.org/0000-0002-0293-2587","observed_orcids":["https://orcid.org/0000-0002-0293-2587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"San\u00edvia Aparecida De Lima Pereira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8270999789237976,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/chagasic-megacolon","display_name":"chagasic megacolon","score":0.847000002861023},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/intestinal-biopsy","display_name":"intestinal biopsy","score":0.43799999356269836},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6140000224113464},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.7864774465560913},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37259596586227417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.345970094203949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.297801673412323},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.09297740459442139},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.04722636938095093}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/11965848","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Although_with_intact_mucosa_at_colonoscopy_chagasic_megacolons_have_an_overexpression_of_Gal-3/11965848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.11965848","doi":"https://doi.org/10.6084/m9.figshare.11965848","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.11965848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.11965848.v1","doi":"https://doi.org/10.6084/m9.figshare.11965848.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.11965848.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/11965848","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Although_with_intact_mucosa_at_colonoscopy_chagasic_megacolons_have_an_overexpression_of_Gal-3/11965848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605489773","https://openalex.org/W2045810312","https://openalex.org/W2019764122","https://openalex.org/W2045969781","https://openalex.org/W2281641534","https://openalex.org/W2054022111","https://openalex.org/W7212065592","https://openalex.org/W2003287869","https://openalex.org/W2258152553","https://openalex.org/W2809604285"],"abstract_inverted_index":{"ABSTRACT":[0],"Objective":[1],"To":[2],"evaluate":[3,85,99],"the":[4,67,86,100,122,140,150,170,177,194,207,215],"density":[5,13,132,192,200],"of":[6,16,23,66,93,106,115,133,155,165,201,223],"anti-galectin-3-immunostained":[7,134,202],"cells,":[8],"collagen":[9,94,166],"percentage,":[10],"mast":[11,101,190],"cell":[12,102,191],"and":[14,56,70,82,95,117,128,175,234],"presence":[15],"pathological":[17,88],"processes":[18],"in":[19,139,167,189,204,206,220],"intestinal":[20,30],"muscle":[21],"biopsies":[22],"patients.":[24],"Methods":[25],"Thirty-five":[26],"patients":[27,45,51,58,124,142,157,171,205,209],"who":[28],"underwent":[29],"biopsy":[31],"were":[32,39,74,78],"selected":[33],"from":[34],"1997":[35],"to":[36,84,98,121,149,169,176],"2015.":[37],"Patients":[38,105],"divided":[40],"into":[41],"three":[42,195],"groups:":[43],"chagasic":[44,50,123,141,156,208],"with":[46,52,59,80,125,143,158,172,180,210,231],"mucosal":[47,61,107,173],"lesion":[48,62,108,174],"(n=13),":[49],"intact":[53,126,144,159,211],"mucosa":[54,127,145,160,212],"(n=12)":[55],"non-chagasic":[57,129,151,178],"no":[60,186],"(n=10).":[63],"Histological":[64],"processing":[65],"biopsied":[68],"fragments":[69],"immunohistochemistry":[71],"for":[72,91,217],"galectin-3":[73],"performed.":[75],"Additional":[76],"sections":[77],"stained":[79],"hematoxylin":[81],"eosin":[83],"general":[87],"processes,":[89],"picrosirius":[90],"evaluation":[92,222],"toluidine":[96],"blue":[97],"density.":[103],"Results":[104],"group":[109,146,154,213],"had":[110],"a":[111,162,181],"significantly":[112,137],"higher":[113,138,163,199],"frequency":[114],"ganglionitis":[116],"myositis":[118],"when":[119,147],"compared":[120,148],"group.":[130,152],"The":[131,153,198],"cells":[135,203],"was":[136,185],"presented":[161],"percentage":[164],"relation":[168],"group,":[179],"significant":[182,187],"difference.":[183],"There":[184],"difference":[188],"among":[193],"groups.":[196],"Conclusion":[197],"suggested":[214],"need":[216],"greater":[218],"attention":[219],"clinical":[221],"these":[224],"patients,":[225],"since":[226],"this":[227],"protein":[228],"is":[229],"associated":[230],"neoplastic":[232],"transformation":[233],"progression.":[235]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}