{"id":"https://openalex.org/W4394512159","doi":"https://doi.org/10.6084/m9.figshare.12429443","title":"Concentrated growth factor promotes gingival regeneration through the AKT/Wnt/\u03b2-catenin and YAP signaling pathways","display_name":"Concentrated growth factor promotes gingival regeneration through the AKT/Wnt/\u03b2-catenin and YAP signaling pathways","publication_year":2020,"publication_date":"2020-06-04","ids":{"openalex":"https://openalex.org/W4394512159","doi":"https://doi.org/10.6084/m9.figshare.12429443"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/12429443","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Concentrated_growth_factor_promotes_gingival_regeneration_through_the_AKT_Wnt_-catenin_and_YAP_signaling_pathways/12429443","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Concentrated_growth_factor_promotes_gingival_regeneration_through_the_AKT_Wnt_-catenin_and_YAP_signaling_pathways/12429443","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qi, Lei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi, Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396514","display_name":"Lu Liu","orcid":"https://orcid.org/0000-0002-7496-5564","observed_orcids":["https://orcid.org/0000-0002-7496-5564","https://orcid.org/0009-0002-7148-8448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104207686","display_name":"Yue Hu","orcid":"https://orcid.org/0009-0005-6189-5789","observed_orcids":["https://orcid.org/0009-0005-6189-5789"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hu, Yue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454139","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-7529-6040","observed_orcids":["https://orcid.org/0000-0002-7529-6040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Jie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446490","display_name":"Jiayi Li","orcid":"https://orcid.org/0000-0003-2696-8960","observed_orcids":["https://orcid.org/0000-0003-2696-8960","https://orcid.org/0009-0007-5344-1300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Jiayi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108889649","display_name":"Ningning Cao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cao, Ningning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080841756","display_name":"Fangxing Zhu","orcid":"https://orcid.org/0000-0001-8581-254X","observed_orcids":["https://orcid.org/0000-0001-8581-254X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhu, Fangxing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102907152","display_name":"Chaoji Shi","orcid":"https://orcid.org/0009-0004-9339-8536","observed_orcids":["https://orcid.org/0009-0004-9339-8536","https://orcid.org/0000-0002-9456-5656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shi, Chaoji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101649633","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-0045-6863","observed_orcids":["https://orcid.org/0000-0002-0045-6863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Lei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/concentrated-growth-factor","display_name":"concentrated growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gingival-regeneration","display_name":"gingival regeneration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gingival-mesenchymal-stem-cells","display_name":"gingival mesenchymal stem cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.984000027179718},{"id":"https://openalex.org/keywords/yap-signaling","display_name":"YAP signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":1.0},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.7760000228881836},{"id":"https://openalex.org/keywords/collagen-1","display_name":"collagen-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9200000166893005},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8607091903686523},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6380489468574524},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5817196369171143},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.577257513999939},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5684502124786377},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4914182424545288},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40441256761550903},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35992705821990967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3005743622779846}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/12429443","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Concentrated_growth_factor_promotes_gingival_regeneration_through_the_AKT_Wnt_-catenin_and_YAP_signaling_pathways/12429443","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.12429443","doi":"https://doi.org/10.6084/m9.figshare.12429443","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12429443","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.12429443.v1","doi":"https://doi.org/10.6084/m9.figshare.12429443.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12429443.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/12429443","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Concentrated_growth_factor_promotes_gingival_regeneration_through_the_AKT_Wnt_-catenin_and_YAP_signaling_pathways/12429443","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2901210600","https://openalex.org/W2511630974","https://openalex.org/W4386581407","https://openalex.org/W2800936214","https://openalex.org/W2945359096","https://openalex.org/W2295906683","https://openalex.org/W4311961953","https://openalex.org/W1499773819","https://openalex.org/W2977285900","https://openalex.org/W2400742721"],"abstract_inverted_index":{"Although":[0],"concentrated":[1],"growth":[2,69],"factor":[3,70,179],"(CGF)":[4],"is":[5],"known":[6],"to":[7,29,155],"promote":[8,166],"gingival":[9,36,41,101,167,189],"regeneration":[10,190],"and":[11,53,61,72,76,80,112,124,135,148,169,191],"improve":[12],"the":[13,18,31,54,77,118,133,139,146,159,173,195],"outcomes":[14],"of":[15,33,51,56,90,120,128,145,194,198],"clinical":[16,196],"treatment,":[17],"mechanisms":[19],"underlying":[20,180],"its":[21],"effects":[22,32,55,89,127],"remain":[23],"unknown.":[24],"Therefore,":[25],"this":[26,39,181],"study":[27],"aimed":[28],"elucidate":[30],"CGF":[34,57,91,107,115,129,164],"on":[35,58],"thickening.":[37],"To":[38],"end,":[40],"mesenchymal":[42],"stem":[43],"cells":[44],"(GMSCs)":[45],"were":[46,86,94,130],"treated":[47],"with":[48,106,138],"different":[49],"concentrations":[50],"CGF,":[52],"cell":[59,110],"proliferation":[60,111],"migration;":[62],"collagen-1":[63],"(Col-1),":[64],"fibronectin":[65],"(FN),":[66],"vascular":[67],"endothelial":[68],"(VEGF),":[71],"angiopoietin-1":[73],"(Ang-1)":[74],"expression;":[75],"AKT,":[78],"Wnt/\u03b2-catenin,":[79],"Yes-associated":[81],"protein":[82],"(YAP)":[83],"signalling":[84],"pathways":[85],"investigated.":[87],"The":[88],"in":[92,97,158,160],"vivo":[93,161],"also":[95,153],"investigated":[96],"a":[98,177,185],"rat":[99],"buccal":[100],"injection":[102],"model.":[103,162],"GMSCs":[104],"cultured":[105],"showed":[108],"improved":[109,117],"migration.":[113],"Moreover,":[114],"treatment":[116],"levels":[119],"FN,":[121],"Col-1,":[122],"VEGF,":[123],"ANG-1.":[125],"These":[126],"mediated":[131],"by":[132],"AKT/Wnt":[134],"YAP":[136,149,151,170],"pathways,":[137],"AKT":[140],"pathway":[141],"possibly":[142],"functioning":[143],"upstream":[144],"Wnt/\u03b2-catenin":[147],"pathways.":[150],"was":[152],"shown":[154],"be":[156,176],"overexpressed":[157],"Thus,":[163],"can":[165],"regeneration,":[168],"transport":[171],"into":[172],"nucleus":[174],"may":[175],"key":[178],"activity,":[182],"which":[183],"provides":[184],"novel":[186],"perspective":[187],"for":[188],"further":[192],"promotion":[193],"application":[197],"CGF.":[199]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}