{"id":"https://openalex.org/W4394505352","doi":"https://doi.org/10.6084/m9.figshare.14776153","title":"Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract","display_name":"Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract","publication_year":2021,"publication_date":"2021-06-13","ids":{"openalex":"https://openalex.org/W4394505352","doi":"https://doi.org/10.6084/m9.figshare.14776153"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/14776153","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Extracellular_acidosis_enhances_Zika_virus_infection_both_in_human_cells_and_ex-vivo_tissue_cultures_from_female_reproductive_tract/14776153","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Extracellular_acidosis_enhances_Zika_virus_infection_both_in_human_cells_and_ex-vivo_tissue_cultures_from_female_reproductive_tract/14776153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057664006","display_name":"Augusto Varese","orcid":"https://orcid.org/0000-0002-3129-2048","observed_orcids":["https://orcid.org/0000-0002-3129-2048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varese, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069395622","display_name":"Ezequiel Dantas","orcid":"https://orcid.org/0000-0003-4934-4632","observed_orcids":["https://orcid.org/0000-0003-4934-4632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dantas, E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014688218","display_name":"Ana Luz Paletta","orcid":"https://orcid.org/0000-0003-2181-8488","observed_orcids":["https://orcid.org/0000-0003-2181-8488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paletta, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017279874","display_name":"Wendy Fitzgerald","orcid":"https://orcid.org/0000-0001-5752-8250","observed_orcids":["https://orcid.org/0000-0001-5752-8250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fitzgerald, W.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070668922","display_name":"Facundo Di Diego Garc\u00eda","orcid":"https://orcid.org/0000-0003-3779-2518","observed_orcids":["https://orcid.org/0000-0003-3779-2518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Di Diego Garc\u00eda, F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025071165","display_name":"Gonzalo Cabrerizo","orcid":"https://orcid.org/0009-0002-9083-2072","observed_orcids":["https://orcid.org/0009-0002-9083-2072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cabrerizo, G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002062431","display_name":"Fernando A. Erra D\u00edaz","orcid":"https://orcid.org/0000-0002-9519-5909","observed_orcids":["https://orcid.org/0000-0002-9519-5909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diaz, F. Erra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081101274","display_name":"Lucas A. Defelipe","orcid":"https://orcid.org/0000-0001-7859-7300","observed_orcids":["https://orcid.org/0000-0001-7859-7300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Defelipe, L. A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083611282","display_name":"Horacio M. Pallar\u00e9s","orcid":"https://orcid.org/0000-0002-2019-8574","observed_orcids":["https://orcid.org/0000-0002-2019-8574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pallares, H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030222788","display_name":"Mart\u00edn M. Dodes Traian","orcid":"https://orcid.org/0000-0003-1515-892X","observed_orcids":["https://orcid.org/0000-0003-1515-892X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Traian, M. Dodes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079676236","display_name":"Andrea Vanesa Gamarnik","orcid":"https://orcid.org/0000-0002-9789-4105","observed_orcids":["https://orcid.org/0000-0002-9789-4105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gamarnik, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059868342","display_name":"Jorge Raul Geffner","orcid":"https://orcid.org/0000-0002-4750-9686","observed_orcids":["https://orcid.org/0000-0002-4750-9686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geffner, J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079386866","display_name":"Federico Remes Lenicov","orcid":"https://orcid.org/0000-0003-4108-6341","observed_orcids":["https://orcid.org/0000-0003-4108-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lenicov, F. Remes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053982479","display_name":"Leonid B Margolis","orcid":"https://orcid.org/0000-0002-1960-1928","observed_orcids":["https://orcid.org/0000-0002-1960-1928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margolis, L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011949298","display_name":"Ana Ceballos","orcid":"https://orcid.org/0000-0003-4564-7361","observed_orcids":["https://orcid.org/0000-0003-4564-7361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ceballos, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zika-virus","display_name":"Zika virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extracellular-acidosis","display_name":"extracellular acidosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/low-ph","display_name":"low pH","score":0.7749999761581421},{"id":"https://openalex.org/keywords/vaginal-ph","display_name":"vaginal pH","score":0.7279999852180481},{"id":"https://openalex.org/keywords/female-reproductive-tract","display_name":"female reproductive tract","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sexual-transmission","display_name":"sexual transmission","score":0.6119999885559082},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.75},{"id":"https://openalex.org/keywords/virus-attachment","display_name":"viral attachment","score":0.48100000619888306},{"id":"https://openalex.org/keywords/ectocervix","display_name":"ectocervix","score":0.8199999928474426},{"id":"https://openalex.org/keywords/endocervix","display_name":"endocervix","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ex-vivo-tissue-culture","display_name":"ex vivo tissue culture","score":0.7360000014305115},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.9449999928474426},{"id":"https://openalex.org/keywords/flavivirus-infection","display_name":"flavivirus infection","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8676152229309082},{"id":"https://openalex.org/C2777053367","wikidata":"https://www.wikidata.org/wiki/Q202864","display_name":"Zika virus","level":3,"score":0.8479373455047607},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6536834836006165},{"id":"https://openalex.org/C2911058409","wikidata":"https://www.wikidata.org/wiki/Q844342","display_name":"Female Reproductive Tract","level":3,"score":0.6308313012123108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5893413424491882},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5635517835617065},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4992530345916748},{"id":"https://openalex.org/C2992003382","wikidata":"https://www.wikidata.org/wiki/Q7895","display_name":"Reproductive tract","level":2,"score":0.44206368923187256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41743916273117065},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3752802312374115},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2903667986392975},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.11229658126831055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1036405861377716},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09649166464805603}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/14776153","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Extracellular_acidosis_enhances_Zika_virus_infection_both_in_human_cells_and_ex-vivo_tissue_cultures_from_female_reproductive_tract/14776153","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.14776153","doi":"https://doi.org/10.6084/m9.figshare.14776153","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.14776153","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.14776153.v1","doi":"https://doi.org/10.6084/m9.figshare.14776153.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.14776153.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/14776153","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Extracellular_acidosis_enhances_Zika_virus_infection_both_in_human_cells_and_ex-vivo_tissue_cultures_from_female_reproductive_tract/14776153","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3212413241","https://openalex.org/W3089643010","https://openalex.org/W2737407610","https://openalex.org/W2805774706","https://openalex.org/W3016733277","https://openalex.org/W2518675224","https://openalex.org/W2793158494","https://openalex.org/W2329996059","https://openalex.org/W4220893072","https://openalex.org/W2950033619"],"abstract_inverted_index":{"Zika":[0],"virus":[1],"(ZIKV)":[2],"is":[3],"a":[4,152],"flavivirus":[5],"transmitted":[6,21],"by":[7,22,89,128],"mosquitoes":[8],"of":[9,36,58,79,87,116,124,136,158,181],"the":[10,65,117,122,137,141,146,159],"genus":[11],"Aedes,":[12],"but":[13,154],"unlike":[14],"other":[15],"flaviviruses,":[16],"ZIKV":[17,53,77,97,125,182],"can":[18],"be":[19],"sexually":[20],"vaginal":[23,27,175],"intercourse.":[24],"The":[25],"healthy":[26],"pH":[28,47,74,91,130,176],"ranges":[29],"from":[30,64],"4.0":[31],"to":[32,102,140],"6.0,":[33],"reaching":[34],"values":[35,48],"6.0\u20137.0":[37],"after":[38],"semen":[39],"deposition.":[40],"Here,":[41],"we":[42],"report":[43],"that":[44,121,173],"low":[45,73,90,129,174],"extracellular":[46],"(range":[49],"6.2\u20136.6)":[50],"dramatically":[51],"increase":[52],"infection":[54,78,88,126],"on":[55,145],"cell":[56,148],"lines":[57],"different":[59,96],"origin":[60],"including":[61],"some":[62],"derived":[63],"female":[66,160],"genital":[67,161],"tract":[68],"and":[69,82,99,112],"monocyte-derived":[70],"macrophages.":[71],"Furthermore,":[72],"significantly":[75],"increased":[76,134],"human":[80],"ectocervix":[81],"endocervix":[83],"cultured":[84],"ex-vivo.":[85],"Enhancement":[86],"was":[92,131],"also":[93],"observed":[94],"using":[95],"strains":[98],"distinct":[100],"methods":[101],"evaluate":[103],"viral":[104,138],"infection,":[105],"i.e.":[106],"plaque":[107],"assays,":[108],"RT\u2013PCR,":[109],"flow":[110],"cytometry,":[111],"fluorescence":[113],"microscopy.":[114],"Analysis":[115],"mechanisms":[118],"involved":[119],"revealed":[120],"enhancement":[123],"induced":[127],"associated":[132],"with":[133,163],"binding":[135],"particles":[139],"heparan":[142],"sulphate":[143],"expressed":[144],"target":[147],"surface.":[149],"Acidosis":[150],"represents":[151],"critical":[153],"generally":[155],"overlooked":[156],"feature":[157],"tract,":[162],"major":[164],"implications":[165],"for":[166],"sexual":[167],"transmission":[168,180],"diseases.":[169],"Our":[170],"results":[171],"suggest":[172],"might":[177],"promote":[178],"male-to-female":[179],"infection.":[183]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-04-08T00:00:00"}
