{"id":"https://openalex.org/W4394499767","doi":"https://doi.org/10.6084/m9.figshare.8143034","title":"N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions","display_name":"N3ICD with the transmembrane domain can effectively inhibit EMT by correcting the position of tight/adherens junctions","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W4394499767","doi":"https://doi.org/10.6084/m9.figshare.8143034"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/8143034","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/N3ICD_with_the_transmembrane_domain_can_effectively_inhibit_EMT_by_correcting_the_position_of_tight_adherens_junctions/8143034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/N3ICD_with_the_transmembrane_domain_can_effectively_inhibit_EMT_by_correcting_the_position_of_tight_adherens_junctions/8143034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086248772","display_name":"Junyu Tan","orcid":"https://orcid.org/0000-0003-1434-0260","observed_orcids":["https://orcid.org/0000-0003-1434-0260"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tan, Junyu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005121626","display_name":"Xixun Zhang","orcid":"https://orcid.org/0009-0007-4744-6340","observed_orcids":["https://orcid.org/0009-0007-4744-6340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Xixun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao, Wenjun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao, Wenjun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379478","display_name":"Xiong Liu","orcid":"https://orcid.org/0000-0001-6536-9544","observed_orcids":["https://orcid.org/0000-0001-6536-9544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Xiong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Li, Chun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Chun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084133399","display_name":"Yuxian Guo","orcid":"https://orcid.org/0000-0001-5493-2864","observed_orcids":["https://orcid.org/0000-0001-5493-2864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo, Yuxian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063841660","display_name":"Wei Xiong","orcid":"https://orcid.org/0000-0003-2754-8888","observed_orcids":["https://orcid.org/0000-0003-2754-8888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiong, Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102874084","display_name":"Yaochen Li","orcid":"https://orcid.org/0000-0001-8794-0123","observed_orcids":["https://orcid.org/0000-0001-8794-0123"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Yaochen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6704000234603882,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.18490000069141388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.08739999681711197,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adherens-junctions","display_name":"adherens junctions","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.8180000185966492},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/epithelial-cell-polarity","display_name":"epithelial polarity","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C201508349","wikidata":"https://www.wikidata.org/wiki/Q45173","display_name":"Adherens junction","level":4,"score":0.9752281904220581},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5556203126907349},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5445454716682434},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5355474948883057},{"id":"https://openalex.org/C198082294","wikidata":"https://www.wikidata.org/wiki/Q3399648","display_name":"Position (finance)","level":2,"score":0.5026347637176514},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4983243942260742},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3558732867240906},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3367350101470947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32578423619270325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25643500685691833},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1430460512638092},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.1397392451763153},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.07404351234436035},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0656774640083313},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.051831603050231934},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:figshare.com:article/8143034","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/N3ICD_with_the_transmembrane_domain_can_effectively_inhibit_EMT_by_correcting_the_position_of_tight_adherens_junctions/8143034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.8143034","doi":"https://doi.org/10.6084/m9.figshare.8143034","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.8143034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.8143034.v1","doi":"https://doi.org/10.6084/m9.figshare.8143034.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.8143034.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.8143034.v2","doi":"https://doi.org/10.6084/m9.figshare.8143034.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.8143034.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/8143034","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/N3ICD_with_the_transmembrane_domain_can_effectively_inhibit_EMT_by_correcting_the_position_of_tight_adherens_junctions/8143034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"score":0.6000000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2556316860","https://openalex.org/W4295766539","https://openalex.org/W4205317986","https://openalex.org/W2886332767","https://openalex.org/W2886082209","https://openalex.org/W4220956312","https://openalex.org/W2323342411","https://openalex.org/W2065105633","https://openalex.org/W2397742443","https://openalex.org/W7010460069"],"abstract_inverted_index":{"EMT":[0,27,78],"allows":[1],"a":[2],"polarized":[3],"epithelium":[4],"to":[5,37,95],"lose":[6],"epithelial":[7],"integrity":[8],"and":[9,54,58,93,102,143],"acquire":[10],"mesenchymal":[11],"characteristics.":[12],"Previously,":[13],"we":[14,35],"found":[15,62],"that":[16,63,110,128],"overexpression":[17,85,129],"of":[18,22,41,56,71,89,99,130,140],"the":[19,39,47,52,68,72,87,97,111],"intracellular":[20],"domain":[21,49],"Notch3":[23,92,115],"(N3ICD)":[24],"can":[25,66,76,132],"inhibit":[26,77,134],"in":[28,121,137,146],"breast":[29,147],"cancer":[30,148],"cells.":[31,123,149],"In":[32],"this":[33],"study,":[34],"aimed":[36],"elucidate":[38],"influence":[40],"N3ICD":[42,44,65,82],"or":[43],"combined":[45],"with":[46,119],"transmembrane":[48],"(TD+N3ICD)":[50],"on":[51],"expression":[53,69,88],"distribution":[55],"TJs/AJs":[57,100,141],"polar":[59],"molecules.":[60],"We":[61],"although":[64],"upregulate":[67],"levels":[70],"above-mentioned":[73],"molecules,":[74],"TD+N3ICD":[75,84,131],"more":[79],"effectively":[80,133],"than":[81],"alone.":[83],"upregulated":[86,112],"endogenous":[90,113],"full-length":[91,114],"contributed":[94],"correcting":[96],"position":[98],"molecules":[101,142],"better":[103,138],"acinar":[104],"structures":[105],"formation.":[106],"Co-immunoprecipitation":[107],"results":[108],"showed":[109],"could":[116],"physically":[117],"interact":[118],"E-ca":[120],"MDA-MB-231/pCMV-(TD+N3ICD)":[122],"Collectively,":[124],"our":[125],"data":[126],"indicate":[127],"EMT,":[135],"resulting":[136],"positioning":[139],"cell-cell":[144],"adhesion":[145],"Abbreviations:":[150],"EMT:":[151],"Epithelial-mesenchymal":[152],"transition;":[153],"TJs:":[154],"Tight":[155],"junctions;":[156,159],"AJs:":[157],"Adherens":[158],"aPKC:":[160],"Atypical":[161],"protein":[162,184],"kinase":[163],"C;":[164],"Crb:":[165],"Crumbs;":[166],"Lgl:":[167],"Lethal":[168],"(2)":[169],"giant":[170,174],"larvae;":[171],"LLGL2:":[172],"lethal":[173],"larvae":[175],"homolog":[176],"2;":[177],"PAR:":[178],"Partitioning":[179],"defective;":[180],"PATJ:":[181],"Pals1-associated":[182],"TJ":[183]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-04-08T00:00:00"}