{"id":"https://openalex.org/W4394495202","doi":"https://doi.org/10.6084/m9.figshare.24645598","title":"Analytical methods for the detection and characterization of unapproved phosphodiesterase type 5 inhibitors (PDE-5i) used in adulteration of dietary supplements- a review","display_name":"Analytical methods for the detection and characterization of unapproved phosphodiesterase type 5 inhibitors (PDE-5i) used in adulteration of dietary supplements- a review","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4394495202","doi":"https://doi.org/10.6084/m9.figshare.24645598"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/24645598","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analytical_methods_for_the_detection_and_characterization_of_unapproved_phosphodiesterase_type_5_inhibitors_PDE-5i_used_in_adulteration_of_dietary_supplements-_a_review/24645598","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Analytical_methods_for_the_detection_and_characterization_of_unapproved_phosphodiesterase_type_5_inhibitors_PDE-5i_used_in_adulteration_of_dietary_supplements-_a_review/24645598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021799244","display_name":"Chee\u2010Leong Kee","orcid":"https://orcid.org/0000-0003-2648-7382","observed_orcids":["https://orcid.org/0000-0003-2648-7382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kee, Chee-Leong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103102915","display_name":"Xiaowei Ge","orcid":"https://orcid.org/0000-0002-4504-4248","observed_orcids":["https://orcid.org/0000-0002-4504-4248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ge, Xiaowei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035564207","display_name":"Min\u2010Yong Low","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Low, Min-Yong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012046932","display_name":"V\u00e9ronique Gilard","orcid":"https://orcid.org/0000-0002-8379-8091","observed_orcids":["https://orcid.org/0000-0002-8379-8091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilard, V\u00e9ronique","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067218895","display_name":"Myriam Malet\u2010Martino","orcid":"https://orcid.org/0000-0002-3702-1679","observed_orcids":["https://orcid.org/0000-0002-3702-1679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malet-Martino, Myriam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12878","display_name":"Pharmaceutical Quality and Counterfeiting","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.984000027179718},{"id":"https://openalex.org/keywords/dietary-supplement-adulteration","display_name":"supplement adulteration","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sildenafil-analogues","display_name":"sildenafil analogues","score":0.8659999966621399},{"id":"https://openalex.org/keywords/male-enhancement-supplements","display_name":"male enhancement supplements","score":0.9390000104904175},{"id":"https://openalex.org/keywords/analytical-detection-methods","display_name":"analytical detection methods","score":0.5379999876022339},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"mass spectrometry","score":0.7409999966621399},{"id":"https://openalex.org/keywords/nmr-spectroscopy","display_name":"NMR spectroscopy","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6345121264457703},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.5466558933258057},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45896175503730774},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36689382791519165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3541618883609772},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3167414963245392},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1809975802898407},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12157893180847168},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11247065663337708}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/24645598","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analytical_methods_for_the_detection_and_characterization_of_unapproved_phosphodiesterase_type_5_inhibitors_PDE-5i_used_in_adulteration_of_dietary_supplements-_a_review/24645598","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.24645598","doi":"https://doi.org/10.6084/m9.figshare.24645598","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.24645598","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.24645598.v1","doi":"https://doi.org/10.6084/m9.figshare.24645598.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.24645598.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/24645598","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analytical_methods_for_the_detection_and_characterization_of_unapproved_phosphodiesterase_type_5_inhibitors_PDE-5i_used_in_adulteration_of_dietary_supplements-_a_review/24645598","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1974904275","https://openalex.org/W2743391370","https://openalex.org/W2043853479","https://openalex.org/W2123709921","https://openalex.org/W2919927774","https://openalex.org/W6920941811","https://openalex.org/W4280649827","https://openalex.org/W2112006336","https://openalex.org/W3024240825","https://openalex.org/W2084462886"],"abstract_inverted_index":{"This":[0],"article":[1],"is":[2,114],"an":[3],"up-to-date":[4],"review":[5],"of":[6,31,37,44,49,56,79,121,168,179,189,211],"112":[7,169,180,190],"unapproved":[8,33],"phosphodiesterase":[9],"type":[10,55],"5":[11],"inhibitors":[12],"(PDE-5i)":[13],"found":[14],"as":[15],"adulterants":[16],"in":[17,64,68,90,102,216,260],"sexual":[18],"enhancement":[19],"dietary":[20,218],"supplements":[21,219],"and":[22,52,71,99,182,205,252],"other":[23,54],"products":[24,60],"from":[25],"2003":[26],"to":[27,239,257],"July":[28],"2023.":[29],"Seventy-five":[30],"these":[32],"PDE-5i":[34],"are":[35,255],"analogues":[36,43,48,81,215,226],"sildenafil":[38],"(67%),":[39],"followed":[40,171],"by":[41,110,134,143,172],"26":[42],"tadalafil":[45],"(23%),":[46],"9":[47],"vardenafil":[50],"(8%)":[51],"2":[53],"compounds":[57],"(2%).":[58],"The":[59],"have":[61],"been":[62,137,153,164,200],"formulated":[63],"various":[65],"packaging,":[66],"primarily":[67],"capsule,":[69],"tablet,":[70],"powder":[72],"forms.":[73],"Common":[74],"screening":[75],"techniques":[76,234],"allowing":[77],"detection":[78,106,133],"such":[80],"include":[82],"high":[83],"performance":[84,87],"or":[85,96,124],"ultra-high":[86],"liquid":[88],"chromatography":[89,101],"tandem":[91,103],"with":[92,104,118,202],"ultra-violet":[93,105],"detector":[94],"(HPLC-UV":[95],"UPLC-UV)":[97],"(50%)":[98],"thin-layer":[100],"(TLC-UV)":[107],"(7%).":[108],"Screening":[109,142],"mass":[111,127,174],"spectrometry":[112,175],"(MS)":[113],"relatively":[115],"less":[116],"common":[117],"the":[119,131,193,212,225,232,241,261],"use":[120],"single-,":[122],"triple-quadrupole":[123],"time-of-flight":[125],"(TOF)":[126],"spectrometers":[128],"(9%).":[129],"Meanwhile,":[130],"combined":[132],"UV-MS":[135],"has":[136,151,163,199],"recorded":[138],"at":[139],"10%":[140],"usage.":[141],"proton":[144],"nuclear":[145],"magnetic":[146],"resonance":[147],"spectroscopy":[148,162,185],"(NMR)":[149],"(11%)":[150],"also":[152],"applied.":[154],"For":[155],"compound":[156],"characterization,":[157],"i.e.":[158],"structural":[159,209,229],"elucidation,":[160],"NMR":[161,250],"preferred":[165],"(100":[166],"out":[167,178,188],"compounds),":[170],"high-resolution":[173],"(HRMS)":[176],"(74":[177],"compounds)":[181],"Fourier-transform":[183],"infrared":[184],"(FTIR)":[186],"(44":[187],"compounds).":[191],"Over":[192],"past":[194],"two":[195],"decades,":[196],"analytical":[197],"technology":[198],"evolving":[201],"enhanced":[203],"sensitivity":[204],"resolution.":[206],"Despite":[207],"this,":[208],"elucidation":[210],"new":[213],"emerging":[214],"adulterated":[217],"remains":[220],"a":[221],"challenge,":[222],"especially":[223],"when":[224],"involve":[227],"complex":[228],"modification.":[230],"Therefore,":[231],"above-mentioned":[233],"may":[235],"not":[236],"be":[237,258],"adequate":[238],"characterize":[240],"analogues.":[242],"Additional":[243],"work":[244],"involving":[245],"chiroptical":[246],"methods,":[247],"two-dimensional":[248],"(2D)":[249],"experiments":[251],"X-ray":[253],"crystallography":[254],"likely":[256],"required":[259],"future.":[262]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}