{"id":"https://openalex.org/W4394487508","doi":"https://doi.org/10.6084/m9.figshare.3405610","title":"Regulation of monocyte induced cell migration by the RNA binding protein, FXR1","display_name":"Regulation of monocyte induced cell migration by the RNA binding protein, FXR1","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W4394487508","doi":"https://doi.org/10.6084/m9.figshare.3405610"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.3405610","doi":"https://doi.org/10.6084/m9.figshare.3405610","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.3405610","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.3405610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018302338","display_name":"Olivier Le Tonqu\u00e8ze","orcid":"https://orcid.org/0000-0002-4943-3566","observed_orcids":["https://orcid.org/0000-0002-4943-3566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Le Tonqueze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076769622","display_name":"Swapna Kollu","orcid":"https://orcid.org/0000-0002-1111-1545","observed_orcids":["https://orcid.org/0000-0002-1111-1545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Kollu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650761","display_name":"Stephen Lee","orcid":"https://orcid.org/0000-0003-2614-286X","observed_orcids":["https://orcid.org/0000-0003-2614-286X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070102546","display_name":"M. Al-Salah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Al-Salah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021342063","display_name":"Samuel Spencer Truesdell","orcid":"https://orcid.org/0000-0003-0016-100X","observed_orcids":["https://orcid.org/0000-0003-0016-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S.S. Truesdell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014834463","display_name":"Shobha Vasudevan","orcid":"https://orcid.org/0000-0001-5938-8335","observed_orcids":["https://orcid.org/0000-0001-5938-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Vasudevan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fxr1","display_name":"FXR1","score":1.0},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/monocyte-migration","display_name":"monocyte migration","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.753000020980835},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.6650000214576721},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.375}],"concepts":[{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6946088075637817},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5946000218391418},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5797624588012695},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5007703304290771},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.48446083068847656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4711305797100067},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4299699366092682},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36119553446769714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3247080445289612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2607692778110504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19620457291603088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11365410685539246}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.6084/m9.figshare.3405610","doi":"https://doi.org/10.6084/m9.figshare.3405610","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.3405610","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.3405610","doi":"https://doi.org/10.6084/m9.figshare.3405610","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.3405610","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2167937389","https://openalex.org/W7161988920","https://openalex.org/W2087250116","https://openalex.org/W6996249559","https://openalex.org/W2194373766","https://openalex.org/W2363459798","https://openalex.org/W2885341302","https://openalex.org/W1981389292","https://openalex.org/W4407170987","https://openalex.org/W2130386584"],"abstract_inverted_index":{"FXR1":[0,23,73,121,127,142,164,197,217,225,247],"belongs":[1],"to":[2,116,232],"a":[3,48,243],"family":[4],"of":[5,15,28,41,51,56,61,64,72,120,130,145,169,196,202,210,224,229,236,246,251],"RNA-binding":[6],"proteins":[7],"that":[8,80,94,126,163,188,222],"play":[9],"critical":[10],"roles":[11],"in":[12,18,31,74,83,88,97,133,136,157,174,177,248],"post-transcriptional":[13],"regulation":[14,27],"gene":[16,98],"expression":[17,99],"immunity,":[19],"development":[20],"and":[21,33,101,135,172,176,186,194,199,213],"cancer.":[22],"is":[24,102],"associated":[25],"with":[26,206],"specific":[29,131,170],"mRNAs":[30,132],"myocytes":[32],"macrophages.":[34],"In":[35],"quiescent":[36,105],"cells":[37,79,231],"(>":[38,106],"24":[39,107,138,179],"h":[40,45,108,139,180],"extended":[42,109],"serum-starvation,":[43],"\u223c30-48":[44],"or":[46,154],"more),":[47],"spliced":[49],"isoform":[50],"FXR1,":[52],"FXR1a,":[53],"promotes":[54],"translation":[55],"the":[57,62,70,118,207,227],"cytokine":[58],"TNF\u03b1,":[59],"independent":[60],"effects":[63],"RNA":[65,113],"levels.":[66],"Here":[67],"we":[68,161],"examined":[69],"role":[71,119,245],"THP1":[75],"human":[76],"monocytic":[77,238],"leukemic":[78],"were":[81],"grown":[82],"serum,":[84],"as":[85,87,149],"well":[86],"early":[89,137,178],"(24":[90],"h)":[91],"serum-starvation":[92,140,181],"conditions":[93],"demonstrates":[95],"differences":[96],"mechanisms":[100],"distinct":[103],"from":[104],"serum-starvation)":[110],"cells.":[111,159,239],"Global":[112],"profiling,":[114],"conducted":[115],"investigate":[117],"on":[122],"mRNA":[123,156,167],"levels,":[124],"revealed":[125],"affects":[128],"levels":[129,144,168,201,209],"serum-grown":[134,158,175],"conditions.":[141,182],"decreases":[143,226],"several":[146],"mRNAs,":[147],"including":[148],"previously":[150],"identified,":[151],"CDKN1A":[152],"(p21CIP1":[153],"p21)":[155],"Interestingly,":[160],"find":[162],"positively":[165],"regulates":[166],"cytokines":[171],"chemokines":[173,215],"These":[183,240],"include":[184],"IL1\u03b2":[185],"CCL2":[187,203,212],"control":[189],"cell":[190,234],"migration.":[191,253],"Accordingly,":[192],"depletion":[193,223],"overexpression":[195],"decreased":[198],"increased":[200],"mRNA.":[204],"Consistent":[205],"reduced":[208],"IL1\u03b2,":[211],"other":[214],"upon":[216],"depletion,":[218],"our":[219],"data":[220,241],"reveal":[221,242],"ability":[228],"these":[230],"induce":[233],"migration":[235],"neighboring":[237],"new":[244],"controlling":[249],"induction":[250],"monocyte":[252]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-04-08T00:00:00"}
