{"id":"https://openalex.org/W4394474256","doi":"https://doi.org/10.6084/m9.figshare.18132538","title":"Additional file 4 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells","display_name":"Additional file 4 of Edaravone activates the GDNF/RET neurotrophic signaling pathway and protects mRNA-induced motor neurons from iPS cells","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4394474256","doi":"https://doi.org/10.6084/m9.figshare.18132538"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/18132538","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Additional_file_4_of_Edaravone_activates_the_GDNF_RET_neurotrophic_signaling_pathway_and_protects_mRNA-induced_motor_neurons_from_iPS_cells/18132538","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Additional_file_4_of_Edaravone_activates_the_GDNF_RET_neurotrophic_signaling_pathway_and_protects_mRNA-induced_motor_neurons_from_iPS_cells/18132538","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100340542","display_name":"Qian Li","orcid":"https://orcid.org/0000-0001-7922-598X","observed_orcids":["https://orcid.org/0000-0001-7922-598X"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Li, Qian","raw_affiliation_strings":["Kennedy Krieger Institute","Chinese Academy of Medical Sciences & Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kennedy Krieger Institute","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"Chinese Academy of Medical Sciences & Peking Union Medical College","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029794800","display_name":"Yi Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng, Yi","raw_affiliation_strings":["Kennedy Krieger Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kennedy Krieger Institute","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017348251","display_name":"Yingchao Xue","orcid":"https://orcid.org/0000-0002-7830-3146","observed_orcids":["https://orcid.org/0000-0002-7830-3146"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue, Yingchao","raw_affiliation_strings":["Kennedy Krieger Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kennedy Krieger Institute","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073521470","display_name":"Xiping Zhan","orcid":"https://orcid.org/0000-0003-2008-6326","observed_orcids":["https://orcid.org/0000-0003-2008-6326"]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhan, Xiping","raw_affiliation_strings":["Howard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard University","institution_ids":["https://openalex.org/I137853757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101923814","display_name":"Yi Fu","orcid":"https://orcid.org/0000-0002-7079-7057","observed_orcids":["https://orcid.org/0000-0002-7079-7057","https://orcid.org/0009-0008-3627-5416"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fu, Yi","raw_affiliation_strings":["Chinese Academy of Medical Sciences & Peking Union Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences & Peking Union Medical College","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055991444","display_name":"Gege Gui","orcid":"https://orcid.org/0000-0002-4141-183X","observed_orcids":["https://orcid.org/0000-0002-4141-183X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gui, Gege","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024411319","display_name":"Weiqiang Zhou","orcid":"https://orcid.org/0000-0001-9396-9571","observed_orcids":["https://orcid.org/0000-0001-9396-9571"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhou, Weiqiang","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103167219","display_name":"Jean\u2010Philippe Richard","orcid":"https://orcid.org/0000-0003-2890-2316","observed_orcids":["https://orcid.org/0000-0003-2890-2316"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard, Jean-Philippe","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053942296","display_name":"Arens Taga","orcid":"https://orcid.org/0000-0001-7059-3604","observed_orcids":["https://orcid.org/0000-0001-7059-3604"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taga, Arens","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047871740","display_name":"Pan P. Li","orcid":"https://orcid.org/0000-0001-6084-6348","observed_orcids":["https://orcid.org/0000-0001-6084-6348","https://orcid.org/0000-0002-0316-0355"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li, Pan","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035672227","display_name":"Xiaobo Mao","orcid":"https://orcid.org/0000-0001-6587-556X","observed_orcids":["https://orcid.org/0000-0001-6587-556X","https://orcid.org/0009-0008-0311-689X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mao, Xiaobo","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031853409","display_name":"Nicholas John Maragakis","orcid":"https://orcid.org/0000-0002-7311-9614","observed_orcids":["https://orcid.org/0000-0002-7311-9614"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maragakis, Nicholas J.","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080005941","display_name":"Mingyao Ying","orcid":"https://orcid.org/0000-0002-6215-4959","observed_orcids":["https://orcid.org/0000-0002-6215-4959"]},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying, Mingyao","raw_affiliation_strings":["Johns Hopkins University","Kennedy Krieger Institute"],"raw_orcid":"https://orcid.org/0000-0002-6215-4959","affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Kennedy Krieger Institute","institution_ids":["https://openalex.org/I1298154867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.1266999989748001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/edaravone","display_name":"edaravone","score":1.0},{"id":"https://openalex.org/keywords/gdnf-ret-signaling","display_name":"GDNF/RET signaling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/motor-neurons","display_name":"motor neurons","score":0.765999972820282},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/rna-seq-gene-expression","display_name":"RNA-seq gene expression","score":0.75},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.9183045625686646},{"id":"https://openalex.org/C2779554857","wikidata":"https://www.wikidata.org/wiki/Q335099","display_name":"Edaravone","level":2,"score":0.6106425523757935},{"id":"https://openalex.org/C94296188","wikidata":"https://www.wikidata.org/wiki/Q5513091","display_name":"GDNF family of ligands","level":5,"score":0.54640132188797},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.542369544506073},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5087500214576721},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4370635747909546},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4231085777282715},{"id":"https://openalex.org/C2777603835","wikidata":"https://www.wikidata.org/wiki/Q22679857","display_name":"Neurturin","level":5,"score":0.4188840091228485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41822347044944763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34530794620513916},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1834159791469574},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13981667160987854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0983051061630249}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/18132538","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Additional_file_4_of_Edaravone_activates_the_GDNF_RET_neurotrophic_signaling_pathway_and_protects_mRNA-induced_motor_neurons_from_iPS_cells/18132538","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.18132538","doi":"https://doi.org/10.6084/m9.figshare.18132538","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.18132538","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.18132538.v1","doi":"https://doi.org/10.6084/m9.figshare.18132538.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.18132538.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/18132538","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Additional_file_4_of_Edaravone_activates_the_GDNF_RET_neurotrophic_signaling_pathway_and_protects_mRNA-induced_motor_neurons_from_iPS_cells/18132538","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1523782066","https://openalex.org/W1561734908","https://openalex.org/W1931706129","https://openalex.org/W1967600860","https://openalex.org/W1968047722","https://openalex.org/W1970762906","https://openalex.org/W1971208141","https://openalex.org/W1977374662","https://openalex.org/W1984305664","https://openalex.org/W1991107962","https://openalex.org/W1993024959","https://openalex.org/W2016961314","https://openalex.org/W2022923808","https://openalex.org/W2026095435","https://openalex.org/W2026129060","https://openalex.org/W2031135204","https://openalex.org/W2037991731","https://openalex.org/W2040027262","https://openalex.org/W2060406470","https://openalex.org/W2077144621","https://openalex.org/W2091746433","https://openalex.org/W2094603776","https://openalex.org/W2098597036","https://openalex.org/W2104005232","https://openalex.org/W2107018762","https://openalex.org/W2114104545","https://openalex.org/W2144993965","https://openalex.org/W2149370276","https://openalex.org/W2155069534","https://openalex.org/W2167141411","https://openalex.org/W2173508366","https://openalex.org/W2207431495","https://openalex.org/W2317226401","https://openalex.org/W2588226816","https://openalex.org/W2618482665","https://openalex.org/W2751591443","https://openalex.org/W2760524820","https://openalex.org/W2766949700","https://openalex.org/W2802796971","https://openalex.org/W2807099927","https://openalex.org/W2898966044","https://openalex.org/W2903898378","https://openalex.org/W2908621307","https://openalex.org/W2964849163","https://openalex.org/W2985919985","https://openalex.org/W2991360048","https://openalex.org/W3174363935","https://openalex.org/W4252979096"],"related_works":["https://openalex.org/W6977674553","https://openalex.org/W4394304929","https://openalex.org/W4394283945","https://openalex.org/W4226189964","https://openalex.org/W2386130279","https://openalex.org/W2085212929","https://openalex.org/W1993642608","https://openalex.org/W2751146647","https://openalex.org/W2387902300","https://openalex.org/W3140585008"],"abstract_inverted_index":{"Additional":[0],"file":[1],"4:":[2],"Table":[3],"S3.":[4],"Expression":[5],"data":[6],"of":[7],"all":[8],"genes":[9],"detected":[10],"by":[11],"RNA-seq.":[12]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-04-08T00:00:00"}