{"id":"https://openalex.org/W4394432316","doi":"https://doi.org/10.6084/m9.figshare.6282665","title":"Supplementary Material for: Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus","display_name":"Supplementary Material for: Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W4394432316","doi":"https://doi.org/10.6084/m9.figshare.6282665"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/6282665","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Uromodulin_mRNA_from_Urinary_Extracellular_Vesicles_Correlate_to_Kidney_Function_Decline_in_Type_2_Diabetes_Mellitus/6282665","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"supplementary-materials","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Uromodulin_mRNA_from_Urinary_Extracellular_Vesicles_Correlate_to_Kidney_Function_Decline_in_Type_2_Diabetes_Mellitus/6282665","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063725818","display_name":"Cindy M. Yamamoto","orcid":"https://orcid.org/0000-0003-3525-138X","observed_orcids":["https://orcid.org/0000-0003-3525-138X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yamamoto, C.M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Murakami, T.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murakami, T.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082817485","display_name":"Melanie Oakes","orcid":"https://orcid.org/0009-0002-2369-4810","observed_orcids":["https://orcid.org/0009-0002-2369-4810"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oakes, M.L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109155104","display_name":"Masato Mitsuhashi","orcid":"https://orcid.org/0000-0002-3392-140X","observed_orcids":["https://orcid.org/0000-0002-3392-140X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuhashi, M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015983613","display_name":"Colleen Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly, C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045462483","display_name":"Robert R. Henry","orcid":"https://orcid.org/0000-0002-4821-0117","observed_orcids":["https://orcid.org/0000-0002-4821-0117"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry, R.R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088903449","display_name":"Kumar Sharma","orcid":"https://orcid.org/0000-0002-7550-8525","observed_orcids":["https://orcid.org/0000-0002-7550-8525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharma, K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uromodulin","display_name":"uromodulin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/urinary-extracellular-vesicles","display_name":"urinary extracellular vesicles","score":0.9100000262260437},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.8529999852180481},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate","display_name":"estimated glomerular filtration rate","score":0.925000011920929},{"id":"https://openalex.org/keywords/albumin-creatinine-ratio","display_name":"albumin-creatinine ratio","score":0.906000018119812},{"id":"https://openalex.org/keywords/multi-gene-signature","display_name":"multi-gene signature","score":0.6740000247955322},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7360000014305115},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7919999957084656},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C74460091","wikidata":"https://www.wikidata.org/wiki/Q420024","display_name":"Tamm\u2013Horsfall protein","level":3,"score":0.9478184580802917},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.8069272041320801},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5606583952903748},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5456957221031189},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.4844512939453125},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.47478386759757996},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4730198383331299},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44566217064857483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4244900345802307},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.413896769285202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3834032118320465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36962902545928955},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35486656427383423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29275643825531006},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23656964302062988},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2104588747024536},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05102694034576416}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/6282665","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Uromodulin_mRNA_from_Urinary_Extracellular_Vesicles_Correlate_to_Kidney_Function_Decline_in_Type_2_Diabetes_Mellitus/6282665","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.6282665","doi":"https://doi.org/10.6084/m9.figshare.6282665","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.6282665","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.6282665.v1","doi":"https://doi.org/10.6084/m9.figshare.6282665.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.6282665.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/6282665","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Uromodulin_mRNA_from_Urinary_Extracellular_Vesicles_Correlate_to_Kidney_Function_Decline_in_Type_2_Diabetes_Mellitus/6282665","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2803275571","https://openalex.org/W4366245580","https://openalex.org/W3207389080","https://openalex.org/W4322723917","https://openalex.org/W3189043443","https://openalex.org/W4415147867","https://openalex.org/W3214666799","https://openalex.org/W2889550118","https://openalex.org/W4397025453","https://openalex.org/W4398233571"],"abstract_inverted_index":{"Background:":[0],"Extracellular":[1],"vesicles":[2],"(EVs)":[3],"enclose":[4],"mRNA":[5,24,78,178,234,255,277],"derived":[6],"from":[7,25,79,154,179,260],"their":[8],"cell":[9],"of":[10,17,62,69,91,197,201,217,228],"origin":[11],"and":[12,39,41,56,88,120,133,141,150,157,171,182,192,199,265,271,287],"are":[13,257],"considered":[14],"a":[15,85,138,187,195,223,246],"source":[16],"potential":[18,51],"biomarkers.":[19],"We":[20,129],"examined":[21],"urinary":[22],"EV":[23,77,123,253,276],"individuals":[26],"with":[27,122,177,194,203,267,282],"diabetic":[28],"kidney":[29,33,54,249],"disease":[30,55],"(DKD),":[31],"chronic":[32],"disease,":[34],"type":[35],"2":[36,117],"diabetes":[37],"(T2DM),":[38],"obese":[40],"healthy":[42,148],"controls":[43,149],"to":[44,52,147,165,221,262],"determine":[45],"if":[46],"such":[47],"biomarkers":[48],"had":[49],"the":[50,89,206,240],"classify":[53],"predict":[57],"patients":[58,113],"at":[59,126],"higher":[60],"risk":[61],"renal":[63],"function":[64],"decline.":[65],"Methods:":[66],"A":[67],"total":[68],"242":[70],"participants":[71],"enrolled":[72],"in":[73,104,110,144,248],"this":[74,233],"study.":[75],"Urinary":[76,252],"all":[80],"subjects":[81],"were":[82,95,114,219],"isolated":[83],"by":[84,97],"filter-based":[86],"platform,":[87],"expression":[90,151,161],"8":[92],"target":[93],"genes":[94],"determined":[96,220],"quantitative":[98],"polymerase":[99],"chain":[100],"reaction":[101],"(qPCR).":[102],"Changes":[103],"estimated":[105],"glomerular":[106],"filtration":[107],"rate":[108],"(eGFR)":[109],"161":[111],"T2DM":[112,183,218,261],"evaluated":[115],"for":[116],"consecutive":[118],"years":[119],"compared":[121,146],"RNA":[124],"profiles":[125],"baseline.":[127],"Results:":[128],"observe":[130],"that":[131],"mild":[132],"severe":[134,180],"DKD":[135,158,181,191,230,263,281],"groups":[136,264],"show":[137],"significant":[139],"3.2-":[140],"\u00ad4.4-fold":[142],"increase":[143],"UMOD":[145,160,254],"increases":[152],"linearly":[153],"healthy,":[155],"diabetic,":[156],"subjects.":[159],"is":[162],"significantly":[163],"correlated":[164],"albumin":[166],"creatinine":[167],"ratio":[168],"(ACR),":[169],"eGFR,":[170],"HbA1c.":[172],"Using":[173],"linear":[174],"discriminant":[175],"analyses":[176],"as":[184],"training":[185],"data,":[186],"multi-gene":[188],"signature":[189,278],"classified":[190],"\u00adnon-DKD":[193],"sensitivity":[196,286],"93%":[198],"specificity":[200],"73%":[202],"area":[204],"under":[205],"receiver":[207],"operating":[208],"characteristic":[209],"(ROC)":[210],"curve":[211],"(AUC)":[212],"=":[213],"0.90.":[214],"Although":[215],"6%":[216],"have":[222],">":[224],"80%":[225],"posterior":[226],"probability":[227],"developing":[229],"based":[231],"on":[232],"profile,":[235],"eGFR":[236,270],"changes":[237],"observed":[238],"within":[239],"2-year":[241],"follow-up":[242],"did":[243],"not":[244],"reveal":[245],"decline":[247],"function.":[250],"Conclusion:":[251],"levels":[256],"progressively":[258],"elevated":[259],"correlate":[266],"widely":[268],"used":[269],"ACR":[272],"diagnostic":[273],"criteria.":[274],"An":[275],"could":[279],"identify":[280],"greater":[283],"than":[284],"90%":[285],"70%":[288],"specificity.":[289]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-04-08T00:00:00"}
