{"id":"https://openalex.org/W4394423249","doi":"https://doi.org/10.6084/m9.figshare.8203577","title":"Altered microRNA expression profiles in large offspring syndrome and Beckwith-Wiedemann syndrome","display_name":"Altered microRNA expression profiles in large offspring syndrome and Beckwith-Wiedemann syndrome","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W4394423249","doi":"https://doi.org/10.6084/m9.figshare.8203577"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/8203577","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Altered_microRNA_expression_profiles_in_large_offspring_syndrome_and_Beckwith-Wiedemann_syndrome/8203577","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Altered_microRNA_expression_profiles_in_large_offspring_syndrome_and_Beckwith-Wiedemann_syndrome/8203577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029499412","display_name":"Yahan Li","orcid":"https://orcid.org/0000-0003-3062-4626","observed_orcids":["https://orcid.org/0000-0003-3062-4626","https://orcid.org/0009-0003-0144-9133"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yahan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014950784","display_name":"Darren E. Hagen","orcid":"https://orcid.org/0000-0001-8295-020X","observed_orcids":["https://orcid.org/0000-0001-8295-020X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hagen, Darren Erich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005418198","display_name":"Tieming Ji","orcid":"https://orcid.org/0000-0002-1915-5892","observed_orcids":["https://orcid.org/0000-0002-1915-5892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tieming Ji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103174563","display_name":"Mohammad Reza Bakhtiarizadeh","orcid":"https://orcid.org/0000-0001-5336-6987","observed_orcids":["https://orcid.org/0000-0001-5336-6987","https://orcid.org/0000-0003-3712-1909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bakhtiarizadeh, Mohammad Reza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033492283","display_name":"Whitney M. Frederic","orcid":"https://orcid.org/0000-0002-0683-4415","observed_orcids":["https://orcid.org/0000-0002-0683-4415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederic, Whitney M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032065900","display_name":"Emily M. Traxler","orcid":"https://orcid.org/0000-0003-2603-2097","observed_orcids":["https://orcid.org/0000-0003-2603-2097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Traxler, Emily M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075046653","display_name":"Jennifer M. Kalish","orcid":"https://orcid.org/0000-0003-1500-9713","observed_orcids":["https://orcid.org/0000-0003-1500-9713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kalish, Jennifer M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086361484","display_name":"Roc\u00edo Melissa Rivera","orcid":"https://orcid.org/0000-0002-9832-9618","observed_orcids":["https://orcid.org/0000-0002-9832-9618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rivera, Roc\u00edo Melissa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-offspring-syndrome","display_name":"large offspring syndrome","score":0.9620000123977661},{"id":"https://openalex.org/keywords/beckwith-wiedemann-syndrome","display_name":"Beckwith-Wiedemann syndrome","score":1.0},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.8059999942779541},{"id":"https://openalex.org/keywords/congenital-overgrowth","display_name":"congenital overgrowth","score":0.8740000128746033},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.9589999914169312},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9850000143051147},{"id":"https://openalex.org/keywords/human-tongue","display_name":"human tongue","score":0.6129999756813049},{"id":"https://openalex.org/keywords/differentially-expressed-mirnas","display_name":"differentially expressed miRNAs","score":0.7689999938011169},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.4269999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2777575177","wikidata":"https://www.wikidata.org/wiki/Q521863","display_name":"Beckwith\u2013Wiedemann syndrome","level":5,"score":0.9139776229858398},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7624080181121826},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6711426973342896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49451372027397156},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4330292046070099},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2642669081687927},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19953438639640808},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1465146541595459},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.07791793346405029}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/8203577","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Altered_microRNA_expression_profiles_in_large_offspring_syndrome_and_Beckwith-Wiedemann_syndrome/8203577","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.8203577","doi":"https://doi.org/10.6084/m9.figshare.8203577","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.8203577","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.8203577.v1","doi":"https://doi.org/10.6084/m9.figshare.8203577.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.8203577.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/8203577","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Altered_microRNA_expression_profiles_in_large_offspring_syndrome_and_Beckwith-Wiedemann_syndrome/8203577","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402793195","https://openalex.org/W2806274619","https://openalex.org/W2034417921","https://openalex.org/W2149500808","https://openalex.org/W3194946359","https://openalex.org/W2978256859","https://openalex.org/W4415197867","https://openalex.org/W4309108464","https://openalex.org/W4394468233","https://openalex.org/W2177088128"],"abstract_inverted_index":{"The":[0],"use":[1],"of":[2,43,163,170,181,216,224,234,242],"assisted":[3],"reproductive":[4],"technologies":[5],"(ART)":[6],"can":[7],"induce":[8],"a":[9],"congenital":[10],"overgrowth":[11],"condition":[12],"in":[13,45,65,88,114,128,153,165,231,245],"humans":[14],"and":[15,21,29,36,67,90,99,109,125,137,155,175,196,221,247],"ruminants,":[16],"namely":[17],"Beckwith-Wiedemann":[18],"syndrome":[19,24],"(BWS)":[20],"large":[22],"offspring":[23],"(LOS),":[25],"respectively.":[26],"Shared":[27],"phenotypes":[28],"epigenotypes":[30],"have":[31,39],"been":[32],"found":[33,200],"between":[34,123,135],"BWS":[35,136],"LOS.":[37,49],"We":[38,58,93],"observed":[40],"global":[41],"misregulation":[42,64,70,244],"transcripts":[44],"bovine":[46,89,106],"foetuses":[47],"with":[48,73,161,179,204],"microRNAs":[50],"(miRNAs)":[51],"are":[52],"important":[53],"post-transcriptional":[54],"gene":[55],"expression":[56,86],"regulators.":[57],"hypothesize":[59],"that":[60,68],"there":[61],"is":[62,71,212],"miRNA":[63,85,146,243],"LOS":[66,126,154,235,246],"this":[69,76],"shared":[72],"BWS.":[74,156,248],"In":[75],"study,":[77],"small":[78],"RNA":[79],"sequencing":[80,107],"was":[81,159,229],"conducted":[82],"to":[83,201],"investigate":[84],"profiles":[87],"human":[91,115,139],"samples.":[92,140],"detected":[94,143,230],"407":[95],"abundant":[96,112],"known":[97],"miRNAs":[98,103,113,119,164],"predicted":[100,174],"196":[101],"putative":[102],"from":[104,144],"the":[105,166,171,185,213,217],"results":[108],"identified":[110,122],"505":[111],"tongue.":[116],"Differentially":[117],"expressed":[118],"(DE-miRNAs)":[120],"were":[121,142,173,199],"control":[124,138,180],"groups":[127],"all":[129],"tissues":[130],"analysed":[131],"as":[132,134],"well":[133],"DE-miRNAs":[141,172],"several":[145],"clusters":[147],"including":[148],"DLK1-DIO3":[149],"genomic":[150],"imprinted":[151],"cluster":[152],"DNA":[157],"hypermethylation":[158],"associated":[160,178,208],"downregulation":[162],"DLK1-DIO3.":[167],"mRNA":[168],"targets":[169],"signalling":[176,187,219],"pathways":[177],"organ":[182],"size":[183],"(including":[184],"Hippo":[186,218],"pathway),":[188],"cell":[189,192,194,197],"proliferation,":[190],"apoptosis,":[191],"survival,":[193],"cycle,":[195],"adhesion":[198],"be":[202],"enriched":[203],"these":[205],"genes.":[206],"Yes":[207],"protein":[209,228],"1":[210],"(YAP1)":[211],"core":[214],"effector":[215],"pathway,":[220],"increased":[222],"level":[223],"active":[225],"(non-phosphorylated)":[226],"YAP1":[227],"skeletal":[232],"muscle":[233],"foetuses.":[236],"Overall,":[237],"our":[238],"data":[239],"provide":[240],"evidence":[241]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}