{"id":"https://openalex.org/W4394420527","doi":"https://doi.org/10.6084/m9.figshare.1301951","title":"Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling","display_name":"Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W4394420527","doi":"https://doi.org/10.6084/m9.figshare.1301951"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/1301951","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analysis_of_Sequence_Data_Under_Multivariate_Trait_Dependent_Sampling/1301951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Analysis_of_Sequence_Data_Under_Multivariate_Trait_Dependent_Sampling/1301951","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tao, Ran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao, Ran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056322441","display_name":"Donglin Zeng","orcid":"https://orcid.org/0000-0003-0843-9280","observed_orcids":["https://orcid.org/0000-0003-0843-9280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeng, Donglin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004946791","display_name":"Nora Franceschini","orcid":"https://orcid.org/0009-0001-8346-3662","observed_orcids":["https://orcid.org/0009-0001-8346-3662","https://orcid.org/0000-0001-9755-2175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franceschini, Nora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062296084","display_name":"Kari E. North","orcid":"https://orcid.org/0000-0002-8903-0366","observed_orcids":["https://orcid.org/0000-0002-8903-0366","https://orcid.org/0000-0002-0581-149X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. North, Kari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044048476","display_name":"Eric Boerwinkle","orcid":"https://orcid.org/0000-0001-8813-0544","observed_orcids":["https://orcid.org/0000-0001-8813-0544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boerwinkle, Eric","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061416108","display_name":"Danyu Y. Lin","orcid":"https://orcid.org/0000-0002-0150-3115","observed_orcids":["https://orcid.org/0000-0002-0150-3115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin, Dan-Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sequencing-data","display_name":"sequence data","score":0.4090000092983246},{"id":"https://openalex.org/keywords/rare-variant-association","display_name":"rare variant association","score":0.6809999942779541},{"id":"https://openalex.org/keywords/likelihood-based-inference","display_name":"likelihood-based inference","score":0.5590000152587891},{"id":"https://openalex.org/keywords/expectation-maximization-algorithm","display_name":"expectation-maximization algorithm","score":0.9229999780654907},{"id":"https://openalex.org/keywords/maximum-likelihood-estimation","display_name":"maximum likelihood estimation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/estimation-bias","display_name":"estimation bias","score":0.6159999966621399},{"id":"https://openalex.org/keywords/type-i-error-inflation","display_name":"type I error inflation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/power-losses","display_name":"power losses","score":0.6190000176429749},{"id":"https://openalex.org/keywords/targeted-sequencing","display_name":"targeted sequencing","score":0.6629999876022339},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.8370000123977661},{"id":"https://openalex.org/keywords/genetic-association-studies","display_name":"genetic association studies","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.6749775409698486},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.628224790096283},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5897862911224365},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5482365489006042},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.5066326260566711},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4479694068431854},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.35823071002960205},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3478550910949707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26175716519355774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16321763396263123},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:figshare.com:article/1301951","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analysis_of_Sequence_Data_Under_Multivariate_Trait_Dependent_Sampling/1301951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1301951","doi":"https://doi.org/10.6084/m9.figshare.1301951","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1301951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1301951.v1","doi":"https://doi.org/10.6084/m9.figshare.1301951.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1301951.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1301951.v2","doi":"https://doi.org/10.6084/m9.figshare.1301951.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1301951.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1301951.v3","doi":"https://doi.org/10.6084/m9.figshare.1301951.v3","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1301951.v3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1301951.v4","doi":"https://doi.org/10.6084/m9.figshare.1301951.v4","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1301951.v4","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/1301951","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Analysis_of_Sequence_Data_Under_Multivariate_Trait_Dependent_Sampling/1301951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012610160","https://openalex.org/W2064420409","https://openalex.org/W2291002025","https://openalex.org/W1977673229","https://openalex.org/W2027942918","https://openalex.org/W2085383456","https://openalex.org/W2587323761","https://openalex.org/W4362591564","https://openalex.org/W2537153370","https://openalex.org/W2023775529"],"abstract_inverted_index":{"High-throughput":[0],"DNA":[1],"sequencing":[2],"allows":[3],"for":[4,12,21,150,175,199],"the":[5,17,22,55,59,98,115,119,155,158,173,187],"genotyping":[6],"of":[7,49,78,82,88,118,157],"common":[8],"and":[9,20,86,101,113,177,186,191],"rare":[10,151],"variants":[11],"genetic":[13],"association":[14,148],"studies.":[15,168],"At":[16],"present":[18],"time":[19],"foreseeable":[23],"future,":[24],"it":[25],"is":[26,41],"not":[27],"economically":[28],"feasible":[29],"to":[30,42,129,146,172],"sequence":[31,43],"all":[32,103],"individuals":[33,45],"in":[34,76,180],"a":[35,50,92,108],"large":[36],"cohort.":[37],"A":[38],"cost-effective":[39],"strategy":[40],"those":[44],"with":[46],"extreme":[47],"values":[48],"quantitative":[51,64],"trait.":[52],"We":[53,90,106,142,153,169],"consider":[54],"design":[56],"under":[57],"which":[58],"sampling":[60,99],"depends":[61],"on":[62,133,139],"multiple":[63,140],"traits.":[65,141],"Under":[66],"such":[67],"trait-dependent":[68],"sampling,":[69],"standard":[70,162],"linear":[71,163],"regression":[72,164],"analysis":[73],"can":[74,126],"result":[75],"bias":[77],"parameter":[79],"estimation,":[80],"inflation":[81],"Type":[83],"I":[84],"error,":[85],"loss":[87],"power.":[89],"construct":[91],"likelihood":[93,122],"function":[94],"that":[95],"properly":[96],"reflects":[97],"mechanism":[100],"uses":[102],"available":[104,203],"data.":[105],"implement":[107],"computationally":[109],"efficient":[110],"EM":[111],"algorithm":[112],"establish":[114],"theoretical":[116],"properties":[117],"resulting":[120],"maximum":[121],"estimators.":[123],"Our":[124],"methods":[125,160],"be":[127],"used":[128],"perform":[130],"separate":[131],"inference":[132,138],"each":[134],"trait":[135],"or":[136],"simultaneous":[137],"pay":[143],"special":[144],"attention":[145],"gene-level":[147],"tests":[149],"variants.":[152],"demonstrate":[154],"superiority":[156],"proposed":[159],"over":[161],"through":[165],"extensive":[166],"simulation":[167],"provide":[170],"applications":[171],"Cohorts":[174],"Heart":[176],"Aging":[178],"Research":[179],"Genomic":[181],"Epidemiology":[182],"Targeted":[183],"Sequencing":[184,195],"Study":[185],"National":[188],"Heart,":[189],"Lung,":[190],"Blood":[192],"Institute":[193],"Exome":[194],"Project.":[196],"Supplementary":[197],"materials":[198],"this":[200],"article":[201],"are":[202],"online.":[204]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-04-08T00:00:00"}
