{"id":"https://openalex.org/W4394396142","doi":"https://doi.org/10.6084/m9.figshare.12850301","title":"What is the best drug treatment for premenopausal women with bleeding irregularities using the levonorgestrel-releasing intrauterine system? A systematic review","display_name":"What is the best drug treatment for premenopausal women with bleeding irregularities using the levonorgestrel-releasing intrauterine system? A systematic review","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W4394396142","doi":"https://doi.org/10.6084/m9.figshare.12850301"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/12850301","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/What_is_the_best_drug_treatment_for_premenopausal_women_with_bleeding_irregularities_using_the_levonorgestrel-releasing_intrauterine_system_A_systematic_review/12850301","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/What_is_the_best_drug_treatment_for_premenopausal_women_with_bleeding_irregularities_using_the_levonorgestrel-releasing_intrauterine_system_A_systematic_review/12850301","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045730265","display_name":"Patty A.H.H. van der Heijden","orcid":"https://orcid.org/0000-0002-5290-7646","observed_orcids":["https://orcid.org/0000-0002-5290-7646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"van der Heijden, P. A. H. H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074875082","display_name":"R. M. G. Tibosch","orcid":"https://orcid.org/0000-0003-1381-3708","observed_orcids":["https://orcid.org/0000-0003-1381-3708"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tibosch, R. M. G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036592494","display_name":"Peggy M. A. J. Geomini","orcid":"https://orcid.org/0000-0002-1951-1076","observed_orcids":["https://orcid.org/0000-0002-1951-1076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geomini, P. M. A. J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057734421","display_name":"Sebastiaan Veersema","orcid":"https://orcid.org/0000-0002-9264-4908","observed_orcids":["https://orcid.org/0000-0002-9264-4908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veersema, S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039922770","display_name":"Lauren Maria Bullens","orcid":"https://orcid.org/0000-0003-0520-657X","observed_orcids":["https://orcid.org/0000-0003-0520-657X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bullens, L. M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002288385","display_name":"E. J. L. G. Delvaux","orcid":"https://orcid.org/0000-0002-9782-1125","observed_orcids":["https://orcid.org/0000-0002-9782-1125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delvaux, E. J. L. G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031366327","display_name":"Bich Ngoc Bui","orcid":"https://orcid.org/0000-0003-3542-6215","observed_orcids":["https://orcid.org/0000-0003-3542-6215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bui, B. N.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065413089","display_name":"Marlies Y. Bongers","orcid":"https://orcid.org/0000-0001-9276-9148","observed_orcids":["https://orcid.org/0000-0001-9276-9148"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bongers, M. Y.","raw_affiliation_strings":["Maastricht University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levonorgestrel-releasing-intrauterine-system","display_name":"levonorgestrel-releasing intrauterine system","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bleeding-irregularities","display_name":"bleeding irregularities","score":0.8560000061988831},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.8679999709129333},{"id":"https://openalex.org/keywords/naproxen","display_name":"naproxen","score":0.8199999928474426},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mifepristone","display_name":"mifepristone","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ulipristal-acetate","display_name":"ulipristal acetate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mefenamic-acid","display_name":"mefenamic acid","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/progesterone-receptor-modulators","display_name":"progesterone receptor modulators","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2780186607","wikidata":"https://www.wikidata.org/wiki/Q416950","display_name":"Levonorgestrel","level":5,"score":0.9809802770614624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6589828729629517},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6587693691253662},{"id":"https://openalex.org/C2776810592","wikidata":"https://www.wikidata.org/wiki/Q899868","display_name":"Intrauterine device","level":5,"score":0.4659009873867035},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4566153883934021},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.42858999967575073},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25874191522598267},{"id":"https://openalex.org/C2779076696","wikidata":"https://www.wikidata.org/wiki/Q1280670","display_name":"Family planning","level":4,"score":0.2081548571586609},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.09378889203071594},{"id":"https://openalex.org/C2986817661","wikidata":"https://www.wikidata.org/wiki/Q185698","display_name":"Research methodology","level":3,"score":0.09364238381385803},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/12850301","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/What_is_the_best_drug_treatment_for_premenopausal_women_with_bleeding_irregularities_using_the_levonorgestrel-releasing_intrauterine_system_A_systematic_review/12850301","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.12850301","doi":"https://doi.org/10.6084/m9.figshare.12850301","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12850301","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.12850301.v1","doi":"https://doi.org/10.6084/m9.figshare.12850301.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12850301.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/12850301","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/What_is_the_best_drug_treatment_for_premenopausal_women_with_bleeding_irregularities_using_the_levonorgestrel-releasing_intrauterine_system_A_systematic_review/12850301","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3005735742","https://openalex.org/W2896945405","https://openalex.org/W2162160149","https://openalex.org/W2028001014","https://openalex.org/W4408704130","https://openalex.org/W6925591241","https://openalex.org/W2140370772","https://openalex.org/W1998892782","https://openalex.org/W4293019577","https://openalex.org/W2040431072"],"abstract_inverted_index":{"Up":[0],"to":[1,31,70],"60%":[2],"of":[3,16,27,47,86,105,115,123,149,175,188,198,215,222,228],"women":[4,39,88,151],"discontinue":[5],"using":[6,40,89],"the":[7,28,41,51,90,121,127,167,185,219,229,239],"levonorgestrel-releasing":[8],"intrauterine":[9],"system":[10],"(LNG-IUS)":[11],"within":[12],"5":[13],"years":[14],"because":[15],"bleeding":[17,36,97,189,207,224],"irregularities,":[18],"pain":[19],"and/or":[20],"systemic":[21],"progestogenic":[22],"adverse":[23],"effects.":[24],"The":[25,117,143,173],"aim":[26],"study":[29],"was":[30,120],"assess":[32],"treatment":[33,95,187,221],"options":[34],"for":[35,63,96,184,218],"irregularities":[37,208,225],"in":[38,204],"52":[42],"mg":[43],"LNG-IUS.":[44],"Database":[45],"searches":[46],"Medline,":[48],"Embase/Ovid":[49],"and":[50,57,83,92,102,138,233],"Cochrane":[52],"Library":[53],"were":[54,59,75,108,153],"carried":[55,109],"out,":[56],"journals":[58],"searched":[60],"by":[61,112],"hand,":[62],"relevant":[64],"studies":[65,82,85,129,145],"published":[66],"from":[67],"database":[68],"inception":[69],"March":[71],"2020.":[72],"Inclusion":[73],"criteria":[74],"randomised":[76],"controlled":[77],"trials":[78],"(RCTs),":[79],"prospective":[80,140],"cohort":[81,141],"case\u2013control":[84],"premenopausal":[87],"LNG-IUS":[91,194,230],"receiving":[93],"medical":[94,220],"irregularities.":[98],"Screening,":[99],"data":[100],"extraction":[101],"quality":[103],"assessment":[104],"retrieved":[106],"articles":[107],"out":[110],"independently":[111],"two":[113,139],"pairs":[114],"reviewers.":[116],"primary":[118],"outcome":[119],"reduction":[122],"bleeding/spotting":[124],"days.":[125],"Of":[126],"3061":[128],"identified,":[130],"eight":[131,144],"met":[132],"our":[133,176],"inclusion":[134],"criteria:":[135],"six":[136],"RCTs":[137],"studies.":[142],"enrolled":[146],"a":[147],"total":[148],"677":[150],"who":[152],"treated":[154],"with":[155],"tamoxifen,":[156],"mifepristone,":[157],"ulipristal":[158],"acetate,":[159],"naproxen,":[160],"oestradiol,":[161],"mefenamic":[162],"acid,":[163],"tranexamic":[164],"acid":[165],"or":[166],"progesterone":[168],"receptor":[169],"modulator":[170],"CDB":[171],"2914.":[172],"results":[174],"analysis":[177],"indicated":[178],"that":[179],"naproxen":[180],"may":[181,201],"be":[182,202],"effective":[183,203],"prophylactic":[186],"immediately":[190],"(<12":[191],"weeks)":[192],"after":[193,211],"insertion":[195,212],"(high":[196],"level":[197,214],"evidence).":[199,216],"Oestradiol":[200],"treating":[205],"ongoing":[206],">6":[209],"months":[210],"(low":[213],"Evidence":[217],"(ongoing)":[223],"during":[226],"use":[227],"is":[231,236],"lacking":[232],"more":[234],"research":[235],"needed":[237],"on":[238],"topic.":[240]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-04-08T00:00:00"}
