{"id":"https://openalex.org/W4394339105","doi":"https://doi.org/10.6084/m9.figshare.20651682","title":"Supplementary Files.zip from GNL3 is an evolutionarily conserved stem cell gene influencing cell proliferation, animal growth and regeneration in the hydrozoan Hydractinia","display_name":"Supplementary Files.zip from GNL3 is an evolutionarily conserved stem cell gene influencing cell proliferation, animal growth and regeneration in the hydrozoan Hydractinia","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4394339105","doi":"https://doi.org/10.6084/m9.figshare.20651682"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/20651682","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Files_zip_from_i_GNL3_i_is_an_evolutionarily_conserved_stem_cell_gene_influencing_cell_proliferation_animal_growth_and_regeneration_in_the_hydrozoan_i_Hydractinia_i_/20651682","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"supplementary-materials","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Supplementary_Files_zip_from_i_GNL3_i_is_an_evolutionarily_conserved_stem_cell_gene_influencing_cell_proliferation_animal_growth_and_regeneration_in_the_hydrozoan_i_Hydractinia_i_/20651682","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014997279","display_name":"Gonzalo Quiroga-Artigas","orcid":"https://orcid.org/0000-0001-5954-6794","observed_orcids":["https://orcid.org/0000-0001-5954-6794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quiroga-Artigas, Gonzalo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5954-6794","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102725930","display_name":"Danielle de Jong","orcid":"https://orcid.org/0000-0002-6773-723X","observed_orcids":["https://orcid.org/0000-0002-6773-723X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"de Jong, Danielle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020817043","display_name":"Christine E. Schnitzler","orcid":"https://orcid.org/0000-0002-5001-6524","observed_orcids":["https://orcid.org/0000-0002-5001-6524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schnitzler, Christine E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gnl3","display_name":"GNL3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nucleostemin","display_name":"nucleostemin","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hydractinia-symbiolongicarpus","display_name":"Hydractinia symbiolongicarpus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.7210000157356262},{"id":"https://openalex.org/keywords/germ-cells","display_name":"germ cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/regeneration","display_name":"regeneration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/animal-growth","display_name":"animal growth","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sexual-reproduction","display_name":"sexual reproduction","score":0.722000002861023},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.46799999475479126},{"id":"https://openalex.org/keywords/crispr-cas9-genome-editing","display_name":"CRISPR/Cas9 genome editing","score":0.7699999809265137},{"id":"https://openalex.org/keywords/larval-development","display_name":"larval development","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7372839450836182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7368507385253906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5536031126976013},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.483053982257843},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4597734212875366},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43878450989723206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3552616238594055},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3408748507499695},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.336264431476593}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/20651682","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Files_zip_from_i_GNL3_i_is_an_evolutionarily_conserved_stem_cell_gene_influencing_cell_proliferation_animal_growth_and_regeneration_in_the_hydrozoan_i_Hydractinia_i_/20651682","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.20651682","doi":"https://doi.org/10.6084/m9.figshare.20651682","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.20651682","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.20651682.v1","doi":"https://doi.org/10.6084/m9.figshare.20651682.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.20651682.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/20651682","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Files_zip_from_i_GNL3_i_is_an_evolutionarily_conserved_stem_cell_gene_influencing_cell_proliferation_animal_growth_and_regeneration_in_the_hydrozoan_i_Hydractinia_i_/20651682","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4294861173","https://openalex.org/W4392985716","https://openalex.org/W4386221762","https://openalex.org/W2465310138","https://openalex.org/W1996192921","https://openalex.org/W2137887198","https://openalex.org/W6884837968","https://openalex.org/W1992289305","https://openalex.org/W6922197159","https://openalex.org/W4367310030"],"abstract_inverted_index":{"Nucleostemin":[0],"(NS)":[1],"is":[2,106,163],"a":[3,39,61,83],"vertebrate":[4,36],"gene":[5,171],"preferentially":[6],"expressed":[7,107],"in":[8,34,77,108,125,139,173,182],"stem":[9,90,109,167,195],"and":[10,22,26,67,96,110,122,153,169,179,184,193],"cancer":[11],"cells,":[12],"which":[13],"acts":[14],"to":[15],"regulate":[16],"cell":[17,168,174,196],"cycle":[18,95],"progression,":[19],"genome":[20],"stability":[21],"ribosome":[23],"biogenesis.":[24],"NS":[25],"its":[27,93],"paralogous":[28],"gene,":[29,45,72],"GNL3-like":[30],"(GNL3":[31],"L),":[32],"arose":[33],"the":[35,65,70,78,118,189],"clade":[37],"after":[38],"duplication":[40],"event":[41],"from":[42],"their":[43],"orthologous":[44],"G":[46],"protein":[47],"Nucleolar":[48],"3":[49],"(GNL3).":[50],"Research":[51],"on":[52],"invertebrate":[53],"GNL3,":[54],"however,":[55],"has":[56],"been":[57],"limited.":[58],"To":[59],"gain":[60],"greater":[62],"understanding":[63],"of":[64,69,115,120,128,133,191,194],"evolution":[66,190],"functions":[68],"GNL3":[71,105,116,135,162,192],"we":[73],"have":[74],"performed":[75],"studies":[76],"hydrozoan":[79],"cnidarian":[80],"Hydractinia":[81,104,126,134],"symbiolongicarpus,":[82],"colonial":[84],"hydroid":[85],"that":[86,103,161],"continuously":[87],"generates":[88],"pluripotent":[89],"cells":[91,124],"throughout":[92],"life":[94],"presents":[97],"impressive":[98],"regenerative":[99],"abilities.":[100],"We":[101],"show":[102],"germline":[111,170],"cells.":[112],"The":[113],"knockdown":[114],"reduces":[117],"number":[119],"mitotic":[121],"S-phase":[123],"larvae":[127],"different":[129],"ages.":[130],"Genome":[131],"editing":[132],"via":[136],"CRISPR/Cas9":[137],"resulted":[138],"colonies":[140],"with":[141,146],"reduced":[142],"growth":[143],"rates,":[144],"polyps":[145],"impaired":[147],"regeneration":[148,178],"capabilities,":[149],"gonadal":[150],"morphological":[151],"defects,":[152],"low":[154],"sperm":[155],"motility.":[156],"Collectively,":[157],"our":[158],"study":[159],"shows":[160],"an":[164],"evolutionarily":[165],"conserved":[166],"involved":[172],"proliferation,":[175],"animal":[176],"growth,":[177],"sexual":[180],"reproduction":[181],"Hydractinia,":[183],"sheds":[185],"new":[186],"light":[187],"into":[188],"systems.":[197]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}