{"id":"https://openalex.org/W4394297900","doi":"https://doi.org/10.6084/m9.figshare.22799950","title":"Additional file 1 of Sex differences in the polygenic architecture of hearing problems in adults","display_name":"Additional file 1 of Sex differences in the polygenic architecture of hearing problems in adults","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4394297900","doi":"https://doi.org/10.6084/m9.figshare.22799950"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/22799950","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Additional_file_1_of_Sex_differences_in_the_polygenic_architecture_of_hearing_problems_in_adults/22799950","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Additional_file_1_of_Sex_differences_in_the_polygenic_architecture_of_hearing_problems_in_adults/22799950","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010617281","display_name":"Flavio De Angelis","orcid":"https://orcid.org/0000-0002-4747-2385","observed_orcids":["https://orcid.org/0000-0002-4747-2385"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"De Angelis, Flavio","raw_affiliation_strings":["Yale University","University of Rome Tor Vergata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"University of Rome Tor Vergata","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057305577","display_name":"Oana Alina Zeleznik","orcid":"https://orcid.org/0000-0002-8705-1163","observed_orcids":["https://orcid.org/0000-0002-8705-1163"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeleznik, Oana A.","raw_affiliation_strings":["Harvard University","Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053756905","display_name":"Frank R. Wendt","orcid":"https://orcid.org/0000-0002-2108-6822","observed_orcids":["https://orcid.org/0000-0002-2108-6822"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendt, Frank R.","raw_affiliation_strings":["Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079061122","display_name":"Gita A. Pathak","orcid":"https://orcid.org/0000-0003-3943-0895","observed_orcids":["https://orcid.org/0000-0003-3943-0895"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pathak, Gita A.","raw_affiliation_strings":["VA Connecticut Healthcare System","Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VA Connecticut Healthcare System","institution_ids":["https://openalex.org/I4210086971"]},{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088147704","display_name":"Daniel S. Tylee","orcid":"https://orcid.org/0000-0002-7579-6096","observed_orcids":["https://orcid.org/0000-0002-7579-6096"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tylee, Daniel S.","raw_affiliation_strings":["Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052727878","display_name":"Antonella De Lillo","orcid":"https://orcid.org/0000-0003-0746-5209","observed_orcids":["https://orcid.org/0000-0003-0746-5209"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"De Lillo, Antonella","raw_affiliation_strings":["Yale University","University of Rome Tor Vergata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"University of Rome Tor Vergata","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044784338","display_name":"D\u00f3ra Koller","orcid":"https://orcid.org/0000-0002-0415-0466","observed_orcids":["https://orcid.org/0000-0002-0415-0466"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Koller, Dora","raw_affiliation_strings":["Yale University","University of Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"University of Barcelona","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013581165","display_name":"Brenda Cabrera\u2010Mendoza","orcid":"https://orcid.org/0000-0003-4729-9997","observed_orcids":["https://orcid.org/0000-0003-4729-9997"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cabrera-Mendoza, Brenda","raw_affiliation_strings":["Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073682906","display_name":"Royce Ellen Clifford","orcid":"https://orcid.org/0000-0002-5515-4336","observed_orcids":["https://orcid.org/0000-0002-5515-4336"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clifford, Royce E.","raw_affiliation_strings":["University of California, San Diego","VA San Diego Healthcare System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032327859","display_name":"Adam X. Maihofer","orcid":"https://orcid.org/0000-0003-4517-1623","observed_orcids":["https://orcid.org/0000-0003-4517-1623"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maihofer, Adam X.","raw_affiliation_strings":["University of California, San Diego","VA San Diego Healthcare System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025127395","display_name":"Caroline M. Nievergelt","orcid":"https://orcid.org/0000-0001-5766-8923","observed_orcids":["https://orcid.org/0000-0001-5766-8923"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nievergelt, Caroline M.","raw_affiliation_strings":["University of California, San Diego","VA San Diego Healthcare System"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"VA San Diego Healthcare System","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051186379","display_name":"Gary C. Curhan","orcid":"https://orcid.org/0000-0001-7386-6305","observed_orcids":["https://orcid.org/0000-0001-7386-6305"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curhan, Gary C.","raw_affiliation_strings":["Harvard University","Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065121190","display_name":"Sharon G. Curhan","orcid":"https://orcid.org/0000-0003-0282-0822","observed_orcids":["https://orcid.org/0000-0003-0282-0822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curhan, Sharon G.","raw_affiliation_strings":["Harvard University","Brigham and Women's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020097225","display_name":"Renato A Polimanti","orcid":"https://orcid.org/0000-0003-0745-6046","observed_orcids":["https://orcid.org/0000-0003-0745-6046"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Polimanti, Renato","raw_affiliation_strings":["Yale University"],"raw_orcid":"https://orcid.org/0000-0003-0745-6046","affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.2549000084400177,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.7990000247955322},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.8050000071525574},{"id":"https://openalex.org/keywords/polygenic-architecture","display_name":"polygenic architecture","score":0.7850000262260437},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/uk-biobank","display_name":"UK Biobank","score":0.746999979019165},{"id":"https://openalex.org/keywords/ancestry-groups","display_name":"ancestry groups","score":0.4399999976158142},{"id":"https://openalex.org/keywords/cadd-score","display_name":"CADD score","score":0.7070000171661377},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.30399999022483826},{"id":"https://openalex.org/keywords/hearing-loss-severity","display_name":"hearing loss severity","score":0.3569999933242798},{"id":"https://openalex.org/keywords/gene-prioritization","display_name":"gene prioritization","score":0.32199999690055847},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.5339999794960022},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.32100000977516174}],"concepts":[{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.5474206209182739},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.44901391863822937},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44340789318084717},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.4342024028301239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42892566323280334},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.40366899967193604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2958988845348358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20734429359436035},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.13858219981193542},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.1304602324962616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0684407651424408},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.056109338998794556},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.052347332239151},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/22799950","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Additional_file_1_of_Sex_differences_in_the_polygenic_architecture_of_hearing_problems_in_adults/22799950","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.22799950","doi":"https://doi.org/10.6084/m9.figshare.22799950","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.22799950","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.22799950.v1","doi":"https://doi.org/10.6084/m9.figshare.22799950.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.22799950.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/22799950","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Additional_file_1_of_Sex_differences_in_the_polygenic_architecture_of_hearing_problems_in_adults/22799950","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.4074000120162964,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6976950283","https://openalex.org/W6977690230","https://openalex.org/W4393531993","https://openalex.org/W4376132003","https://openalex.org/W4210539250","https://openalex.org/W4398250799","https://openalex.org/W3011857650","https://openalex.org/W4392598048","https://openalex.org/W4318070741","https://openalex.org/W4412477663"],"abstract_inverted_index":{"Additional":[0],"file":[1],"1:":[2],"Table":[3,31,39,49,72,105,124,144,163,182,216,236,256,276,296,313,322,337,361,385,439],"S1.":[4],"Definition":[5],"of":[6,28,43,108,127,147,166,219,239,259,279,305,444],"the":[7,14,18,36,54,81,109,116,121,128,135,140,148,155,160,167,174,179,220,227,232,240,247,252,260,267,272,280,287,292,317,334,405,419,445],"combined":[8,22,142],"four-category":[9],"ordinal":[10],"phenotype":[11],"based":[12],"on":[13],"traits":[15,56],"defined":[16],"in":[17,35,58,80,90,120,139,159,178,186,191,211,231,251,271,291,333,359,378,399],"UKB.":[19,192],"Binary":[20],"definitionswere":[21],"to":[23,346],"define":[24],"a":[25,301],"severity/probability":[26],"scalAQe":[27],"hearing":[29,44],"problems.":[30],"S2.":[32],"Environments":[33],"investigated":[34],"GEWIS":[37],"analysis.":[38],"S3.":[40],"Inflation":[41],"statistics":[42],"problem":[45],"genome-wide":[46],"association":[47],"studies.":[48],"S4.":[50],"Genetic":[51],"correlations":[52],"among":[53],"HP":[55,367],"assessed":[57],"UKB":[59,233,253,273,293],"considering":[60,300,368],"sex-combined":[61,118,137,229,249,269,289,347,369],"and":[62,63,213,348],"sex-stratified":[64,335,349],"analyses.":[65,336,350],"rg:":[66,380],"genetic":[67,364,381,406,411,420,425,434],"correlation;":[68,382],"se:":[69,310,415],"standard":[70,311,416,431],"error.":[71,104,312,384],"S5.":[73],"Effect":[74],"size":[75],"comparison":[76],"between":[77],"sex-specific":[78],"findings":[79],"meta-analyses.":[82],"Results":[83,351,371,391],"surviving":[84,352,372,392],"multiple":[85,329,354,373,394],"testing":[86,330,355,374,395],"correction":[87,331,356,375,396],"are":[88,209,357,376,397],"highlighted":[89,210,358],"red.":[91,400],"GWS:genome-wide":[92],"significance":[93],"in;":[94],"REF:":[95,193],"reference":[96,194],"allele;":[97,100,102,195,198],"ALT:":[98,196],"alternative":[99,197],"A1:Effect":[101],"SE:standard":[103],"S6.":[106],"Association":[107,126,146,165,218,238,258,278],"hearing-problem":[110,129,149,168,221,241,261,281],"polygenic":[111,130,150,169,222,242,262,282],"risk":[112,131,151,170,223,243,263,283],"score":[113,132,152,171,224,244,264,284,303],"derived":[114,133,153,172,225,245,265,285],"from":[115,134,154,173,226,246,266,286,428,437],"UKB-NHS-HPFS":[117,228,248,268,288],"meta-analysis":[119,230,250,270,290],"MVP":[122],"cohort.":[123],"S7.":[125],"UKB-only":[136,156,175],"GWAS":[138,158,177],"NHS-HPFS":[141],"sample.":[143,162,181,235,255,275,295],"S8.":[145],"female-specific":[157],"NHS":[161],"S9.":[164],"male-specific":[176],"HPFS":[180],"S10.":[183],"Single-variant":[184],"replication":[185],"other":[187],"ancestry":[188],"groups":[189],"available":[190],"se:standard":[199,383],"error;":[200],"pval:P;":[201],"af:allele":[202],"frequency.":[203],"FDR":[204],"significantand":[205],"nominally":[206,449],"significant":[207,450],"replications":[208],"yellow":[212],"red,":[214],"respectively.":[215],"S11.":[217],"AFR":[234],"S12.":[237],"AMR":[254],"S13.":[257],"CSA":[274],"S14.":[277],"EAS":[294],"S15.":[297],"Prioritized":[298],"genes":[299],"CADD":[302],"threshold":[304],"10.":[306],"MAF:Minor":[307],"allele":[308],"frequency;":[309],"S16.":[314],"HP-associated":[315],"genesin":[316],"Multi-tissue":[318,324],"TWAS":[319],"using":[320],"S-MultiXcan.":[321],"S17.":[323],"TWS":[325],"associations":[326],"after":[327],"Bonferroni":[328,353,393],"identified":[332],"S18.":[338],"Enrichment":[339],"for":[340,389,404,418,433],"specific":[341],"genomic":[342],"features":[343],"with":[344,366,448],"respect":[345],"yellow.":[360],"S19.":[362],"Phenome-wide":[363],"correlation":[365,426,435],"GWAS.":[370],"highlgihted":[377],"red":[379],"S20.":[386],"LCV":[387],"analysis":[388],"HP.":[390],"indicated":[398],"gcp":[401,414],"p:":[402],"p-value":[403],"causality":[407,412,421],"proportion;":[408,413],"gcp:":[409],"posterior":[410],"error":[417,432],"proportion":[422],"estimate;":[423],"rho.est:":[424],"estimate":[427,436],"LCV;":[429],"rho.err:":[430],"LCV.":[438],"S21.":[440],"Environment-specific":[441],"Bayes":[442],"factors":[443],"LD-independent":[446],"variants":[447],"multi-environment":[451],"interactions.":[452]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}