{"id":"https://openalex.org/W4394196434","doi":"https://doi.org/10.6084/m9.figshare.21732916","title":"Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice","display_name":"Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4394196434","doi":"https://doi.org/10.6084/m9.figshare.21732916"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/21732916","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Lack_of_bombesin_receptor-activated_protein_homologous_protein_impairs_hippocampal_synaptic_plasticity_and_promotes_chronic_unpredictable_mild_stress_induced_behavioral_changes_in_mice/21732916","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Lack_of_bombesin_receptor-activated_protein_homologous_protein_impairs_hippocampal_synaptic_plasticity_and_promotes_chronic_unpredictable_mild_stress_induced_behavioral_changes_in_mice/21732916","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067655682","display_name":"Xueping Yao","orcid":"https://orcid.org/0000-0001-7414-5550","observed_orcids":["https://orcid.org/0000-0001-7414-5550"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yao, Xueping","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102943181","display_name":"Xiaoqun Qin","orcid":"https://orcid.org/0000-0002-6729-6796","observed_orcids":["https://orcid.org/0000-0002-6729-6796"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin, Xiaoqun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460757","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0002-2454-3814","observed_orcids":["https://orcid.org/0000-0002-2454-3814","https://orcid.org/0009-0000-3042-3504","https://orcid.org/0009-0002-0833-5019","https://orcid.org/0009-0004-9952-4943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Hui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090298774","display_name":"Jiaoyun Zheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng, Jiaoyun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086358253","display_name":"Zhi Fei Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng, Zhi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008284177","display_name":"Jie Wang","orcid":"https://orcid.org/0000-0002-1399-7079","observed_orcids":["https://orcid.org/0000-0002-1399-7079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Jie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026086311","display_name":"Horst Christian Weber","orcid":"https://orcid.org/0000-0001-9005-6988","observed_orcids":["https://orcid.org/0000-0001-9005-6988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weber, Horst Christian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Liu, Rujiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Rujiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhang, Wenrui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Wenrui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048945123","display_name":"Ji Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeng, Ji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040317451","display_name":"Suhui Zuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuo, Suhui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334241","display_name":"Hui Chen","orcid":"https://orcid.org/0009-0003-2312-3142","observed_orcids":["https://orcid.org/0009-0003-2312-3142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Hui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082981111","display_name":"Yang Xiang","orcid":"https://orcid.org/0000-0002-7865-2565","observed_orcids":["https://orcid.org/0000-0002-7865-2565","https://orcid.org/0000-0001-5865-665X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang, Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100705188","display_name":"Chi Liu","orcid":"https://orcid.org/0000-0003-2872-9576","observed_orcids":["https://orcid.org/0000-0003-2872-9576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Chi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104094395","display_name":"Huijun Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Huijun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062538432","display_name":"Lang Pan","orcid":"https://orcid.org/0000-0003-2324-2144","observed_orcids":["https://orcid.org/0000-0003-2324-2144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pan, Lang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043003419","display_name":"Xiangping Qu","orcid":"https://orcid.org/0000-0003-2794-168X","observed_orcids":["https://orcid.org/0000-0003-2794-168X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qu, Xiangping","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4542999863624573,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4542999863624573,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.3882000148296356,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.5910000205039978},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chronic-unpredictable-mild-stress","display_name":"chronic unpredictable mild stress","score":0.9110000133514404},{"id":"https://openalex.org/keywords/stress-related-disorders","display_name":"stress-related disorders","score":0.722000002861023},{"id":"https://openalex.org/keywords/dendritic-spine-formation","display_name":"dendritic spine formation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dendritic-length","display_name":"dendritic length","score":0.6869999766349792},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.8669999837875366},{"id":"https://openalex.org/keywords/glun2a","display_name":"GluN2A","score":0.8849999904632568},{"id":"https://openalex.org/keywords/synaptophysin","display_name":"synaptophysin","score":0.996999979019165},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6039999723434448},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.6690000295639038},{"id":"https://openalex.org/keywords/sucrose-preference","display_name":"sucrose preference","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6512073278427124},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5647516846656799},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48516613245010376},{"id":"https://openalex.org/C2778654844","wikidata":"https://www.wikidata.org/wiki/Q3305232","display_name":"Chronic stress","level":2,"score":0.47771406173706055},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.408803790807724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3615415096282959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3532257676124573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31669068336486816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09143257141113281}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/21732916","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Lack_of_bombesin_receptor-activated_protein_homologous_protein_impairs_hippocampal_synaptic_plasticity_and_promotes_chronic_unpredictable_mild_stress_induced_behavioral_changes_in_mice/21732916","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.21732916","doi":"https://doi.org/10.6084/m9.figshare.21732916","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.21732916","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.21732916.v1","doi":"https://doi.org/10.6084/m9.figshare.21732916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.21732916.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/21732916","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Lack_of_bombesin_receptor-activated_protein_homologous_protein_impairs_hippocampal_synaptic_plasticity_and_promotes_chronic_unpredictable_mild_stress_induced_behavioral_changes_in_mice/21732916","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6187000274658203}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2356030834","https://openalex.org/W4205250212","https://openalex.org/W2104419734","https://openalex.org/W1992523889","https://openalex.org/W2162743207","https://openalex.org/W2145413665","https://openalex.org/W2545340219","https://openalex.org/W4378347520","https://openalex.org/W4385628866","https://openalex.org/W4382986926"],"abstract_inverted_index":{"Bombesin":[0],"receptor-activated":[1],"protein":[2,7,121,224],"(BRAP)":[3],"and":[4,55,74,80,88,150,170,194,213,241],"its":[5],"homologous":[6,120,223],"in":[8,19,96,109,128,137,215,244],"mice,":[9],"which":[10],"is":[11],"encoded":[12],"by":[13,142],"bc004004":[14],"gene,":[15],"were":[16,40,93],"expressed":[17],"abundantly":[18],"brain":[20],"tissues":[21],"with":[22,29,64],"unknown":[23],"functions.":[24],"We":[25],"treated":[26,63],"bc004004-/-":[27,73,97,132,188],"mice":[28,39,76,98,133,189],"chronic":[30],"unpredictable":[31],"mild":[32],"stress":[33,151,235],"(CUMS)":[34],"to":[35,43,102,125,159,185,234],"test":[36,58],"whether":[37],"those":[38],"more":[41],"vulnerable":[42],"stress-related":[44,126],"disorders.":[45],"The":[46],"results":[47],"of":[48,118,168,172,180,197,206],"forced":[49],"swimming":[50],"test,":[51,54],"sucrose":[52],"preference":[53],"open":[56],"field":[57],"showed":[59,134],"that":[60,116,221],"after":[61,99,111],"being":[62,100],"CUMS":[65,103,113],"for":[66,104],"28":[67],"days":[68,71],"or":[69],"35":[70],"both":[72],"bc004004+/+":[75,87,110],"exhibited":[77,190],"behavioural":[78,91,153,232],"changes":[79,92,149,154,167],"there":[81],"was":[82],"no":[83],"significant":[84],"difference":[85],"between":[86],"bc004004-/-.":[89],"However,":[90],"observed":[94],"only":[95],"exposed":[101],"21":[105],"days,":[106],"but":[107],"not":[108],"21-day":[112],"exposure,":[114],"indicating":[115],"lack":[117],"BRAP":[119,222],"may":[122,225],"cause":[123],"vulnerability":[124],"disorders":[127],"mice.":[129],"In":[130],"addition,":[131],"a":[135,227],"reduction":[136],"recognition":[138,145],"memory":[139,148],"as":[140,175,177,200,202],"revealed":[141],"novel":[143],"object":[144],"test.":[146],"Since":[147],"related":[152,158,184,208],"are":[155],"all":[156],"closely":[157,183],"the":[160,166,216,231,245],"hippocampus":[161],"function":[162],"we":[163],"further":[164],"analyzed":[165],"dendrites":[169],"synapses":[171],"hippocampal":[173],"neurons":[174],"well":[176,201],"expression":[178,204],"levels":[179],"some":[181],"proteins":[182,209],"synaptic":[186,207,242],"function.":[187],"decreased":[191],"dendritic":[192,238],"lengths":[193],"increased":[195],"amount":[196],"immature":[198],"spines,":[199],"altered":[203],"pattern":[205],"including":[210],"GluN2A,":[211],"synaptophysin":[212],"BDNF":[214],"hippocampus.":[217,246],"Those":[218],"findings":[219],"suggest":[220],"have":[226],"protective":[228],"effect":[229],"on":[230],"response":[233],"via":[236],"regulating":[237],"spine":[239],"formation":[240],"plasticity":[243]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}
