{"id":"https://openalex.org/W4394147273","doi":"https://doi.org/10.6084/m9.figshare.1434067","title":"MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori","display_name":"MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W4394147273","doi":"https://doi.org/10.6084/m9.figshare.1434067"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/1434067","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/MiR_2_family_targets_i_awd_i_and_i_fng_i_to_regulate_wing_morphogenesis_in_i_Bombyx_mori_i_/1434067","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/MiR_2_family_targets_i_awd_i_and_i_fng_i_to_regulate_wing_morphogenesis_in_i_Bombyx_mori_i_/1434067","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100721706","display_name":"Ling Lin","orcid":"https://orcid.org/0009-0003-4153-6143","observed_orcids":["https://orcid.org/0009-0003-4153-6143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling, Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008484460","display_name":"Xie Ge","orcid":"https://orcid.org/0000-0002-9410-5174","observed_orcids":["https://orcid.org/0000-0002-9410-5174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ge, Xie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078716119","display_name":"Zhiqian Li","orcid":"https://orcid.org/0000-0002-2932-6798","observed_orcids":["https://orcid.org/0000-0002-2932-6798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Zhiqian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101788613","display_name":"Baosheng Zeng","orcid":"https://orcid.org/0000-0003-2428-7598","observed_orcids":["https://orcid.org/0000-0003-2428-7598"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeng, Baosheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084845938","display_name":"Jun Qiang Xu","orcid":"https://orcid.org/0000-0002-7963-0253","observed_orcids":["https://orcid.org/0000-0002-7963-0253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu, Jun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Chen, Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101612164","display_name":"Peng Shang","orcid":"https://orcid.org/0000-0002-9149-8961","observed_orcids":["https://orcid.org/0000-0002-9149-8961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shang, Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039756363","display_name":"Anthony Amade James","orcid":"https://orcid.org/0000-0001-5577-3308","observed_orcids":["https://orcid.org/0000-0001-5577-3308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A James, Anthony","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112117529","display_name":"Yongping Huang","orcid":"https://orcid.org/0000-0002-3266-1327","observed_orcids":["https://orcid.org/0000-0002-3266-1327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huang, Yongping","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103155114","display_name":"Anjiang Tan","orcid":"https://orcid.org/0000-0003-2431-6168","observed_orcids":["https://orcid.org/0000-0003-2431-6168","https://orcid.org/0000-0002-4425-4315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tan, Anjiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.3353999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.12300000339746475,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wing-morphogenesis","display_name":"wing morphogenesis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/bombyx-mori","display_name":"Bombyx mori","score":0.9670000076293945},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8930000066757202},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.843999981880188},{"id":"https://openalex.org/keywords/microrna-target-validation","display_name":"miRNA target validation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/wing-disc","display_name":"wing disc","score":0.32100000977516174},{"id":"https://openalex.org/keywords/lepidopteran-pest-control","display_name":"lepidopteran pest control","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2778487026","wikidata":"https://www.wikidata.org/wiki/Q134747","display_name":"Bombyx mori","level":3,"score":0.7926238775253296},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.6013652086257935},{"id":"https://openalex.org/C97257150","wikidata":"https://www.wikidata.org/wiki/Q161358","display_name":"Wing","level":2,"score":0.6009988784790039},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40274786949157715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39132213592529297},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14808857440948486},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13297128677368164},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.10608404874801636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06378883123397827}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:figshare.com:article/1434067","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/MiR_2_family_targets_i_awd_i_and_i_fng_i_to_regulate_wing_morphogenesis_in_i_Bombyx_mori_i_/1434067","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1434067","doi":"https://doi.org/10.6084/m9.figshare.1434067","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1434067","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1434067.v1","doi":"https://doi.org/10.6084/m9.figshare.1434067.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1434067.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1434067.v2","doi":"https://doi.org/10.6084/m9.figshare.1434067.v2","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1434067.v2","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.1434067.v3","doi":"https://doi.org/10.6084/m9.figshare.1434067.v3","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.1434067.v3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/1434067","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/MiR_2_family_targets_i_awd_i_and_i_fng_i_to_regulate_wing_morphogenesis_in_i_Bombyx_mori_i_/1434067","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2906429832","https://openalex.org/W2040667858","https://openalex.org/W3025497745","https://openalex.org/W2947268126","https://openalex.org/W4394199771","https://openalex.org/W1978634052","https://openalex.org/W2112578023","https://openalex.org/W2810375091","https://openalex.org/W4322397548","https://openalex.org/W7099996958"],"abstract_inverted_index":{"MicroRNAs":[0],"(miRNAs)":[1],"are":[2,107,113],"post-transcriptional":[3],"regulators":[4,109],"that":[5,30,52,88],"target":[6,191],"specific":[7],"mRNAs":[8],"for":[9,93],"repression":[10],"and":[11,103,118,131,154,160],"thus":[12],"play":[13],"key":[14],"roles":[15],"in":[16,34,43,58,61,81,110,138,143,165,172,183,192],"many":[17],"biological":[18],"processes,":[19],"including":[20],"insect":[21],"wing":[22,59,95,100,146,185],"morphogenesis.":[23,96],"miR-2":[24,53,74,89,116,174,182],"is":[25],"an":[26],"invertebrate-specific":[27],"miRNA":[28],"family":[29],"has":[31],"been":[32],"predicted":[33],"the":[35,45,62,86,144,157,173],"fruit":[36],"fly,":[37],"Drosophila":[38],"melanogaster,":[39],"to":[40,169],"be":[41],"involved":[42],"regulating":[44],"Notch":[46,111],"signaling":[47],"pathway.":[48],"We":[49],"show":[50],"here":[51],"plays":[54],"a":[55,66,73,77,121,189],"critical":[56,179],"role":[57,180],"morphogenesis":[60,186],"silkworm,":[63],"Bombyx":[64,184],"mori,":[65],"lepidopteran":[67,194],"model":[68],"insect.":[69],"Transgenic":[70],"over-expression":[71,175],"of":[72,128,152,181],"cluster":[75],"using":[76,156],"Gal4/UAS":[78],"system":[79,159],"results":[80],"deformed":[82,166],"adult":[83],"wings,":[84],"supporting":[85],"conclusion":[87],"regulates":[90],"functions":[91],"essential":[92],"normal":[94],"Two":[97],"genes,":[98],"abnormal":[99,145],"disc":[101],"(awd)":[102],"fringe":[104],"(fng),":[105],"which":[106],"positive":[108],"signaling,":[112],"identified":[114],"as":[115],"targets":[117],"validated":[119],"by":[120],"dual-luciferase":[122],"reporter":[123],"assay.":[124],"The":[125,178],"relative":[126],"abundance":[127],"both":[129],"awd":[130,153],"fng":[132,155],"expression":[133],"products":[134],"was":[135],"reduced":[136],"significantly":[137],"transgenic":[139,176],"animals,":[140],"implicating":[141],"them":[142],"phenotype.":[147],"Furthermore,":[148],"somatic":[149],"mutagenesis":[150],"analysis":[151],"CRISPR/Cas9":[158],"knock-out":[161],"mutants":[162],"also":[163],"resulted":[164],"wings":[167],"similar":[168],"those":[170],"observed":[171],"animals.":[177],"may":[187],"provide":[188],"potential":[190],"future":[193],"pest":[195],"control.":[196]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-04-08T00:00:00"}