{"id":"https://openalex.org/W4394094375","doi":"https://doi.org/10.6084/m9.figshare.5104444","title":"Supplementary Material for: The structures of mouse and human L1 elements reflect their insertion mechanism","display_name":"Supplementary Material for: The structures of mouse and human L1 elements reflect their insertion mechanism","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W4394094375","doi":"https://doi.org/10.6084/m9.figshare.5104444"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/5104444","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_The_structures_of_mouse_and_human_L1_elements_reflect_their_insertion_mechanism/5104444","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"supplementary-materials","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_The_structures_of_mouse_and_human_L1_elements_reflect_their_insertion_mechanism/5104444","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071390116","display_name":"Sandra L. Martin","orcid":"https://orcid.org/0000-0002-6274-1475","observed_orcids":["https://orcid.org/0000-0002-6274-1475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin, S.L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101445735","display_name":"Pai Li","orcid":"https://orcid.org/0000-0003-3919-3543","observed_orcids":["https://orcid.org/0000-0003-3919-3543","https://orcid.org/0009-0008-3485-4449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W-L.P., Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109386937","display_name":"Anthony V. Furano","orcid":"https://orcid.org/0000-0002-4489-6828","observed_orcids":["https://orcid.org/0000-0002-4489-6828"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Furano, A.V.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084509179","display_name":"St\u00e9phane Boissinot","orcid":"https://orcid.org/0000-0002-8760-1284","observed_orcids":["https://orcid.org/0000-0002-8760-1284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boissinot, S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/line-1-retrotransposons","display_name":"LINE-1 retrotransposons","score":0.9350000023841858},{"id":"https://openalex.org/keywords/retrotransposition","display_name":"retrotransposition","score":0.7179999947547913},{"id":"https://openalex.org/keywords/target-site-duplication","display_name":"target site duplication","score":0.8899999856948853},{"id":"https://openalex.org/keywords/insertion-mechanism","display_name":"insertion mechanism","score":0.8339999914169312},{"id":"https://openalex.org/keywords/interspersed-repetitive-dna","display_name":"interspersed repetitive DNA","score":0.7059999704360962},{"id":"https://openalex.org/keywords/mouse-genome","display_name":"mouse genome","score":0.5910000205039978},{"id":"https://openalex.org/keywords/human-genome","display_name":"human genome","score":1.0}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.8465738892555237},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3806651830673218},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.322134792804718},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24244782328605652},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13034537434577942},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/5104444","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_The_structures_of_mouse_and_human_L1_elements_reflect_their_insertion_mechanism/5104444","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.5104444","doi":"https://doi.org/10.6084/m9.figshare.5104444","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.5104444","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.5104444.v1","doi":"https://doi.org/10.6084/m9.figshare.5104444.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.5104444.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/5104444","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_The_structures_of_mouse_and_human_L1_elements_reflect_their_insertion_mechanism/5104444","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2081293476","https://openalex.org/W2151097873","https://openalex.org/W1980126223","https://openalex.org/W2056788947","https://openalex.org/W2127001813","https://openalex.org/W4415666300","https://openalex.org/W2132556378","https://openalex.org/W1968023581","https://openalex.org/W1965141089","https://openalex.org/W2153586836"],"abstract_inverted_index":{"L1":[0,24,38,75,86,132,198],"is":[1,59,111,121,166,184,195],"an":[2],"abundant,":[3],"interspersed":[4],"repeated":[5],"DNA":[6,28],"element":[7],"of":[8,52,70,73,84,114,150,206],"mammalian":[9],"genomes.":[10],"It":[11,58],"has":[12],"achieved":[13],"its":[14],"high":[15],"copy":[16],"number":[17],"via":[18],"retrotransposition.":[19],"Like":[20],"other":[21],"non-LTR":[22],"retrotransposons,":[23],"insertion":[25,140],"into":[26],"chromosomal":[27],"apparently":[29],"occurs":[30,142],"by":[31,49,143,197],"target-site":[32],"primed":[33],"reverse":[34,76,182],"transcription,":[35],"or":[36],"TPRT.":[37],"retrotransposition":[39],"often":[40],"generates":[41],"elements":[42,66,87],"with":[43,102,131],"5\u2032":[44,64,186],"truncations":[45],"that":[46,62,81,99,119,141,194],"are":[47,67,95],"flanked":[48],"a":[50,112,137,172,190,200],"duplication":[51],"the":[53,63,68,74,82,90,103,148,154,157,176],"genomic":[54],"target":[55,104,126,158],"site":[56,127,159],"(TSD).":[57],"typically":[60],"assumed":[61],"truncated":[65,96],"consequence":[69,113],"poor":[71,115],"processivity":[72],"transcriptase.":[77],"However,":[78],"we":[79,117],"find":[80],"majority":[83],"young":[85],"from":[88],"both":[89],"human":[91],"and":[92,160,179],"mouse":[93],"genomes":[94],"at":[97],"sequences":[98],"can":[100,129],"basepair":[101,130],"site.":[105],"Thus,":[106],"to":[107,123,202],"whatever":[108],"extent":[109],"truncation":[110,120,187],"processivity,":[116],"suggest":[118],"likely":[122],"occur":[124],"when":[125],"sequence":[128],"sequence.":[133],"This":[134],"finding":[135],"supports":[136],"model":[138],"for":[139,169],"two":[144],"sequential":[145],"TPRT":[146],"reactions,":[147],"second":[149],"which":[151],"relies":[152],"upon":[153],"homology":[155],"between":[156,175],"L1.":[161],"Because":[162],"perfect":[163],"heteroduplex":[164],"formation":[165],"not":[167],"required":[168],"all":[170],"insertions,":[171],"dynamic":[173],"relationship":[174],"primer,":[177],"template":[178],"enzyme":[180],"during":[181],"transcription":[183],"inferred.":[185],"may":[188],"be":[189],"successful":[191],"evolutionary":[192],"strategy":[193],"exploited":[196],"as":[199],"means":[201],"escape":[203],"host":[204],"suppression":[205],"transposition.":[207]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-04-08T00:00:00"}