{"id":"https://openalex.org/W4394085605","doi":"https://doi.org/10.6084/m9.figshare.12932839","title":"Supplementary Material for: Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants","display_name":"Supplementary Material for: Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W4394085605","doi":"https://doi.org/10.6084/m9.figshare.12932839"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/12932839","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Tubular_Biomarkers_and_Chronic_Kidney_Disease_Progression_in_SPRINT_Participants/12932839","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"supplementary-materials","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Tubular_Biomarkers_and_Chronic_Kidney_Disease_Progression_in_SPRINT_Participants/12932839","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067435702","display_name":"Vasantha Jotwani","orcid":"https://orcid.org/0000-0003-1913-3957","observed_orcids":["https://orcid.org/0000-0003-1913-3957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jotwani, V.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002533372","display_name":"PRASAD S GARIMELLA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garimella, P.S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022346670","display_name":"Ronit Katz","orcid":"https://orcid.org/0000-0001-7723-7469","observed_orcids":["https://orcid.org/0000-0001-7723-7469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katz, R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013377913","display_name":"Rakesh Malhotra","orcid":"https://orcid.org/0000-0002-4352-2103","observed_orcids":["https://orcid.org/0000-0002-4352-2103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malhotra, R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088618031","display_name":"Jeffrey T. Bates","orcid":"https://orcid.org/0000-0003-1643-675X","observed_orcids":["https://orcid.org/0000-0003-1643-675X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bates, J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054409151","display_name":"Alfred K. Cheung","orcid":"https://orcid.org/0000-0002-7304-9476","observed_orcids":["https://orcid.org/0000-0002-7304-9476"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheung, A.K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110182882","display_name":"Michel Chonchol","orcid":"https://orcid.org/0000-0001-6195-1318","observed_orcids":["https://orcid.org/0000-0001-6195-1318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chonchol, M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046932523","display_name":"Paul E. Drawz","orcid":"https://orcid.org/0000-0001-7301-9253","observed_orcids":["https://orcid.org/0000-0001-7301-9253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Drawz, P.E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087036525","display_name":"Barry I. Freedman","orcid":"https://orcid.org/0000-0003-0275-5530","observed_orcids":["https://orcid.org/0000-0003-0275-5530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freedman, B.I.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103166719","display_name":"William E. Haley","orcid":"https://orcid.org/0000-0002-5312-8660","observed_orcids":["https://orcid.org/0000-0002-5312-8660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haley, W.E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086792088","display_name":"Anthony A. Killeen","orcid":"https://orcid.org/0000-0003-1629-9468","observed_orcids":["https://orcid.org/0000-0003-1629-9468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Killeen, A.A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085471610","display_name":"Henry A. Punzi","orcid":"https://orcid.org/0000-0002-4766-1565","observed_orcids":["https://orcid.org/0000-0002-4766-1565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Punzi, H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076361487","display_name":"Mark J. Sarnak","orcid":"https://orcid.org/0000-0002-2457-6368","observed_orcids":["https://orcid.org/0000-0002-2457-6368","https://orcid.org/0000-0003-4927-6609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarnak, M.J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028740326","display_name":"Mark S. Segal","orcid":"https://orcid.org/0000-0002-5502-2042","observed_orcids":["https://orcid.org/0000-0002-5502-2042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Segal, M.S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071585977","display_name":"Michael G. Shlipak","orcid":"https://orcid.org/0000-0002-9559-204X","observed_orcids":["https://orcid.org/0000-0002-9559-204X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shlipak, M.G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024425228","display_name":"Joachim H. Ix","orcid":"https://orcid.org/0000-0002-8084-9869","observed_orcids":["https://orcid.org/0000-0002-8084-9869"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ix, J.H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5095015066","display_name":"For The SPRINT Research Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"For The SPRINT Research Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tubular-biomarkers","display_name":"tubular biomarkers","score":0.765999972820282},{"id":"https://openalex.org/keywords/uromodulin","display_name":"uromodulin","score":0.902999997138977},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/alpha-1-microglobulin","display_name":"alpha1-microglobulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estimated-glomerular-filtration-rate-decline","display_name":"estimated glomerular filtration rate decline","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.652999997138977},{"id":"https://openalex.org/keywords/intensive-blood-pressure-control","display_name":"intensive blood pressure control","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sprint-trial","display_name":"SPRINT trial","score":0.8659999966621399},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.6729999780654907},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2776868573","wikidata":"https://www.wikidata.org/wiki/Q46855","display_name":"Sprint","level":2,"score":0.7693947553634644},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6559221148490906},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5113996863365173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5047534704208374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4345112144947052},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.23579269647598267}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/12932839","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Tubular_Biomarkers_and_Chronic_Kidney_Disease_Progression_in_SPRINT_Participants/12932839","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.12932839","doi":"https://doi.org/10.6084/m9.figshare.12932839","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12932839","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.12932839.v1","doi":"https://doi.org/10.6084/m9.figshare.12932839.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.12932839.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/12932839","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Material_for_Tubular_Biomarkers_and_Chronic_Kidney_Disease_Progression_in_SPRINT_Participants/12932839","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2012225890"],"abstract_inverted_index":{"Background:":[0],"Kidney":[1],"tubular":[2,17,244],"atrophy":[3],"on":[4],"biopsy":[5],"is":[6,19],"a":[7],"strong":[8],"predictor":[9],"of":[10,38,59,69,243],"chronic":[11],"kidney":[12,252],"disease":[13],"(CKD)":[14],"progression,":[15],"but":[16],"health":[18],"poorly":[20],"quantified":[21],"by":[22,98,196,259],"traditional":[23],"measures":[24,242],"including":[25,165],"estimated":[26],"glomerular":[27],"filtration":[28],"rate":[29],"(eGFR)":[30],"and":[31,63,112,168,173,239],"albuminuria.":[32,169],"We":[33,54,82],"hypothesized":[34],"that":[35],"urinary":[36,130,147],"biomarkers":[37],"impaired":[39],"tubule":[40],"function":[41,245],"would":[42],"be":[43],"associated":[44,133,150,217,247],"with":[45,51,76,91,134,151,218,237,248],"faster":[46,152],"eGFR":[47,78,113,138,155,167,219],"declines":[48,250],"in":[49,95,162,179,221,251],"persons":[50],"CKD.":[52],"Methods:":[53],"measured":[55],"baseline":[56,166,241],"urine":[57],"concentrations":[58],"uromodulin,":[60],"\u03b22-microglobulin":[61],"(\u03b22m),":[62],"\u03b11-microglobulin":[64],"(\u03b11m)":[65],"among":[66],"2,428":[67],"participants":[68,236],"the":[70,104,121,180,222],"Systolic":[71],"Blood":[72],"Pressure":[73],"Intervention":[74],"Trial":[75],"an":[77],"<60":[79],"mL/min/1.73":[80,118],"m2.":[81,119],"used":[83],"linear":[84],"mixed":[85],"models":[86,164],"to":[87],"evaluate":[88],"biomarker":[89],"associations":[90,256],"annualized":[92],"relative":[93],"change":[94],"eGFR,":[96],"stratified":[97],"randomization":[99],"arm.":[100,232],"Results:":[101],"At":[102],"baseline,":[103],"mean":[105],"age":[106],"was":[107,114,132,149,214],"73":[108],"\u00b1":[109,116],"9":[110],"years":[111],"46":[115],"11":[117],"In":[120],"standard":[122,223],"blood":[123,182,261],"pressure":[124,183,262],"treatment":[125,184,197],"arm,":[126],"each":[127],"2-fold":[128],"higher":[129,146],"uromodulin":[131,188],"slower":[135],"%":[136,153],"annual":[137,154],"decline":[139,156,220],"(0.34":[140],"[95%":[141,158],"CI:":[142,159],"0.08,":[143],"0.60]),":[144],"whereas":[145],"\u03b22m":[148,202],"(\u22120.10":[157],"\u22120.18,":[160],"\u22120.02])":[161],"multivariable-adjusted":[163],"Associations":[170],"were":[171,246,257],"weaker":[172],"did":[174],"not":[175,215],"reach":[176],"statistical":[177],"significance":[178],"intensive":[181,228,260],"arm":[185,198],"for":[186,194,208],"either":[187],"(0.11":[189],"[\u22120.13,":[190],"0.35],":[191],"p":[192,206],"value":[193,207],"interaction":[195,209],"=":[199,210],"0.045)":[200],"or":[201,227],"(\u22120.01":[203],"[\u22120.08,":[204],"0.08],":[205],"0.001).":[211],"Urinary":[212],"\u03b11m":[213],"independently":[216],"(0.01":[224],"[\u22120.22,":[225],"0.23])":[226],"(0.03":[229],"[\u22120.20,":[230],"0.25])":[231],"Conclusions:":[233],"Among":[234],"trial":[235],"hypertension":[238],"CKD,":[240],"subsequent":[249],"function,":[253],"although":[254],"these":[255],"diminished":[258],"control.":[263]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}