{"id":"https://openalex.org/W4394069713","doi":"https://doi.org/10.6084/m9.figshare.14320485","title":"A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs","display_name":"A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4394069713","doi":"https://doi.org/10.6084/m9.figshare.14320485"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/14320485","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_comparison_of_mRNA_and_circRNA_expression_between_squamous_cell_carcinoma_and_adenocarcinoma_of_the_lungs/14320485","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/dataset/A_comparison_of_mRNA_and_circRNA_expression_between_squamous_cell_carcinoma_and_adenocarcinoma_of_the_lungs/14320485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yu, Min","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu, Min","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085595821","display_name":"Yingxuan Tian","orcid":"https://orcid.org/0000-0002-6515-9114","observed_orcids":["https://orcid.org/0000-0002-6515-9114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tian, Yingxuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044019415","display_name":"Min Huan Wu","orcid":"https://orcid.org/0000-0001-5462-6920","observed_orcids":["https://orcid.org/0000-0001-5462-6920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wu, Min","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080976966","display_name":"Jinglong Gao","orcid":"https://orcid.org/0000-0002-4466-0516","observed_orcids":["https://orcid.org/0000-0002-4466-0516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gao, Jinglong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344924","display_name":"Yuan Wang","orcid":"https://orcid.org/0009-0006-5941-0081","observed_orcids":["https://orcid.org/0009-0006-5941-0081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Yuan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733017","display_name":"Fuqiang Liu","orcid":"https://orcid.org/0000-0003-0371-639X","observed_orcids":["https://orcid.org/0000-0003-0371-639X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Fuqiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063909441","display_name":"Sen Sheng","orcid":"https://orcid.org/0000-0002-7433-8253","observed_orcids":["https://orcid.org/0000-0002-7433-8253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheng, Sen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084216790","display_name":"Shufen Huo","orcid":"https://orcid.org/0000-0002-1095-6263","observed_orcids":["https://orcid.org/0000-0002-1095-6263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huo, Shufen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056070962","display_name":"Jun Bai","orcid":"https://orcid.org/0000-0003-4589-6560","observed_orcids":["https://orcid.org/0000-0003-4589-6560"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bai, Jun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8949999809265137},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mrna-profiling","display_name":"mRNA expression profiling","score":0.781000018119812},{"id":"https://openalex.org/keywords/competitive-endogenous-rna-network","display_name":"competing endogenous RNA network","score":0.9629999995231628},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5170000195503235},{"id":"https://openalex.org/keywords/epha2","display_name":"EphA2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/epha7","display_name":"EphA7","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ntrk2","display_name":"NTRK2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":1.0},{"id":"https://openalex.org/keywords/stxbp1","display_name":"STXBP1","score":0.8199999928474426},{"id":"https://openalex.org/keywords/pmepa1","display_name":"PMEPA1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk1-erk2-signaling","display_name":"ERK1/ERK2 signaling","score":0.8809999823570251},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6202218532562256},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.590083658695221},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5132558345794678},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44316500425338745},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4233095049858093},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.42286211252212524},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39354002475738525},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38357794284820557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32145628333091736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2881784737110138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27157890796661377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22983336448669434},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2155354619026184},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14397186040878296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08612215518951416},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/14320485","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_comparison_of_mRNA_and_circRNA_expression_between_squamous_cell_carcinoma_and_adenocarcinoma_of_the_lungs/14320485","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.14320485","doi":"https://doi.org/10.6084/m9.figshare.14320485","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.14320485","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.14320485.v1","doi":"https://doi.org/10.6084/m9.figshare.14320485.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.14320485.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/14320485","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_comparison_of_mRNA_and_circRNA_expression_between_squamous_cell_carcinoma_and_adenocarcinoma_of_the_lungs/14320485","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2991357518","https://openalex.org/W4404978490","https://openalex.org/W3179381213","https://openalex.org/W2971895659","https://openalex.org/W2992140692","https://openalex.org/W2997681488","https://openalex.org/W6920934343","https://openalex.org/W4243411944","https://openalex.org/W3009881917","https://openalex.org/W3028347924"],"abstract_inverted_index":{"Abstract":[0],"Lung":[1],"squamous":[2],"cell":[3],"carcinoma":[4],"(LUSC)":[5],"and":[6,26,32,40,49,58,63,70,88,95,114,122,136,144,154,158,167,178,193,204],"lung":[7,17],"adenocarcinoma":[8],"(LUAD)":[9],"are":[10],"the":[11,148,184],"two":[12,185],"major":[13,186],"subtypes":[14,188],"of":[15,150,189],"non\u2013small-cell":[16],"cancer":[18],"(NSCLC).":[19],"This":[20],"study":[21],"aimed":[22],"to":[23,46,75],"compare":[24],"mRNA":[25,48],"circRNA":[27,50],"expression":[28,51,118],"patterns":[29,119,182],"between":[30,61,120],"LUSC":[31,38,62,121,166,203],"LUAD.":[33,123],"Cancer":[34],"tissues":[35],"from":[36],"8":[37],"patients":[39,43],"12":[41],"LUAD":[42,64,153],"were":[44,65,73,98,131,146],"collected":[45],"obtain":[47],"profiles.":[52],"The":[53,100],"differentially":[54],"expressed":[55],"mRNAs":[56],"(DEmRNAs)":[57],"circRNAs":[59],"(DE-circRNAs)":[60],"screened.":[66],"Afterwards,":[67],"miRNA\u2013DEcircRNA":[68],"pairs":[69,72],"miRNA\u2013DEmRNA":[71],"predicted":[74],"construct":[76],"a":[77],"competing":[78],"endogenous":[79],"RNAs":[80],"(ceRNAs)":[81],"network,":[82],"followed":[83],"by":[84],"functional":[85,125],"enrichment":[86,126],"analysis":[87,102,127],"survival":[89],"analysis.":[90],"In":[91,170],"total,":[92],"635":[93],"DEmRNAs":[94,130],"245":[96],"DEcircRNAs":[97],"obtained.":[99],"ceRNA":[101],"revealed":[103],"that":[104,129,142],"genes,":[105],"such":[106,173],"as":[107,162,174,198],"EPHA2,":[108,175],"EPHA7,":[109,176],"NTRK2,":[110,177],"CDK6,":[111],"hsa_circ_027570,":[112],"hsa_circ_006089,":[113],"hsa-circ_035997,":[115],"had":[116,180],"distinct":[117],"Also,":[124],"indicated":[128],"mainly":[132],"enriched":[133],"in":[134,183],"ERK1":[135],"ERK2":[137],"cascade.":[138],"Survival":[139],"analyses":[140],"suggested":[141],"STXBP1":[143],"PMEPA1":[145],"associated":[147],"prognosis":[149],"with":[151],"both":[152],"LUSC,":[155],"whereas":[156],"EPHA2":[157,192],"CDK6":[159,179,194],"might":[160,195],"serve":[161],"prognostic":[163],"factors":[164],"for":[165,202],"LUAD,":[168,205],"respectively.":[169,206],"conclusion,":[171],"genes":[172],"different":[181],"histological":[187],"NSCLC.":[190],"Notably,":[191],"be":[196],"considered":[197],"potential":[199],"therapeutic":[200],"targets":[201]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-04-08T00:00:00"}